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Antibiotic Resistance Genes in the Human-Impacted Environment:A One Health Perspective

Pedosphere 2019年第3期29卷 273-282页

作者： James M. TIEDJE WANG Fang celia M. MANAIA Marko VIRTA SHENG Hongjie MA Liping ZHANG Tong Edward TOPP Key Laboratory of Soil Environment and Pollution Remediation Institute of Soil Science Chinese Academy of Sciences Nanjing 210008 (China) Center for Microbial Ecology Department of Plant Soil and Microbial Sciences Michigan State University East Lansing MI 48824 (USA) University of Chinese Academy of Sciences Beijing 100049 (China) Universidade catolica Portuguesa CBQF-Centro de Biotecnologia e Quimica Fina一Laboratorio Associado Escola Superior de Biotecnologia Porto 4200-374 (Portugal) Department of Microbiology University of Helsinki Helsinki 00014 (Finland) Environmental Biotechnology Lab The University of Hong Kong Hong Kong (China) London Research and Development Centre Agriculture and Agri-Food Canada and University of Western Ontario London ON N6G 0J3 (Canada)

Antibiotic resistance and its environmental component are gaining more attention as part of combating the growing healthcare crisis. The One Health framework, promulgated by many global health agencies, recognizes that antimicrobial resistance is a truly inter-domain problem in which human health, animal agriculture, and the environment are the core and interrelated *** prospectus presents the status and issues relevant to the environmental component of antibiotic resistance, namely, the needs for advancing surveillance methodology: the environmental reservoirs and sources of resistance, namely, urban wastewater treatment plants, aquaculture production systems, soil receiving manure and biosolid, and the atmosphere which includes longer range ***, much work has been done describing antibiotic resistance genes in various environments;now quantitative, mechanistic,and hypothesis-driven studies are needed to identify practices that reduce real risks and maintain the effectiveness of our current antibiotics as long as possible. Advanced deployable detection methods for antibiotic resistance in diverse environmental samples are needed in order to provide the surveillance information to identify risks and define barriers that can reduce risks. Also needed are practices that reduce antibiotic use and thereby reduce selection for resistance, as well as practices that limit the dispersal of or destroy antibiotic-resistant bacteria or their resistance genes that are feasible for these varied environmental domains.

关键词： animal agriculture antibiotic-resistant bacteria antimicrobial resistance aquaculture human health One Health framework soil contamination wastewater and sludge

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Diversity, Endemism and Conservation of Ferns(Polypodiales) in the Mexican Mountain Component

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Journal of Mountain Science 2015年第4期12卷 891-904页

作者： SANGINéS-FRANCO celia LUNA-VEGA Isolda CONTRERAS-MEDINA Raúl ESPINOSA David TEJERO-DíEZ José Daniel RIVAS Gerardo Laboratorio de Biogeografía y Sistemática Departamento de Biología Evolutiva Facultad de Ciencias Universidad Nacional Autónoma de México (UNAM) Escuela de Ciencias Universidad Autónoma "Benito Juárez" de Oaxaca (UABJO) Av.Universidad s/n Ex Hacienda de Cinco Se?ores Oaxaca de Juárez CP 68120 Oaxaca México Facultad de Estudios Superiores Zaragoza Unidad Multidisciplinaria de Investigación Experimental ZaragozaUniversidad Nacional Autónoma de México (UNAM) carrera de Biología Facultad de Estudios Superiores Iztacala Universidad Nacional Autónoma de México MéxicoAvenida de los Barrios Número 1 Colonia Los Reyes Iztacala Tlalnepantla CP 54090 Estado de México México Laboratorio de Biogeografía Acuática Departamento de Biología Comparada Facultad de Ciencias Universidad Nacional Autónoma de México (UNAM)

We analyzed the distributional patterns of95 selected species of leptosporangiate ferns inhabiting the Mexican Mountain Component, using grid-cells of one geographical degree as unit areas,applying endemism indices and richness and beta diversity *** data were obtained from several herbaria and specialized *** grid-cells appear to be important for fern species richness, as they contain 35 to 49 *** gridcells are located in the Sierra Madre Oriental(SMO),Trans-Mexican Volcanic Belt(TMVB) and the Sierra Madre del Sur(SMS).Mean richness by latitudinal belts of one degree showed that the belts with highest values are related to the TMVB and SMS.A total of 13grid-cells were recognized as important from theperspective of endemism; most of them are located also in the SMO, TMVB and *** richest gridcells coincided with one of the main centres of endemism for ferns obtained in this study, located in the convergence of the southern part of the SMO, the eastern portion of the TMVB and the northern part of the SMS, reflecting the high humidity existing on the mountain slopes facing the Gulf of *** important grid-cells recognized from richness and endemism analyses coincide with Mexican Natural Protected *** beta diversity analysis showed a low degree of similarity among grid-cells, implying a high species replacement, as the result of environmental heterogeneity occurring in the Mexican mountain *** the other hand, the spatial analysis suggested a pattern of phytogeographical regionalization comprising twomain areas: the Mexican Transition Zone and the Mexican Central *** play an important role in the Mexican biodiversity and contributing to the beta diversity of Mexico.

关键词： Biogeography Distributional patterns Leptosporangiate ferns Mexico

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梅州市石窟河健康评价分析

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陕西水利 2024年第9期 75-77,80页

作者：郭晓娟蔡金妤钟伟强广东省水利水电科学研究院广东广州510635 河口水利技术国家地方联合工程实验室广东广州510635 广东省水动力学应用研究重点实验室广东广州510635

通过构建石窟河健康评价指标体系,对“盆”“水”、生物、社会服务功能4个准则层共计16个指标进行评价,获得梅州市石窟河健康状况。结果显示石窟河为二类河流,处于健康状态。针对石窟河纵向连通性差、大型底栖无脊椎动物和鱼类保有指数... 详细信息

通过构建石窟河健康评价指标体系,对“盆”“水”、生物、社会服务功能4个准则层共计16个指标进行评价,获得梅州市石窟河健康状况。结果显示石窟河为二类河流,处于健康状态。针对石窟河纵向连通性差、大型底栖无脊椎动物和鱼类保有指数低等健康问题提出保护对策,以更好地发挥石窟河的生态环境和社会服务功能。

关键词：健康评价石窟河河湖管理

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POLES OF ZETA FUNCTIONS OF COMPLETE INTERSECTIONS

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Chinese Annals of Mathematics,Series B 2000年第2期21卷 187-200页

作者： WAN DAQING(Department of Mathematics, University of california, Irvine, ca 92697-3875, USA.) Department of Mathematics University of California Irvine CA 92697-3875 USA

A vanishing theorem is proved for e-adic cohomology with compact support on an affine (singular) complete intersection. As an application, it is shown that for an affine complete intersection defined over a finite field of q elements, the reciprocal "poles" of the zeta function are always divisible by q as algebraic integers. A p-adic proof is also given, which leads to further q-divisibiliy of the poles or equivalently an improvement of the polar part of the AxKatz theorem for an affine complete intersection. Similar results hold for a projective complete intersection.

关键词： Pole Zeta function Complete intersection

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COVID-19 ocular findings in children: a case series

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World Journal of Pediatrics 2021年第3期17卷 329-334页

作者： celia Fernandez Alcalde Maria Granados Fernandez Maria Nieves Moreno Cristina calvo Rey Iker Fakes Romero Susana Noval Martin Department of Ophthalmology Hospital Universitario La PazPaseo de la Castellana 26128046 Madrid28046 MadridMadridEspana Paediatric and Infectious Diseases Department Hospital Universitario La Paz and Fundacion IdipazMadridSpain Translational Research Network in Pediatric Infectious Diseases(RITIP) MadridSpain Microbiology and Parasitology Department Hospital Universitario La PazMadridSpain Universidad Autonoma de Madrid MadridSpain

Children account for 1%of cases of COVID-19 in most published series,with significantly reduced risk of developing severe forms of disease or death[1-3].Because most children present with mild forms of acute respiratory infections,interest has been focused initially on children with underly-ing/comorbid diseases and concentrated rare fatalities[1,4].

关键词： acute ocular respiratory

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Biological Stress as a Principle of Nature: A Review of Literature

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Open Journal of Biophysics 2020年第3期10卷 150-173页

作者： celia Martins Cortez Dilson Silva Department of Applied Mathematics Rio de Janeiro State University UERJ Rio de Janeiro Brazil Biomanguinhos Foundation Oswaldo Cruz FIOCruz Rio de Janeiro Brazil

This review paper attempts to approximate the concept of biological stress to the stress concept in Physics using the phenomenological view of physics to discuss the source of generator forces of biological stress state. Based on the literature, parallels are drawn between the two concepts and a discussion on the steady state in open systems and homeostatic state in biological systems is developed. Using the concepts of thermodynamic entropy and informational entropy, and comparing stress in living systems and nonliving, we attempt to build a basis for a view of stress as a principle of nature linked to the adaptability property of matter, opposing entropy. It is known that the increasing number of microstates possible in a complex system increases the entropy. In that way, entropy is related to the amount of additional information needed to specify the exact physical state of a system, given its macroscopic specification. By controlling the metabolic processes (catabolism-anabolism) to decrease the entropy, stress reduces the number of possible states for which the living system could evolve, avoiding the loss of “life information”, preserving its characteristics and preventing its extinction. The loss of function of a species within an ecosystem or of cells within an organ can be showing that the limits of the stress principle were “transgressed”. That is, the intensity and/or duration of stress exceeded the capacity of living organism to process of information extracted from stressor and reprogram its physiological mechanisms, activating its adaptability process, while its internal balance is preserved.

关键词： Stress Concept Biological Stress Thermodynamic Entropy Information Entropy State of Stress

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全容积IVIM直方图分析对乳腺良恶性病变的影响

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中国CT和MRI杂志 2024年第3期22卷 82-85页

作者：李俊蔡小丽吴奇川牟方胜重庆大学附属三峡医院放射科重庆404000

目的探讨全容积测量体素内不相干运动(IVIM)直方图参数对乳腺良恶性病变的诊断价值。方法收集我院2021年2月-2022年10月术前行多模态磁共振检查并获得病理的153例女性共158例肿瘤。利用直方图处理软件得到肿瘤IVIM(D、D*、f)的直方图... 详细信息

目的探讨全容积测量体素内不相干运动(IVIM)直方图参数对乳腺良恶性病变的诊断价值。方法收集我院2021年2月-2022年10月术前行多模态磁共振检查并获得病理的153例女性共158例肿瘤。利用直方图处理软件得到肿瘤IVIM(D、D*、f)的直方图参数。采用两独立样本t检验(正态分布)或Mann-WhitneyU检验(偏态分布)比较乳腺良、恶性病灶的IVIM直方图参数的差异。绘制ROC评价IVIM直方图参数独立和联合鉴别诊断乳腺良、恶性病变的效能,Z检验评价联合诊断ROC下面积(AUC)差异性。单变量及多变量二元logisti回归分析独立影响因素。结果乳腺恶性病变116个,良性病变42个。良、恶性病变D(90th、熵、峰度、均值、中位数、最小值、偏度)、f峰度、D*(90th、熵、峰度、均值、中位数、最大值、偏度)单因素分析有统计学意义。AUC最大为D偏度(0.818);敏感度最高为D熵(0.957);特异度最高为D偏度(0.857);准确度最高为D偏度(0.797)。D直方图联合诊断AUC、敏感度、特异度、准确度分别为0.903、0.948、0.786、0.88;f直方图联合诊断分别为0.604、0.672、0.548、0.73;D*直方图联合诊断为0.833、0.897、0.619、0.823;IVIM直方图联合诊断为0.953、0.982、0.833、0.924;IVIM直方图联合诊断AUC面积最大,与D值、f值、D*直方图分别联合诊断AUC差异有统计学意义。D熵(OR=2.943;P=0.037)及D中位数(OR=0.984;P=0.029)为乳腺恶性病变独立影响因素。结论乳腺磁共振IVIM直方图参数联合能显著提高判断乳腺良恶性病变诊断效能,D熵及D中位数为乳腺恶性病变独立影响因素。

关键词：乳腺病变体素内不相干运动成像联合诊断影响因素

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Design of Sliding Mode Control with Disturbance Observers for Inertial Platform 25th

Design of Sliding Mode Control with Disturbance Observers fo...

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第25届中国控制与决策会议

作者： Yue Hu Yuan ca Shifeng Zhang College of Aerospace Science and Engineering National University of Defense and Technology

ISBN: (纸本)9781467355339

In the flight process, the disturbances such as vibrations and frictions affect the stability accuracy of the servo loop of the inertial platform. Besides, the model uncertainties exist due to the couplings of the three subsystem of the inertial platform. This paper presents a sliding mode controller based on a proportional integral （PI） disturbance observer. The state variables and disturbing torque are estimated accurately by the PI observer. Additionally, an integral sliding mode controller is designed. The vibration and stability error are reduced by employing the integral items of the states in designing the sliding mode surface. The simulation results show that the proposed methods can improve the control precision of the servo loop of the platform.

关键词： integral sliding mode control disturbance observer stabilized control of platform

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Optimization of phenol degradation by candida tropicalis Z-04 using Plackett-Burman design and response surface methodology

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Journal of Environmental Sciences 2011年第1期23卷 22-30页

作者： Jiangya Zhou Xiaojuan Yu Cong Ding Zhiping Wang Qianqian Zhou Hao Pao Weimin ca School of Environmental Science and Engineering Shanghai Jiaotong University Dongchuan Road 800 Shanghai 200240 China.

Statistical experimental designs were used to optimize the process of phenol degradation by candida tropicalis Z-04, isolated from phenol-degrading aerobic granules. The most important factors influencing phenol degradation （p 〈 0.05）, as identified by a two-level Plackett-Burman design with 11 variables, were yeast extract, phenol, inoculum size, and temperature. Steepest ascent method was undertaken to determine the optimal regions of these four significant factors. Central composite design （CCD） and response surface analysis were adopted to further investigate the mutual interactions between these variables and to identify their optimal values that would generate maximum phenol degradation. The analysis results indicated that interactions between yeast extract and temperature, phenol and temperature, inocuhim size and temperature affected the response variable （phenol degradation） significantly. The predicted results showed that the maximum removal efficiency of phenol （99.10%） could be obtained under the optimum conditions of yeast extract 0.41 g/L, phenol 1.03 g/L, inoculum size 1.43% （V/V） and temperature 30.04℃. These predicted values were further verified by validation experiments. The excellent correlation between predicted and experimental values confirmed the validity and practicability of this statistical optimum strategy. This study indicated the excellent ability of C. tropicalis Z-04 in degrading high-strength phenol. Optimal conditions obtained in this experiment laid a solid foundation for further use of this microorganism in the treatment of highstrength phenol effluents.

关键词： phenol degradation candida tropicalis Z-04 optimization Plackett-Burman design response surface methodology

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Randomized clinical study of five days apostrophe therapy with mebendazole compared to quinacrine in the treatment of symptomatic giardiasis in children

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World Journal of Gastroenterology 2006年第39期12卷 6366-6370页

作者： Roberto caete Angel A Escobedo María E González Pedro Almirall Hygiene Epidemiology and Microbiology Centre Matanzas City Cuba Academic Paediatric Hospital "Pedro Borrás" Havana City Cuba Institute of Gastro-enterology Havana City Cuba "Pedro Kourí" Institute Havana City Cuba

AIM： To compare the efficacy and safety of five days apostrophe therapy of mebendazole （MBZ） versus quinacrine （QC） on human giardiasis in children.METHODS： A clinical trial was carried out in paediatric patients （aged 5-15 years） with confirmed symptomatic G. duodenalis mono-infection. Patients were randomly assigned to receive either MBZ [200 mg taken three times per day GRID）（n = 61）] or QC [2 mg/kg bodyweight tid （n = 61）], both for five days. Follow-up faecal samples were obtained at 3, 5 and 7 d after the end of the treatment.RESULTS： Although the frequency of cure was higher for QC （83.6%） than for MBZ （78.7%）, the difference was not statistically significant （P 〉 0.05）. Adverse events were reported more in the QC group （P 〈 0.05）, all of them transient and self-limiting.CONCLUSION： Despite final cure rates ocurring lower than expected, the overall results of this study reconfirmed the efficacy of MBZ in giardiasis and also indicate that, although comparable to QC, at least in this setting the 5 d course of MBZ did not appear to improve the cure rates in this intestinal parasitic infection.

关键词： Giardia infection/drug therapy Children Me- bendazole/therapeutic use Quinacrine/therapeutic use Benzimidazoles/therapeutic use Giardiasis/drug therapy Cuba

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