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Type 1 diabetes and celiac disease:The effects of gluten free diet on metabolic control

World Journal of Diabetes 2013年第4期4卷 130-134页

作者： Andrea E Scaramuzza cecilia mantegazza Alessandra Bosetti Gian Vincenzo Zuccotti Department of Pediatrics Luigi Sacco Hospital University of Milano

Type 1 diabetes mellitus is associated with celiac disease,with a prevalence that varies between 0.6% and 16.4%,according to different *** a diagnosis of celiac disease is confirmed by small bowel biopsy,patients are advised to commence a gluten-free diet(GFD).This dietary restriction may be particularly difficult for the child with diabetes,but in Europe(and in Italy) many food stores have targeted this section of the market with better labeling of products and more availability of specific GFD *** with a GFD in symptomatic patients has been shown to improve the symptoms,signs and complications of celiac ***,the effects of a GFD on diabetic control are less well *** reports of improved hypoglycemic control were based on children who were diagnosed with celiac disease associated with malabsorption,but there have subsequently been reports of improvement in patients with type 1 diabetes with subclinical celiac *** are other studies reporting no effect,improved control and an improvement of hypoglycemic ***,in this review we wish to focus on low glycemic index foods,often suggested in people with type 1 diabetes,since they might reduce postprandial glycemic excursion and enhance longterm glycemic *** contrast,GFD may be rich in high glycemic index foods that can increase the risk of obesity,insulin resistance and cardiovascular disease,worsening the metabolic control of the child with ***,it is important to evaluate the impact of a GFD on metabolic control,growth and nutritional status in children with type 1 diabetes.

关键词： Adolescents Celiac disease Children Glycemic control Type 1 diabetes

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