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Recent advances and new insights in the management of early-stage epidermal growth factor receptor-mutated non-small-cell lung cancer

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World Journal of Clinical Oncology 2021年第10期12卷 912-925页

作者： Miguel J Sotelo Jose Luis García cesar torres-mattos Héctor Milián Carlos Carracedo María Angeles González-Ruiz Xabier Mielgo-Rubio Juan Carlos Trujillo-Reyes Felipe Couñago Department of Medical Oncology Hospital María AuxiliadoraDepartment of Medical OncologyCentro Oncológico AliadaOncological Research UnitClínica San GabrielLima 15801Peru Department of Thoracic Surgery Hospital Universitario La PrincesaDepartment of Thoracic SurgeryMD Anderson Cancer CenterDepartment of Thoracic SurgeryHospital HMMadrid 28006Spain Department of Medical Oncology Hospital Nacional Guillermo AlmenaraOncological Research UnitClínica San GabrielLima 15033Peru Department of Thoracic Surgery Hospital Universitario La PrincesaMadrid 28006Spain Department of Medical Oncology Centro Oncológico AliadaLima 15036Peru Department of Radiation Oncology Hospital Universitario Virgen MacarenaSevilla 41009Spain Department of Oncology Hospital Universitario Fundación AlcorcónAlcorcón 28922MadridSpain Department of Thoracic Surgery Hospital de la Santa Creu i Sant PauBarcelona 08041Spain Department of Radiation Oncology Hospital Universitario Quirónsalud MadridHospital La LuzUniversidad Europea de MadridMadrid 28223Spain

Patients with early-stage non-small-cell lung cancer(NSCLC)are candidates for curative surgery;however,despite multiple advances in lung cancer management,recurrence rates remain *** chemotherapy has been demonstrated to significantly prolong overall survival(OS),but this benefit is modest and there is an urgent need for effective new therapies to provide a cure for more *** high efficacy of tyrosine kinase inhibitors(TKIs)against epidermal growth factor receptor-mutated(EGFR)in patients with advanced EGFR-mutated NSCLC has led to the evaluation of these agents in early stages of the *** clinical trials have evaluated the safety and efficacy of EGFR TKIs as an adjuvant treatment,in patients with resected EGFR-mutated NSCLC,and shown that they significantly prolong disease-free survival(DFS),but this benefit does not translate to ***,an interim analysis of the ADAURA trial demonstrated that,surprisingly,osimertinib improved *** led to the study being stopped early,leaving many unanswered questions about its potential effect on OS and its incorporation as a standard adjuvant treatment in this patient *** targeted agents are also being evaluated in locally-advanced disease,with promising results,although prospective studies with larger sample sizes are needed to confirm these *** this article,we review the most relevant studies on the role of EGFR TKIs in the management of early-stage EGFR-mutated NSCLC.

关键词： Non-small-cell lung cancer Early stage Epidermal growth factor receptormutated Epidermal growth factor receptor-mutated-tyrosine kinase inhibitor Adjuvant Neoadjuvant

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Impact of multidrug resistance on the management of bacterial infections in cirrhosis

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World Journal of Clinical Cases 2023年第3期11卷 534-544页

作者： Carlos Terra Ângelo Zambam de mattos Marcelo Souza Chagas Andre torres Denusa Wiltgen Barbara Muniz Souza Renata Mello Perez Gastroenterology-Liver Unit State University of Rio de JaneiroRio de Janeiro 20551-030Rio de JaneiroBrazil Liver Unit Casa de Saúde São José-Rede Santa CatarinaRio de Janeiro 22271-080Rio de JaneiroBrazil Alliance of Brazilian Centers for Cirrhosis Car The ABC GroupRio de Janeiro 20551-030Rio de JaneiroBrazil Liver Unit Federal Hospital of LagoaRio de Janeiro 22470-050Rio de JaneiroBrazil Graduate Program in Medicine:Hepatology Federal University of Health Sciences of Porto AlegrePorto Alegre 90020-090Rio Grande do SulBrazil Gastroenterology and Hepatology Unit Irmandade Santa Casa de Misericórdia de Porto AlegrePorto Alegre 90020-090Rio Grande do SulBrazil Internal Medicine Federal Hospital of LagoaRio de Janeiro 22470-050Rio de JaneiroBrazil Department of Internal Medicine Federal University of Health Sciences of Porto AlegrePorto Alegre 90020-090Brazil Hepatology Division Federal University of Rio de JaneiroRio de Janeiro 21941-617Rio de JaneiroBrazil IDOR D’Or Institute for Research and EducationRio de Janeiro 22281-100Rio de JaneiroBrazil

Patients with cirrhosis have an increased risk of infection and differently from other complications,that over the years are improving in their outcomes,infections in cirrhotic patients are still a major cause of hospitalization and death(up to 50%in-hospital mortality).Infections by multidrug-resistant organisms(MDRO)have become a major challenge in the management of cirrhotic patients with significant prognostic and cost-related *** one third of cirrhotic patients with bacterial infections is infected with MDR bacteria and their prevalence has increased in recent *** infections have a worse prognosis compared to infections by non-resistant bacteria because they are associated with lower rate of infection *** adequate management of cirrhotic patients with infections caused by MDR bacteria depends on the knowledge of some epidemiological aspects,such as the type of infection(spontaneous bacterial peritonitis,pneumonia,urinary tract infection and spontaneous bacteremia),bacteriological profile of antibiotic resistance at each health care unit and site of infection acquisition(community acquired,healthcare associated or nosocomial).Furthermore,regional variations in the prevalence of MDR infections determine that the choice of empirical antibiotic therapy must be adapted to the local microbiological *** treatment is the most effective measure to treat infections caused by ***,optimizing antibiotic prescribing is critical to effectively treat these *** of risk factors for multidrug resistance is essential to define the best antibiotic treatment strategy in each case and the choice of an effective empirical antibiotic therapy and its early administration is cardinal to reduce *** the other hand,the supply of new agents to treat these infections is very ***,specific protocols that include preventive measures must be implemented in order to limit the negative impact of this sev

关键词： Cirrhosis Infection Multidrug-resistance Bacterial Antibiotics Microbiota

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A Comparison between Deductive and Inductive Approaches for Teaching EFL Grammar to High School Students

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基础教育外语教学研究 2023年第6期 29-39页

作者： Carmen Benitez-Correa Paul Gonzalez-torres cesar Ochoa-Cueva Alba Vargas-Saritama 不详

This study had the purpose of testingtwo methods for teaching grammar in Englishasa Foreign Language(EFL)class:the deductive and inductive approaches in terms of effectiveness and *** research was conducted in a public high school in *** students enrolled in the second year of senior high school *** in-service teacher taught the EFL classes during the process of intervention(10 weeks),and two EFL teachers observed all of these classes and recorded the information by filling in observation *** students were administered grammar pretests and post-tests in order to assess their grammar *** results of the tests showed a significant difference in the scores in favor of the inductive *** the statistical analysis of the data obtained from the tests and observation sheets,we concluded that the inductive approach is more effective for teaching grammar in the EFL classroom in terms of instruction and rapport.

关键词： inductive approach deductive approach EFL teaching rapport teaching Grammar

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Mixed-Species Allometric Equations to Quantify Stem Volume and Tree Biomass in Dry Afromontane Forest of Ethiopia

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Open Journal of Forestry 2022年第3期12卷 263-296页

作者： Mindaye Teshome Carlos Moreira Miquelino Eleto torres Gudeta Weldesemayat Sileshi Patricia Povoa de mattos Evaldo Muñoz Braz Hailemariam Temesgen Samuel José Silva Soares da Rocha Mehari Alebachew Departamento de Engenharia Florestal Universidade Federal de Vi&#231 osa (UFV) Vi&#231 osa MG Brazil Central Ethiopia Environment and Forest Research Centre Addis Ababa Ethiopia University of Kwazulu-Natal Pietermaritzburg South Africa Embrapa Florestas Colombo PR Brazil Department of Forest Engineering Resources and Management College of Forestry Oregon State University Corvallis USA Departamento de Ciências Florestais Universidade Federal de Lavras (UFLA) Lavras MG Brazil

Volume and biomass equations are essential tools to determine forest productivity and enable forest managers to make informed decisions. However, volume and biomass estimation equations are scarce for Afromontane forests in Africa in general and Ethiopia in particular. This limits our knowledge of the standing volume of wood, biomass, and carbon stock of the forests therein. In this study, we developed a new mixed-species volume and biomass equations for Afromontane forests and compared them with generic pantropical and local models. A total of 193 sampled trees from seven dominant tree species were used to develop the equations. Various volume and biomass equations were fitted using robust linear and nonlinear regression. Model comparison indicated that the best model to estimate stem volume was ln(v)=-9.909+ 0.954*ln(d2h), whereas the best model to estimate biomass was ln(b)=-2.983+ 0.949*ln(ρd2h) . These equations explained over 85% of the variations in the stem volume and biomass measurements. The mean density and basal area of trees in the forest with d ≥ 2 cm was 631.5 stems·ha-1 and 24.4 m2·ha-1. Based on the newly developed equations, the forest has on average 303.0 m3·ha-1 standing volume of wood and 283.8 Mg·ha-1 biomass stock. The newly developed allometric equations derived from this study can be used to accurately determine the stem volume, biomass, and carbon storage in the Afromontane forests in Ethiopia and elsewhere with similar stand characteristics and ecological conditions. By contrast, the generic pan-tropical and other local models appear to provide biased estimates and are not suitable for dry Afromontane forests in Ethiopia. The estimated stem biomass and carbon stock in the Chilimo forest are comparable with the estimates from various tropical forests and woodlands elsewhere in Africa, indicating the importance of dry Afromontane fores

关键词： Carbon Stock Site-Specific Model Robust Regression Natural Forest

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Functional N-Representability in 2-Matrix,1-Matrix,and Density Functional Theories

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Journal of Modern Physics 2013年第3期4卷 391-400页

作者： Eduardo V.Ludena F.Javier torres cesar Costa Prometheus Program SenescytQuitocuador Grupo Ecuatoriano para el Estudio Experimental y Teorico de Nanosistemas(GETNano) Universidad San Francisco de Quito(USFQ)Edificion NewtonOficina N102C Diego de Robles y Via InteroceanicaQuitoEcuador Grupo de Quimica Computacional y Teorica(QCT-USFQ) Universidad San Francisco de Quito(USFQ)Diego de Robles y Via InteroceanicaC.P.17-1200-841QuitoEcuador Departamento de Fisica Escuela Politecnica Nacional(EPN)Ladron de Guevara E11-256QuitoEcuador

The N-representability conditions on the reduced second-order reduced density matrix (2-RDM), impose restrictions not only in the context of reduced density matrix theory (RDMT), but also on functionals advanced in one-matrix theory such as natural orbital functional theory (NOFT), and on functionals depending on the one-electron density such as those of density functional theory (DFT). We review some aspects of the applications of these N-representability conditions in these theories and present some conclusions.

关键词： N-Representability DFT D1-Matrix Theory D2-Matrix Theory

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Sustainable Potato Production in the Mountain Area of Ecuador, an Approach to Increase Productivity with Small Scale Farmers

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Agricultural Sciences 2022年第10期13卷 1080-1090页

作者： Alicia Villavicencio Chang Hwan Park Kangjin Cho Rona Bae Diego Peñ aherrera Gabriela Narváez Victoria López José Camacho Jovanny Suquillo Fausto Yumisaca cesar Asaquibay María Nieto David Ortega Verónica Quimbiamba Cristian torres Edwin Naranjo Stalin Cuenca Ricardo Alvarez Korean Program on International Agriculture and Technology—KOPIA Quito Ecuador Instituto Nacional de Investigaciones Agropecuarias—INIAP Quito Ecuador Extension Services KOPIA-INIAP Quito Ecuador

Ecuador potato crop is family based production system. Potato production has two roles in their economy, the first is providing food for their families and the second is a source of income for the household. However small scale farmers have limited access to local markets and most of the sales are through intermediates’ who purchase directly in the field at the lowest price possible. Potato production challenges for the small-scale farmers are among others availability of quality potato seed, direct sales, purchase of agrochemical inputs to maintain their crops and lack of education. In 2021, only 4% of potato farmers used certified seed. Potato yield is still low around 16.1 t·ha-1, in the last 10 years the total potato cultivated area was reduced by at least 50%. The farmers produce “Bokashi” and other organic fertilizer and these are effective to improve soil fertility and plant health. Homemade bio-pesticides reduce agrochemical pesticides. The Decision Support System (DSS) is a handheld device to control late blight, minimizes fungicide applications and improve fungicide rotation. In 2018 Candidatus Liberibacter solanacearum (Lso), the causal agent of zebra chip, and its vector, the potato psyllid Bactericera cockerelli, together created havoc for farmers and researchers. Promotion of early potato varieties INIAP—Libertad is an alternative to lower the impact of this newest pest.

关键词： Potato Yield Small-Scale Farmers Agro-Ecological Production Quality Seed

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Behavioral study with Erythrina velutina fractions

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Asian Pacific Journal of Tropical Medicine 2009年第5期2卷 30-33页

作者： Silvania Maria Mendes Vasconcelos Natalia Martins Lima Lucas Siqueira de Lucena Alexandre cesar Praxedes Rodrigues Edilberto Rocha Silveira Carlos Clayton torres Aguiar Paula Matias Soares Francisca Clea Florenco de Sousa Glauce Socorro de Barros Viana Department of Physiology and Pharmacology Federal University of CearaRua Cel.Nunes de Melo 112760431-270FortalezaCearaBrazil Department of Organic Chemistry Federal University of CearaAv.Mister Hull60455-760FortalezaCearaBrazil

Objective:To study the behavioral effects of semi purified fraction prepared from the stem bark of Erythrina velutina on ***:Three chloroformic fractions(CA) at 50 or 100 mg/kg(CA1,CA2 and CA3) were tested in two behavioral tests;plus maze and open ***:In the plus maze test,it was observed a decrease in the number of entries in the closed arms(NECA) CA2 at both doses as compared to the control *** the open field test,CA2 and CA3 fractions decreased the number of squares crossed and the time of permanence on the bar,increased the number of falls at both doses in the rota rod *** CA2 fraction decreased the NECA,but this data did not characterize an anxiolytic *** was the consequence from decrease of locomotor activity(LA) observed in the open field test,that the decrease of LA and rearing,the number of falls and the decrease in time of permanence on the bar in rota rod test were observed after treatment with CA2 and CA3 at both doses,suggesting sedative ***:The present work demonstrated that CA2 and CA3 fractions have impairing effect on LA and motor coordination.

关键词： Erythrina relutina Fraction Locomotor activity Motor coordination

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Estimation of Genetic Parameters of Turiacu Pineapple Clones and Genetic Correlation between Traits

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Agricultural Sciences 2017年第11期8卷 1253-1262页

作者： Guilherme Barbosa Abreu Marcos Miranda Toledo Marcelo mattos Cavallari Jose Ribamar Gusmao Araujo Antonia Alice Costa Rodrigues Luiz Gustavo de Lima Melo Augusto cesar Vieira Neves Junior Embrapa Cocais(CPACP) Sao LuisBrazil Embrapa Pecuária Sudeste(CPPSE) Sao CarlosBrazil Universidade Estadual do Maranhao(UEMA) Sao LuisBrazil Universidade Federal Rural de Pernambuco(UFRPE) RecifeBrazil

This study aimed to estimate genetic parameters of Turiaçu pineapple clones using mixed models;and estimate genetic correlation coefficient between traits, to provide important information to breeding programs. For this, 19 pineapple plants were visually selected and its slips were collected and planted in a single environment and nine traits were evaluated. The genetic parameters of most evaluated traits presented significant differences between the 19 clones. Some traits, such as Fusarium wilt resistance, showed high magnitudes of heritability. Clones did not differ in relation to total titratable acidity (TTA) and total soluble solids (TSS). However, these traits, which have implications to fruit quality, showed to be negatively correlated to fruit mass (-0.46 and -0.67). The results indicate that the population of Turiaçu pineapple is suitable for selection, especially for Fusarium wilt resistance. Also, Turiaçu clones can be used in breeding programs of pineapple.

关键词： Quantitative Genetics Plant Breeding Ananas comosus

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Can we really opt in terms of ergonomic methodologies and/or approaches?

Can we really opt in terms of ergonomic methodologies and/or...

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第十七届国际工效学大会暨中国人类工效学会成立20周年庆祝大会

作者： Marcello Silva e Santos José Mario Carvo Daniela Alessandra Cassano Raphael Pacheco da Rocha Carolina Moura mattos José Roberto Mafra Renato José Bonfatti Mario cesar Vidal Ergonomic Research Unit GENTELuis Alberto Coimbra Research InstituteCOPPEFederal University of Rio de JaneiroUFRJ

The aim of this paper is to contribute to the discussion of the supposed epistemological conflict among ergonomic *** supposed unifying lemma of ergonomics-fit the task to the humans-in reality set us in front of serious dilemmas concerning the adequate choice of pertinent *** the singularity of the majority of micro-ergonomics approaches,Ergonomics work analysis and Macroergonomics,we shows an alternative approach-the ergonomic screening-enlightened by two case studies in building and in a process *** conclusion,some major advise should be outlined,under a practitioner point of view:a) obtaining a few positives results is much better than have no results at all;b) The present is the door for the past as well as it leads to the Future,c) Beginning is just a start,but we must do it before proceeding.

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Combining Ability and Heterosis in Corn Breeding Lines to Forage and Grain

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American Journal of Plant Sciences 2014年第6期5卷 845-856页

作者： cesar Guerrero Guerrero Miguel A. Gallegos Robles José Guadalupe Luna Ortega Ignacio Orona Castillo Cirilo Vázquez Vázquez Mario García Carrillo Alejandro Moreno Resendez Anselmo González torres Catederatico de la Universidad Politécnica de la Región Laguna México Catederaticos de la UAAAAUL Torreon México Direccion General de Educación Tecnológica Industrial Torreón México Universidad Juárez del Estado de Durango Venecia Dgo México

This study was conducted in two stages, in 2006 the formation of cross, in the experimental field of the Universidad Autonoma Agraria Antonio Narro Unidad Laguna (UAAANUL), and the evaluation of the same in 2007;at two locations with three environments, a locality was the experimental field of UAAANUL during spring and summer cycles and another location was the Niagara, Municipality of Aguascalientes, during the spring cycle. The genetic material used consisted of three groups of lines: the first group formed by four lines from the UAAANUL, the second group, two lines from INIFAP, and the third group, 10 lines of the International Center for Maize Improvement and Wheat (CIMMYT). The main objective was to estimate the effects of general combining ability (GCA) of the lines, and the specific combining ability (SCA) of their crosses and heterosis, to estimate its use in a breeding program. Estimates of general combining ability (GCA) and specific combining ability (SCA) were obtained using an analysis of line x line. To forage yield (FY), B-40 (16.84 t·ha-1) and AN-447 (1.54 t·ha-1) and to grain yield (GY), AN-388R (2.31 t·ha-1) had the greatest effect of GCA in both types of yield. The greatest effects of SCA for (FY) were cross AN-447XCML-264 (17.56 t·ha-1) and AN-388RXCML-319 (16.54 t·ha-1), in (GY) were cross AN-447XCML-315 (1.94 t·ha-1) and B-40XCML-319 (1.78 t·ha-1). For heterosis, higher value in forage yield was cross AN-447XCML-264 (20.7%), in grain yield, were B-40XCML-319 (27.1%) and B-32XCML-319 (22.1%) crosses. These results show that it is possible to structure a hybrid program using best lines from CIMMYT, INIFAP and UAAANUL.

关键词： Zea mays L. Hybrids Genetic Material Crosses SCA

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