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Bone marrow biopsy findings in brucellosis patients with hematologic abnormalities

Chinese Medical Journal 2012年第11期125卷 1871-1876页

作者： cengiz demir Mustafa Kasim Karahocagil Ramazan Esen Murat Atmaca Hayriye Gonullu Hayrettin Akdeniz Department of Hematology Faculty of Medicine Yuzuncu Yil University Van Turkey Department of Infectious Diseases and Clinical Microbiology Faculty of Medicine Yuzuncu Yil University Van Turkey Department of Emergency Medicine Faculty of Medicine Yuzuncu Yil University Van Turkey

Background Brucellosis can mimic various multisytem diseases, showing wide clinical polymorphism that frequently leads to misdiagnosis and treatment delay, further increasing the complication rates. In this study, we aimed to examine bone marrow biopsy findings in brucellosis cases presenting with hematologic abnormalities. Methods Forty-eight brucellosis cases were prospectively investigated. Complaints and physical examination findings of patients were recorded. Patients＇ complete blood count, routine biochemical tests, erythrocyte sedimentation rate, C-reactive protein and serological screenings were performed. Bone marrow biopsy and aspiration was performed in patients with cytopenia, for bone marrow examination and brucella culture, in accordance with the standard procedures from spina iliaca posterior superior region of pelvic bone. Results Of the 48 patients, 35 （73%） were female and 13 （27%） were male. Mean age was （34.8±15.4） years （age range： 15-70 years）. Anemia, leukopenia, thrombocytopenia and pancytopenia were found in 39 （81%）, 28 （58%）, 22 （46%） and 10 patients （21%）, respectively. In the examination of bone marrow, hypercellularity was found in 35 （73%） patients. Increased megacariocytic, erythroid and granulocytic series were found in 28 （58%）, 15 （31%） and 5 （10%） patients, respectively. In addition, hemophagocytosis was observed in 15 （31%） patients, granuloma observed in 12 （25%） and increased eosinophil and plasma cells observed in 9 （19%） patients. Conclusion According to the results of our series, hemophagocytosis, microgranuloma formation and hypersplenism may be responsible for hematologic complications of brucellosis.

关键词： brucellosis hematologic abnormality bone marrow findings

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Gastroprotective activity of Nigella sativa L oil and its constituent, thymoquinone against acute alcohol-induced gastric mucosal injury in rats

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World Journal of Gastroenterology 2005年第42期11卷 6662-6666页

作者： Mehmet Kanter Halit demir cengiz Karakaya Hanefi Ozbek Department of Histology and Embryology Faculty of Medicine Trakya University Edirne Turkey Department of Chemistry Faculty of Art and Science Yuzuncu Yil University Van Turkey Department of Biochemistry Faculty of Medicine Yuzuncu Yil University VanTurkey Department of Pharmacology Faculty of Medicine Yuzuncu Yil University Van Turkey

AIM: To evaluate the role of reactive oxygen species in the pathogenesis of acute ethanol-induced gastric mucosal lesions and the effect of Nigella sativa L oil (NS) and its constituent thymoquinone (TQ) in an experimental ***: Male Wistar albino rats were assigned into 4groups. Control group was given physiologic saline orally (10 mL/kg body weight) as the vehicle (gavage); ethanol group was administrated 1 mL (per rat) absolute alcohol by gavage; the third and fourth groups were given NS (10 mL/kg body weight) and TQ (10 mg/kg body weight p.o) respectively 1 h prior to alcohol intake. One hour after ethanol administration, stomach tissues were excised for macroscopic examination and biochemical ***: NS and TQ could protect gastric mucosa against the injurious effect of absolute alcohol and promote ulcer healing as evidenced from the ulcer index (UI) values. NS prevented alcohol-induced increase in thiobarbituric acid-reactive substances (TBARS), an index of lipid peroxidation. NS also increased gastric glutathione content (GSH), enzymatic activities of gastric superoxide dismutase (SOD) and glutathione-S-transferase (GST). Likewise, TQ protected against the ulcerating effect of alcohol and mitigated most of the biochemical adverse effects induced by alcohol in gastric mucosa, but to a lesser extent than NS. Neither NS nor TQ affected catalase activity in gastric ***: Both NS and TQ, particularly NS can partly protect gastric mucosa from acute alcohol-induced mucosal injury, and these gastroprotective effects might be induced, at least partly by their radical scavenging activity.

关键词： Nigella sativa Thymoquinone Ulcer Antioxidant Rat

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The relation between epicardial fat thickness and metabolic syndrome

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Journal of Geriatric Cardiology 2016年第4期13卷 369-370页

作者： Sevket Balta cengiz Ozturk Mustafa Aparci Mustafa demir Ali Osman Yildirim Turgay Celik Department of Cardiology Gulhane Medical Academy Ankara Turkey Department of Cardiology Haydarpasa Military Hospital Istanbul Turkey

To the editor We read the article Usefulness of the epicardial fat tissue thickness as a diagnostic criterion for geriatric patients with metabolic syndrome by Kaya, et al. The authors aimed to evaluate the epicardial fat tissue thickness （EFT） as a diagnostic criterion for geriatric patients with metabolic syndrome （MetS）. They concluded that EFT levels were higher in geriatric patients with MetS and can therefore be used as a diagnostic criterion for MetS.

关键词： Atherosclerosis Epicardial fat thickness Metabolic syndrome

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Mortal condition in an unusual localization,analysis of isolated tongue and tongue base abscesses

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World Journal of Clinical Cases 2023年第32期11卷 7778-7784页

作者： Kemal Koray Bal Harun Gür Ibrahim demir Onur Ismi Yusuf Vayisoglu Kemal Gorur cengiz Ozcan Murat Unal Department of Otorhinolaryngology Mersin UniversityMersin 33160MersinTurkey

BACKGROUND Tongue abscess(TA)is a very rare clinical condition and its treatment is very *** drainage is at the forefront in the *** study includes patients with tongue and tongue base *** To discuss the clinical and laboratory findings of these patients emphasizing the underlying causes and treatment options with the largest patient series in the English *** We included patients with isolated TA who applied to our clinic between January 1,2020 and January 1,*** who lack the recorded data,those who are not between the ages of 18-66,those who have not undergone surgery-interventional procedure,and those who have infection and/or abscess in another place were excluded from the *** There were two female(18%)and nine male(82%)patients in our series consisting of 11 *** ages ranged from 18 to 66,and the mean±SD was 48.63±*** the localization of the abscess,three anterior abscesses(27%),two lateral abscesses(18%),and six abscesses at the base of the tongue(54%)were *** Tongue abscesses can cause acute upper airway obstruction and respiratory *** may be necessary to act quickly for the tracheotomy procedure and this procedure can usually be performed under local anesthesia as intubation cannot be *** we encounter an abscess in an unexpected organ,difficulties may be encountered in the management of the patient.

关键词： Tongue Abscess Neutrophils Blood platelets Lymphocytes

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Frequency and safety of COVID-19 vaccination in children with multisystem inflammatory syndrome:a telephonic interview-based analysis

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World Journal of Pediatrics 2022年第10期18卷 700-705页

作者： Kubra Aykac Kubra Ozturk Osman Oguz demir Dilan demir Gumus Sevgi Aslan Ela Cem Miray Yilmaz Celebi Mustafa Dogan Karabacak Gulsum Alkan Fatma Dilsad Aksoy Burcu Ceylan Cura Yayla Eda Kepenekli Solmaz Celebi Melike Emiroglu Ilker Devrim Ali Bulent cengiz Mehmet Ceyhan Yasemin Ozsurekci Faculty of Medicine Department of Pediatric Infectious DiseasesHacettepe UniversityAnkaraTurkey Goztepe Prof.Dr.Suleyman Department of Pediatric RheumatologyYalcın City HospitalIstanbulTurkey Faculty of Medicine Department of Pediatric DiseasesHacettepe UniversityAnkaraTurkey Department of Pediatric Infectious Diseases Marmara University School of MedicineIstanbulTurkey Department of Pediatric Infectious Diseases Dr.Behçet Uz Children’s HospitalízmirTurkey Faculty of Medicine Department of Pediatric Infectious DiseasesSelcuk UniversityKonyaTurkey Faculty of Medicine Department of Pediatric Infectious DiseasesUludag UniversityBursaTurkey Department of Pediatric Infectious Diseases University of Health Science Ankara Training and Research HospitalAnkaraTurkey

Coronavirus disease 2019(COVID-19)vaccines are currently approved or authorized to prevent serious outcomes,such as severe disease,hospitalization,and *** Pfizer-BioNTech vaccine is recommended for everyone aged five and older in the United States(US)to prevent severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection[1,2].However,it is unclear whether children with a history of multisystem,inflammatory syndrome in children(MIS-C)may be at risk for a MIS-like response following COVID-19 vaccination or SARS-CoV-2 reinfection[2].Therefore,physicians remain uncertain about vaccinating children with a history of *** study investigates the occurrence of severe,systemic side effects of COVID-19 vaccines and the recurrence of the MIS-C symptoms in children with a history of MIS-C to overcome vaccine hesitancy.

关键词： vaccination vaccine Pfizer

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Comparison of two different treatment regimens’ efficacy in neovascular age-related macular degeneration in Turkish population—based on real life data-Bosphorus RWE Study Group

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International Journal of Ophthalmology(English edition) 2020年第1期13卷 104-111页

作者： Burak Erden Selim Bolükbasi Abdullah Ozkaya Levent Karabas cengiz Alagoz Zeynep Alkin Ozgür Artunay Sadik Etka Bayramoglu Gokhan demir Mehmet demir Ali demircan Gürkan Erdogan Mehmet Erdogan Erdem Eris Havva Kaldirim Ismail Umut Onur Ozen Ayranci Osmanbasoglu Sezin Ozdogan Erkul Mine Oztürk Irfan Perente Kübra Sarici Nihat Sayin Dilek Yasa Ihsan Yilmaz Zeynep Yilmazabdurrahmanoglu 无 Ophthalmology Clinic Okmeydani Training and Research Hospital Ophthalmology Clinic Memorial Sisli Hospital Department of Ophthalmology Kocaeli University Faculty of Medicine Ophthalmology Clinic Beyoglu Eye Training and Research Hospital Ophthalmology Clinic Kanuni Sultan Süleyman Training and Research Hospital Ophthalmology Clinic Sisli Etfal Training and Research Hospital Ophthalmology Clinic Bagcilar Training and Research Hospital Ophthalmology Clinic Bakirkoy Dr.Sadi Konuk Training and Research Hospital Ophthalmology Clinic Istanbul Training and Research Hospital1 Ophthalmology Clinic Haseki Training and Research Hospital Bosphorus Retina Study Group

AIM: To compare two different anti-vascular endothelial growth factor(anti-VEGF) treatment regimens'-a priori pro re nata(PRN) and PRN regimen following^(th)e loading phaseanatomical and functional results in neovascular agerelated macular degeneration(n AMD) patients. METHODS: Totally 544 n AMD patients followed and treated with aflibercept(n=135) and ranibizumab(n=409)at 9 different centers between 2013 and 2015 were enrolled into^(th)is retrospective multicenter study. Patients with initial best corrected visual acuity(BCVA) interval of 1.3-0.3(log MAR) and a minimum follow-up of 12 mo were included. Patients under two different regimens-a priori pro re nata(1+PRN) or 3 consecutive intravitreal injections followed by a PRN regimen(3+PRN)-were compared in BCVA at 3^(th), 6^(th) and 12^(th) months, and in central macular^(th)ickness(CMT) at 6^(th) and 12^(th) months. The total study group, intravitreal ranibizumab(IVR) and intravitreal aflibercept(IVA) groups were evaluated separately. RESULTS: The mean CMT decreased in^(th)e 1+PRN(n=101) regimen from 407 to 358 and 340 μm and in^(th)e 3+PRN(n=443) group from 398 to 318 and finally to 310 μm at months 6 and 12, respectively. Anatomically,^(th)e CMT reduction at 6^(th) month(48.5 vs 76.4;P<0.05) was statistically significant in favor of 3+PRN group. BCVA changed in 1+PRN group from 0.77 to 0.78, 0.75 and 0.75;in 3+PRN group from 0.81 to 0.69, 0.72, and 0.76 at months 3, 6, and 12, respectively. Visual gain was statistically better in 3+PRN group at 3^(th) month(-0.01 vs 0.12;P<0.001). In IVR group, CMT reduction was in greater in 3+PRN at 6^(th)(44 vs 72) and 12^(th) month(61 vs 84), but statistically insignificant. The 3+PRN group revealed statistically better visual results at 3^(th) month(-0.02 vs 0.11, P<0.05). In IVA group, although statistically insignificant, CMT reduction(61 vs 89, 6^(th) month;85 vs 97, 12^(th) month) and visual gain(0.02 vs 0.16;0.02 vs 0.14;0.05 vs 0.11) was found in favor of 3+PRN group

关键词： aflibercept neovascular age-related macular degeneration ranibizumab loading dose treatment regimen

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