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An epidemiological study of collagenous colitis in southern Sweden from 2001-2010

World Journal of Gastroenterology 2012年第22期18卷 2821-2826页

作者： Lina Vigren Martin Olesen cecilia benoni Klas Sjberg Division of Gastroenterology Department of Clinical Sciences Skne University Hospital Lund University SE-205 02 Malm Sweden University and Regional Laboratories Region Sk ne Department of Pathology Skne University Hospital SE-205 02 Malm Sweden

AIM： To estimate the incidence of collagenous colitis （CC） in southern Sweden during 2001-2010. METHODS： Cases were identified by searching for CC in the diagnostic registers at the Pathology Departments in the county of Skane. The catchment area comprised the south-west part of the county （394 307 inhabitants in 2010） and is a mixed urban and rural type with limited migration. CC patients that had under- gone colonoscopy during the defined period and were living in this area were included in the study regardless of where in Skane they had been diagnosed. Medical records were scrutinized and uncertain cases were re- assessed to ensure that only newly diagnosed CC cases were included. The diagnosis of CC was based on both clinical and histopathological criteria. The clinical crite-rion was non-bloody watery diarrhoea. The histopatho- logical criteria were a chronic inflammatory infiltrate in the lamina propria, a thickened subepithelial collagen layer ≥10 micrometers （um） and epithelial damage such as flattening and detachment. RESULTS： During the ten year period from 2001-2010, 198 CC patients in the south-west part of the county of Skane in southern Sweden were newly diagnosed. Of these, 146 were women and 52 were men, i.e., a female： male ratio of 2.8：1. The median age at diag- nosis was 71 years （range 28-95/inter-quartile range 59-81）, for women median age was 71 （range 28-95） years and was 73 （range 48-92） years for men. The mean annual incidence was 5.4/105 inhabitants. During the time periods 2001-2005 and 2006-2010, the mean annual incidence rates were 5.4/105 for both periods [95% confidence interval （CI）： 4.3-6.5 in 2001-2005 and 4.4-6.4 in 2006-2010, respectively, and 4.7-6.2 for the whole period]. Although the incidence varied over the years （minimum 3.7 to maximum 6.7/105） no increase or decrease in the incidence could be identi- fied. The odds ratio （OR） for CC in women compared to men was estimated to be 2.8 （95% CI： 2.0-3.7）. The OR for women 65 year

关键词： Collagenous colitis Epidemiology Incidence Microscopic colitis

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Mucosa-associated bacteria in two middle-aged women diagnosed with collagenous colitis

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World Journal of Gastroenterology 2012年第14期18卷 1628-1634页

作者： Rita J Gustafsson Bodil Ohlsson cecilia benoni Bengt Jeppsson Crister Olsson Department of Clinical Sciences Gastroenterology SectionSkne University HospitalLund University20502 MalmSweden Department of Surgery Skne University HospitalLund University20502 MalmSweden Food Technology Engineering and Nutrition Lund University22100 LundSweden

AIM:To characterize the colon microbiota in two women histologically diagnosed with collagenous colitis using a culture-independent ***:Biopsies were taken from the ascending colon and the total DNA was *** bacterial primers were used to amplify the bacterial 16S rRNA *** amplicons were then cloned into competent Escherichia coli *** clones were sequenced and identified by comparison to known ***:The clones could be divided into 44 different *** microbiota was dominated by Firmicutes and *** phylotypes werefound in both patients and constituted 47.5% of the total number of *** these,the most dominating were clones similar to Bacteroides cellulosilyticus,Bacteroides caccae,Bacteroides thetaiotaomicron,Bacteroides uniformis and Bacteroides dorei within *** similar to Faecalibacterium prausnitzii and Clostridium citroniae were also found in both ***:A predominance of potentially pathogenic Bacteroides spp.,and the presence of clones showing similarity to Clostridium clostridioforme were found but the overall colon microbiota showed similarities to a healthy *** for collagenous colitis other than an adverse bacterial flora must also be considered.

关键词： Microscopic colitis Collagenous colitis Lymphocytic colitis Colonic microbiota 16S rRNA sequencing

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