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A DNA tetrahedron-based ferroptosis-suppressing nanoparticle: superior delivery of curcumin and alleviation of diabetic osteoporosis

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Bone Research 2024年第1期12卷 227-239页

作者： Yong Li Zhengwen Cai Wenjuan ma Long Bai en Luo Yunfeng Lin State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases West China Hospital of StomatologySichuan UniversityChengduSichuan 610041PR China Department of Oral and maxillofacial Surgery Affiliated Stomatological HospitalSouthwest Medical UniversityLuzhouSichuan 646000PR China Sichuan Provincial engineering Research Center of Oral Biomaterials ChengduSichuan 610041China

Diabetic osteoporosis(DOP)is a significant complication that poses continuous threat to the bone health of patients with diabetes;however,currently,there are no effective treatment *** patients with diabetes,the increased levels of ferroptosis affect the osteogenic commitment and differentiation of bone mesenchymal stem cells(BMSCs),leading to significant skeletal *** address this issue,we aimed to target ferroptosis and propose a novel therapeutic approach for the treatment of *** synthesized ferroptosis-suppressing nanoparticles,which could deliver curcumin,a natural compound,to the bone marrow using tetrahedral framework nucleic acid(tFNA).This delivery system demonstrated excellent curcumin bioavailability and stability,as well as synergistic properties with *** in vitro and in vivo experiments revealed that nanoparticles could enhance mitochondrial function by activating the nuclear factor E2-related factor 2(NRF2)/glutathione peroxidase 4(GPX4)pathway,inhibiting ferroptosis,promoting the osteogenic differentiation of BMSCs in the diabetic microenvironment,reducing trabecular loss,and increasing bone *** findings suggest that curcumin-containing DNA tetrahedron-based ferroptosissuppressing nanoparticles have a promising potential for the treatment of DOP and other ferroptosis-related diseases.

关键词： curcumin osteoporosis diabetic

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On the Proper Holomorphic mappings between Equidimensional Hartogs Domains over Hermitian Symmetric manifolds

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Acta mathematica Sinica,english Series 2024年第5期40卷 1215-1228页

作者： en Chao BI School of mathematics and Statistics Qingdao UniversityQingdao 266071P.R.China

In this paper,we study a family of Hartogs domains fibred over Hermitian symmetric manifolds being a unit ball in C^(m).The aim of the present study is to establish the rigidity results about proper holomorphic mappings between two equidimensional Hartogs domains over Hermitian symmetric *** particular,we can fully determine its biholomorphic equivalence and automorphism group.

关键词： Proper holomorphic mapping Hartogs domains Hermitian symmetric manifolds

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Spherical Polyelectrolyte Brush Nanoreactor:Preparation of Hollow TiO_(2) Nanospheres and Characterization by Small Angle X-Ray Scattering

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Chinese Journal of Polymer Science 2024年第9期42卷 1393-1400,I0009页

作者： Yu-Hua Zhang Zi-Yu Zhang Xin Liu en-Guang ma Jiang-Tao Guo Li Li Xu-Hong Guo State Key Laboratory of Chemical engineering East China University of Science and TechnologyShanghai200237China Shandong Provincial Key Laboratory of Monocrystalline Silicon Semiconductor materials and Technology College of Chemistry and Chemical EngineeringDezhou UniversityDezhou253023China Institute of Bast Fiber Crops&Center of Southern Economic Crops Chinese Academy of Agricultural SciencesChangsha410205China

Titanium dioxide(TiO_(2))hollow nanoparticles present significant potential for photocatalytic applications while their straightforward preparation with precise structure control is still *** work reports the approach to preparing tunable hollow TiO_(2) nanospheres by utilization of spherical polyelectrolyte brushes(SPB)as nanoreactors and *** the preparation,the evolution of the structure was characterized by small angle X-ray scattering(SAXS),and in combination with dynamic light scattering and transmission electron *** formation of TiO_(2) shell within the brush(SPB@TiO_(2))is confirmed by the significant increase of the electron density,and its internal structure has been analyzed by fitting SAXS data,which can be influenced by Titanium precursors and ammonia *** calcining SPB@TiO_(2) in a muffle furnace,hollow TiO_(2) nanospheres are produced,and their transition to the anatase crystal form is triggered,as confirmed by X-ray diffraction *** the advantages of their hollow structure,these TiO_(2) nanospheres exhibit exceptional catalytic degradation efficiency of methylene blue(MB),tetracycline(TC),and 2,4-dichlorophenoxyacetic acid(2,4-D),and also demonstrate excellent recyclability.

关键词： Spherical polyelectrolyte brush Nanoreactor Hollow titanium dioxide X-ray scattering

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New direction for surgery:Super minimally invasive surgery

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World Journal of Gastroenterology 2024年第12期30卷 1676-1679页

作者： en-Qiang Linghu Department of Gastroenterology First Medical Center of Chinese PLA General HospitalBeijing 100853China

The top goal of modern medicine is treating disease without destroying organ structures and making patients as healthy as they were before their *** invasive surgery(MIS)has dominated the surgical realm because of its lesser ***,changes in anatomical structures of the body and reconstruction of internal organs or different organs are common after traditional surgery or MIS,decreasing the quality of life of patients ***,I propose a new treatment mode,super MIS(SMIS),which is defined as“curing a disease or lesion which used to be treated by MIS while preserving the integrity of the organs”.In this study,I describe the origin,definition,operative channels,advantages,and future perspectives of SMIS.

关键词： Super minimally invasive surgery Minimally invasive surgery Treatment mode Traditional Surgery New direction for surgery

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Improved Segmented Belief Propagation List Decoding for Polar Codes with Bit-Flipping

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China Communications 2024年第3期21卷 19-36页

作者： mao Yinyou Yang Dong Liu Xingcheng Zou en School of Electronics and Information Technology(SEIT) Sun Yat-sen University(SYSU)Guangzhou 510006China School of Information Science Guangzhou Xinhua UniversityGuangzhou 510520China Southern marine Science and engineering Guangdong Laboratory(Zhuhai) Zhuhai 519080China

Belief propagation list(BPL) decoding for polar codes has attracted more attention due to its inherent parallel nature. However, a large gap still exists with CRC-aided SCL(CA-SCL) *** this work, an improved segmented belief propagation list decoding based on bit flipping(SBPL-BF) is proposed. On the one hand, the proposed algorithm makes use of the cooperative characteristic in BPL decoding such that the codeword is decoded in different BP decoders. Based on this characteristic, the unreliable bits for flipping could be split into multiple subblocks and could be flipped in different decoders simultaneously. On the other hand, a more flexible and effective processing strategy for the priori information of the unfrozen bits that do not need to be flipped is designed to improve the decoding convergence. In addition, this is the first proposal in BPL decoding which jointly optimizes the bit flipping of the information bits and the code bits. In particular, for bit flipping of the code bits, a H-matrix aided bit-flipping algorithm is designed to enhance the accuracy in identifying erroneous code bits. The simulation results show that the proposed algorithm significantly improves the errorcorrection performance of BPL decoding for medium and long codes. It is more than 0.25 d B better than the state-of-the-art BPL decoding at a block error rate(BLER) of 10^(-5), and outperforms CA-SCL decoding in the low signal-to-noise(SNR) region for(1024, 0.5)polar codes.

关键词： belief propagation list(BPL)decoding bit-flipping polar codes segmented CRC

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Melt flow,heat transfer and solidification in a flexible thin slab continuous casting mold with vertical-combined electromagnetic braking

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Journal of Iron and Steel Research International 2024年第2期31卷 401-415页

作者： Lin Xu Ze-feng Han Christian Karcher en-gang Wang Key Laboratory of Electromagnetic Processing of materials(Ministry of Education) Northeastern UniversityShenyang110819LiaoningChina Key Laboratory of Liaoning Province for Clean Combustion Power Generation and Heating Technology Shenyang Institute of EngineeringShenyang110136LiaoningChina Institute of Thermodynamics and Fluid Mechanics Technische Universität IlmenauIlmenau98684Germany

During continuous casting of steel slabs,the application of electromagnetic braking technology(EMBr)provides an effective tool to influence solidification by controlling the pattern of melt flow in the ***,the quality of the final product can be improved considerably.A new electromagnetic braking(EMBr)method,named vertical-combined electromagnetic braking(VC-EMBr),is proposed to be applied to a flexible thin slab casting(FTSC)*** evaluate the beneficial effects of the VC-EMBr,the melt flow,heat transfer,and solidification processes in the FTSC mold are studied by means of numerical *** detail,a Reynolds-averaged Navier–Stokes turbulence model together with an enthalpy-porosity approach was *** numerical findings are compared with respective simulations using the traditional *** results demonstrate that the application of the VC-EMBr contributes significantly to preventing relative slab *** contrast to the Ruler-EMBr,the additional vertical magnetic poles of the VC-EMBr preferentially suppress the direct impact of jet flow on the narrow face of FSTC mold and considerably diminish the level fluctuation near the meniscus *** instance,by applying a magnetic flux density of 0.3 T,the maximum amplitude of meniscus deflection reduces by about 80%.Moreover,the braking effect of the VC-EMBr effectively improves the homogeneity of temperature distribution in the upper recirculation region and increases the solidified shell thickness along the casting *** this basis,the newly proposed VC-EMBr shows a beneficial effect in preventing relative slab defects for FTSC thin slab continuous casting.

关键词： Electromagnetic braking Mold Melt flow Heat transfer Solidification

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Boost VS_(2) electrochemical reactive kinetics by regulating crystallographic planes and coupling carbon matrix for high performance sodium-ion storage

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Rare Metals 2024年第1期43卷 98-112页

作者： Min Zeng Ming-Shan Wang Lin Chen en-Zhi Li Zhen-Liang Yang Dan Zhou Hai-Jiao Xie Jun-Chen Chen Zhi-Yuan ma Bing-Shu Guo Bo Yu Xing Li School of New energy and materials Southwest Petroleum UniversityChengdu 610500China energy Storage Research Institute Southwest Petroleum UniversityChengdu 610500China Institute of materials China Academy of Engineering PhysicsMianyang 621908China Beijing Advanced Innovation Center for materials Genome engineering University of Science and TechnologyBeijingBeijing 100083China Hangzhou Yanqu Information Technology Co. Ltd.Hangzhou 310003China

Vanadium disulfide(VS_(2)) as a typical two-dimensional transition metal chalcogenide has excellent competitiveness for sodium-ion storage due to its wide layer spacing(0.575 nm),high theoretical capacity of 932mah·g^(-1) originating from multi-electron electrochemical ***,continuous sodiation process accompanied by crystal structural evolution and collapse cause rapid capacity ***,novel few-layer VS_(2)nanosheets with open(001) crystal planes are in-situ constructed on reduced graphene oxide to solve these issues mentioned *** indicates that few-layer VS_(2)provides more Na^(+) storage activity due to the low Na^(+)surface migration energy barrier on exposed crystal(001)*** flexible and high electronic conductivity of carbon matrix also effectively builds multi-level buffer structure and electron transport kinetics to boost the Na^(+)insertion/conversion reactive activity on VS_(2) as well as Na^(+) pseudocapacitance storage kinetics on edges and defects of nano *** coupling effects result in high rate capability and long cycling stability as a battery/capacitor *** delivers conspicuous high energy density of 81 and 40 Wh·kg^(-1) at power density of 118 and 10,286W·kg^(-1),as well as 80% energy retention rate after 5000cycles,confirming its great application potential in sodiumbased storage devices.

关键词： Vanadium disulfide Reduced graphene oxide Anode Sodium-ion battery Sodium-ion capacitor

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The Perturbed Compound Poisson Risk Model with Proportional Investment

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Acta mathematicae Applicatae Sinica 2024年第1期40卷 109-128页

作者： Nai-dan Deng Chun-wei Wang Jia-en Xu School of mathematics and Statistics Henan University of Science and TechnologyLuoyang471023China

In this paper, the insurance company considers venture capital and risk-free investment in a constant proportion. The surplus process is perturbed by diffusion. At first, the integro-differential equations satisfied by the expected discounted dividend payments and the Gerber-Shiu function are derived. Then, the approximate solutions of the integro-differential equations are obtained through the sinc method. Finally, the numerical examples are given when the claim sizes follow different distributions. Furthermore, the errors between the explicit solution and the numerical solution are discussed in a special case.

关键词： expected discounted dividend payments lognormal distribution proportional investment perturbed risk model sinc numerical method

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In situ direct reprogramming of astrocytes to neurons via polypyrimidine tract-binding protein 1 knockdown in a mouse model of ischemic stroke

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Neural Regeneration Research 2024年第10期19卷 2240-2248页

作者： Meng Yuan Yao Tang Tianwen Huang Lining Ke en Huang Key Laboratory of Brain Aging and Neurodegenerative Diseases of Fujian Province Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Human Anatomy School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Scientific Research Center School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurology Fujian Medical University Union HospitalFuzhouFujian ProvinceChina Fujian Key Laboratory of Vascular Aging Fujian Medical UniversityFuzhouFujian ProvinceChina

In situ direct reprogramming technology can directly convert endogenous glial cells into functional neurons in vivo for central nervous system repair. Polypyrimidine tract-binding protein 1(PTB) knockdown has been shown to reprogram astrocytes to functional neurons in situ. In this study, we used AAV-PHP.e B-GFAP-sh PTB to knockdown PTB in a mouse model of ischemic stroke induced by endothelin-1, and investigated the effects of GFAP-sh PTB-mediated direct reprogramming to neurons. Our results showed that in the mouse model of ischemic stroke, PTB knockdown effectively reprogrammed GFAP-positive cells to neurons in ischemic foci, restored neural tissue structure, reduced inflammatory response, and improved behavioral function. These findings validate the effectiveness of in situ transdifferentiation of astrocytes, and suggest that the approach may be a promising strategy for stroke treatment.

关键词： astrocyte in situ direct reprogramming ischemic stroke miR-30 based shRNA neuron polypyrimidine tract-binding protein 1 transdifferentiation

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Near real-time gravitational wave data analysis of the massive black hole binary with TianQin

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Science China(Physics,Mechanics & Astronomy) 2024年第7期67卷 175-186页

作者： Hong-Yu Chen Xiang-Yu Lyu en-Kun Li Yi-Ming Hu MOE Key Laboratory of TianQin Mission TianQin Research Center for Gravitational Physics&School of Physics and AstronomyFrontiers Science Center for TianQinGravitational Wave Research Center of CNSASun Yat-sen University(Zhuhai Campus)Zhuhai 519082China

Space-borne gravitational wave(GW)detectors can detect the merger of massive black *** early warning and localization of GW events before merging can be used to inform electromagnetic telescopes and conduct multimessenger ***,this requires real-time data transmission and analysis *** geocentric orbit of the space-borne GW detector Tian Qin makes it possible to conduct real-time data *** this study,we develop a search and localization pipeline for massive black hole binaries(MBHBs)with Tian Qin under both regular and real-time data transmission *** demonstrate that,with real-time data transmission,MBHBs can be accurately localized on the *** the approaching merger,each analysis can be finished in only 40 *** an MBHB system at a distance of 1 Gpc,if we receive data every hour,then we can pinpoint its location to within less than 1 deg^(2)on the final day before the merger.

关键词： gravitational wave detectors and experiments black holes data analysis algorithms and implementation data management

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