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Hepatitis C virus and non-Hodgkin's lymphomas:Metaanalysisof epidemiology data and therapy options

World Journal of Hepatology 2016年第2期8卷 107-116页

作者： Gabriele Pozzato cesare mazzaro Luigino Dal Maso Endri Mauro Francesca Zorat Giulia Moratelli PietroBulian Diego Serraino Valter Gattei Department of Medical and Surgical Sciences University of Trieste34100 TriesteItaly Department of Oncology-Haematology Centro di Riferimento OncologicoIRCCS33081 AvianoItaly Epidemiology and Biostatistics Units Centro di Riferimento OncologicoIRCCS33081 AvianoItaly Department of Internal Medicine Pordenone General Hospital33170 PordenoneItaly

Hepatitis C virus(HCV) is a global health problem affecting a large fraction of the world's population: This virus is able to determine both hepatic and extrahepatic diseases. Mixed cryoglobulinemia, a B-cell "benign" lymphoproliferative disorders, represents the most closely related as well as the most investigated HCVrelated extrahepatic disorder. Since this virus is able to determine extrahepatic [non-Hodgkin's lymphoma(NHL)] as well as hepatic malignancies(hepatocellular carcinoma), HCV has been included among human cancer viruses. The most common histological types of HCV-associated NHL are the marginal zone, the lymphoplasmacytic and diffuse large cell lymphomas. The role of the HCV in the pathogenesis of the B-cell lymphoproliferative disorders is confirmed also by the responsiveness of the NHL to antiviral therapy. The purpose of this review is to provide an overview of the recent literature and a meta analysis of the epidemiology data, to explain the role of HCV in the development of NHL's lymphoma. Furthermore, the possibility to treat these HCV-related NHL with the antiviral therapy or with other therapeutic options, like chemotherapy, is also discussed.

关键词： Hepatitis C virus Non-Hodgkin's lymphoma Hepatitis C virus genotypes Alpha-interferon

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