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predictors of functional independence, quality of life, and return to work in patients with burn injuries in China's Mainland

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Burns & Trauma 2016年第4期4卷 273-283页

作者： Dan Tang cecilia w.p.li-tsang Ricky K.C.Au Xia Shen Kui-cheng li Xian-feng Yi lin-rong liao Hai-yan Cao Ya-nan Feng Chuan-shun liu Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHung HomHong Kong Special Administrative RegionChina Guangdong provincial work Injury Rehabilitation Hospital GuangzhouChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHung HomHong Kong Special Administrative RegionChina Department of physiotherapy Guangdong Provincial Work Injury Rehabilitation HospitalGuangzhouChina Department of Occupational Therapy Guangdong Provincial Work Injury Rehabilitation HospitalGuangzhouChina Department of Burn Surgery and Burn Rehabilitation Guangdong Provincial Work Injury Rehabilitation HospitalGuangzhouChina

Background:Burn injury may be associated with long-term rehabilitation and disability,while research studies on the functional performance after injuries,quality of life(QOL),and abilities to return to work of burn patients are *** outcomes are related not just to the degree and nature of injuries,but also to the socio-economical background of the *** study aimed to identify the factors which might affect burn patients’abilities to reintegrate back to the society based on a sample in China's ***:A retrospective study was conducted to collect data of demographic characteristics,medical data about burn injuries,physical and psychological status,and self-perceived QOL at the initial phase and upon discharge from a rehabilitation hospital,timing of rehabilitation,and duration of rehabilitation *** hundred fifteen patients with burn injuries were recruited in the *** linear regression and logistic regression were used to obtain a model to predict the functional abilities and the perceived QOL at discharge and their changes during rehabilitation,as well as the post-injury work status within 6 months after ***:The functional performance at discharge and its change were significantly predicted by the functional abilities and QOL at the admission,duration of treatment,timing of rehabilitation,payer source,and total body surface area *** perceived QOL at discharge and its change were significantly predicted by the baseline QOL at admission and duration of *** significant predictors of work status within 6 months post-discharge included age,education,payer source,total body surface area burned,perceived QOL,and bodily pain at ***:The present study identified a number of factors affecting the rehabilitation outcomes of people with burn *** of these predictors may help clinicians assess the rehabilitation potential of burn survivors and assist in resource

关键词： Burns Functional independence Quality of life Return to work predictors Rehabilitation

Application of tissue ultrasound palpation system （TUpS） in objective scar evaluation

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Application of tissue ultrasound palpation system （TUPS） i...

第八届全国烧伤外科学年会

作者： Joy C.M. Lau cecilia w.p.li-tsang Department of Rehabilitation Sciences The Hong Kong Polytechnic University

＜正＞One of the characteristics of hypertrophic scarfing is its raised *** maturation often results in increased *** rely on subjective observation and palpation to document scar thickness. The result of these subjective assessments may reflect onlythe superficial scar thickness but is unable to measure the whole scar volume and thickness under the skin *** of scarthickness using ultrasound imaging has been previously reported,but has not been commonly used in clinics due to its complex operationmethod and high *** this study,we have adopted a newly developed and user-friendly Tissue ultrasound palpation system （TUpS） for theassessment of scar *** consists of a finger size palpation probe,connected to an ultrasound transducer and an in-series load cell to measure the thickness of the soft tissue over the human *** method of operation is easy and it can be used to measure skin thickness on various parts of the body,thus reflecting the skin *** reliability of the TUpS in clinical application was tested on 30 subjects with a hypertrophic scar at a local *** raters implemented two assessments on each subject to study its test-retest and inter-rater *** was then used to assess 100 subjects with various severity of hypertrophic scar caused by trauma,scald,burn or *** were assessed using TUpS as well as the Vancouver Scar Scale （VSS） for rating scar thickness,pliability,pigmentation and *** mixed intra-class correlation showed a high test-retest reliability with Intraclass Correlation Coefficient （ICC）=0.98 and inter-rater reliability ICC=*** positive correlations with VSS thickness score and VSS total score r=0.34 （p＜0.05） and 0.42 （p＜ 0.05）,respectively.A significant difference between two scar type groups （50 burn scald scars and 50 surgical scars） was demonstrated （d.f.=52.94,t=3.99,p＜0.01）.TUpS was proved to have high inter-rater,test-rete

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Validation of an objective scar pigmentation measurement by using a spectrocolorimeter

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Validation of an objective scar pigmentation measurement by ...

第八届全国烧伤外科学年会

作者： cecilia w.p.li-tsang Joy C．M．Lau Sally K．Y．liu Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHung HomKowloonHong KongPR China Occupational Therapy Department Pamela Youde Nethersole Eastern HospitalHospital AuthorityChai WanHong KongPR China

＜正＞Scar pigmentation changes throughout its maturation process and it is often used as one of the indicators for scar maturation,yet it is often rated *** purpose of this study was to investigate the application of a commercial spectrocolorimeter to produce a reliable measurement on scar *** Internationale de l’Eclairage （CIE） model of color has been adopted in this study for measurement of scar pigmentation 24 patients with hypertrophic scars at different stages of maturation were selected for the study,were inspected by two therapists using the Vancouver scar scale （VSS） and then using spectrocolorimeter for inter-rater *** measurements were taken after 30 min by the same group of therapists （test-retest reliability）.Results indicated that the inter-rater reliability among the three therapists was satisfactory,with intra-class correlation coefficient （ICC）（2,2） from 0.50 to 0.99 in all the three color *** test-retest reliability of the spectrocolorimeterwas satisfactory with ICC （3,6） ranged from 0.95 to *** difference was also noted between the measurements of normal skin and hypertrophic scar （p＜0.00,t-values:from 2.78 to 0.05,d.f.:from 29.7 to 46.00） in all color parameters,except the chroma C*.we also found a positive relationship between VSS scores and the spectrocolorimeter *** spectrocolorimeter is found to be a reliable instrument to quantify scar pigmentation and to differentiate normal skin and scar *** further studies,the constructs of scar properties could further be explored using this spectrocolorimeter. 2003 Elsevier Ltd and *** rights reserved.

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prevalence of hypertrophic scar formation and its characteristics among the Chinese population

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Prevalence of hypertrophic scar formation and its characteri...

第八届全国烧伤外科学年会

作者： cecilia w.p.li-tsang Joy C.M.Lau Chetwyn C.H.Chan Occupational Therapy Section Department of Rehabilitation SciencesThe Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARChina

Each year in Hong Kong,about 350,000 surgical procedures are conducted for various types of *** review indicated that the prevalence of hypertrophic scar among Caucasians ranged from 15% to 63% and that the incidence was even higher among *** study aims to find out the prevalence rate of hypertrophic scar among the Hong Kong Chinese population after standardized surgical procedures.A systematic and objective scar measurement protocol is implemented in this *** spectrocolorimeter,Miniscan XE plus was used to measure the scar pigmentation based on the theory of the CIE colour *** tissue ultrasound palpation system (TUpS) was employed to measure scar *** May 2001 to December 2003,154 patients,who received surgical intervention at the Department of Orthopaedics and Traumatology of a large regional hospital,were invited to join a scar-screening *** hundred and fifteen patients (74.67%) were found to have signs of hypertrophic scar based on thickness,pliability,pigmentation and vascularity (using the Vancouver scar scale (VSS) score).One hundred and one patients consented to have more comprehensive scar assessment. Results indicated that the scar thickness was 4.91.03 *** with the adjacent normal skin,the color of hypertrophic scar was significantly different in terms of lightness (d.f.=100,t=9.36,ppwness (d.f.=100,t=1.48,ppaired t-test *** point five percent and 33.7% among patients reported pain (2.19.74) and itchiness (1,47.53) over the *** objective scar assessments showed that more than 70% of scars had increase in thickness and pigmentation after *** than 40% of patients reported pain and *** results showed that more than 70% of the scars in the HK Chinese population had become hypertrophic in terms of pigmentation,thickness and physical symptoms such as pain and itchiness 1 month after the surgical

关键词： Hypertrophic scar Scar prevalence Chinese Objective measurement

A prospective randomized clinical trial to investigate the effect of silicone gel sheeting （Cica-Care） on post-traumatic hypertrophic scar among the Chinese population

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A prospective randomized clinical trial to investigate the e...

第八届全国烧伤外科学年会

作者： cecilia w.p.li-tsang Joy C.M. Lau Jenny Choi Chetwyn C.C. Chan Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHung HomHKSARHong Kong

＜正＞Background This study aimed to determine the efficacy of silicone gel （Cica-Care） on severe ost-traumatic hypertophic scars among theChinese *** and materials A randomized clinical trial （RCT） was conducted on 45 Chinese patients with post-traumatic hypertrophic ***-two subjects were placed in the experimental group with silicone gel sheeting （SGS） applied 24 h per day for 6 months while allsubjects were taught to massage the scar daily for 15 min serving as the control *** assessments were conducted regularly tomeasure the changes in thickness, pigmentation,vascularity,pliability,itchiness and *** Two-way repeated ANOVA showed a significant difference between MT group and SGS group on scar *** post hoccomparison analysis showed that the difference was significant at the post-2-month （p=0.008） and post-6-month （p＜ 0.001） *** SGS group also showed changes in pigmentation which resembled normal skin but no statistical significance was ***,itchinessand pliability were also improved after intervention. Conclusion This study indicated that silicone gel sheeting （Cica-Care） was effective to reduce thickness, pain,itchiness and pliability of thesevere hypertrophic scar among the Chinese *** moisturization effect of the tough and hard scar might contribute to the reductionof the skin thickness after 6 month’s intervention.# 2006 Elsevier Ltd and *** rights reserved.

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烧伤患者瘢痕重塑期增生性瘢痕机械信号转导分子与伤后时间的相关性研究

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中华烧伤杂志 2018年第10期34卷 690-695页

作者：张玉婷李攀罗伦李曾慧平四川大学华西医院康复医学中心成都610041 成都市第二人民医院康复医学科香港理工大学康复科学系

目的分析烧伤患者增生性瘢痕重塑期整合素β1、局部黏着斑激酶（FAK）及胞外信号调节激酶1/2（ERK1/2）表达与伤后时间的相关性。方法采用方便抽样法纳入2013年5月—2016年4月成都市第二人民医院烧伤整形科、陆军军医大学（原第三军医... 详细信息

目的分析烧伤患者增生性瘢痕重塑期整合素β1、局部黏着斑激酶（FAK）及胞外信号调节激酶1/2（ERK1/2）表达与伤后时间的相关性。方法采用方便抽样法纳入2013年5月—2016年4月成都市第二人民医院烧伤整形科、陆军军医大学（原第三军医大学）第一附属医院全军烧伤研究所的34例住院烧伤患者34个增生性瘢痕，另取上述单位6例瘢痕切除植皮手术患者的供皮区正常皮肤，进行横断面、观察性研究。采用温哥华瘢痕量表评估瘢痕高度、血管化、色素沉着、柔软度情况，超声诊断仪测量瘢痕厚度，免疫组织化学法观察瘢痕和正常皮肤真皮和表皮的整合素β1、FAK、ERK1/2表达。对伤后时间与瘢痕厚度，伤后时间分别与瘢痕表皮整合素β1、FAK、ERK1/2表达量，伤后时间分别与瘢痕真皮整合素β1、FAK、ERK1/2表达量，瘢痕真皮整合素β1、FAK、ERK1/2分别与表皮相同蛋白酶表达量行pearson相关分析。采用局部多项式回归拟合分析瘢痕表皮和真皮中整合素β1、FAK、ERK1/2以及瘢痕厚度与伤后时间的非线性回归关系。结果（1）本组患者的瘢痕评分总分为（8.3±2.3）分，其中高度（2.2±0.7）分、血管化（2.0±0.8）分、色素沉着（2.3±0.7）分、柔软度（1.9±0.7）分；瘢痕厚度为（2.8±1.1）mm。（2）瘢痕表皮和真皮中整合素β1、FAK、ERK1/2表达量均多于正常皮肤。（3）伤后时间与瘢痕厚度呈明显正相关（r＝0.39，p〈0.05）。伤后时间与瘢痕表皮整合素β1表达量呈明显正相关（r＝0.33，p〈0.05），与瘢痕表皮FAK、ERK1/2表达量无明显相关性（r＝－0.03、－0.04，p〉0.05）。伤后时间与瘢痕真皮FAK表达量呈明显负相关（r＝－0.34，p〈0.05），与瘢痕真皮整合素β1、ERK1/2表达量无明显相关性（r＝0.07、－0.23，p〉0.05）。瘢痕表皮和真皮的整合素β1、FAK、ERK1/2表达量呈明显正相关（r＝0.70、0.60、0.64，p〈0.01）。（4）瘢痕表皮和真皮中整合素β1、FAK、ERK 1/2的表达量从伤后1～2个月的下降趋势转变为伤后2～3个月期间的上升趋势，且在伤后3～4个月期间达到顶峰，此后表皮中机械信号转导分子表达量逐渐下降，而真皮中机械信号转导分子表达量在伤后半年内维持在较高的水平。瘢痕厚度从伤后1个月后呈现稳定上升趋势。结论烧伤患者瘢痕重塑期，增生性瘢痕厚度在瘢痕形成早期随伤后时间持续增加；增生性瘢痕中整合素β1、FAK、ERK1/2对外界机械力的易感性在受伤后4个月内逐渐增强。

关键词：瘢痕整合素类机械信号转导局部黏着斑激酶

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儿童面部烧伤瘢痕的压力治疗研究进展

中华烧伤杂志 2017年第5期33卷 277-280页

作者：魏亚婷付晋凤李曾慧平昆明医科大学第二附属医院烧伤科 650101 昆明医科大学附属儿童医院烧创伤整形科香港理工大学康复治疗科学系

烧伤是儿童最常见的外伤之一，在我国儿童意外损伤中排名前3。儿童面部烧伤导致的面部瘢痕挛缩畸形可影响患儿自我认知及心理发育，并且随着患儿的年龄增长而产生持续长期的负面作用，导致其社会心理功能受损，行为障碍，降低其长远的... 详细信息

烧伤是儿童最常见的外伤之一，在我国儿童意外损伤中排名前3。儿童面部烧伤导致的面部瘢痕挛缩畸形可影响患儿自我认知及心理发育，并且随着患儿的年龄增长而产生持续长期的负面作用，导致其社会心理功能受损，行为障碍，降低其长远的生活质量。

关键词：烧伤儿童面部瘢痕压力治疗

Multifaceted superoxide dismutase 1 expression in amyotrophic lateral sclerosis patients:a rare occurrence?

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Neural Regeneration Research 2025年第1期20卷 130-138页

作者： Ilaria Martinelli Jessica Mandrioli Andrea Ghezzi Elisabetta Zucchi Giulia Gianferrari cecilia Simonini Francesco Cavallieri Franco Valzania Department of Neurosciences Azienda Ospedaliero Universitaria di ModenaModenaItaly Clinical and Experimental Medicine ph.D.program University of Modena and Reggio EmiliaModenaItaly Department of Biomedical Metabolic and Neural SciencesUniversity of Modena and Reggio EmiliaModenaItaly Neurology Unit Neuromotor&Rehabilitation DepartmentAzienda USL-IRCCS di Reggio EmiliaReggio EmiliaItaly

Amyotrophic lateral sclerosis(ALS)is a neuromuscular condition resulting from the progressive degeneration of motor neurons in the cortex,brainstem,and spinal *** the typical clinical phenotype of ALS involves both upper and lower motor neurons,human and animal studies over the years have highlighted the potential spread to other motor and non-motor regions,expanding the phenotype of *** superoxide dismutase 1(SOD1)mutations represent a minority of ALS cases,the SOD1 gene remains a milestone in ALS research as it represents the first genetic target for personalized *** numerous single case reports or case series exhibiting extramotor symptoms in patients with ALS mutations in SOD1(SOD1-ALS),no studies have comprehensively explored the full spectrum of extramotor neurological manifestations in this *** this narrative review,we analyze and discuss the available literature on extrapyramidal and non-motor features during *** multifaceted expression of SOD1 could deepen our understanding of the pathogenic mechanisms,pointing towards a multidisciplinary approach for affected patients in light of new therapeutic strategies for SOD1-ALS.

关键词： amyotrophic lateral sclerosis(ALS) autonomic extramotor genotype-phenotype multisystem involvement parkinson’s disease sensory SOD1 superoxide dismutase 1 urinary vocal cord palsy

Insights into the genetic architecture of congenital heart disease from animal modeling

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Zoological Research 2023年第3期44卷 577-590页

作者： wenjuan Zhu cecilia w.Lo The Chinese University of Hong Kong Hong Kong SARChina Department of Developmental Biology University of Pittsburgh School of MedicinePittsburghPA15201 USA Kunming Institute of Zoology-The Chinese University of Hong Kong(KIZ-CUHK)Joint Laboratory of Bioresources and Molecular Research of Common Diseases Hong Kong SARChina

Congenital heart disease(CHD)is observed in up to 1%of live births and is one of the leading causes of mortality from birth *** hundreds of genes have been implicated in the genetic etiology of CHD,their role in CHD pathogenesis is still poorly *** is largely a reflection of the sporadic nature of CHD,as well as its variable expressivity and incomplete *** reviewed the monogenic causes and evidence for oligogenic etiology of CHD,as well as the role of de novo mutations,common variants,and genetic *** further mechanistic insight,we leveraged single-cell data across species to investigate the cellular expression characteristics of genes implicated in CHD in developing human and mouse embryonic *** the genetic etiology of CHD may enable the application of precision medicine and prenatal diagnosis,thereby facilitating early intervention to improve outcomes for patients with CHD.

关键词： Congenital heart disease Genetic modifier Single cell sequencing De novo mutation protective variant Common copy number variant