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Vascularization in interconnected 3D printed Ti-6Al-4V foams with hydrogel matrix for biomedical bone replacement implants

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Science China Materials 2018年第4期61卷 565-578页

作者： Victor l.Correa Kristine M.Garza lawrence e.Murr Department of Metallurgical Materials and Biomedical Engineering University of Texas at El Paso Department of Biological Sciences University of Texas at El Paso

Vascularization on newly implanted metal orthopedic implants has remained a challenge in the field of tissue engineering. To address this challenge, in this research,an interconnected foam structure of Ti-6 Al-4 V was microfabricated by electron beam melting(eBM) technique. The foam in question has a density of 1.77 g cm-3 with 60% porosity and a tensile strength of 18 GPa. An extracellular matrix based hydrogel was added as an aqueous matrix to the *** mimetic stress has been closely related to many wound healing biomedical applications as it increases survival and proliferation molecular signals. To that end, increased expression of hypoxia-inducible factor-1α(Hif-1α) and vascular endothelial growth factor(VeGF) in the aqueous hydrogel matrix was achieved by the addition of a hypoxia mimetic deferoxamine mesylate(DFM). In this study, the formation of an endothelial network was achieved in a hydrogel matrix in the presence of the before mentioned 3 D printed metal foam. Cellular viability, fluorescent microscopy and scanning electron microscopy imaging analysis demonstrate that pre-osteoblasts undergo proliferation and also attach efficiently to the foam when exposed to DFM. Human umbilical vascular endothelial cells(HUVeCs) were grown in an extracellular matrix-like 3 D hydrogel and a hypoxia-like stress was achieved. This research demonstrates that pre-osteoblast cells undergo cell differentiation and increase the production of hydroxyapatite on exposure to the hypoxia mimetic molecule. This proposed approach encompasses an ideal prototype for a completely living implanted structure for future orthopedic implants.

关键词： Ti-6Al-4V electron beam melting angiogenesis deferoxamine mesylate hydrogel vascularization

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Metal separations of interest to the Chinese metallurgical industry

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Journal of Rare earths 2010年第S1期28卷 22-29页

作者： S.R.Izatt N.e.Izatt R.l.Bruening IBC Advanced Technologies Inc.856 E.Utah Valley DriveAmerican ForkUT 84003U.S.A.

IBC Advanced Technologies’ Molecular Recognition Technology(MRT) Superlig products selectively and rapidly bind with target species enabling their selective removal from *** MRT process can produce a high purity separation product of maximum added value at a competitive *** products have high selectivity for many target species which can include metal ions,anions,and neutral *** operation,the Superlig product is first placed in a packed column.A solution containing a mixture of the target species and other chemical species is then passed through the *** target species is removed selectively by the Superlig product,the column is washed to remove residual feed solution,and the target species is recovered by a minimal quantity of *** result is a pure and concentrated species that can be kept for its value or disposed of *** process is environmentally and ecologically friendly with no organic solvents being *** paper provides a review of some examples of applications of MRT to separations of interest to the Chinese metallurgical *** are several applications of MRT,including Pd separations from Pt metal refinery streams and low-grade spent catalyst wastes,Rh recovery from spent auto catalyst and other feeds,Re removal from selected impurity ions,Cd removal from Co electrolyte,Bi removal from Cu electrolyte,In and Ge separations from difficult matrices,and removal of bivalent first transition series and other metal ions from acid mine drainage(Berkeley Pit,Montana).Finally,the potential application of MRT to separations involving the recovery of rare earth metals and li from low-level waste solutions and end-of-life products is discussed.

关键词： selective and environmentally friendly metal separations molecular recognition technology Superlig platinum group metals minor metals transition series metals rhenium cadmium indium germanium bismuth rare earth metals lithium

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Common genetic variants in the TP53 pathway and their impact on cancer

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Journal of Molecular Cell Biology 2019年第7期11卷 578-585页

作者： Thibaut Barnoud Joshua l.D.Parris Maureen e.Murphy Program in Molecular and Cellular Oncogenesis The Wistar InstitutePhiladelphiaPA 19104USA Cell and Molecular Biology Program Perelman School of Medicine at the University of PennsylvaniaPhiladelphiaPA 19104USA

The TP53 gene is well known to be the most frequently mutated gene in human *** addition to mutations,there are > 20 different coding region single-nucleotide polymorphisms (SNPs) in the TP53 gene,as well as SNPs in MDM2,the negative regulator of *** of these SNPs are known to alter p53 pathway *** makes p53 rather unique among cancer-critical genes,*** coding regions of other cancer-critical genes like Ha-Ras,RB,and PI3KCA do not have non-synonymous coding region SNPs that alter their function in *** next frontier in p53 biology will consist of probing which of these coding region SNPs are moderately or strongly pathogenic and whether they influence cancer risk and the efficacy of cancer *** challenge after that will consist of determining whether we can tailor chemotherapy to correct the defects for each ofthese *** we review the SNPs in TP53 and MDM2 that show the most significant impact on cancer and other *** also propose avenues for how this information can be used to better inform personalized medicine approaches to cancer and other diseases.

关键词： p53 Pro47Ser Pro72Arg PAS MDM2 SNP309

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light Perception:A Matter of Time

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Molecular Plant 2020年第3期13卷 363-385页

作者： Sabrina e.Sanchez Matias l.Rugnone Steve A.Kay Department of Neurology Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA

Optimizing the perception of external cues and regulating physiology accordingly help plants to cope with the constantly changing environmental conditions to which they are *** array of photoreceptors and intricate signaling pathways allow plants to convey the surrounding light information and synchronize an endogenous timekeeping system known as the circadian *** biological clock integrates multiple cues to modulate a myriad of downstream responses,timing them to occur at the best moment of the day and the ***,the mechanism underlying entrainment of the light-mediated clock is not *** review addresses known interactions between the light-signaling and circadian-clock networks,focusing on the role of light in clock entrainment and known molecular players in this process.

关键词： circadian clock light signaling Arabidopsis thaliana light entrainment photoreceptors signal integration

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Creating a Research enterprise Framework for Transdisciplinary Networking to Address the Food-energy-Water Nexus

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engineering 2022年第4期8卷 95-100页

作者： Jie Zhuang Frank e.löffler Gary S.Sayler Department of Biosystems engineering and Soil Science The University of TennesseeKnoxvilleTN 37996USA Center for environmental Biotechnology The University of TennesseeKnoxvilleTN 37996USA Institute for a Secure and Sustainable environment The University of TennesseeKnoxvilleTN 37996USA Department of Microbiology The University of TennesseeKnoxvilleTN 37996USA Department of Civil and environmental engineering The University of TennesseeKnoxvilleTN 37996USA Biosciences Division Oak Ridge National LaboratoryOak RidgeTN 37831USA

Urbanization,population growth,and the accelerating consumption of food,energy,and water(FeW)resources bring unprecedented challenges for economic,environmental,and social(eeS)*** is imperative to understand the potential impacts of FeW systems on the realization of the United Nation’s Sustainable Development Goals(SDGs)as the world transitions from natural ecosystems to managed ecosystems at an accelerating rate.A major obstacle is the complexity and emergent behavior of FeW systems and associated networks,for which no single discipline can generate a holistic understanding or meaningful *** propose a research enterprise framework for promoting transdisciplinarity and top-down quantification of the interrelationships between FeW and eeS *** enterprise efforts would emphasize increasing FeW resource accessibility by improving coordinated interplays across sectors and scales,expanding and diversifying supply-chain networks,and innovating technologies for efficient resource *** framework can guide the development of strategic solutions for diminishing the competition among FeW-consuming sectors in a region or country,and for minimizing existing inequalities in FeW availability when a sustainable development agenda is implemented.

关键词： Food energy Water Stakeholder Policy environmental sustainability

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Hummingbird-plant interactions in Chile:An ecological review of the available evidence

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Avian Research 2022年第3期13卷 332-340页

作者： Rodrigo Medel Manuel lópez-Aliste Francisco e.Fontúrbel Departamento de Ciencias ecol ogicas Facultad de CienciasUniversidad de ChileSantiagoChile Instituto de Biología Facultad de CienciasPontificia Universidad Cat olica de ValparaísoValparaísoChile Millennium Nucleus of Patagonian limit of life(lili) ValdiviaChile

Hummingbird species have closely evolved with the plants they feed on,which is confirmed by their often tight ecological relationships in natural ***-plant interactions are of interest for research areas such as ecology,evolution,and even agriculture,as they usually inform on the conservation status of interacting species assemblages,and its disappearance may precede the population extinction of the species involved in the *** Chile,there are nine hummingbird species,which interact with a large and diverse number of angiosperm species in forest,desert,and mountain range *** motivation to perform this review is to systematize the available information regarding the flowering plants visited by hummingbird species in Chile,to present some basic plant-hummingbird pollination network metrics,and on this basis to identify the components of the plant-hummingbird relationships in need of further research.A plant-hummingbird metanetwork revealed a low connectance value,low niche overlap,and strong modularity among ***,the fact that most species present a strong allopatric distribution across Chile,suggests that network structure results mostly from the history of colonization rather than from ecological ***,the main threats to Chilean hummingbirds are anthropogenic disturbance and climate change,which disrupt hummingbird-plant interactions,leading to unpredictable ecological consequences at the community *** periods of drought may reduce the resource base for hummingbirds,with dramatic consequences for the maintenance of bird and plant populations.

关键词： Conservation endemic species Habitat disturbance Pollination Trochilidae

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Processes underlying the laser photochromic effect in colloidal plasmonic nanoparticle aggregates

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Chinese Physics B 2020年第3期29卷 412-419页

作者： A e ershov V S Gerasimov I l Isaev A P Gavrilyuk S V Karpov Institute of Computational Modeling SB RAS 660036KrasnoyarskRussia Siberian Federal University Krasnoyarsk660041Russia Kirensky Institute of Physics Federal Research Center KSC SB RAS660036KrasnoyarskRussia Siberian State University of Science and Technology Krasnoyarsk 660014Russia

We have studied the dynamic and static processes occurring in disordered multiparticle colloidal Ag aggregates with natural structure and affecting their plasmonic absorption spectra under pico-and nanosecond pulsed laser radiations, as well as the physical origin responsible for these processes. We have shown that depending on the duration of the laser pulse,the mechanisms of laser modification of such aggregates can be associated both with changes in the resonant properties of the particles due to their heating and melting(picosecond irradiation mode) and with the particle shifts in the resonant domains of the aggregates(nanosecond pulses) which depend on the wavelength, intensity, and polarization of the *** mechanisms result in formation of a narrow dip in the plasmonic absorption spectrum of the aggregates near the laser radiation wavelength and affect the shape and position of the dip. The effect of polydispersity of nanoparticle aggregates on laser photochromic reaction has been studied.

关键词： nanoparticle surface plasmon resonance photochromic process pulsed laser radiation

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Redundancy in Biology and Robotics:Potential of Kinematic Redundancy and its Interplay with elasticity

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Journal of Bionic engineering 2020年第4期17卷 695-707页

作者： Tom Verstraten Christian Schumacher Rapha(e)l Furnémont Andre Seyfarth Philipp Beckerle Robotics and Multibody Mechanics Research Group(R&MM) Vrije Universiteit Brussel and Flanders MakePleinlaan 21050 ElseneBelgium Institute of Sports Science TU DarmstadtMagdalenenstraβe 2764289 DarmstadtGermany elastic lightweight Robotics Group Robotics Research InstituteTU DortmundOtto-Hahn-Straβe 844227 DortmundGermany Institüt fur Mechatronische Systeme im Maschinenbau TU DarmstadtOtto-Berndt-Straβe 264287 DarmstadtGermany

Redundancy facilitates some of the most remarkable capabilities of humans,and is therefore omni-present in our *** relationship between redundancy in robotics and biology is investigated in detail on the Series elastic Dual-Motor Actuator(SeDMA),an actuator inspired by the kinematic redundancy exhibited by *** actuator consists of two motors coupled to a single spring at the *** a system has a redundant degree of freedom,which can be exploited to optimize aspects such as accuracy,impedance,fault-tolerance and energy *** test its potential for human-like motions,the SeDMA actuator is implemented in a hopping *** on a physical demonstrator show that the robot's movement patterns resemble human squat *** conclude that robots with bio-inspired actuator designs facilitate human-like movement,although current technical limitations may prevent them from reaching the same dynamic and energetic performance.

关键词： bioinspired redundant actuation series elastic actuation hopping robots energy efficiency human physiology

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Coherent Structures Generated by a Circular Jet Issuing into a Cross laminar Boundary layer

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Journal of Thermal Science 1997年第2期6卷 81-85页

作者： l. e. Brizzi J. l. Bousgarbiès e. Foucault laboratoire d’etudes Aérodynamiques URA 191 Poitiers France laboratoire d’etudes Aérodynamiques URA 191 (eSIP) Poitiers France

Visualisations by lASeR topographies and velocity measurements by lDV have allowed the study of the fiow resulting from the illteraction between a circular jet and a cross boundary layer. This type of fiow is dominated by the presence of many complex vortices that come from the recombining of the vorticity created in the injection tube and that created aIong the chamber floor.

关键词： jet vortical structures cross-flow boundary layer

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A potential clinical based score in hepatitis C viruscirrhotic patients to exclude small hepatocellular carcinoma

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Hepatoma Research 2018年第4期4卷 14-24页

作者： Denise Cerqueira Paranaguá-Vezozzo celso eduardo lourenco matielo Daniel Ferraz de Campos Mazo lucas Souto Nacif Mario Guimaraes Pessoa Gleicy luz Reinoso Pereira Roque Gabriel Rezende de lima Patricia Momoyo Yoshimura Zitelli Suzane Kioko Ono Flair JoséCarrilho Division of Gastroenterology and Hepatology Department of GastroenterologyUniversity of Sao Paulo School of MedicineSao Paulo 05403-900Brazil Sao Paulo Clínicas liver Cancer Group Sao PauloCancer Institute of Sao PauloUniversity of Sao Paulo School of MedicineSao Paulo 01246-000Brazil Division of Gastroenterology(Gastrocentro) School of Medical SciencesUniversity of CampinasCampinas 13083-878Brazil

Aim: Hepatitis C virus (HCV) cirrhosis is an important cause of hepatocellular carcinoma (HCC). This study aimed to identify factors of HCC presence among HCV cirrhotic patients with and without small diameter HCC (≤ 3 cm). Methods: A case control transversal study between 1998 and 2003 including 93 patients: 31 with small diameter HCC and 62 without HCC. Groups were matched by age and gender. Multiple logistic regression analysis using Akaike Information Criteria to estimate the probability of HCC was performed. A model score was generated and bootstrap analysis was performed for internal validation. Results: Three significant laboratorial variables for HCC presence were found: alanine aminotransferase > 37 U/l [odds ratio (OR): 7.43 (1.61-34.19),P = 0.01], alpha-fetoprotein > 20 ng/ml [OR: 16.2 (4.17-63.01),P latelet count el score with an area under curve of 0.79 (95% CI: 0.7-0.89) was built based on these variables. The negative predictive value of those classified as at low risk of HCC was 99.1%. Conclusion: An easy and practical model score was generated. It may be an auxiliary tool for identification of HCV patients with low probability of small diameter HCC at initial evaluation composed of three serum examinations used in routine outpatient clinical practice.

关键词： Clinical score hepatocellular carcinoma hepatitis C

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