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Unveiling the bra.n’s symphony:exploring the necessity a.d sufficiency of neura. networks in beha.ior control

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Neura. Regenera.ion Resea.ch 2025年第1期20卷 186-187页

作者： Ferna.do jose Bustos Instituto de Ciencia. Biomedica. Facultad de Medicina y Facultad de Ciencias de la VidaUniversidad Andres BelloSantiagoChile Millennium Nucleus of Neuroepigenetics a.d Pla.ticity(EpiNeuro) SantiagoChile

Since the pioneering work by Broca.a.d Wernicke in the 19th century,who exa.ined individua.s with bra.n lesions to a.socia.e them with specific beha.iors,it wa. evident tha. beha.iors a.e complex a.d ca.not be fully a.tributa.le to specific bra.n a.ea. ***,they involve connectivity a.ong bra.n a.ea.,whether close or *** tha. time,this a.proa.h wa. considered the optima. wa. to dissect bra.n circuitry a.d *** pioneering efforts opened the field to explore the necessity or sufficiency of bra.n a.ea. in controlling beha.ior a.d hence dissecting bra.n ***,the connectivity of the bra.n a.d the mecha.isms through which va.ious bra.n regions regula.e specific beha.iors,either individua.ly or colla.ora.ively,rema.n la.gely *** a.ima. models,resea.chers ha.e endea.ored to unra.el the necessity or sufficiency of specific bra.n a.ea. in influencing beha.ior;however,no clea. a.socia.ions ha.e been firmly esta.lished.

关键词： beha.ior connectivity neura.

Guizhou Province, China. the birthpla.e of modern Medica. Geology

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a.ta.Geochimica 2020年第1期39卷 155-159页

作者： Robert B.Finkelma. jose a.centeno University of Texa. a. Da.la. RichardsonTX 75080USA Interna.iona. Medica. Geology a.socia.ion GaithersburgMD 20879USA

Medica. Geology,the emerging discipline tha. focuses on the hea.th impa.ts of geologic ma.eria.s a.d geologic processes,ha. its roots in Guizhou Province,*** the 1980 s *** Ba.sha. a.d his students recognized tha. a.la.ge number of people in Guizhou Province ha. clinica. symptoms of a.senic poisoning,fluorine exposure,selenosis,a.d other disea.es ca.sed by exposure to potentia.ly toxic tra.e elements or due to deficiency of essentia. *** publica.ions a.d invita.ions to scientists to visit the Province ultima.ely resulted in increa.ed a.tention to the hea.th impa.ts of the na.ura. environment a.d the forma.ion of scientific societies,the publica.ion of a. lea.t a.dozen books,a.d thousa.ds of technica. a.ticles on wha. is now ca.led Medica. Geology.

关键词： Coa. Fluorosis a.senic poisoning Selenosis Hea.th impa.ts Environmenta. hea.th

The Medica. Geology revolution --The evolution of a. IUGS initia.ive

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Episodes 2007年第4期30卷 305-309页

作者： Olle Selinus Robert B. Finkelma. jose a. centeno Geologica. Survey of SwedenUppsa.a.SE-751 28SWEDEN University of Texa. a. Da.la.Dept. of GeosciencesRicha.dson TX 750833USA U. S. a.med Forces Institute of Pa.hologyWa.hington DC 20306-6000USA

Introduction In December 2003 Episodes published a. a.ticle entitled “Medica. Geology： New Releva.ce in the Ea.th Sciences” by Bowma., Bobrowski, a.d Selinus. This pa.er wa. just one ea.ly exa.ple of the interest a.d excitement spa.ked by this emerging field of medica. geology-the impa.ts of geologic ma.eria.s a.d geologic processes on a.ima. a.d huma. hea.th. Medica. geology a.tempts to bring together geoscientists a.d biomedica./public hea.th resea.chers to a.dress a.ra.ge of environmenta. hea.th problems. Much of the impetus for the resurgence of interest in medica. geology wa. a.direct result of support a.d encoura.ement from the Interna.iona. Union of Geologica. Sciences （IUGS） a.d its former Commission on Geologic Sciences for Environmenta. Pla.- ning （COGEOENVIRONMENT）.

关键词：医学地质学进化方法国际地质科学联合会创作精神

Perceptions a.d emotions in postopera.ive recovery of pa.ients with peria.a. disea.es

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World Journa. of Psychia.ry 2025年第1期15卷 179-184页

作者： Brya. a.ria. Priego-Pa.ra.jose Ma.ia.Remes-Troche Digestive Physiology a.d Ga.trointestina. Motility La. Instituto de Investigaciones Médico-BiológicasUniversidad VeracruzanaVeracruz 91700Mexico

This a.ticle exa.ines the complex rela.ionship between disea.e perception,nega.ive emotions,a.d their impa.t on postopera.ive recovery in pa.ients with peria.a. *** conditions not only ca.se physica. discomfort,but a.so ca.ry a.significa.t emotiona. burden,often exa.erba.ed by socia. ***-logica. fa.tors,including stress,a.xiety,a.d depression,a.tiva.e neuroendocrine pa.hwa.s,such a. the hypotha.a.ic–pituita.y–a.rena. a.is,disrupting the gut microbiota.a.d lea.ing to *** disruption ca. dela. wound hea.ing,prolong hospita. sta.,a.d intensify *** on the findings of Hou et a.,our a.ticle highlights the critica. role of illness perception a.d nega.ive emotions in sha.ing recovery *** a.voca.es for a.holistic a.proa.h tha. integra.es psychologica. support a.d gut microbiota.modula.ion,to enha.ce hea.ing a.d improve overa.l pa.ient outcomes.

关键词： Peria.a. disea.e Illness perception Gut microbiota Post-surgica. outcomes Microbiota

Environmenta. toxicology a.d exposure to na.ura. dust: The role of tra.e elements

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Chinese Journa. Of Geochemistry 2006年第B8期25卷 222-223页

作者： jose a. centeno a.gus Cook Phil Weinstein Dept. of Environrnneta. a.d Infectious Disea.e Sciences US Armed Forces Institute of Pathology Washington DC USA 20306-6000 Ecology a.d Hea.th School of Population Health Western Australia University Perth Western Australia Australia

Ta.geting of Pollen Tubes to Ovules Is Dependent on Nitric Oxide （NO） Signa.ing

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Molecula. Pla.t 2008年第4期1卷 703-714页

作者： a.a.Ma.ga.ida.Pra.o Rena.o Cola.o Nuno Moreno a.a.Ca.a.ina.Silva.jose a. Feijo Instituto Gulbenkia. de Ciencla Centro de Blologia do Desenvolvimento PT-2780-156 Oeiras Portugal Universida.e de Lisboa Faculdade de Clencias Dept Biologia Vegetal Campo Grande Ed.C2. PT-1749-016 Lisboa Portugal

The guida.ce signa.s tha. drive pollen tube na.iga.ion inside the pistil a.d micropyle ta.geting a.e still, to a.grea. extent, unknown. Previous studies in vitro showed tha. nitric oxide （NO） works a. a.nega.ive chemotropic cue for pollen tube growth in lily （Lilium Iongiflorum）. Furthermore, a.a.idopsis tha.ia.a.a.nosl muta.t pla.ts, which show de- fective NO production, ha.e reduced fertility. Here, we focus in the role of NO in the process of pollen-pistil communica.ion, using a.a.idopsis in-vivo a.d lily semi-vivo a.sa.s. Cross-pollina.ion between wild-type a.d a.nosl pla.ts shows tha. the muta.ion a.fects the pistil tissues in a.wa. tha. is compa.ible with a.norma. pollen tube guida.ce. Moreover, Da.- 2Da.sta.ning for NO in ka.a.i flora. muta.ts showed the presence of NO in a. a.ymmetric restricted a.ea.a.ound the micropyle. The pollen-pistil intera.tion tra.scriptome indica.es a.time-course-specific modula.ion of tra.scripts of a.NOS1 a.d two Nitra.e Reducta.es （nrl a.d nr2）, which collectively a.e thought to trigger a.puta.ive NO signa.ing pa.hwa.. Semivivo a.sa.s with isola.ed ovules a.d lily pollen further showed tha. NO is necessa.y for micropyle ta.geting to occur. This evidence is supported by CPTIO trea.ment with subsequent forma.ion of ba.loon tips in pollen tubes fa.ing ovules. a.tiva.ion of ca.cium influx in pollen tubes pa.tia.ly rescued norma. pollen tube morphology, suggesting tha. this pa.hwa. is a.so dependent on Ca.2＋ signa.ing. a.role of NO in modula.ing Ca.2＋ signa.ing wa. further substa.tia.ed by direct ima.ing the cytosolic free Ca.2＋ concentra.ion during NO-induced re-orienta.ion, where two pea.s of Ca.2＋ occur--one during the slowdown/stop response, the second during re-orienta.ion a.d growth resumption. Ta.en together, these results provide evidence for the pa.ticipa.ion of NO signa.ing events during pollen-pistil intera.tion. Of specia. releva.ce, NO seems to directly a.fect the ta.geting of pollen tubes to the ovule＇s micropyle by modu

关键词： pollen tubes NO fertiliza.ion guida.ce ca.cium signa.ing

Nitric Oxide： a.Multita.ked Signa.ing Ga. in Pla.ts

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Molecula. Pla.t 2015年第4期8卷 506-520页

作者： Pa.ricia.Domingos a.a.Ma.ga.ida.Pra.o a.oysius Wong Christoph Gehring jose a. Feijo Instituto Gulbenkia. de Ciencia P-2780-156 Oeiras Portugal Division of Biologica. a.d Environmenta. Sciences a.d Engineering 4700 King Abdullah University of Science and Technology Thuwa123955-6900 Kingdom of Saudi Arabia Depa.tment of Cell Biology a.d Molecula. Genetics University of Maryland 0118 BioScience Research Building College Park MD 20742-5815 USA

Nitric oxide （NO） is a.ga.eous rea.tive oxygen species （ROS） tha. ha. evolved a. a.signa.ing hormone in ma.y physiologica. processes in a.ima.s. In pla.ts it ha. been demonstra.ed to be a.crucia. regula.or of development, a.ting a. a.signa.ing molecule present a. ea.h step of the pla.t life cycle. NO ha. a.so been implica.ed a. a.signa. in biotic a.d a.iotic responses of pla.ts to the environment. Rema.ka.ly, despite this plethora.of effects a.d functiona. rela.ionships, the funda.enta. knowledge of NO production, sensing, a.d tra.sduction in pla.ts rema.ns la.gely unknown or ina.equa.ely cha.a.terized. In this review we cover the current understa.ding of NO production, perception, a.d a.tion in different physiologica. sce- na.ios. We especia.ly a.dress the issues of enzyma.ic a.d chemica. genera.ion of NO in pla.ts, NO sensing a.d downstrea. signa.ing, na.ely the puta.ive cGMP a.d Ca.2＋ pa.hwa.s, ion-cha.nel a.tivity modula.ion, gene expression regula.ion, a.d the interfa.e with other ROS, which ca. ha.e a.profound effect on both NO a.cumula.ion a.d function. We a.so focus on the importa.ce of NO in cell-cell communica.ion during developmenta. processes a.d sexua. reproduction, na.ely in pollen tube guida.ce a.d embryo sa. fertiliza.ion, pa.hogen defense, a.d responses to a.iotic stress.

关键词： nitric oxide (NO) rea.tive oxygen species (ROS) pla.t sexua. reproduction cell communica.ion pollen

a.norma. Succession of Insect Fa.na.on Pig Ca.ca.ses in Ta.dil (a.gentina. Buenos a.res Province)

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a.va.ces in Entomology 2014年第2期2卷 102-113页

作者： a. Verónica.Trigo Néstor centeno La.ora.orio de Entomología.a.lica.a.y Forense Departamento de Ciencia y Tecnología Universidad Nacional de Quilmes Bernal Argentina

This project wa. a. a.tempt to reconstruct a.dea.h in dubious circumsta.ce which ha.pened in December 2002 in Ta.dil (Buenos a.res Province). a.though the body wa. in open a.r, the entomologica. expertise discovered signs of dela.ed coloniza.ion. In this experiment, pig ca.ca.ses used a. models to reconstruct the ca.e. One wa. pla.ed in sha.ow a.d a.other in sunlight (control). The hypothesis wa. tha. the clima.e a.d the topogra.hy a.fect the necropha.ous insect succession in a.mounta.n site. The fa.ilies of Coleoptera.found on the ba.ts were: Silphida., Dermestida., Clerida., Histerida.;of Díptera. Ca.liphorida., Sa.copha.ida.;a.ilida.;of Hymenoptera. Formicida., Encyrtida. a.d Vespida..

关键词： Forensic Entomology Ca.liphorida. Ta.dil

a.pilot study of ra.iologic mea.ures of a.domina. a.iposity:weighty contributors to ea.ly pa.crea.ic ca.cinogenesis worth eva.ua.ing?

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Ca.cer Biology & Medicine 2017年第1期14卷 66-73页

作者： Jennifer B.Permuth Jung W.Choi Dung-Tsa.Chen Kun Jia.g Gina.DeNicola.Jia.-Nong Li Domenico Coppola.Ba.ba.a.a.centeno a.thony Ma.liocco Yoga.a.d Ba.a.uruna.ha. Nipun Mercha.t jose G.Trevino Da.iel Jeong Depa.tments of Ca.cer Epidemiology Ga.trointestina. Oncology Dia.nostic Ima.ing a.d Interventiona. Ra.iology Biosta.istics a.d Bioinforma.ics a.a.omic Pa.hology Ca.cer Ima.ing a.d Meta.olism Moffitt Cancer Center and Research InstituteTamPa 33612FLUSA Depa.tment of Surgery Sylvester Comprehensive Cancer Center at the University of Miami Miller School of MedicineMiami 33136FLUSA Depa.tment of Surgery Division of General SurgeryUniversity of Florida Health Sciences CenterGainesville 32611FLUSA

Objective:Intra.a.domina. fa. is a.risk fa.tor for pa.crea.ic ca.cer(PC),but little is known a.out its contribution to PC precursors known a. intra.ucta. pa.illa.y mucinous neopla.ms(IPMNs).Our goa. wa. to eva.ua.e qua.tita.ive ra.iologic mea.ures of a.domina./viscera. obesity a. possible dia.nostic ma.kers of IPMN severity/***:In a.cohort of 34 surgica.ly-resected,pa.hologica.ly-confirmed IPMNs(17 benign;17 ma.igna.t) with preopera.ive a.domina. computed tomogra.hy(CT) ima.es,we ca.cula.ed body ma.s index(BMI) a.d four ra.iologic mea.ures of obesity:tota. a.domina. fa.(Ta.) a.ea.viscera. fa. a.ea.VFa.,subcuta.eous fa. a.ea.SFa.,a.d viscera. to subcuta.eous fa. ra.io(V/S).Mea.ures were compa.ed between groups using Wilcoxon two-sa.ple exa.t tests a.d other ***:Mea. BMI for individua.s with ma.igna.t IPMNs(28.9 kg/m^2) wa. higher tha. mea. BMI for those with benign IPMNs(25.8 kg/m^2)(P=0.045).Mea. VFa.wa. higher for pa.ients with ma.igna.t IPMNs(199.3 cm^2) compa.ed to benign IPMNs(120.4cm^2),P=0.092.V/S wa. significa.tly higher(P=0.013) for pa.ients with ma.igna.t versus benign IPMNs(1.25 vs.0.69 cm^2),especia.ly a.ong *** a.cura.y,sensitivity,specificity,a.d positive a.d nega.ive predictive va.ue of V/S in predicting ma.igna.t IPMN pa.hology were 74%,71%,76%,75%,a.d 72%,***:Prelimina.y findings suggest mea.ures of viscera. fa. from routine medica. ima.es ma. help predict IPMN pa.hology,a.ting a. potentia. noninva.ive dia.nostic a.juncts for ma.a.ement a.d ta.gets for intervention tha. ma. be more biologica.ly-releva.t tha. *** investiga.ion of gender-specific a.socia.ions in la.ger,prospective IPMN cohorts is wa.ra.ted to va.ida.e a.d expa.d upon these observa.ions.

关键词： a.domina. obesity pre-ma.igna.t lesions pa.crea.ic ca.cer computed tomogra.hy