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Antidiabetic therapy and increased risk of hepatocellular carcinoma in chronic liver disease

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World Journal of Gastroenterology 2009年第20期15卷 2506-2511页

作者： Valter Donadon Massimiliano Balbi Michela Ghersetti Silvia Grazioli Antonio Perciaccante Giovanni Della Valentina Rita Gardenal Maria Dal Mas Pietro Casarin Giorgio Zanette cesare miranda Department of Medicine Internal Medicine 3rd Pordenone Hospital Diabetes Clinic Pordenone Hospital Via Montereale 24 Pordenone 33170 Italy

AIM： To explore the association between hepatocellular carcinoma （HCC） and type 2 diabetes mellitus, describe the temporal relations between the onset of diabetes and the development of HCC and evaluate the possible effects of antidiabetic therapy on HCC risk,METHODS： We recruited 465 HCC patients, 618 with cirrhosis and 490 control subjects. We evaluated the odds ratio （OR） for HCC by univariate and multivariate analysis. Moreover, OR for HCC in diabetic subjects treated with insulin or sulphanylureas and with metformin were ***： The prevalence of diabetes mellitus was 31.2% in HCC, 233% in cirrhotic patients and 12.7% in the Control group. By univariate and multivariate analysis, the OR for HCC in diabetic patients were respectively 3.12 （CI 2.2-4.4, P 〈 0.001） and 2.2 （CI 1.2-4.4, P = 0.01）. In 84.9% of cases, type 2 diabetes mellitus was present before the diagnosis of HCC. Moreover, we report an OR for HCC of 2.99 （CI 1.34-6.65, P = 0.007） in diabetic patients treated with insulin or sulphanylureas, and an OR of 0.33 （CI 0.1-0.7, P = 0.006） in diabetic patients treated with ***： Our study confirms that type 2 diabetes mellitus is an independent risk factor for HCC and pre-exists in the majority of HCC patients. Moreover, in male patients with type 2 diabetes meUitus, our data shows a direct association of HCC with insulin and sulphanylureas treatment and an inverse relationship with metformin therapy.

关键词： Hepatocellular carcinoma Type 2 diabetes mellitus Insulin Sulphanylureas Metformin

Comparison of laboratory and field electrical resistivity measurements of a gypsum rock for mining prospection applications

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International Journal of Mining Science and Technology 2019年第6期29卷 841-849页

作者： Chiara Caselle Sabrina Bonetto cesare Comina Department of Earth Science (DST) Torino University

Geophysical surveys are frequently applied in mining prospection to detect the presence and volume of ore bodies of different ***,in gypsum ore bodies exploitation,electrical resistivity measurements are usually the most used ***,it has been observed that different electrical resistivity values can be obtained depending on geometrical features and composition of ***,electrical resistivity of gypsum rocks depends on several parameters,such as gypsum purity,nature of secondary minerals,porosity,saturation and interstitial fluid *** and hydrogeological setting,in particular,were recognized as the most influencing *** conditions of gypsum rock masses are also very relevant for exploitability,safety conditions and economic feasibility and should be accurately known during the prospection and planning phases of the *** this work,a relationship between electrical resistivity and saturation degree of gypsum is *** possibility to estimate gypsum porosity with the use of this relationship is also *** reliability of laboratory measurements is finally verified in comparison with field and modelled resistivity *** reported results underline the potentiality of the proposed approach to obtain a reliable characterization of the studied ore body.

关键词： Gypsum rock Electrical resistivity Saturation Porosity Archie ERT Quarry

The neural bases of vitality forms

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National Science Review 2020年第1期7卷 202-213页

作者： Giuseppe Di cesare Marzio Gerbella Giacomo Rizzolatti Cognitive Architecture for Collaborative Technologies Unit Italian Institute of Technology 2. Department of Medicine and Surgery Neuroscience Unit University of Parma Istituto di Neuroscienze Consiglio nazionale delle Ricerche

Unlike emotions, which are short-lasting events accompanied by viscero-motor responses, vitality forms are continuous internal states that modulate the motor behaviors of individuals and are devoid of the autonomic modifications that characterize real emotions. Despite the importance of vitality forms in social life, only recently have neurophysiological studies been devoted to this issue. The first part of this review describes f MRI experiments, showing that the dorso-central insula is activated during the execution, the perception and the imagination of arm actions endowed with different vitality forms as well as during the hearing and the production of speech conveying vitality forms. In the second part, we address the means by which the dorso-central insula modulates the networks for controlling action execution and how the sensory and interoceptive information is conveyed to this insular sector. Finally, we present behavioral data showing the importance of vitality forms in social interactions.

关键词： action observation social interactions emotions insula mirror mechanism

Data-based Fault Tolerant Control for Affine Nonlinear Systems Through Particle Swarm Optimized Neural Networks

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IEEE/CAA Journal of Automatica Sinica 2020年第4期7卷 954-964页

作者： Haowei Lin Bo Zhao Derong Liu cesare Alippi the School of Automation Guangdong University of TechnologyGuangzhou 510006China the School of Systems Science Beijing Normal UniversityBeijing 100875China the Dipartimento di Elettronica e Informazione Politecnico di MilanoMilano 20133Italy the Universita’Della Svizzera Italiana LuganoSwitzerland

In this paper, a data-based fault tolerant control(FTC) scheme is investigated for unknown continuous-time(CT)affine nonlinear systems with actuator faults. First, a neural network(NN) identifier based on particle swarm optimization(PSO) is constructed to model the unknown system dynamics. By utilizing the estimated system states, the particle swarm optimized critic neural network(PSOCNN) is employed to solve the Hamilton-Jacobi-Bellman equation(HJBE) more ***, a data-based FTC scheme, which consists of the NN identifier and the fault compensator, is proposed to achieve actuator fault tolerance. The stability of the closed-loop system under actuator faults is guaranteed by the Lyapunov stability theorem. Finally, simulations are provided to demonstrate the effectiveness of the developed method.

关键词： Adaptive dynamic programming(ADP) critic neural network data-based fault tolerant control(FTC) particle swarm optimization(PSO)

Steady-State Performance Evaluation of Linux TCPs versus TCP Wave over Leaky Satellite Links

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China Communications 2017年第3期14卷 17-30页

作者： Ahmed Abdelsalam cesare Roseti Francesco Zampognaro Department of Electronics Engineering University of Rome "Tor Vergata" Via del Politecnico 1 Rome 00133 Italy

Internet access is becoming even more heterogeneous, including different wireless backhauling links, with Ka-band satellites as a possible alternative. Since communication path is unknown a priori, adoption of PEP solutions to optimize TCP performance over satellite is discouraged to allow dynamic network reconfigurations. To opposite, an endto-end TCP performance evaluation on such a challenging scenario, with possible large latency and transmission losses, is herein considered of paramount importance. Several TCP variants exist to tackle different aspects of communication networks. In Linux, the different TCP congestion control schemes differ from the theoretical formulations and RFC specifications, introducing a varying set of optimizations and options. This aspect makes difficult to identify a standard/reference TCP version for the proposed scenario, while testing with the real protocol stacks is deemed necessary to obtain consistent results. In addition, an innovative end-to-end TCP, namely TCP Wave, is introduced to replace the traditional window-based transmission with a burst-based strategy, representing a valid alternative to Linux TCP. To offer a fair, realistic and comprehensive evaluation, we configured a simulation setup where different Linux TCPs can be run within ns-3 network simulator and compared with TCP Wave.

关键词： TCP satellite internet leaky channels Linux ns-3

Three Dimensional Coupling between Elastic and Thermal Fields in the Static Analysis of Multilayered Composite Shells

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Computer Modeling in Engineering & Sciences 2023年第9期136卷 2551-2594页

作者： Salvatore Brischetto Roberto Torre Domenico cesare Department of Mechanical and Aerospace Engineering.Politecnico di Torino Torino10129Italy

This new work aims to develop a full coupled thermomechanical method including both the temperature profile and displacements as primary unknowns of the *** generic full coupled 3D exact shell model permits the thermal stress investigation of laminated isotropic,composite and sandwich *** and spherical panels,cylinders and plates are analyzed in orthogonal mixed curved reference *** 3D equilibrium relations and the 3D Fourier heat conduction equation for spherical shells are coupled and they trivially can be simplified in those for plates and cylindrical *** exponential matrix methodology is used to find the solutions of a full coupled model based on coupled differential relations with respect to the thickness *** analytical solution is based on theories of simply supported edges and harmonic relations for displacement components and *** sovra-temperature magnitudes are directly applied at the outer faces through static state *** a consequence,the sovra-temperature description is assumed to be an unknown variable of themodel and it is calculated in the sameway as the three *** final systemis based on a set of coupled homogeneous differential relations of second order in the thickness *** system is reduced in a first order differential relation system by redoubling the number of ***,the exponential matrix methodology is applied to calculate the *** temperature field effects are evaluated in the static investigation of shells and plates in terms of displacement and stress *** an appropriate preliminary validation,new benchmarks are discussed for several thickness ratios,geometrical data,lamination sequences,materials and sovra-temperature values imposed at the outer *** make evident the accordance between the uncoupled thermo-mechanical model and this new full coupled thermo-mechanical model without the need to se

关键词： Three-dimensional exact thermo-elastic shellmodel full coupled thermoelasticity three-dimensional fourier heat conduction relation plate and shell geometries laminated and sandwich configurations

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World Journal of Gastroenterology 2010年第32期16卷 4013-4018页

作者： Imerio Angriman Marco Scarpa cesare Ruffolo Department of Surgical and Gastroenterological Sciences University of PadovaVia Giustiniani 2Padova 35128Italy Department of Surgery Veneto Oncological Institute(IOV-IRCCS)Via Giustiniani 2Padova 35128Italy Department of Surgery(IV unit) Regional Hospital Cà FoncelloPiazza Ospedale 1Treviso 31100Italy

Diverticular disease(DD) of the colon is very common in developed countries and is ranked the fifth most important gastrointestinal disease *** management of acute diverticulitis without perforation and peritonitis is still *** related quality of life(HRQL),subjectively perceived by patients,is becoming a major issue in the evaluation of any therapeutic intervention,mainly in patients with chronic *** date only a few published studies can be found on Medline examining HRQL in patients with *** aim of this study was to review the impact of surgery for DD on *** Medline articles regarding HRQL after surgery for colonic DD,particularly those comparing different surgical approaches,were *** has a negative impact on HRQL with lower scores in bowel function and systemic *** surgery-related complications and disease activity have a significant impact on patients' *** no signif icant differences in HRQL between different operations for DD in non-randomized studies were revealed,the only prospective double-blind randomized study that compared laparoscopic and open colectomy found that patients undergoing laparoscopic colectomy had signif icantly reduced major postoperative complication rates and subsequently had better HRQL *** assessment of HRQL could be a good instrument in the selection of appropriate patients for elective surgery as well as in the assessment of surgical outcome.

关键词： Colonic diverticular disease Health related quality of life Laparoscopy

Windmills： Ancestors of the wind power generation

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Frontiers of Mechanical Engineering 2017年第3期12卷 389-396页

作者： cesare ROSSI Flavio RUSSO Sergio SAVINO Department of Industrial Engineering University of Naples "Federico Ⅱ" via Claudio Naples 80125 Italy Consultant of Ufficio Storico Stato Maggiore Esercito Torre Del Greco 80059 Italy

A brief description of the windmills from the second millennium BC to the Renaissance is presented. This survey is a part of several studies conducted by the authors on technology in the ancient world. The windmills are the first motor, other than human muscles, and are the ancestors of the modem wind turbines. Some authors＇ virtual reconstructions of old windmills are also presented. The paper shows that the operating principle of many modem machines had already been conceived in the ancient times by using a technology that was more advanced than expected, but with two main differences, as follows： Similar tasks were accomplished by using much less energy; and the environmental impact was nil or very low. Modem designers should sometimes consider simplicity rather than the use of a large amount of energy.

关键词： windmills ancient machines history of windmill

Analysis of suitable geometrical parameters for designing a tendon-driven under-actuated mechanical finger

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Frontiers of Mechanical Engineering 2016年第2期11卷 184-194页

作者： Francesco PENTA cesare ROSSI Sergio SAVINO Department of Industrial Engineering University of Naples 'FedericoII' Naples 80125 Italy

This study aims to optimize the geometrical parameters of an under-actuated mechanical finger by conducting a theoretical analysis of these parameters. The finger is actuated by a flexion tendon and an extension tendon. The considered parameters are the tendon guide positions with respect to the hinges. By applying such an optimization, the correct kinematical and dynamical behavior of the closing cycle of the finger can be obtained. The results of this study are useful for avoiding the snap- through and the single joint hyperflexion, which are the two breakdowns most frequently observed during experi- mentation on prototypes. Diagrams are established to identify the optimum values for the tendon guides position of a finger with specified dimensions. The findings of this study can serve as guide for future finger design.

关键词： tendon-driven fingers mechanical fingerdesign under-actuated mechanical systems