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A potential clinical based score in hepatitis C viruscirrhotic patients to exclude small hepatocellular carcinoma

Hepatoma Research 2018年第4期4卷 14-24页

作者： Denise Cerqueira Paranaguá-Vezozzo celso eduardo lourenco matielo Daniel Ferraz de Campos Mazo Lucas Souto Nacif Mario Guimaraes Pessoa Gleicy Luz Reinoso Pereira Roque Gabriel Rezende de Lima Patricia Momoyo Yoshimura Zitelli Suzane Kioko Ono Flair JoséCarrilho Division of Gastroenterology and Hepatology Department of GastroenterologyUniversity of Sao Paulo School of MedicineSao Paulo 05403-900Brazil Sao Paulo Clínicas Liver Cancer Group Sao PauloCancer Institute of Sao PauloUniversity of Sao Paulo School of MedicineSao Paulo 01246-000Brazil Division of Gastroenterology(Gastrocentro) School of Medical SciencesUniversity of CampinasCampinas 13083-878Brazil

Aim: Hepatitis C virus (HCV) cirrhosis is an important cause of hepatocellular carcinoma (HCC). This study aimed to identify factors of HCC presence among HCV cirrhotic patients with and without small diameter HCC (≤ 3 cm). Methods: A case control transversal study between 1998 and 2003 including 93 patients: 31 with small diameter HCC and 62 without HCC. Groups were matched by age and gender. Multiple logistic regression analysis using Akaike Information Criteria to estimate the probability of HCC was performed. A model score was generated and bootstrap analysis was performed for internal validation. Results: Three significant laboratorial variables for HCC presence were found: alanine aminotransferase > 37 U/L [odds ratio (OR): 7.43 (1.61-34.19),P = 0.01], alpha-fetoprotein > 20 ng/mL [OR: 16.2 (4.17-63.01),P < 0.001] and platelet count < 100,000/mm3 (OR: 3.62 (1.43-9.14),P = 0.007)A model score with an area under curve of 0.79 (95% CI: 0.7-0.89) was built based on these variables. The negative predictive value of those classified as at low risk of HCC was 99.1%. Conclusion: An easy and practical model score was generated. It may be an auxiliary tool for identification of HCV patients with low probability of small diameter HCC at initial evaluation composed of three serum examinations used in routine outpatient clinical practice.

关键词： Clinical score hepatocellular carcinoma hepatitis C

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Non-wetting Additive as a Solution to Minimize the Corrosion of Refractory Castables Against Molten Aluminum

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China's Refractories 2016年第1期25卷 20-25页

作者： Fernando VERNILLI Adriel Claro de FARIA Mateus Gomes VERNILLI Augusto celso AMOEDO eduardo Jose Togni CARDILLO Taner Augusto MAIA Matheus MARTINI Engineering School of Lorena University of Sao Paulo Lorena 12600-970 Brazil Togni S/A Materiais Refratarios Pocos de Caldas 37704-356 Brazil

The ternary compound barium aluminosilicate BaAl2Si2O8, known as celsian, a non-wetting additive that increases the corrosion resistance of refractor） materials against molten aluminum, was incorporated into the matrix of a high-alumina low cement castable after its synthesis using barite and a low cost source of alumina and silica. This paper presents the influence of this phase on the wetting angle formed between liquid aluminum alloy and solid refractory castable surface.

关键词： refractories con'osion non-wetting additive aluminmn alloy

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Comprehensive analysis of HFE gene in hereditary hemochromatosis and in diseases associated with acquired iron overload

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World Journal of Hepatology 2019年第2期11卷 186-198页

作者： Wagner Narciso de Campos Juliana Doblas Massaro eduardo Luiz Rachid Can?ado Cláudia Emília Vieira Wiezel Aguinaldo Luiz Sim?es Andreza Correa Teixeira Fernanda Fernandes de Souza celso Teixeira Mendes-Junior Ana de Lourdes Candolo Martinelli eduardo Ant?nio Donadi Division of Clinical Immunology Department of MedicineRibeir?o Preto Medical SchoolUniversity of S?o Paulo Department of Gastroenterology Clinical Gastroenterology and Clinical Hepatology of Clinical HospitalUniversity of S?o Paulo School of Medicine Department of Genetics Ribeir?o Preto Medical SchoolUniversity of S?o Paulo Division of Gastroenterology Department of MedicineRibeir?o Preto Medical SchoolUniversity of S?o Paulo Departamento de Química Laboratório de Pesquisas Forenses e Gen?micasFaculdade de FilosofiaCiências e Letras de Ribeir?o PretoUniversidade de S?o Paulo

BACKGROUND Patients with hepatitis C virus(HCV) and hepatocellular carcinoma(HCC) may or not develop iron overload(IO),which is associated with worst prognosis,because can cause serious damage to *** gene controls the iron uptake from gut,particularly in patients with hereditary hemochromatosis(HH).AIM To identify associations between HFE coding region in patients exhibiting hereditary hemochromatosis and in diseases associated with acquired *** We sequenced exons 2 to 5 and boundary introns of HFE gene,evaluating all polymorphic sites in patients presenting hereditary(hemochromatosis) or acquired iron overload HCV and HCC) and in healthy controls,using Sanger *** also determined the ensemble of extended haplotype in healthy control individuals,including several major histocompatibility complex loci,using sequence specific *** reconstruction was performed using the Arlequin and Phase softwares,and linkage disequilibrium(LD) between histocompatibility loci and HFE gene was performed using the Haploview *** The HFE*003 allele was overrepresented(f = 71%) and HFE*001 allele was underrepresented(f = 14%) in HH patients compared to all groups.A strong linkage disequilibrium was observed among the H63 D-G,IVS2(+4)-C and C282 YG gene variants,particularly in HH;however,the mutation IVS2(+4)T>C was not directly associated with HH *** HFE*001/HFE*002 genotype conferred susceptibility to HCC in HCV patients exhibiting IO(P = 0.02,OR =14.14).Although HFE is telomeric to other histocompatibility genes,the H63 DG/IVS2(+4)-C(P ≤ 0.00001/P ≤ 0.0057) combination was in LD with HLA-B*44 allele group in healthy *** LD was observed between HFE alleles and other major histocompatibility *** A differential HFE association was observed for HH and for diseases associated with acquired IO(HCV,HCC).Since HFE is very distant from other histocompatibility loci,only weak associations were observed with these a

关键词： HFE gene Hepatocellular carcinoma Hepatitis C Hemochromatosis hereditary Alleles Haplotypes

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Spatial Modeling of Soil Lime Requirements with Uncertainty Assessment Using Geostatistical Sequential Indicator Simulation

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Open Journal of Soil Science 2017年第7期7卷 133-148页

作者： Jussara de Oliveira Ortiz Carlos Alberto Felgueiras eduardo celso Gerbi Camargo Camilo Daleles Rennó Manoel Jimenez Ortiz INPE-Brazilian National Institute for Space Researches DPI-Divisão de Processamento de Imagens S&#227o José dos Campos Brazil Geopixel Soluções em Geotecnologias e TI S&#227o José dos Campos Brazil

This work presents and analyses a geostatistical methodology for spatial modelling of Soil Lime Requirements (SLR) considering punctual samples of Cation Exchange Capacity (CEC) and Base Saturation (BS) soil properties. Geostatistical Sequential Indicator Simulation is used to draw realizations from the joint uncertainty distributions of the CEC and the BS input variables. The joint distributions are accomplished applying the Principal Component Analyses (PCA) approach. The Monte Carlo method for handling error propagations is used to obtain realization values of the SLR model which are considered to compute and store statistics from the output uncertainty model. From these statistics, it is obtained predictions and uncertainty maps that represent the spatial variation of the output variable and the propagated uncertainty respectively. Therefore, the prediction map of the output model is qualified with uncertainty information that should be used on decision making activities related to the planning and management of environmental phenomena. The proposed methodology for SLR modelling presented in this article is illustrated using CEC and BS input sample sets obtained in a farm located in Ponta Grossa city, Paraná state, Brazil.

关键词： Spatial Modeling of Soil Attributes Indicator Geostatistics Joint Simulation Principal Component Analyses Spatial Uncertainty Analyses

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Energy Efficiency Technologies for Hydroelectric Power Plants: A Case Study in Brazil

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Journal of Power and Energy Engineering 2022年第5期10卷 90-115页

作者： Thiago Averaldo Bimestre José Antonio Mantovani Júnior Eliana Vieira Canettieri celso eduardo Tuna Pedro Magalhães Sobrinho Chemistry and Energy Department School of Engineering S&#227o Paulo State University UNESP Guaratinguetá Brazil Center for Weather Forecasting and Climate Studies National Institute for Space Research CPTEC/INPE Cachoeira Paulista Brazil

Hydroelectricity has great importance for the global macroeconomy. In Brazil, hydroelectricity has been highlighted as the main source of generation of the electric system both for its economic competitiveness and for the abundance of this energy resource. Based on a diagnosis methodology, this article presents a case study in a Brazilian hydroelectric plant in order to optimize the use of energy and propose improvements regarding the rationalization of its application. The systems associated with energy generation were evaluated and the results proved to be potentially advantageous with an estimated savings of 2910 MWh/year in the electricity consumption of the installation itself, with better use of the equipment and the possibility of increasing the power generated.

关键词： Hydropower Plant Renewable Energy Technology Energy Efficiency Energetic Diagnosis Sustainable

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Calibration of Hargreaves-Samani Equation for Estimating Reference Evapotranspiration in Sub-Humid Region of Brazil

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Journal of Water Resource and Protection 2013年第12期5卷 1-5页

作者： José Romualdo de Sousa Lima Antonio celso Dantas Antonino eduardo Soares de Souza Claude Hammecker Suzana Maria Gico Lima Montenegro Carlos Alberto Brayner de Oliveira Lira Academic Unity of Garanhuns Federal Rural University of Pernambuco Garanhuns Brazil Academic Unity of Serra Talhada Federal Rural University of Pernambuco Serra Talhada Brazil Land Development Department Office of Science for Land Development IRD Montpellier France Nuclear Energy Department Federal University of Pernambuco Recife Brazil

Reference evapotranspiration (ETo) is an important parameter used in numerous applications, such as climatological and hydrological studies, as well as for water resources planning and management. There are several methods to estimate ETo, being that the FAO Penman-Monteith (EToPM) method is considered standard. This method needs many parameters (solar radiation, air temperature, humidity and wind speed), however there are still many uncovered areas, suggesting the need for methods of calculating evapotranspiration based on few meteorological elements, such as air temperature. Therefore, this study aimed to determine the ETo by Hargreaves-Samani method in the experimental watershed of the “Riacho do Papagaio” farm, in county of Sao Joao, in north-eastern Brazil, using data of 2011 and 2012. Reference evapotranspiration estimated by non-calibrated Hargreaves-Samani method (EToHS) was overestimated in all months (RMSE = 1.43 mm·d-1), mainly in months of lower evaporative demand (from May to July). Because of these tendencies, this method cannot be used in its original form to estimate ET for this region;therefore, a calibration of radiation adjustment coefficient (kRs) was performed. The calibrated Hargreaves-Samani method (EToHSc) had better performance (RMSE = 0.52 mm·d-1), being suitable for predicting ETo in this region.

关键词： Reference Evapotranspiration Penman-Monteith Hargreaves-Samani Air Temperature

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Gasification of Municipal Solid Waste for Power Generation in Brazil, a Review of Available Technologies and Their Environmental Benefits

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Journal of Chemistry and Chemical Engineering 2016年第6期10卷 249-255页

作者： Diego Mauricio Yepes Maya Angie Lizeth Espinosa Sarmiento Cristina Aparecida Vilas Boas de Sales Oliveira Electo eduardo Silva Lora RubenildoVierira Andrade Excellence Group in Thermal Power and Distributed Generation Institute of Mechanical Engineering Federal University ofltajuba Av. BPS 1303 Itajuba MG CEP 37500-903 Brazil Federal Center of Technological Education of Rio de Janeiro celso Suckow da Fonseca CEFET-RJ Areal Street 522 Angra dosReis R J CEP 23953-030 Brazil

This article reviews the literature on thermochemical processing of municipal solid waste as the final disposal in Brazil, explores recent publications in the field of solid waste generated, its origin, characteristics and removal mechanisms currently employed, in the same way, available technologies for the thermochemical treatment of MSW with an emphasis on gasification and clean technology are evaluated, highlighting the current technical and reported in the literature in order to identify indicators of efficiency and flexibility of the technology. From the review it is concluded that gasification is a technically feasible option for the thermochemical conversion of municipal solid waste and subsequent power generation, besides being a technology that meets the applicable emission limits. Some of the main advantages of gasification of municipal solid waste are：（a） the sharp reduction in the waste mass （about 70-80%） and volume （approximately 80-90%）; （b） the drastic reduction in land use, 1：3000; （c） destruction of organic pollutants and other halogenated hydrocarbons; （d） concentration and immobilisation of inorganic contaminants so that they can be used effectively and safely removed; （e） use recyclables, such as ferrous metals, ferrous ash and slag materials; （f） reducing emissions of greenhouse gases by anaerobic decomposition of organic waste and （g） power generation.

关键词： MSW waste to energy gasification thermo-chemical conversion environmental advantage.

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Health 2020年第10期12卷 1360-1370页

作者： Lucas Lima de Carvalho Lucas Rodrigues Claro Amanda dos Santos Cabral Marcela Pereira da Silva Mello Bruna Liane Passos Lucas Marcelly Valadares Souza Simone Fonseca Lucas Alexandre Oliveira Tellles Ravini Fernandez dos Santos Vieira dos Santos Marcia Augusta Pereira dos Santos Claudia Lima Campos Alzuguir Maria Cristina Dias da Silva Antonio eduardo Vieira dos Santos Maria Antonieta Rubio Tyrrell eduardo Alexander Júlio César Fonseca Lucas Anna Nery School of Nursing Federal University of Rio de Janeiro Rio de Janeiro Brazil celso Lisboa University Center Rio de Janeiro Brazil State Secretariat of Education of Rio de Janeiro Rio de Janeiro Brazil Department of Medicine in Primary Health Care Faculty of Medicine Federal University of Rio de Janeiro Rio de Janeiro Brazil Department of Maternal and Child Nursing Faculty of Nursing State University of Rio de Janeiro Rio de Janeiro Brazil Department of Maternal-Child Nursing Faculty of Nursing Fernandez Figueira Institute of the Oswaldo Cruz Foundation State University of Rio de Janeiro Rio de Janeiro Brazil

This documentary research aimed to describe the results of an epidemiological survey that sought to determine the prevalence of Infections Related to Health Care (IRHC) in newborns admitted to a Neonatal Intensive Care Unit (NICU) at the city of Rio de Janeiro. For methodology, the existing data in the original research database were used as the primary source. The method used was the case study in a quantitative approach. The data have been statistically arranged by odds ratio, which measured the possibility of IRHC development at the 102 newborns, by exposition at the risk factors. Results: IRHC prevalence with pneumonias, sepsis, navel’s infection and ocular infections predominance rises. Prematures are 4.10 more susceptible. Twelve hours after amniotic rupture there are 1.77 more chances of infections. Babies with more than 10 days of hospitalization are 4.70 more susceptible than those with 10 days. The registers examined were incipient at the IRHC’s characterization, beginning and duration, which make the IRHC’s diagnostic/notification difficult.

关键词： Neonatal Nursing Cross Infection Data Interpretation Statistical

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Biomechanical Analysis of the STS Movement and Impact of an Assistive Device on the Elderly and People with Displacement Difficulties

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Journal of Mechanics Engineering and Automation 2019年第4期9卷 111-119页

作者： Rodrigo Goncalves de Souza Maciel Daniel Kioshi Kawasaki Cavalcanti Carlos eduardo Guedes Catunda Fernando Ribeiro da Silva Department of Mechanical Engineering Federal Center of Technological Education Celso Suckow da Fonseca(CEFET/RJ)Rio de JaneiroRJ20271-110Brazil

This study presents a biomechanical analysis of the performance of the STS(sit-to-stand)movement applied to elderly and people with difficulty of displacement comparing it with and without an assistive technology device.A biomechanical kinemetry method was used for the movement evaluation.A two-dimensional virtual human model was developed through segmented ergonomic video analysis and the data obtained were numerically simulated to measure the inertial forces and torques of the complete execution of the STS *** device allows a vertical elevation of 0 to 400 mm and an anterior slope of up to 25°.A prototype was used to compare the movement with and without the assistive *** a result,the torques in the lower limbs’joints and the vertical ground reaction forces were reduced by up to 60%and 23%,*** was a reduction of up to 37°in the maximum trunk flexion angle during the *** horizontal displacement of the center of mass was reduced by up to 70%.

关键词： STS biomechanics assistive technologies kinemetry method ergonomics video analysis human model posture

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