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南部美学访艺术家SAGG NAPOLI

青年视觉 2018年第5期 176-187页

作者： celeste Yang 无不详 the artist Likealittle DisasterJupiter Woods

SAGG NAPOLI是意大利青年女艺术家Sofia Alice Ginevra Gianni半自传体艺术研究项目的名称,也是她艺术创作中使用的名字。艺术家于1991年出生.于那不勒斯,毕业于英国坎伯韦尔艺术学院,现生活、工作于伦敦与那不勒斯两地,是意大利青年艺... 详细信息

SAGG NAPOLI是意大利青年女艺术家Sofia Alice Ginevra Gianni半自传体艺术研究项目的名称,也是她艺术创作中使用的名字。艺术家于1991年出生.于那不勒斯,毕业于英国坎伯韦尔艺术学院,现生活、工作于伦敦与那不勒斯两地,是意大利青年艺术家中的活跃分子。SAGG NAPOLI的艺术创作植根于她的故乡那不勒斯独特的社会、文化和政治环境,除了对女权问题的探索,她的作品也关注南部欧洲的政治经济问题。像许多出生于上世纪九十年代的青年人一样,SAGG NAPOLI也在Instagram上拥有多个账号,并将社交媒体融入了自己的创作之中。

关键词：社交媒体女艺术家艺术创作九十年代 SAG NAP 青年艺术家

Therapeutic and prophylactic thalidomide in TNBS-induced colitis: Synergistic effects on TNF-α, IL-12 and VEGF production

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World Journal of Gastroenterology 2007年第15期13卷 2166-2173页

作者： Ana Teresa Carvalho Heitor Souza Antonio Jose Carneiro Morgana Castelo-Branco Kalil Madi Alberto Schanaider Flavia Silva Fernando Antonio Pereira Júnior Márcia G Pereira Cláudio Tortori Ilana Dines Jane Carvalho Eduardo Rocha celeste Elia Departamento de Clínica Médica Hospital Universitário Clementino Fraga Filho Brazil Departamento de Histologia e Embriologia Laboratório de Imunologia Celular Instituto de Ci(e|^)ncias BiomédicasUniversidade Federal do Rio de Janeiro21941-590Brazil Laboratório Multidisciplinar de Pesquisa Anatomia Patológica Hospital Universitário Clementino Fraga FilhoBrazil e Cirurgia Experimental Hospital Universitário Clementino Fraga Filho Brazil

AIM： To evaluated the therapeutic and prophylactic effect of thalidomide on 2, 4, 6-trinitrobenzene sulfonic acid （TNBS）-induced colitis. Thalidomide has been reported to downregulate the expression of tumor necrosis factor α （TNF-α）, IL-12, and vascular endothelial growth factor （VEGF）, hallmarks of intestinal inflammation in Crohn＇s disease （CD）. METHODS： Male Wistar rats were divided in five groups of ten animals each. Four groups received a rectal infusion of TNBS in ethanol. The first group was sacrificed 7 d after colitis induction. The second and third groups received either thalidomide or placebo by gavage and were sacrificed at 14 d. The fourth group received thalidomide 6 h before TNBS administration, and was sacrificed 7 d after induction. The fifth group acted as the control group and colitis was not induced. Histological inflammatory scores of the colon were performed and lamina propria CD4＋ T cells, macrophages, and VEGF＋ cells were detected by immunohistochemistry. TNF-α and IL-12 were quantified in the supernatant of organ cultures by ELISA. RESULTS： Significant reduction in the inflammatory score and in the percentage of VEGF＋ cells was observed in the group treated with thalidomide compared with animals not treated with thalidomide. Both TNF-α and IL-12 levels were significantly reduced among TNBS induced colitis animals treated with thalidomide compared with animals that did not receive thalidomide. TNF-α levels were also significantly reduced among the animals receiving thalidomide prophylaxis compared with untreated animals with TNBS-induced colitis. Intestinal levels of TNF-α and IL-12 were significantly correlated with the inflammatory score and the number of VEGF＋ cells. CONCLUSION： Thalidomide significantly attenuates TNBS-induced colitis by inhibiting the intestinal production of TNF-α, IL-12, and VEGF. This effect may support the use of thalidomide as an alternate approach in selected patients with CD.

关键词： Thalidomide Experimental colitis Inflammatory bowel disease Tumor necrosis factor α IL-12 Vascular endothelial growth factor

Adipose-derived stem cells improve grafted burn wound healing by promoting wound bed blood flow

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Burns & Trauma 2020年第1期8卷 326-337页

作者： Osamu Fujiwara Anesh Prasai Dannelys Perez-Bello Amina El Ayadi Irene Y.Petrov Rinat O.Esenaliev Yuriy Petrov David N.Herndon celeste C.Finnerty Donald S.Prough Perenlei Enkhbaatar Department of Anesthesiology University of Texas Medical BranchGalvestonTXUSA Department of Surgery University of Texas Medical BranchGalveston301 University BLVD TX 77555USA Shriners Hospitals for Children–Galveston 815 Market Street GalvestonTX 77555USA Sealy Center for Molecular Medicine and the Institute for Translational SciencesUniversity of Texas Medical Branch301 University BLVD GalvestonTX 77555USA Center for Biomedical Engineering University of Texas Medical Branch601 Harbor Side Dr.GalvestonTX 77555USA Department of Neuroscience Cell Biologyand AnatomyUniversity of Texas Medical Branch301 University BLVD GalvestonTX 77555USA

Background:Researchers have explored the use of adipose-derived stem cells(ASCs)as a cellbased therapy to cover wounds in burn patients;however,underlying mechanistic aspects are not completely *** hypothesized that ASCs would improve post-burn wound healing after eschar excision and grafting by increasing wound blood flow via induction of angiogenesis-related ***:To test the hypothesis,we used an ovine burn model.A 5 cm^(2) full thickness burn wound was induced on each side of the *** 24 hours,the burned skin was excised and a 2 cm^(2) patch of autologous donor skin was *** wound sites were randomly allocated to either topical application of 7 million allogeneic ASCs or placebo treatment(phosphate-buffered saline[PBS]).Effects of ASCs culture media was also compared to those of *** healing was assessed at one and two weeks following the application of *** ASCs were isolated,cultured and characterized from non-injured healthy *** identity of the ASCs was confirmed by flow cytometry analysis,differentiation into multiple lineages and gene expression via real-time polymerase chain *** blood flow,epithelialization,graft size and take and the expression of vascular endothelial growth factor(VEGF)were determined via enzyme-linked immunosorbent assay and Western ***:Treatment with ASCs accelerated the patch graft growth compared to the control(p<0.05).Topical application of ASCs significantly increased wound blood flow(p<0.05).Expression of VEGF was significantly higher in the wounds treated with ASCs compared to control(p<0.05).Conclusions:ASCs accelerated grafted skin growth possibly by increasing the blood flow via angiogenesis induced by a VEGF-dependent pathway.

关键词： Wound healing Burn Adipose-derived stem cells Angiogenesis Vascular endothelial growth factor VEGF blood flow

Cognitive and Functional Profiles in Mild-to-Moderate Alzheimer’s Disease and Mild Cognitive Impairment Compared to Healthy Elderly

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Advances in Alzheimer's Disease 2014年第4期3卷 168-186页

作者： Mark Marsico celeste A. de Jager April Grant Xingshu Zhu Arwen Markwick Julie Chandler Epidemiology Department Merck Research Laboratories North Wales USA OPTIMA Nuffield Department of Medicine University of Oxford Oxford UK Division of Geriatric Medicine Department of Medicine Faculty of Health Sciences University of Cape Town Cape Town South Africa Statistical Programming Merck Research Laboratories North Wales USA

Background: Amnestic mild cognitive impairment (aMCI) and mild-to-moderate Alzheimer’s disease (AD) are clinically distinct but impact cognitive and functional ability similarly. Comprehensive assessment of cognitive and functional deficits may prove useful in informing differential diagnosis in early stages of dementia and in informing endpoint selection in therapeutic AD trials. Objective: The objective of this study was to characterize patterns of cognitive and functional impairment in aMCI and mild-to-moderate AD subjects compared to cognitively intact healthy elderly (HE). Methods: Thirty-one healthy elderly, 20 aMCI and 19 AD participants were administered a cognitive test battery that included the ADAS-Cog and functional assessments. Z-scores were calculated for all endpoints based on the HE reference group. Results: Cognitive deficits were observed in AD and aMCI participants relative to the referent group. On average, aMCI participants performed 1 - 2 standard deviations below HE on cognitive tests, and AD participants performed 2 - 3 standard deviations below HE. Domain-specific functional deficits among AD participants (z- score -0.4 to -6.4) were consistently greater than those of aMCI participants (z-score 0 to -1.7). Conclusion: This study provides further support for comprehensive assessment and monitoring of cognitive and functional domain scores in the diagnosis and treatment of aMCI and mild AD. Domain-specific cognitive scores may be more useful than composite scores in characterizing impairment and decline. Measuring domains such as attention, processing speed and executive function may increase the sensitivity of detecting disease progression and therapeutic effects, particularly in mild-moderate AD where memory decline may be too slow to detect drug effects during a typical clinical trial.

关键词： Alzheimer’s Disease Amnestic Mild Cognitive Impairment Dementia Cognition

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体育末等生的逆袭

新东方英语（中学版） 2014年第8期 46-48页

作者： celeste Simmons 李笑

有时候,弱点利用好了,就会变成一种优势。杰克是个笨拙的小孩。他出生时身形瘦小,肤色苍白。随着他慢慢长大,这种体格成了他的一部分特征。他在学业方面表现还可以,属于成绩中等的学生。他做家庭作业,并尽最大的努力做好。但是,每天的... 详细信息

有时候,弱点利用好了,就会变成一种优势。杰克是个笨拙的小孩。他出生时身形瘦小,肤色苍白。随着他慢慢长大,这种体格成了他的一部分特征。他在学业方面表现还可以,属于成绩中等的学生。他做家庭作业,并尽最大的努力做好。但是,每天的上学时间里,总有一段最让他讨厌,那就是体育课。他们每天都必须玩一种新的运动,每天的结果也都一样——他又会发现一种他不会玩的运动,天天如此。体育课上最令他尴尬的时刻之一就是他们挑人组队的时候。队长们会一个接一个地挑选自己想要的队员。

关键词：学业方面 everyone 游乐设施生时 talking 跑来跑去 devise steps someone steal

How to Use Proper Etiquette When Answering a Business Call

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大学英语 2016年第1期 24-25页

作者： celeste Harrison 王玥

Answering the phone at work： it is a small task, performed numerous times during theday. Although it is a small task, it is important to do it properly. The telephone isoften the primary means of communicating with clients or colleagues in other locations. Theperson on the other end of the telephone may not be familiar with you or your work. Whenyou take a business telephone call with proper etiquette you can convey professionalism andcompetence in a matter of seconds.

关键词：高校英语学习学习方法阅读知识阅读材料

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小小小小的火

作者： (美)伍绮诗(celeste Ng)

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附录A 模块化太阳敏感器

控制工程（北京） 2004年第4期 53-64页

作者： Carlo Zaffanella celeste McGorty

EDO公司Barnes工程部,一个老资格的高质量地球敏感器生产者,最近面向低价格高性能的小卫星市场,开发出一套新型太阳敏感器。这种敏感器强调结构模块化、封装方式流线化、性能测试自动化,以便大量生产。一小套基本模块,以极低价格满足新... 详细信息

EDO公司Barnes工程部,一个老资格的高质量地球敏感器生产者,最近面向低价格高性能的小卫星市场,开发出一套新型太阳敏感器。这种敏感器强调结构模块化、封装方式流线化、性能测试自动化,以便大量生产。一小套基本模块,以极低价格满足新任务的要求。

关键词：太阳敏感器地球敏感器小卫星模块化公司市场低价格生产者任务资格

Primary maxillary chondrosarcoma: A case report

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World Journal of Clinical Cases 2020年第1期8卷 126-132页

作者： Juan Carlos Cuevas-González Jesús Oscar Reyes-Escalera JoséLuis González celeste Sánchez-Romero León Francisco Espinosa-Cristóbal Simón Yobanny Reyes-López Karla Lizette Tovar Carrillo Alejandro Donohue Cornejo Stomatology Department Biomedical Sciences InstituteAutonomous University of Ciudad JuárezCiudad Juárez 32310Mexico Maxillofacial Surgery Department Faculty of DentistryJuarez University of the State of DurangoDurango 34000Mexico Madero Pathology Laboratory Durango 34000Mexico Molecular Pathology Area Faculty of DentistryUniversity of the RepublicMontevideo 10000Uruguay

BACKGROUND Sarcomas of the head and neck region are rare tumors,constituting less than 1%of malignant neoplasms in this area,of which few cases(20%)originate from bone or *** is a malignant neoplasm that develops in bone,with a predilection for the pelvis,chest wall,and scapula,and is uncommon in the maxilla and *** this type of lesion has locally aggressive behavior,destroying the affected bone,it can metastasize when it is not diagnosed early and compromise the patient's *** SUMMARY On intraoral examination of a 32-year-old female with a tumor in the middle third of the face,a well-defined rise in volume of approximately 3 cm in diameter was *** tomography with 3-dimensional reconstruction was performed,and we observed that the osteolytic lesion affected the vestibular cortex as the palatal *** and eosin staining revealed an appearance that was similar to mature hyaline cartilage,hypercellularity,nuclear and cellular pleomorphism,and multinucleated cells,with significant *** Determination of the clinical and histopathological characteristics of rare neoplasms in the maxillofacial region,such as chondrosarcomas,allows the pathologist and surgeon to make the appropriate therapeutic decisions,optimizing the patient’s prognosis.

关键词： Chondrosarcoma Rare neoplasms Maxillofacial region Case report