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Fungi between extremotolerance and opportunistic pathogenicity on humans

Fungal Diversity 2018年第6期93卷 195-213页

作者： cene gostincar Janja Zajc Metka Lenassi Ana Plemenitas Sybren de Hoog Abdullah M.S.Al-Hatmi Nina Gunde-Cimerman Department of Biology Biotechnical FacultyUniversity of LjubljanaJamnikarjeva 1011000 LjubljanaSlovenia Department of Molecular and Biomedical Sciences Jozˇef Stefan InstituteJamova 391000 LjubljanaSlovenia National Institute of Biology Vecˇna pot 1111000 LjubljanaSlovenia Institute of Biochemistry Faculty of MedicineUniversity of LjubljanaVrazov trg 21000 LjubljanaSlovenia Westerdijk Fungal Biodiversity Institute UtrechtThe Netherlands Center of Expertise in Mycology of RadboudUMC/Canisius Wilhelmina Ziekenhuis NijmegenThe Netherlands Directorate General of Health Services IbriOman

Numerous agents of infections in humans and other mammals are found among fungi that are able to survive extreme environmental conditions and to quickly adapt to novel ***,the relationship between opportunistic potential and polyextremotolerance was not yet studied systematically in ***,the link between polyextremotolerance and opportunistic pathogenicity is shown in a kingdom-wide phylogenetic analysis as a statistically significant co-occurrence of extremotolerance(*** and psychrotolerance)and opportunism at the level of fungal *** addition to extremotolerance,fungal opportunists share another characteristic—an apparent lack of specialised virulence *** is illustrated by a comparative genomic analysis of 20 dothideomycetous and eurotiomycetous black *** the genomes of specialised fungal plant pathogens were significantly enriched in known virulence-associated genes that encode secreted proteases,carbohydrate active enzyme families,polyketide synthases,and non-ribosomal peptide synthetases,no such signatures were observed in human *** the presented results have several *** infection of human hosts is a side effect of fungal stress tolerance and adaptability,the human body is most likely neither the preferred habitat of such species,nor important for their evolutionary *** defines opportunism as opposed to pathogenicity,where infection is advantageous for the species’*** opportunists are generally incapable of the host-to-host transmission,any host-specific adaptations are likely to be lost with the resolution of the infection,explaining the observed lack of specialised virulence *** this scenario opportunistic infections should be seen as an evolutionary dead end and unlikely to lead to true pathogenicity.

关键词： Virulence factor Extremotolerance Stress tolerance Mycosis Opportunistic infection Black yeast

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