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Efficacy of intramuscular matrine in the treatment of chronic hepatitis B

Hepatobiliary & Pancreatic Diseases International 2004年第1期3卷 69-72页

作者： Yao Long, Xiao-Tian Lin, Kun-Lun Zeng and Lian Zhang Zhanjiang, china Department of Infectious Diseases, Affiliated hospital of guangdong medical College, Zhanjiang 524001, china Haibin centre hospital, Zhanjiang 524005, china centre of hepatology of nanfang hospital, first military medical university, guang- zhou 510515, china Department of Infectious Diseases Affiliated Hospital of Guangdong Medical College Zhanjiang 524001 China. zjlongyao@***

BACKGROUND: Hepatitis B virus (HBV) infection, a glo- bal public health problem, is the leading cause of cirrhosis and hepatocellular carcinoma (HCC) worldwide. There are more than 350 million HBV carriers in the world and up to one million die annually due to hepatitis B associated liv- er disease. So far no optimal treatment is available for pa- tients with chronic hepatitis B. In the paper we investigated the efficacy of intramuscular matrine in the treatment of chronic hepatitis B. METHODS: One hundred and twenty patients with chronic hepatitis B were randomly divided into matrine treatment group (n =60) and control group (n =60). The patients of the matrine group were given intramuscularly with matrine (an alkaloid extracted from a traditional Chinese herb Radix Sophorae Flavescentis by guangzhou Ming Xing Pharmaceu cal Factory, guangzhou, china) of 100 mg daily for 90 days in addition to conventional liver-protective drugs in- cluding glucurone, inosine, compound vitamin B and caryophyllin. The control group received conventional liv- er-protective drugs alone. Clinical manifestations and labo- ratory parameters including liver biochemistry and serum hepatitis B virus markers were monitored before and after treatment in the two groups. RESULTS: Significant differences were seen between the two groups in terms of improvement of clinical symptoms and signs, recovery of liver functions, and serum conver- sion from hepatitis Be antigen to HBe antibody and from positive to negative serum HBV DNA (P <0.05-0.01). The result of the matrine group was more marked than that of the control group. Serious side-effects were not observed except mild pain at the site of injection of matrine in a few patients. CONCLUSION: These results indicate that intramuscular matrine may be an economical, efficacious, safe drug for the treatment of chronic hepatitis B.

关键词： chronic hepatitis B/therapy matrine/therapeutical effect HBV DNA hepatitis B surface antigen hepatitis Be antigen seroconversion

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Liver histological changes in untreated chronic hepatitis B patients in indeterminate phase

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World Journal of hepatology 2024年第6期16卷 920-931页

作者： De-Liang Huang Qin-Xian Cai guang-De zhou Hong Yu Zhi-Bin Zhu Jing-Han Peng Jun Chen Department of Liver Diseases The Third People’s Hospital of ShenzhenShenzhen 510000Guangdong ProvinceChina Department of Pathology Beijing Youan HospitalCapital Medical UniversityBeijing 100000China Department of Pathology National Clinical Research Centre for Infectious DiseaseThe Third People's Hospital of Shenzhen and the Second Hospital Affiliated with the Southern University of Science and TechnologyShenzhen 518112Guangdong ProvinceChina

BACKGROUND Studies with large size samples on the liver histological changes of indeterminate phase chronic hepatitis B(CHB)patients were not previously *** To assess the liver histological changes in the indeterminate phase CHB patients using liver *** The clinical and laboratory data of 1532 untreated CHB patients were collected,and all patients had least once liver biopsy from January 2015 to December *** significant differences among different phases of CHB infection were compared with t-test,and the risk factors of significant liver histological changes were analyzed by the multivariate logistic regression *** Among 1532 untreated CHB patients,814(53.13%)patients were in the indeterminate *** liver histological changes(defined as biopsy score≥G2 and/or≥S2)were found in 488/814(59.95%)CHB patients in the indete-rminate *** liver histological changes were significant differences among different age,platelets(PLTs),and alanine aminotransferase(ALT)subgroup in indeterminate *** logistic regression analysis indicated that age≥40 years old[adjust odd risk(aOR),1.44;95%confidence interval(CI):1.06-1.97;P=0.02],PLTs≤150×10^(9)/L(aOR,2.99;95%CI:1.85-4.83;P<0.0001),and ALT≥upper limits of normal(aOR,1.48;95%CI:1.08,2.05,P=0.0163)were independent risk factors for significant liver histological changes in CHB patients in the indeterminate *** Our results suggested that significant liver histological changes were not rare among the untreated CHB patients in indeterminate phase,and additional strategies are urgently required for the management of these patients.

关键词： Chronic hepatitis B Indeterminate phase Gray-zone Liver biopsy Pathological histology Risk factors

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Neurosyphilis complicated by anti-γ-aminobutyric acid-B receptor encephalitis: A case report

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World Journal of Clinical Cases 2024年第11期12卷 1960-1966页

作者： Ya-Xiu Fang Xiao-Ming zhou Dong Zheng guang-Hui Liu Peng-Bo Gao Xiao-Zhen Huang Zhi-Cheng Chen Hui Zhang Lin Chen Ya-Fang Hu Department of Neurology The Affiliated Brain Hospital of Guangzhou Medical UniversityGuangzhou 510000Guangdong ProvinceChina Department of Neurology Nanfang HospitalSouthern Medical UniversityGuangzhou 510000Guangdong ProvinceChina

BACKGROUND Syphilis is an infectious disease caused by Treponema pallidum that can invade the central nervous system,causing *** cases of anti-N-methyl-Daspartate receptor autoimmune encephalitis(AE)secondary to neurosyphilis have been *** report a neurosyphilis patient with anti-γ-aminobutyric acid-B receptor(GABABR)*** SUMMARY A young man in his 30s who presented with acute epileptic status was admitted to a local *** was diagnosed with neurosyphilis,according to serum and cerebrospinal fluid(CSF)tests for *** 14 d of antiepileptic treatment and anti-Treponema pallidum therapy with penicillin,epilepsy was controlled but serious cognitive impairment,behavioral,and serious psychiatric symptoms were *** was then transferred to our *** Mini-Mental State Examination(MMSE)crude test results showed only 2 *** magnetic resonance imaging revealed significant cerebral atrophy and multiple fluidattenuated inversion recovery high signals in the white matter surrounding both lateral ventricles,left amygdala and bilateral ***-GABABR antibodies were discovered in CSF(1:3.2)and serum(1:100).The patient was diagnosed with neurosyphilis complicated by anti-GABABR AE,and received methylprednisolone and *** treatment,his mental symptoms were *** impairment was significantly improved,with a MMSE of 8 *** anti-GABABR antibody titer decreased to 1:*** patient received methylprednisolone and penicillin after *** months later,the patient’s condition was stable,but the serum anti-GABABR antibody titer was 1:*** This patient with neurosyphilis combined with anti-GABABR encephalitis benefited from immunotherapy.

关键词： Anti-γ-aminobutyric acid-B receptor GABABR Neurosyphilis Tissue-based assay Magnetic resonance imaging Mini-mental state examination Case report

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Leukocyte cell-derived chemotaxin 2(LECT2)regulates liver ischemia-reperfusion injury

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Liver Research 2024年第3期8卷 165-171页

作者： Meng-Qi Dong Yuan Xie Zhi-Liang Tang Xue-Wen Zhao Fu-Zhen Lin guang-Yu Zhang Zhi-Hao Huang Zhi-Min Liu Yuan Lin Feng-Yong Liu Wei-Jie zhou State Key Laboratory of Organ Failure Research Department of General SurgeryGuangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal TumorNanfang HospitalSouthern Medical UniversityGuangzhouGuangdongChina Department of Hepato-Biliary-Pancreatic and Hernia Surgery The First People's Hospital of ZhaoqingZhaoqingGuangdongChina Department of Interventional Radiology Senior Department of OncologyFifth Medical Center of PLA General HospitalBeijingChina

Background and aim Hepatic ischemia–reperfusion injury(IRI)is a significant challenge in liver transplantation,trauma,hypovolemic shock,and hepatectomy,with limited effective interventions *** study aimed to investigate the role of leukocyte cell-derived chemotaxin 2(LECT2)in hepatic IRI and assess the therapeutic potential of Lect2-short hairpin RNA(shRNA)delivered through adeno-associated virus(AAV)*** and methods This study analyzed human liver and serum samples from five patients undergoing the Pringle ***2-knockout and C57BL/6J mice were *** IRI was induced by clamping the hepatic *** included recombinant human LECT2(rLECT2)and ***2 expression levels and serum biomarkers including alanine aminotransferase(ALT),aspartate aminotransferase(AST),creatinine,and blood urea nitrogen(BUN)were *** analysis of liver necrosis and quantitative reverse-transcription polymerase chain reaction were *** Serum and liver LECT2 levels were elevated during hepatic *** LECT2 protein and mRNA levels increased post ***2-knockout mice had reduced weight loss;hepatic necrosis;and serum ALT,AST,creatinine,and BUN ***2 treatment exacerbated weight loss,hepatic necrosis,and serum biomarkers(ALT,AST,creatinine,and BUN).AAV-Lect2-shRNA treatment significantly reduced weight loss,hepatic necrosis,and serum biomarkers(ALT,AST,creatinine,and BUN),indicating therapeutic *** Elevated LECT2 levels during hepatic IRI increased liver *** knockout or shRNA-mediated knockdown of Lect2 reduced liver damage,indicating its therapeutic ***-mediated Lect2-shRNA delivery mitigated hepatic IRI,offering a potential new treatment strategy to enhance clinical outcomes for patients undergoing liver-related surgeries or trauma.

关键词： Hepatic ischemia-reperfusion injury(IRI) Leukocyte cell-derived chemotaxin 2 (LECT2) Adeno-associated virus(AAV)

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Enhanced Antileukemia Efficacy but not Cardiotoxicity Exerted by Proteasome Inhibitor/Imatinib Combinations in Chronic Myeloid Leukemia

Enhanced Antileukemia Efficacy but not Cardiotoxicity Exerte...

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第五届全国化学生物学学术会议

作者： Zheng Hu~1 Xiao-Fen Pan~1 Jing-Lei Liu~(1,5) Da-Peng Liu~1 Xiao-Li Liu~2 Fan-Yi Meng~2 Feng-Xiang Zhang~1 Fu-Qun Wu~1 Juan Li~4 Zhu Chen~3 Sai-Juan Chen~3 guang-Biao zhou~(1*) 1 Laboratory of Molecular Target-Based Therapy for Cancer,guangzhou Institute of Biomedicine and Health,Chinese Academy of Sciences,guangzhou 510663 2 Department of Hematology,nanfang hospital Affiliated to nanfang medical university,guangzhou,510515 3 State Key Laboratory of medical Genomics and Shanghai Institute of Hematology, Rui Jin hospital Affiliated to Shanghai Jiao Tong university School of Medicine,Shanghai, 200025 4 Department of Hematology,the first Affiliated hospital,Sun Yat-Sen university,guangzhou,510080 5 university of Science and Technology of china,Hefei,230027,china.

＜正＞Resistance developed by leukemic cells,cardiotoxity,and unsatisfactory efficacy on patients with chronic myeloid leukemia（CML）at accelerated and blastic phases,have been limitations for imatinib mesylate（IM）in treating *** IM based combinatory regimens could be one of the strategies to overcome these limitations needs more *** we showed that the

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糖尿病对全膝关节置换围手术期并发症的影响:一项基于NSQIP数据库的回顾性分析研究

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岭南急诊医学杂志 2024年第5期29卷 492-495,515页

作者：李思逸周光清南方医科大学卫生管理学院 510515 南方医科大学南方医院健康管理中心

目的:分析合并糖尿病的关节置换患者围手术期并发症的特点。方法:研究数据取自美国外科医生学会NSQIP数据库,将接受全膝关节置换术的患者分为糖尿病组与非糖尿病组。采用倾向评分匹配法(Propensity Score Matching,PSM)匹配两组患者,并... 详细信息

目的:分析合并糖尿病的关节置换患者围手术期并发症的特点。方法:研究数据取自美国外科医生学会NSQIP数据库,将接受全膝关节置换术的患者分为糖尿病组与非糖尿病组。采用倾向评分匹配法(Propensity Score Matching,PSM)匹配两组患者,并对比分析围术期并发症发生率。通过多因素Logistic回归分析筛选与糖尿病独立相关的并发症。结果:糖尿病组患者高血压、肥胖、甲状腺功能减退、慢性肺病、抑郁、慢性肾病、痛风、慢性心力衰竭的患病率较高;术后贫血、电解质紊乱、急性肾功能损伤、尿路感染、呼吸衰竭、急性肺炎的发病率也较高。多因素回归分析表明糖尿病是上述并发症的危险因素。结论:糖尿病患者在关节置换围手术期发生术后贫血、电解质紊乱、急性肾功能损伤、尿路感染等并发症的风险较高,需采取针对性措施降低这些并发症的发生。

关键词：全膝关节置换糖尿病围手术期并发症 NSQIP数据库

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氟康唑治疗真菌性角膜溃疡的护理体会

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实用护理杂志 1999年第3期15卷 31-33页

作者：杜兰芳唐娜周宏珍李苏云第一军医大学南方医院眼科

角膜真菌病是一种广泛化脓性炎症。氟康唑作为一类抗真菌新药，具有抗菌谱广、副作用小，有较好的组织亲和性和使用方便等特点。报告２０例用氟康唑治疗真菌性角膜溃疡的护理体会。认为：治疗前责任护士应进行入院评估，做好心理护理，... 详细信息

角膜真菌病是一种广泛化脓性炎症。氟康唑作为一类抗真菌新药，具有抗菌谱广、副作用小，有较好的组织亲和性和使用方便等特点。报告２０例用氟康唑治疗真菌性角膜溃疡的护理体会。认为：治疗前责任护士应进行入院评估，做好心理护理，直接采样取材，尽快确定病原。治疗过程中应认真观察并发症并及时对症处理，观察用药反应，确保用药及时准确。同时做好病区的清洁、通风、消毒和提高病人的防病意识，做好卫生健康教育，这样有利于治疗和降低本病的发生率。

关键词：氟康唑真菌性角膜溃疡护理药物疗法

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临床生物化学检验期末考试试卷分析与思考

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山西医科大学学报（基础医学教育版） 2010年第11期12卷 1118-1120页

作者：包杰曾方银张鹏熊石龙郑磊王前南方医科大学南方医院检验系广州510515

了解南方医科大学医学检验专业本科生临床生物化学检验考试的总体情况,促进教学方法的改进和教学质量的提高。采用抽样的方法分析南方医科大学49名2007级医学检验本科临床生物化学检验期末考试试卷。试卷难度、区分度和信度分别为0.66,0... 详细信息

了解南方医科大学医学检验专业本科生临床生物化学检验考试的总体情况,促进教学方法的改进和教学质量的提高。采用抽样的方法分析南方医科大学49名2007级医学检验本科临床生物化学检验期末考试试卷。试卷难度、区分度和信度分别为0.66,0.20和0.63。试卷平均分66.74分,标准差7.95。该试卷反映了学生对临床生物化学检验的掌握程度,难度适中,区分度良好,信度略低,为今后提高试卷命题水平及调整教学安排提供了经验。

关键词：临床生物化学检验试卷分析教学质量

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血管内皮细胞生长因子诱导大肠癌LOVO细胞粘附作用

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胃肠病学和肝病学杂志 2001年第2期10卷 137-139页

作者：赖卓胜毛华袁爱力彭齐荣赵敏芳第一军医大学南方医院全军消化疾病研究所广州510505 解放军458医院全军传染病中心广州510515 第一军医大学珠江医院放疗科广州510515

目的　观察血管内皮生长因子 (VascularEndothelialGrowthFactor ,VEGF)对大肠癌LOVO细胞粘附作用。方法　采用3H-TdR掺入鼠尾胶粘附实验测定VEGF诱导大肠癌LOVO细胞同质性和异质性粘附作用。结果　 1ng/mL、5ng/mLVEGF诱导LOVO细胞 6 ... 详细信息

目的　观察血管内皮生长因子 (VascularEndothelialGrowthFactor ,VEGF)对大肠癌LOVO细胞粘附作用。方法　采用3H-TdR掺入鼠尾胶粘附实验测定VEGF诱导大肠癌LOVO细胞同质性和异质性粘附作用。结果　 1ng/mL、5ng/mLVEGF诱导LOVO细胞 6 0分钟、90分钟3H -TdR掺入实验 (dpm/min)分别为 1380 .0 3± 198.0 5 ,130 2 .2± 2 0 1.0 4和 2 6 41.6± 473 .2 4、2 797.5± 413 .2 4,10ng/mLVEGF诱导LOVO细胞 6 0分钟、90分钟、12 0分钟3H TdR掺入实验分别为 2 75 3 .0 3± 310 .31、1891.5 9± 2 2 3 .80、2 0 6 6 .79±187.97,显著低于对照组 6 0、90、12 0分钟的 1948.14± 2 16 .74、336 1± 175 .2 7、4173 .4± 373 .98,P <0 .0 5或 0 .0 1;5ng/mL、10ng/mLVEGF诱导LOVO细胞 6 0分钟鼠尾胶粘附实验OD值为 0 .2 5 0± 0 .0 18、0 .2 3± 0 .0 36 ,1ng/mL、5ng/mL、10ng/mLVEGF诱导LOVO细胞 90分钟、12 0分钟鼠尾胶粘附实验OD值分别为 0 .2 6 3± 0 .0 2 1、0 .373± 0 .0 83、0 .378± 0 .0 79和 0 .32 9± 0 .0 5 6、0 .389± 0 .0 95、0 .419± 0 .10 2 ,分别高于对照组的 0 .130± 0 .0 2 5、0 .14 3± 0 .0 36、0 .2 10± 0 .0 2 8,P <0 .0 5或 0 .0 1。

关键词：血管内皮生长物质细胞株粘附肿瘤转移大肠癌

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Dynamics of glutamine synthetase expression in hepatic ischemiareperfusion injury: Implications for therapeutic interventions

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World Journal of hepatology 2024年第8期16卷 1177-1184页

作者： Zhi-Hao Huang Meng-Qi Dong Feng-Yong Liu Wei-Jie zhou State Key Laboratory of Organ Failure Research Department of General SurgeryGuangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal TumorNanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of Interventional Radiology Senior Department of OncologyFifth Medical Center of PLA General HospitalBeijing 100853China

BACKGROUND Hepatic ischemia-reperfusion injury(IRI)poses a great challenge in liver surgery and transplantation because of oxidative stress and inflammatory *** changes in glutamine synthetase(GS)expression during hepatic IRI remain *** To investigate the dynamic expression of GS during hepatic *** Following hepatic ischemia for 1 h and reperfusion,liver tissue samples were collected at 0.5,6,and 24 hours postreperfusion for fixation,embedding,*** and eosin staining and GS staining were *** GS expression rapidly decreases in hepatocytes around the central vein after IRI,reaching its lowest point at 6 hours postreperfusion,and then gradually *** GS is highly sensitive to IRI,highlighting its potential role as an indicator of liver injury states and a target for therapeutic intervention.

关键词： Hepatic ischemia-reperfusion Glutamine synthetase Central vein Liver Injury repair

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