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Correction to： Gender difference in acquired seizure susceptibility in adult rats after early complex febrile seizures

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Neuroscience Bulletin 2018年第2期34卷 403-404页

作者： Yun-Jian Dai Zheng-Hao xu Bo Feng ceng-lin xu Hua-Wei Zhao Deng-Chang Wu Wei-Wei Hu Zhong Chen Department of Pharmacology Key Laboratory of Medical Neurobiology of the Ministry of Health of China Zhejiang Province Key Laboratory of Neurobiology Basic Medical College College of Pharmaceutical Sciences Zhejiang University Hangzhou 310058 China Department of Neurology Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China

In the original publication of the article, the representativeEEG of female rat pups with FS in Figure 1 C and D wasincorrectly intercepted from that of male rat pups. Thiscorrection does not affect the conclusions of...

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Low frequency stimulation of entorhinal cortex inhibits hippocampal neuronal activities and fast kindling seizures

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Low frequency stimulation of entorhinal cortex inhibits hipp...

Pyroptosis,ferroptosis,and autophagy in spinal cord injury:regulatory mechanisms and therapeutic targets

中国神经科学学会第十届全国学术会议

作者： Zheng-hao xu Yi WANG An-Feng TAO ceng-lin xu Miao-Miao JIN Kai ZHONG Shi-Hong ZHANG Zhong CHEN Zhejiang University Department of Pharmacology Key Laboratory of Medical Neurobiology of the Ministry of Health of China and Zhejiang Province Key Laboratory of Neurobiology College of Pharmaceutical Sciences School of Medicine

Objective The entorhinal cortex（EC） is a potential target for low frequency stimulation（LFS,1Hz）treatment of temporal lobe epilepsy（TLE）.However,the neuronal basis of LFS at EC is *** on the anatomy of entorhinal-hippocampal circuit,the present study was designed to determine whether LFS at EC interfere with hippocampal neural activities and *** The effects of LFS at EC on the neural activity of dentate gyrus（DG） were examined using single-unit extracellular recordings in anesthetized rats and *** effect of LFS at EC on hippocampal fast kindling seizures was *** The spontaneous activity of the majority neurons（104/115 neurons） in DG were repeatedly interrupted as soon as LFS-on and quickly backed to baseline after *** stimulation pulse mainly induced two distinct types of neural response in DG:the commonly observed type（81/115neurons） displayed a 179±12 ms inhibition of neural firing 13±2 ms after stimulation;the second type（23/115 neurons）firstly displayed an excitatory response and then a 130±15 ms inhibition of neural firing 25±5 ms after *** effect of EC stimulation on DG neural activities were mimicked by stimulation of the main projections from the EC to DG（perforant pathway,PP） or optogenetic selective stimulation of axonal projections in *** of EC also interrupted neurons in hippocampal CA3 and CA1 but not in substantia ***,LFS of EC immediately after kindling stimulation but not after the cessation of afterdischarge interfered with kindling and kindled *** LFS of EC directly interrupted the spontaneous activity hippocampal neural activities,which may through its axonal projections to the hippocampus;and LFS of EC interferes with hippocampal fast kindling seizures in a time-dependent *** results suggest EC is a promising target for closed-loop LFS treatment of TLE.

关键词： epilepsy low-frequency stimulation entorhinal cortex kindling

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Neural Regeneration Research 2025年第10期20卷 2787-2806页

作者： Qingcong Zheng Du Wang Rongjie lin Weihong xu Department of Spinal Surgery the First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian ProvinceChina Arthritis Clinical and Research Center Peking University People’s HospitalBeijingChina Department of Orthopedic Surgery Fujian Medical University Union HospitalFuzhouFujian ProvinceChina

Regulated cell death is a form of cell death that is actively controlled by *** studies have shown that regulated cell death plays a key role after spinal cord *** and ferroptosis are newly discovered types of regulated cell deaths that have been shown to exacerbate inflammation and lead to cell death in damaged spinal ***,a complex form of cell death that is interconnected with various regulated cell death mechanisms,has garnered significant attention in the study of spinal cord *** injury triggers not only cell death but also cellular survival *** signaling pathways play pivotal roles in influencing the processes of both deterioration and repair in spinal cord injury by regulating pyroptosis,ferroptosis,and ***,this review aims to comprehensively examine the mechanisms underlying regulated cell deaths,the signaling pathways that modulate these mechanisms,and the potential therapeutic targets for spinal cord *** analysis suggests that targeting the common regulatory signaling pathways of different regulated cell deaths could be a promising strategy to promote cell survival and enhance the repair of spinal cord ***,a holistic approach that incorporates multiple regulated cell deaths and their regulatory pathways presents a promising multi-target therapeutic strategy for the management of spinal cord injury.

关键词： autophagy cell death ferroptosis inflammation pathological mechanisms pyroptosis regulated cell death regulatory pathways spinal cord injury therapeutic targets

Mainchain conformation ordering self-assembly tailored room temperature phosphorescence emission

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Science China Chemistry 2025年第1期68卷 329-336页

作者： Yuzhu Li Yumeng Gao Feng Tian Yu Wang Yuan Yao Shaoliang lin Xiang Ma Binbin xu Shanghai Key Laboratory of Advanced Polymeric Materials Key Laboratory for Ultrafine Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology Shanghai Synchrotron Radiation Facility Shanghai Advanced Research Institute Chinese Academy of Sciences Key Laboratory for Advance Materials and Feringa Noble Prize Scientist Joint Research Centre Frontiers Science for Materiobiology and Dynamic Chemistry School of Chemistry and Molecular Engineering East China University of Science & Technology

Developing organic room-temperature phosphorescence （RTP） materials with a wide range of tunable-emission is significant in expanding the applications of RTP ***,we rationally designed amphiphilic alternating copolymers poly(1,2-bis（4-alkoxyphenyl）ethane-1,2-dione-alt-（ethylene glycol）x)(P（Bz-alt-EGx）) that combined the advantage of alternating benzil and EGxskeleton,and tunable mainchain *** a mainchain conformation ordering assembly （COA） process,P（Bz-alt-EGx） self-assembled into well-defined platelets,and such assemblies emitted blue RTP at ca.425 nm due to the ordered folded-chain conformation and confined *** contrast,traditional self-assembly （TA） of P（Bz-alt-EGx） obtained less ordered aggregates,such as asymmetric worms,vesicles,and rod-like *** resultant less ordered aggregates exhibited yellow-green RTP at ca.550 *** wide-tuning RTP emission in solution （between blue and yellow-green,over125 nm） is realized using the P（Bz-alt-EGx） alternating copolymers under the treatment of different self-assembly *** study uncovers a new strategy to tailor the RTP emission through different self-assembly pathways and holds great promise for the fabrication of advanced optical materials.

关键词： self-assembly conformation ordering alternating copolymer phosphorescence emission

Multi-model ensemble learning for battery state-of-health estimation:Recent advances and perspectives

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Journal of Energy Chemistry 2025年第1期100卷 739-759页

作者： Chuanping lin Jun xu Delong Jiang Jiayang Hou Ying Liang Zhongyue Zou xuesong Mei State Key Laboratory for Manufacturing Systems Engineering Xi'an Jiaotong University Shaanxi Key Laboratory of Intelligent Robots School of Mechanical Engineering Xi'an Jiaotong University Department of Electrical Engineering and Automation Luoyang Institute of Science and Technology School of Mechanical Engineering Hangzhou Dianzi University

The burgeoning market for lithium-ion batteries has stimulated a growing need for more reliable battery performance monitoring. Accurate state-of-health(SOH) estimation is critical for ensuring battery operational performance. Despite numerous data-driven methods reported in existing research for battery SOH estimation, these methods often exhibit inconsistent performance across different application scenarios. To address this issue and overcome the performance limitations of individual data-driven models,integrating multiple models for SOH estimation has received considerable attention. Ensemble learning(EL) typically leverages the strengths of multiple base models to achieve more robust and accurate outputs. However, the lack of a clear review of current research hinders the further development of ensemble methods in SOH estimation. Therefore, this paper comprehensively reviews multi-model ensemble learning methods for battery SOH estimation. First, existing ensemble methods are systematically categorized into 6 classes based on their combination strategies. Different realizations and underlying connections are meticulously analyzed for each category of EL methods, highlighting distinctions, innovations, and typical applications. Subsequently, these ensemble methods are comprehensively compared in terms of base models, combination strategies, and publication trends. Evaluations across 6 dimensions underscore the outstanding performance of stacking-based ensemble methods. Following this, these ensemble methods are further inspected from the perspectives of weighted ensemble and diversity, aiming to inspire potential approaches for enhancing ensemble performance. Moreover, addressing challenges such as base model selection, measuring model robustness and uncertainty, and interpretability of ensemble models in practical applications is emphasized. Finally, future research prospects are outlined, specifically noting that deep learning ensemble is poised to advance ens

关键词： Contrastive Learning

Advances in the Development of Gradient Scaffolds Made of Nano‑Micromaterials for Musculoskeletal Tissue Regeneration

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Nano-Micro Letters 2025年第3期17卷 455-500页

作者： Lei Fang Xiaoqi lin Ruian xu Lu Liu Yu Zhang Feng Tian Jiao Jiao Li Jiajia xue Beijing Laboratory of Biomedical Materials Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China School of Biomedical Engineering Faculty of Engineering and ITUniversity of Technology SydneySydneyNSW 2007Australia

The intricate hierarchical structure of musculoskeletal tissues,including bone and interface tissues,necessitates the use of complex scaffold designs and material structures to serve as tissue-engineered *** has led to growing interest in the development of gradient bone scaffolds with hierarchical structures mimicking the extracellular matrix of native tissues to achieve improved therapeutic *** on the anatomical characteristics of bone and interfacial tissues,this review provides a summary of current strategies used to design and fabricate biomimetic gradient scaffolds for repairing musculoskeletal tissues,specifically focusing on methods used to construct compositional and structural gradients within the *** latest applications of gradient scaffolds for the regeneration of bone,osteochondral,and tendon-to-bone interfaces are ***,the current progress of testing gradient scaffolds in physiologically relevant animal models of skeletal repair is discussed,as well as the challenges and prospects of moving these scaffolds into clinical application for treating musculoskeletal injuries.

关键词： Gradient scaffolds Musculoskeletal tissues Advanced manufacturing Biomaterials Tissue regeneration

The crucial period for focal low frequency stimulation inhibiting the development of amygdala-kindling in rats

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The crucial period for focal low frequency stimulation inhib...

Depolarized subicular microcircuits mediate generalized seizure in temporal lobe epilepsy

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Yi WANG,Zheng-Hao xu,Yang LIU,Kai ZHONG,ceng-lin xu,Wei-Wei HOU,Shi-Hong ZHANG,Zhong CHEN~* Institute of Neuroscience,Department of Pharmacology,College of Pharmaceutical Sciences,School of Medicine, Zhejiang University,Hangzhou 310058,China

＜正＞Objective To investigate whether there is a crucial period for focal low frequency stimulation（LFS） inhibiting the development of amygdala-kindling in *** The effect of focal LFS（1 Hz,15 min） applied in different periods of the kindling development process were *** was initiated immediately after daily kindling *** LFS given in the first week of kindling or during the whole kindling process had similar antiepileptic effect on the development of kindling,indicated by the slowed development of seizure stage and the shortened afterdischarge duration,while LFS applied after the first week of kindling had no effect,even aggravated afterdischarge *** the rats in the control group or received LFS after the first week were fully kindled within 20 ***,only 44%rats received LFS in the first week and 32.5%rats received LFS during the whole kindling process were fully kindled within 20 *** The first week of kindling process is a crucial period for focal LFS inhibiting the development of *** early period in epileptogenesis may be an ideal time for LFS treatment.

关键词： LFS epilepsy amygdala kindling crucial period

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Impacts of Nutlin-3a and exercise on murine double minute 2-enriched glioma treatment

中国神经科学学会第十二届全国学术会议

作者： Yi Wang ceng-lin xu Zheng-Hao xu Cai-Hong Ji Jiao Liang Ying Wang Bin Chen Xiao-Hua Wu Feng Gao Shuang Wang Yi Guo Xiaoming Li Jian-Hong Luo Shu-ming Duan Zhong Chen Department of Pharmacology Key Laboratory of Medical Neurobiology of the Ministry of Health of China College of Pharmaceutical Sciences School of Medicine Zhejiang University Epilepsy Center Second Affiliated Hospital School of Medicine Zhejiang University College of Basic Medical Science Zhejiang Chinese Medical University Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases First Affiliated Hospital School of Medicine Zhejiang University

Secondary generalized seizure（s GS） is a major source of disability in temporal lobe epilepsy（TLE） with unclear cellular/circuit mechanisms. Here we found that clinical TLE patients with s GS showed the reduced volume specifically in the subiculum compared with those without s GS. Further, using optogenetics and extracellular electrophysiological recording in mice models, we found that photoactivation of subicular GABAergic neurons retarded s GS acquisition by inhibiting the firing of pyramidal neurons. While once s GS had been stably acquired, photoactivation of those neurons aggravated s GS expression via depolarized GABAergic signaling. Subicular somatostatin but not parvalbumin subtype GABAergic neurons were not easily depolarized in s GS expression. Finally, photostimulation of subicular pyramidal neurons genetically targeted with proton pump Arch, rather than chloride pump Np HR3.0, alleviated s GS expression. These results demonstrated that depolarized GABAergic signaling in subicular microcircuit mediates s GS in TLE. This may be of therapeutic interest in understanding the pathological neuronal circuitry underlying s GS.

关键词： epilepsy generalized seizure optogenetics subiculum depolarized GABAergic signaling

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Neural Regeneration Research 2025年第4期20卷 1135-1152页

作者： Yisheng Chen Zhongcheng Fan Zhiwen Luo xueran Kang Renwen Wan Fangqi Li Weiwei lin Zhihua Han Beijie Qi Jinrong lin Yaying Sun Jiebin Huang Yuzhen xu Shiyi Chen Department of Sport Medicine Huashan HospitalFudan UniversityShanghaiChina Department of Orthopedic Surgery Hainan Province Clinical Medical CenterHaikou Affiliated Hospital of Central South University Xiangya School of MedicineHaikouHainan ProvinceChina Department of Basic Medicine Shanghai Jiao Tong University School of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Neurosurgery Second Affiliated Hospital of Zhejiang University School of MedicineZhejiang UniversityHangzhouZhejiang ProvinceChina Department of Orthopedics Shanghai General HospitalSchool of Medicine Shanghai Jiao Tong UniversityShanghaiChina Department of Infectious Diseases Children’s Hospital of Fudan UniversityNational Children’s Medical CenterShanghaiChina Department of Rehabilitation The Second Affiliated Hospital of Shandong First Medical UniversityTaianShandong ProvinceChina

Recent research has demonstrated the impact of physical activity on the prognosis of glioma patients,with evidence suggesting exercise may reduce mortality risks and aid neural *** role of the small ubiquitin-like modifier(SUMO)protein,especially post-exercise,in cancer progression,is gaining attention,as are the potential anti-cancer effects of *** used machine learning to create the exercise and SUMO-related gene signature(ESLRS).This signature shows how physical activity might help improve the outlook for low-grade glioma and other *** demonstrated the prognostic and immunotherapeutic significance of ESLRS markers,specifically highlighting how murine double minute 2(MDM2),a component of the ESLRS,can be targeted by *** underscores the intricate relationship between natural compounds such as nutlin-3 and immune *** comprehensive CRISPR screening,we validated the effects of specific ESLRS genes on low-grade glioma *** also revealed insights into the effectiveness of Nutlin-3a as a potent MDM2 inhibitor through molecular docking and dynamic ***-3a inhibited glioma cell proliferation and activated the p53 *** efficacy decreased with MDM2 overexpression,and this was reversed by Nutlin-3a or *** using a low-grade glioma mouse model highlighted the effect of physical activity on oxidative stress and molecular pathway ***,both physical exercise and Nutlin-3a administration improved physical function in mice bearing tumors derived from MDM2-overexpressing *** results suggest the potential for Nutlin-3a,an MDM2 inhibitor,with physical exercise as a therapeutic approach for glioma *** research also supports the use of natural products for therapy and sheds light on the interaction of exercise,natural products,and immune regulation in cancer treatment.

关键词： exercise and SUMO-related gene signatures(ESLRS) glioblastoma management low-grade glioma natural bioactives neural regeneration physical exercise