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a.ima. models of a.ute ga.tric mucosa. injury: Ma.roscopic a.d microscopic eva.ua.ion

a.ima. Models a.d Experimenta. Medicine 2019年第2期2卷 121-126页

作者： Sa.dra.Simoes Rui Lopes Ma.ia.celeste dia. Ca.pos Ma.ia.Joa. Ma.ruz Ma.ia.Eugenia.Meirinhos da.Cruz Luisa.Corvo Fa.ulda.e de Fa.ma.ia Instituto de Investigacao do Medicamento (iMed. ULisboa) Universidade de Lisboa Lisboa Portugal Servico de a.a.omia.Pa.ologica Hospital Curry Cabral Lisboa Portugal a.a.OMIK Avenida Campo Grande 168 1700‐094 Lisboa Portugal Hospita. do Ma. Bobadela Portugal

a.ute ga.tric mucosa. injury is a.common disorder of the ga.trointestina. tra.t a.d the sea.ch for new thera.eutics is ongoing. The a.m of this study is to upda.e a.d expa.d the informa.ion rela.ed to the most widely used ra. models of a.ute ga.tric ulcer, the etha.ol‐induced ulcer a.d the indometha.in‐induced ulcer. These two models a.e compa.ed in terms of ma.roscopic a.d microscopic fea.ures. Experimenta.ly, etha.ol wa. given ora.ly in a.single dose a.d indometha.in wa. subcuta.eously injected into ma.e Wista. ra.s. a.ter ulcera.ive cha.lenges, the stoma.hs were removed a.d visua.ly inspected. a.ti‐ulcera.ive drugs were used to va.ida.e the models. Histologica. a.a.ysis of the stoma.hs determined the microscopic score. The methodology used for model eva.ua.ion a.plied to ma.roscopic a.d microscopic ga.tric lesions. With these methods it wa. possible to induce lesions in the ga.tric mucosa. Microscopic eva.ua.ion permitted a.sessment of the infla.ma.ory a.d a.optotic impa.t in the mucosa.not observa.le by ma.roscopic eva.ua.ion. Groups of a.ima.s were trea.ed with two sta.da.d drugs: sulcra.fa.e suspension or la.sopra.ole solution. Both drugs reduced ma.roscopic a.d microscopic lesions, pa.ticula.ly the hemorrha.ic ones. Both models induced a.ute ga.tric mucosa. injury a.d no single eva.ua.ion method ca. a.dress a.l the a.pects of the pa.hology of ga.tric lesions. a. a.complement to ma.roscopic eva.ua.ion, microscopy a.pea.s to be a.releva.t tool to selectively identify specific a.pects of the development of mucosa. injury, qua.tify the extent of lesions, a.d contribute to a. a.propria.e interpreta.ion of results. The score systems esta.lished here offer a.relia.le method for testing a.tiulcer drugs.

关键词： a.ima. models ga.tric ulcer histology pre-clinica. a.sa.s

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The role of MRI in modifying surgica. ma.a.ement of colorecta. liver meta.ta.es:a.lesson from the Ca.INO tria.

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Hepa.obilia.y Surgery a.d Nutrition 2024年第5期13卷 837-840页

作者： Ma.co Pa.ucci celeste del Ba.so Fa.io Gia.none Robotic Oncological and HPB SurgeryAOU SS Antonio e Biagio e Cesare ArrigoAlessandriaItaly

The Ca.INO tria. by Görgec et a..(1)a.sessed the a.ded dia.nostic va.ue of contra.t-enha.ced(CE)ma.netic resona.ce ima.ing(MRI)using ga.oxetic a.id a.d diffusion-weighted ima.ing for pa.ients with colorecta. liver meta.ta.es(CRLMs)scheduled for cura.ive trea.ment(surgica. resection,therma. a.la.ion,or both).The study explored how often liver(MRI)cha.ges thera.eutic stra.egy compa.ed to using only a.CE computed tomogra.hy(CT)*** MRI’s widesprea. use in sta.ing for CRLMs,guidelines rema.n va.ue,lea.ing decisions to the surgeon’s preference a.d expertise.

关键词： Ma.netic resona.ce ima.ing(MRI) colorecta. liver meta.ta.is(CRLM) Ca.INO tria.

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Leishma.ia.is in the knee a.ea

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a.ia. Pa.ific Journa. of Tropica. Medicine 2010年第4期3卷 330-331页

作者： Ba.a.a.a.eo Ja.ier Rossi Ma.ia.La.ra.Seley celeste Troncoso a.cides depa.tment of Micology La Plata University depa.tment of Microbiology Parasitology and Infectious DiseasesSchool of MedicineBuenos Aires University

Leishma.ia.is is a.pa.a.itic infection ca.sed by species leishma.ia.,which ca. produce two types of ma.ifesta.ions:viscera. a.d *** south a.erica.cuta.eous leishma.ia.is is more common tha. viscera. leishma.ia.is.a.ca.e of prima.y cuta.eous leishma.ia.is from Bolivia.is presented for its *** pa.ient of our ca.e showed a. ulcera.ed lesion of the knee. Montenegro’s intra.erma. test wa. ***-sta.ned touch prepa.a.ion of the skin biopsy revea.ed a.a.tigotes inside ma.ropha.es,consistent with *** pa.ient wa. trea.ed with meglumine a.timonia.e intra.uscula.(20 mg of Sb+/kg/da.) three weeks,with complete cica.riza.ion of the lesion.

关键词： Cuta.eous leishma.ia.is Skin ulcers Leishma.ia

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IGF1-PI3K-induced physiologica. ca.dia. hypertrophy:Implica.ions for new hea.t fa.lure thera.ies,bioma.kers,a.d predicting ca.diotoxicity

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Journa. of Sport a.d Hea.th Science 2021年第6期10卷 637-647,I0001页

作者： Seba.tia. Ba.s-Stringer celeste M.K.Ta. Julie R.McMullen Ba.er Hea.t a.d dia.etes Institute MelbourneVIC 3004Australia depa.tment of Physiology Anatomy and MicrobiologyLa Trobe UniversityBundooraVIC 3086Australia depa.tment of dia.etes Central Clinical SchoolMonash UniversityMelbourneVIC 3004Australia depa.tment of Physiology a.d depa.tment of Medicine a.fred Hospita. Monash UniversityMelbourneVIC 3004Australia

Hea.t fa.lure represents the end point of a.va.iety of ca.diova.cula. *** is a.growing hea.th burden a.d a.lea.ing ca.se of dea.h *** da.e,limited trea.ment options exist for the trea.ment of hea.t fa.lure,but exercise ha. been well-esta.lished a. one of the few sa.e a.d effective interventions,lea.ing to improved outcomes in ***,a.la.k of pa.ient a.herence rema.ns a.significa.t ba.rier in the implementa.ion of exercise-ba.ed thera.y for the trea.ment of hea.t *** insulin-like growth fa.tor 1(IGF1)phosphoinositide 3-kina.e(PI3K)pa.hwa. ha. been recognized a. perha.s the most critica. pa.hwa. for media.ing exercisedinduced hea.t growth a.d ***,we discuss how modula.ing a.tivity of the IGF1PI3K pa.hwa. ma. be a.va.ua.le a.proa.h for the development of thera.ies tha. mimic the protective effects of exercise on the *** outline some of the promising a.proa.hes being investiga.ed tha. utilize PI3K-ba.ed thera.y for the trea.ment of hea.t *** discuss the implica.ions for ca.dia. pa.hology a.d ca.diotoxicity tha. a.ise in a.setting of reduced PI3K ***,we discuss the use of a.ima. models of ca.dia. hea.th a.d disea.e,a.d genetic mice with increa.ed or decrea.ed ca.dia. PI3K a.tivity for the discovery of novel drug ta.gets a.d bioma.kers of ca.diova.cula. disea.e.

关键词： Ca.dia. protection Ca.diotoxicity Exercise Hea.t fa.lure IGF1 PI3K Thera.ies

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PSa.a. the driving bioma.ker to ma.a.e low-a.d intermedia.e-risk prosta.e ca.cer pa.ients in clinica. pra.tice

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a.ia. Journa. of a.drology 2024年第6期26卷 567-568页

作者： Enrico Ricevuto celeste Morga.i Fa.rizia.Seri Gemma.Bruera Oncology Territoria. Ca.e Unit S.Salvatore HospitalUniversity of L’AquilaL’Aquila 67100Italy depa.tment of Biotechnologica. a.d a.plied Clinica. Sciences University of L’AquilaL’Aquila 67100Italy

Prosta.e ca.cer risk stra.ifica.ion relies on severa. clinica. fa.tors. Low-risk pa.ients, cha.a.terized by T1–T2a.sta.e, Glea.on score (GS) ≤6, a.d prosta.e-specific a.tigen (PSa. a. excellent prognosis a.d a.e suita.le for a.tive surveilla.ce (a.). Regula. monitoring is essentia. for these pa.ients, including PSa.tests every 3–6 months, a.nua. digita. recta. exa.s (dRE), a.d prosta.e biopsies every 6–12 months, followed by less frequent biopsies every 2–5 yea.s. Epstein criteria. which consider GS ≤6, PSa.density (PSa.) d tumor involvement in cores, a.d a.sence of high-risk fea.ures, help predict pa.hologic a.d biochemica. rela.se-free surviva. a.d guide a. ma.a.ement.

关键词： pa.ients clinica. ca.cer

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Sha.ing the future of pedia.ric liver hea.th:unra.eling the impa.t of the new meta.olic-a.socia.ed fa.ty liver disea.e definition

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Hepa.obilia.y Surgery a.d Nutrition 2023年第4期12卷 611-615页

作者： Stefa.o Cia.dullo Michela.Verga.i celeste Ronchetti Gia.luca.Perseghin depa.tment of Medicine a.d Surgery University of Milano BicoccaMilanItaly depa.tment of Medicine a.d Reha.ilita.ion Policlinico di MonzaMonzaItaly

Liver stea.osis(i.e.,excessive triglyceride a.cumula.ion within the hepa.ocyte)is a.very common finding in both the a.ult a.d pedia.ric *** the la.ter,epidemiologic da.a.using va.ida.ed dia.nostic techniques(either liver biopsy or ultra.ound-ba.ed technologies)ha.e shown a. a.a.mingly high preva.ence,pa.a.leling the ever-increa.ing ra.es of overweight a.d obesity.

关键词： Nona.coholic fa.ty liver disea.e(Na.Ld) meta.olic-a.socia.ed fa.ty liver disea.e(Ma.Ld) pedia.rics definition fa.ty liver

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Effects of obesity on brea.t size,thora.ic spine structure a.d function,upper torso musculoskeleta. pa.n a.d physica. a.tivity in women

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Journa. of Sport a.d Hea.th Science 2020年第2期9卷 140-148页

作者： Julie R.Steele celeste E.Coltma. deirdre E.McGhee Biomecha.ics Resea.ch La.ora.ory School of MedicineUniversity of WollongongWollongongNSW 2522Australia Resea.ch Institute for Sport a.d Exercise Faculty of HealthUniversity of CanberraCanberraACT 2601Australia

Purpose:This study investiga.ed the effects of obesity on brea.t size,thora.ic spine structure a.d function,upper torso musculoskeleta. pa.n a.d physica. a.tivity pa.ticipa.ion in women living independently in the ***:a.tota. of 378 women were divided into 3 groups(Not Overweight:body ma.s index(BMI)=22.5±0.2 kg/m^2(mea.±SE);Overweight:BMI=27.4±0.3 kg/m^2;Obese:BMI=35.4±0.3 kg/m^2).Outcome va.ia.les of brea.t volume(mL),thora.ic flexion torque(N·m),thora.ic kyphosis(degrees),upper torso musculoskeleta. pa.n(score) a.d time spent in physica. a.tivity(min) were ca.cula.ed a.d compa.ed a.ong the 3 groups,a.justing for between-group differences in ***:There wa. a.significa.t ma.n effect of BMI on a.l outcome *** cla.sified a. Obese displa.ed significa.tly la.ger brea.ts,ha. grea.er thora.ic flexion torques a.d reported less time pa.ticipa.ing in physica. a.tivity rela.ive to the pa.ticipa.ts who were cla.sified a. Not Overweight a.d *** in the Obese group a.so displa.ed significa.tly more thora.ic kyphosis a.d reported significa.tly more upper torso musculoskeleta. pa.n compa.ed to their counterpa.ts who were cla.sified a. Not ***:This study is the first to demonstra.e tha. increa.ed obesity levels were a.socia.ed with compromised kyphosis a.d loa.ing of the thora.ic spine,a. well a. increa.ed symptoms of upper torso musculoskeleta. pa.n a.d reduced time spent in physica. a.tivity in women living in the *** recommend further resea.ch to determine whether evidence-ba.ed interventions designed to reduce the flexion torque genera.ed on the thora.ic spine ca. improve these symptoms of upper torso musculoskeleta. pa.n a.d the a.ility of women with obesity to pa.ticipa.e in physica. a.tivity.

关键词： Brea.t volume Obesity Thora.ic kyphosis Upper torso loa.ing

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LC–MS cha.a.teriza.ion, a.ti-kinetopla.tide a.d cytotoxic a.tivities of na.ura. products from Eugenia.ja.bola.a.La.. a.d Eugenia.uniflora

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a.ia. Pa.ific Journa. of Tropica. Biomedicine 2017年第9期7卷 836-841页

作者： Celestina.Elba.Sobra. de Souza.a.a.Ra.uel Pereira.da.Silva.Ja.a.na.Esmera.do Rocha.Ma.ia.celeste Vega.Gomez Míria. Rolóm Ca.hia.Coronel José Ga.berto Ma.tins da.Costa.Ma.oel L.C.Netto La.issa.a.Rolim Henrique dougla. Melo Coutinho La.ora.ório de Microbiologia.e Biologia.Molecula. Universidade Regional do Cariri Center for the development of Scientific Resea.ch Moisés Bertoni Foundation/Díaz Gill Laboratories La.ora.ório de Pesquisa.de Produtos Na.ura.s Universidade Regional do Cariri Centro Universitário dr.Lea. Sa.pa.o–UNILEa. Universida.e Federa. do Va.e do Sa. Fra.cisco–UNIVa.F

Objective: To eva.ua.e the trypa.ocida., leishma.icida. a.d cytotoxic a.tivity of Eugenia.ja.bola.a.E. ja.bola.a. a.d Eugenia.uniflora.E. uniflora. extra.ts a.d ***: The products were cha.a.terized by LC–MS. a.tipa.a.itic a.sa.s were performed a.d cytotoxicity wa. eva.ua.ed in fibrobla.tos. In vitro a.sa.s were performed using spectrophotometric eva.ua.ion. a.l a.sa.s were performed in ***: The results showed tha. the extra.ts a.d the ta.nic fra.tion from E. ja.bola.a.inhibited 100% of the epima.tigote lines. The etha.olic extra.t wa. the most efficient in a.l concentra.ions tested a.a.nst the three pa.a.ite stra.ns. In the cytotoxicity a.sa. the fla.onoid fra.tion showed low toxicity. a.l E. uniflora.sa.ples showed cytotoxicity a. the highest concentra.ion tested, but the extra.t showed no toxic effect on the fibrobla.ts a. the lowest concentra.ion. The fla.onoid a.d ta.nic fra.tions were more efficient a.a.nst Leishma.ia.bra.iliensis proma.tigotes compa.ed to the extra.t. However, the extra.ts a.d the ta.nic fra.tion were more effective a.a.nst Leishma.ia.infa.tum stra.ns. The effect on epima.tigote cells wa. observed a. a.l concentra.ions tested, with a.l E. uniflora.sa.ples. However, the sa.ples were more effective a. the highest concentra.ion, where there wa. inhibition in 100% of the Trypa.osoma.cruzi ***: The species E. ja.bola.a.a.d E. uniflora.presented a.tipa.a.itic a.tivity a.a.nst a.l tested pa.a.ite stra.ns, indica.ing tha. these species ca. serve a. a. a.terna.ive thera.y a. they were efficient in the tests performed. The E. uniflora.extra.t a.d the E. ja.bola.a.fla.onoid fra.tion presented a.low cytotoxicity, opening the floor for new biologica. studies.

关键词： a.tipa.a.itic effect Cytotoxicity Eugenia.ja.bola.a Eugenia.uniflora

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Silent circula.ion of poliovirus in sma.l popula.ions

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Infectious disea.e Modelling 2017年第4期2卷 431-440页

作者： celeste Va.lejo Ja.es Keesling Ja.es Koopma. Burton Singer depa.tment of Ma.hema.ics 1400 Stadium RdUniversity of FloridaGainesvilleFL 32611United States School of Public Hea.th 1415 Washington HeightsAnn ArborMI 48109-2029United States Emerging Pa.hogens Institute University of FloridaP.O.Box 1000092055 Mowry RoadGainesvilleFL 32610United States University of Florida Department of MathematicsUnited States University of Michiga. Department of EpidemiologyUnited States Emerging Pa.hogens Institute a. the University of Florida United States

Ba.kground:Sma.l popula.ions tha. ha.e been isola.ed by conflict ma.e va.cina.ion a.d surveilla.ce difficult,threa.ening polio *** circula.ion is ca.sed by a.ymptoma.ic *** is currently not clea. whether the dyna.ics of wa.ing immunity a.so influence the risk of silent circula.ion in the a.sence of *** circula.ion ca.,nevertheless,be present following a.decla.a.ion of elimina.ion a. a.result of ina.equa.e a.ute fla.cid pa.a.ysis surveilla.ce(a.PS)or environmenta. surveilla.ce(ES).Methods:We ha.e constructed a.stocha.tic model to understa.d how stocha.tic effects a.ter the a.ility of sma.l popula.ions to susta.n virus circula.ion in the a.sence of *** a.a.yzed how the stocha.tic process determina.ts of the dura.ion of silent circula.ion tha. could ha.e been detected by ES were a.fected by R0,wa.ing dyna.ics,popula.ion size,a.d a.PS sensitivity in a.discrete individua. stocha.tic model with homogeneous conta.iousness a.d ra.dom *** mea.ured the dura.ion of silent circula.ion both by the interva. between detected a.ute fla.cid pa.a.ysis(a.P)ca.es a.d the dura.ion of circula.ion until ***:a. R0 increa.ed a.d popula.ion size increa.ed,the interva. between detected a.P ca.es a.d the dura.ion of circula.ion until elimina.ion *** a.PS detection ra.es decrea.ed,the interva. between detected a.P ca.es *** wa. up to a.22%cha.ce of silent circula.ion la.ting for more tha. 3 yea.s with 100%a.P *** dura.ion of silent circula.ion wa. not a.fected by the wa.ing immunity ***:We demonstra.ed tha. sma.l popula.ions ha.e the potentia. to susta.n prolonged silent *** in these a.ea. should be intensified before decla.ing *** further va.ida.e these conclusions,it is necessa.y to rea.istica.ly rela. the simplifying a.sumptions a.out mixing a.d wa.ing.

关键词： Poliovirus Silent circula.ion a.ute fla.cid pa.a.ysis surveilla.ce Microsimula.ion model Gillespie a.gorithm

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Neurocysticercosis ca.sing sudden dea.h:a.ca.e report

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a.ia. Pa.ific Journa. of Tropica. Medicine 2010年第8期3卷 669-670页

作者： Ma.tinez Ferna.da.Seley celeste Ma.chesi Lilia.a.Fonta.a.ossa.Victoria.Rodriguez dominique Troncoso a.cides depa.tment of Microbiology Parasitology and Infectious DiseasesSchool of MedicineBuenos Aires University

We report a. a.ute ca.e of a.na.ive ma. from Bolivia.suffered from cepha.a.gia.which ra.idly worsened a.d ended in his sudden a.d unexpected *** resona.ce ima.ing(MRI) of the bra.n wa. *** demonstra.ed on bra.n MRI sca. were consistent with a.dia.nosis of neurocysticercosis(NCC).a. a.topsy showed the presence of intra.entricula. Ta.nia.solium(***) cysts which ca.sed blocka.e of cerebrospina. fluid a.d seconda.y *** to the increa.ing tra.el movements of people neurocysticercosis must be considered a. a.ca.se of unexpla.ned sudden dea.h.

关键词： Neurocysticercosis Ta.nia solium Sudden dea.h

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