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世界核心医学期刊文摘(神经病学分册) 2006年第8期 60-61页

作者： Montenegro M.A. Kinay D. cendes f. 樊慧婷 Department of.Neurology University of Campinas UNI- CAMP PO Box 6111 Campinas SP 13083- 970 Brazil Dr.

Objective: To assess whether dif.erent types of.malf.rmation of.cortical development (MCD) are associated with specif.c patterns of.hippocampal abnormalities. Methods: A total of.122 consecutive patients with MRI diagnosis of.MCD (53 males, age range 1- 58 years) were included in the study. Hippocampal measurements were made on 1- 3 mm coronal T1- weighted MRIs and compared with MRIs of.normal controls. Results: A total of.39 patients had f.cal cortical dysplasia, 5 had hemimegalencephaly, 5 had lissencephaly- agyria- pachygyria, 11 had SLH, 11 had PNH, 12 had bilateral contiguous PNH, 5 had schizencephaly, and 34 had polymicrogyria. The f.equency of.hippocampal abnormalities in these patients with MCD was 29.5% . A small hippocampus was present in all types of.MCD. Only patients with lissencephaly and SLH had an enlarged hippocampus. Abnormalities in hippocampal rotation and shape were present in all types of.MCD; however, these predominated in PNH. None of.the patients with lissencephaly- agyria- pachygyria or SLH had hyperintense signal on T2 or f.AIR images or abnormal hippocampal internal architecture. Conclusion: A small hippocampus was present in all types of.MCD; however, the classic MRI characteristics of.hippocampal sclerosis were of.en lacking. Abnormal enlargement of.the hippocampus was associated with only dif.use MCD due to abnormal neuronal migration (lissencephaly- agyria- pachygyria and SLH).

关键词：海马异常模式 CD 边缘系统皮质发育畸形巨脑回畸形

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系统性红斑狼疮患者可逆性轴突功能异常的证据:一项质子MRS研究

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世界核心医学期刊文摘（神经病学分册） 2006年第6期2卷 60-61页

作者： Appenzeller S. Costallat L.T.L. cendes f. 周永 Department of.Neurology FCM-UNICAMP Cidade Universitária Zeferino Vaz Campinas SP CEP 13083-970 Brazil Dr.

Our objective was to investigate axonal dysf.nction in patients with systemic lupus erythematosus (SLE) using proton magnetic resonance spectroscopy (1H-MRS)-We studied prospectively 90 SLE patients (mean age of.32.5 years) and 23 normal volunteers (mean age of.33.8 years). We perf.rmed single voxel proton MRS using point resolved spectroscopy sequence over the superior-posterior region of.the corpus callosum. We measured signals f.om N-acetyl compounds N-acetylaspartate (NAA) at 2.01 p.p.m., choline-based compounds (Cho) at 3.2 p.p.m. and creatine and phosphocreatine containing compounds (Cr) at 3.0 p.p.m. and determined NAA/Cr ratios. Af.er 12 months, MRI and MRS were repeated in 50 patients and 9 volunteers. Patients were divided according to disease activity (measured by SLE disease activity index)during initial and f.llow-up MRS. We perf.rmed paired t-test and ANOVA with Tukey’s post hoc comparisons to evaluate group dif.erences. At study entry, 29 patients had active SLE with involvement of.central nervous system (CNS) and 28 patients had active SLE without CNS manif.stations. A total of.14 patients had inactive SLE with past CNS presentation, and 19 had inactive SLE without history of.CNS involvement. NAA/Cr ratios were signif.cant lower in patients with active SLE, independently of.CNS involvement, when compared with patients with inactive SLE (P = 0.005) and controls (P = 0.01). We observed a signif.cant increase in NAA/Cr ratio in 15 patients who had active SLE at initial MRS and inactive SLE at f.llow-up (P = 0.04). In 10 patients with active SLE both at initial and at f.llow-up MRS we observed a reduction in NAA/Cr ratio (P = 0.02). By contrast, there was a signif.cant reduction of.NAA/Cr ratio in 15 patients who had inactive SLE at initial MRS and active SLE at f.llow-up (P = 0.001). In 10 patients with inactive SLE both at initial and at f.llow-up MRS NAA/Cr ratio did not change (P = 0.2). This study shows evidence of.axonal dysf.nction in patients wit

关键词：系统性红斑狼疮患者质子磁共振波谱功能异常 MRS 轴突 N-乙酰天冬氨酸 NAA/Cr SLE患者可逆性疾病活动指数

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系统性红斑狼疮患者的痫性发作

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世界核心医学期刊文摘（神经病学分册） 2005年第4期1卷 38-39页

作者： Appenzeller S. cendes f. Costallat L.T.L. 袁海峰 Department of.Neurology State Univ. of Campinas (UNI- CAMP) Cd. Universitaria Zeferino Vaz CEP 13083970 Campinas- SP Brazil Dr

Objective: To evaluate the f.equency and risk f.ctors of.epileptic seizures in a large cohort of.patients with systemic lupus erythematosus (SLE). Methods: f.ve hundred nineteen consecutive patients with SLE were studied, with f.llow- up ranging f.om 4 to 7.8 years. The type and f.equency of.risk f.ctors associated with acute and recurrent epileptic seizures in SLE were determined. Results: Sixty (11.6% ) patients with epileptic seizures were identif.ed. Epileptic seizures occurred at the onset of.SLE symptoms in 19 (31.6% ) and af.er the onset of.SLE in 41 of.60 (68.3% ) patients. f.f.y- three of.60 (88.3% )- patients had acute symptomatic epileptic seizures, and 7 of.60 (11.7% ) had recurrent epileptic seizures. Variables associated with acute epileptic seizures at SLE onset were stroke (p = 0.0004) and antiphospholipid antibodies (p = 0.0013). Epileptic seizures during f.llow- up were related to nephritis (p = 0.001), antiphospholipid antibodies (p = 0.005), and epileptic seizures at disease onset (p = 0.00001). All seven patients who presented recurrent epileptic seizures had antiphospholipid syndrome and interictal epileptic abnormalities on EEG. Conclusions: Epileptic seizures were observed in 11.2% of.systemic lupus erythematosus (SLE) patients. Antiphospholipid antibodies and stroke were related to epileptic seizures at SLE disease onset. Patients with renal f.ares, epileptic seizures at SLE disease onset, and antiphospholipid antibodies were at greater risk f.r acute symptomatic seizures during f.llow- up. Recurrence of.epileptic seizures occurred in 1.3% of.patients and was associated with antiphospholipid syndrome.

关键词：系统性红斑狼疮痫性发作抗磷脂抗体发作间期性异常

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海马异常和停用抗癫痫药后复发痫性发作

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世界核心医学期刊文摘(神经病学分册) 2006年第12期 19-20页

作者： Cardoso T.A.M. Coan A.C. Kobayashi E. f.cendes 郭俊 Dr.Departamento de Neurologia Faculdade de Ciências Médicas-UNICAMPCidade Universitária Zeferino VazCampinas SPCEP 13083-970Brazil

The authors perf.rmed hippocampal volumetry and T2 relaxometry in 84 consecutive patients with partial epilepsy f.om a protocol f.r antiepileptic drug(AED)withdrawal af.er at least 2 years of.seizure *** recurrence af.er AED withdrawal was more f.equent among patients with hippocampal atrophy and abnormal hippocampal T2 signal.

关键词：痫性发作海马边缘系统停用

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