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Macroalgal deep genomics illuminate multiple paths to aquatic,photosynthetic multicellularity

Molecular Plant 2024年第5期17卷 747-771页

作者： David R.Nelson Alexandra Mystikou Ashish Jaiswal cecilia rad-menendez Michael J.Preston Frederik De Boever Diana C.El Assal Sarah Daakour Michael W.Lomas Jean-Claude Twizere David H.Green William C.Ratcliff Kourosh Salehi-Ashtiani Division of Science and Math New York University Abu DhabiAbu DhabiUAE Center for Genomics and Systems Biology(CGSB) New York University Abu DhabiAbu DhabiUAE Biotechnology Research Center Technology Innovation InstitutePO Box 9639Masdar CityAbu DhabiUAE Culture Collection of Algae and Protozoa Scottish Association for Marine ScienceObanScotlandUK National Center for Marine Algae and Microbiota Bigelow Laboratory for Ocean SciencesEast BoothbayMEUSA Laboratory of Viral Interactomes GIGA InstituteUniversity of LiegeLiegeBelgium School of Biological Sciences Georgia Institute of TechnologyAtlantaGAUSA

Macroalgae are multicellular,aquatic autotrophs that play vital roles in global climate maintenance and have diverse applications in biotechnology and eco-engineering,which are directly linked to their multicellularity ***,their genomic diversity and the evolutionary mechanisms underlying multicellularity in these organisms remain *** this study,we sequenced 110 macroalgal genomes from diverse climates and phyla,and identified key genomic features that distinguish them from their microalgal *** for cell adhesion,extracellular matrix formation,cell polarity,transport,and cell differentiation distinguish macroalgae from microalgae across all three major phyla,constituting conserved and unique gene sets supporting multicellular *** genes show phylum-and climate-specific expansions that may facilitate niche ***,our study reveals genetic determinants of convergent and divergent evolutionary trajectories that have shaped morphological diversity in macroalgae and provides genome-wide frameworks to understand photosynthetic multicellular evolution in aquatic environments.

关键词： macroalgae multicellularity comparative genomics evolution adhesome endogenous viral elements

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Antisense therapy:a potential breakthrough in the treatment of neurodegenerative diseases

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Neural Regeneration Research 2024年第5期19卷 1027-1035页

作者： Roberta Romano cecilia Bucci Department of Biological and Environmental Sciences and Technologies(DiSTeBA) University of SalentoLecceItaly

Neurodegenerative diseases are a group of disorders characterized by the progressive degeneration of neurons in the central or peripheral nervous ***,there is no cure for neurodegenerative diseases and this means a heavy burden for patients and the health system ***,it is necessary to find new therapeutic approaches,and antisense therapies offer this possibility,having the great advantage of not modifying cellular genome and potentially being *** preclinical and clinical studies aim to test the safety and effectiveness of antisense therapies in the treatment of neurodegenerative *** objective of this review is to summarize the recent advances in the development of these new technologies to treat the most common neurodegenerative diseases,with a focus on those antisense therapies that have already received the approval of the *** and Drug Administration.

关键词： Alzheimer’s disease amyotrophic lateral sclerosis antisense oligonucleotide Huntington’s disease neurodegenerative disorders Parkinson’s disease siRNA

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Green building research in South Africa:A scoping review and future roadmaps

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Energy and Built Environment 2024年第2期5卷 316-335页

作者： Favour D.Agbajor Modupe cecilia Mewomo Department of Construction Management and Quantity Surveying Durban University of TechnologySteve Biko CampusDurban4001South Africa

The construction industry is recognised to pose serious environmental threats due to its anthropogenic *** confront this challenge,green building has been famed as an auspicious strategy to alleviate energy-related carbon emissions alongside climate change ***,it has birthed diverse empirical studies and holistic reviews by the research ***,these previous studies have been carried out from a global and continental viewpoint regardless of the green building development specifically in emerging *** present study seeks to fill the sparse research upshots on the synthesis of green building research at the country level with core focus on South *** this light,the current study provides a scoping overview of the intellectual exploration on green building research in the South African *** study’s findings highlight the varying growth regarding the subject matter,the drivers,drawbacks,and socio-economic issues confronting in developing green building projects in the *** optimize the advancement of green building in the region,this study recommends the implementation of financing schemes,utilization of advanced digital technologies,and promotion of green and sustainable building curricula across the institutions as well as post-occupancy-related studies within the green building spectrum towards a safe and salutogenic built-environment in the country.

关键词： Green building Sustainable construction Energy efficiency Review South Africa

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Insights into the hydrogen evolution reaction in vanadium redox flow batteries:A synchrotron radiation based X-ray imaging study

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Journal of Energy Chemistry 2024年第4期91卷 132-144页

作者： Kerstin Köble Alexey Ershov Kangjun Duan Monja Schilling Alexander Rampf Angelica cecilia TomášFaragó Marcus Zuber Tilo Baumbach Roswitha Zeis Helmholtz Institute Ulm Karlsruhe Institute of Technology89081 UlmGermany Laboratory for Applications of Synchrotron radiation Karlsruhe Institute of Technology76131 KarlsruheGermany Institute for Photon Science and Synchrotron radiation Karlsruhe Institute of Technology76344 Eggenstein-LeopoldshafenGermany Department of Electrical Electronicsand Communication EngineeringFaculty of EngineeringFriedrich-Alexander-Universität Erlangen-Nürnberg(FAU)91058 ErlangenGermany Department of Mechanical and Industrial Engineering University of TorontoToronto M5S 3G8OntarioCanada

The parasitic hydrogen evolution reaction(HER)in the negative half-cell of vanadium redox flow batteries(VRFBs)causes severe efficiency ***,a deeper understanding of this process and the accompanying bubble formation is *** benchmarking study locally analyzes the bubble distribution in thick,porous electrodes for the first time using deep learning-based image segmentation of synchrotron X-ray *** large three-dimensional data set was processed precisely in less than one minute while minimizing human errors and pointing out areas of increased HER activity in *** study systematically varies the electrode potential and material,concluding that more negative electrode potentials of-200 m V *** hydrogen electrode(RHE)and lower cause more substantial bubble formation,resulting in bubble fractions of around 15%–20%in carbon felt ***,the bubble fractions stay only around 2%in an electrode combining carbon felt and carbon *** detected areas with high HER activity,such as the border subregion with more than 30%bubble fraction in carbon felt electrodes,the cutting edges,and preferential spots in the electrode bulk,are potential-independent and suggest that larger electrodes with a higher bulk-to-border ratio might reduce HER-related performance *** described combination of electrochemical measurements,local X-ray microtomography,AI-based segmentation,and 3D morphometric analysis is a powerful and novel approach for local bubble analysis in three-dimensional porous electrodes,providing an essential toolkit for a broad community working on bubble-generating electrochemical systems.

关键词： Vanadium redox flow battery Synchrotron X-ray imaging Tomography Hydrogen evolution reaction Gas bubbles Deep learning

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Assessing the relationship between health literacy intervention and hypertension self-management:A 7-year systematic review from January 2016 to December 2022

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Journal of Integrative Nursing 2024年第2期6卷 127-135页

作者： Feyisayo Iyabo BAMIDELE cecilia Bukola BELLO Oladayo Damilola AKINWALE Mubo Stella FALANA Department of Nursing Afe Babalola UniversityAdo‑EkitiEkiti StateNigeria Department of Nursing Redeemer’s UniversityEdeOsun StateNigeria

Hypertension(HTN)is one of the most common chronic diseases affecting over 30%of the adult population globally,with a growing incidence *** review assesses the relationship between health literacy(HL)intervention and hypertension(HTN)self-management among people with *** study design was a systematic review of empirical research articles using a well-defined *** journals were accessed through databases such as PubMed,CINAHL,Google Scholar,ProQuest,Global Health,WHOLIS,Embase,and EbscoHost,spanning from January 2016 to December 2022 as the scope of the *** selected for inclusion were those published in English during the specified time frame and adhering to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and Sample,Phenomenon of Interest,Design,Evaluation,Research Type framework for systematic review,focusing on criteria related to the sample,the phenomenon of interest,study design,evaluation,and research *** of 180 studies initially identified in the database search,20 studies were ultimately included in the *** findings were reported based on these five emerging themes:Relationship between HL and HTN self-management;Effect of HL intervention on HTN self-management;Factors predicting self-care behaviors among HTN patients with low HL;Effect of HL and self-management efficacy on health-related quality of life(HRQoL);and level of self-care *** review highlights a relationship between HL,self-efficacy,self-care,and HRQoL,underscoring the necessity for further well-designed intervention studies focused on enhancing HL in individuals with HTN in Nigeria to enhance their quality of life.

关键词： Health literacy intervention health-related quality of life people living with hypertension self-management

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Effect of pediatric Tuina on children's recurrent acute respiratory tract infections: a retrospective cohort study in Southern China

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Journal of Traditional Chinese Medicine 2024年第3期44卷 586-594页

作者： YIN Lingjia ST?LSBY LUNDBORG cecilia WU Darong YANG Jinghua ALVESSON Helle M?lsted CAI Jianxiong LU Taoying XIE Qianwen MARRONE Gaetano Department of Global Public Health Karolinska Institutet State Key Laboratory of Dampness Syndrome of Chinese Medicine the Second Affiliated Hospital of Guangzhou University of Chinese Medicine Outcome Assessment Research Team in Chinese Medicine the Second Affiliated Hospital of Guangzhou University of Chinese Medicine Health Construction Administration Centre Guangdong Provincial Hospital of Chinese Medicine Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome the Second Affiliated Hospital of Guangzhou University of Chinese Medicine Department of Pediatrics the Second Affiliated Hospital of Guangzhou University of Chinese Medicine

OBJECTIVE: To determine the effectiveness of pediatric Tuina(PT) in preventing recurrent acute respiratory tract infections(ARTIs) in children. METHODS: This is a retrospective cohort study based on the electronic medical records of children with recurrent ARTIs in 2016. Children were divided into a PT group or a non-PT group, according to whether they had received PT or not in 2016. The primary outcome was the number of ARTI episodes in 2017 and 2018. The secondary outcomes were the number of ARTIs leading to outpatient department visits and outpatient antibiotic prescriptions due to ARTIs in the same time period. Negative binomial regressions were used to detect the association between PT and the outcomes. RESULTS: A total of 2303 children were included in the analysis, including 94 in the PT group and 2209 in the non-PT group. Children who received PT six or more times in 2016 had fewer episodes of ARTIs in 2017 [incidence rate ratio(IRR): 0.59, 95% confidence interval(CI)(0.42-0.84)] and 2018 [IRR: 0.58, 95% CI(0.36-0.94)] and fewer outpatient department visits due to ARTIs in 2017 [IRR: 0.56, 95% CI(0.38-0.83)] than children who had not received PT in 2016. There was no significant difference in the number of outpatient antibiotic prescriptions between the two groups. CONCLUSIONS: Receiving PT six or more times within one year is associated with a decrease in recurrent ARTIs in children in the following two years. Randomized controlled trials are needed for effect evaluation prior to establishing PT as a method for preventing recurrent ARTIs among children.

关键词： child massage pediatric Tuina respiratory tract infections

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Identifying Malaria Hotspots Regions in Ghana Using Bayesian Spatial and Spatiotemporal Models

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Infectious Diseases & Immunity 2024年第2期4卷 69-78页

作者： Abdul-Karim Iddrisu Dominic Otoo Gordon Hinneh Yakubu Dekongmene Kanyiri Kanimam Yaaba Samuel cecilia Kubio Francis Balungnaa Dhari Veriegh Department of Mathematics and Statistics University of Energy and Natural ResourcesSunyani 233Ghana Department of Statistical Service Ghana Statistical ServiceBono RegionSunyani 233Ghana Department of Mathematics and ICT Gambaga College of EducationSunyani 233Ghana Human Resources Division University of Energy and Natural ResourcesSunyani 233Ghana Department of Biological Science University of Energy and Natural ResourcesSunyani 233Ghana.

Background:Malaria remains a significant public health concern in Ghana,with varying risk levels across different geographical *** affects millions of people each year and imposes a substantial burden on the health care system and *** risk estimation and mapping are crucial for effectively allocating resources and implementing targeted interventions to identify regions with disease *** study aimed to identify regions exhibiting elevated malaria risk so that public health interventions can be implemented,and to identify malaria risk predictors that can be controlled as part of public health interventions for malaria ***:The data on laboratory-confirmed malaria cases from 2015 to 2021 were obtained from the Ghana Health Service and Ghana Statistical *** studied the spatial and spatiotemporal patterns of the relative risk of malaria using Bayesian spatial and spatiotemporal *** malaria risk for each region was mapped to visually identify regions with malaria *** and heterogeneity of disease risks were established using correlated and uncorrelated structures via the conditional autoregressive and Gaussian models,*** estimates from the marginal posterior distribution were estimated within the Integrated Nested Laplace Approximation using the R ***:The spatial model indicated an increased risk of malaria in the North East,Bono East,Ahafo,Central,Upper West,Brong Ahafo,Ashanti,and Eastern *** spatiotemporal model results highlighted an elevated malaria risk in the North East,Upper West,Upper East,Savannah,Bono East,Central,Bono,and Ahafo *** spatial and spatiotemporal models identified the North East,Upper West,Bono East,Central,and Ahafo Regions as hotspots for malaria *** variations in risk were evident across regions(H=104.9,P<0.001).Although climatic and economic factors influenced malaria infection,statistical significance was not

关键词： Malaria Disease hotspot Bayesian modeling Conditional auto-regressive Integrated Nested Laplace Approximation Spatial and spatiotemporal models

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Machine learning and tectonic setting determination:Bridging the gap between Earth scientists and data scientists

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Geoscience Frontiers 2024年第1期15卷 339-353页

作者： Pratchaya Takaew Jianhong cecilia Xia Luc S.Doucet Department of Spatial Sciences School of Earth and Planetary SciencesCurtin University6845 PerthWAAustralia Earth Dynamics Research Group School of Earth and Planetary SciencesCurtin University6845 PerthWAAustralia State Key Laboratory of Geological Processes and Mineral Resources China University of GeosciencesWuhanHubei 430074China

Technological progress and the rapid increase in geochemical data often create bottlenecks in many studies,because current methods are designed using limited number of data and cannot handle large *** geoscience,tectonic discrimination illustrates this issue,using geochemical analyses to define tectonic settings when most of the geological record is missing,which is the case for most of the older portion of the Earth’s *** are the primary target for tectonic discrimination because they are volcanic rocks found within all tectonic settings,and their chemical compositions can be an effective way to understand tectonics-related mantle ***,the classical geochemical discriminant methods have limitations as they are based on a limited number of 2 or 3-dimensional diagrams and need successive and subjective steps that often offers non-unique ***,weathering,erosion,and orogenic processes can modify the chemical composition of basalts and eliminate or obscure other complementary geotectonic *** address those limitations,supervised machine learning techniques(a part of artificial intelligence)are being utilized more often as a tool to analyze multidimensional datasets and statistically process data to tackle big data *** contribution starts by reviewing the current state of tectonic discrimination methods using supervised machine *** learning,especially Convolutional Neural Network(CNN)is the most accurate ***,it requires a large dataset and considerable processing time,and the gain of accuracy can be at the expense of ***,this study designed guidelines for data pre-processing,tectonic setting classification and objectively evaluating the model *** also identify research gaps and propose potential directions for the application of supervised machine learning to tectonic discrimination research,aimed at closing the divide between earth scientists and data scie

关键词： Machine learning Artificial intelligence Geochemistry Igneous petrology Basalts Tectonic settings

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Characterization of Arroyo Verde Epithermal Deposit:Paragenesis,Mineral Geochemistry,Geochronology and Fluid Inclusions in Lower Chon Aike Volcanism,Argentina

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Journal of Earth Science 2024年第1期35卷 62-84页

作者： cecilia Pavón Pivetta Leonardo Benedini Paulo Marcos Ma.Agustina Cócola Mercedes Virginia Barros Daniel Gregori Leonardo Strazzere Anderson Costa dos Santos Mauro C.Geraldes Instituto Geologico del Sur(INGEOSUR) Universidad Nacional del Sur(UNS)-Consejo Nacional de Investigaciones Cientificas y Tecnicas(CONICET)Bahia Blanca 8000Argentina Dpto.de Geologia Universidad Nacional del Sur(UNS)Bahia Blanca 8000Argentina Universidad Nacional de Rio Negro Instituto de Investigacion en Paleobiologia y GeologiaGeneral Roca 8332Argentina Universidade do Estado do Rio de Janeiro Faculdade de GeologiaDepartamento de Mineralogia e Petrologia igneaRiodeJaneiro20559-900Brazil Geobiotec Departamento de GeocienciasUniversidade de AveiroAveiro 3800-002Portuga

Arroyo Verde epithermal deposit,in the North Patagonia region of Argentina,is located within the Lower Chon Aike volcanism and is developed between 192.6±2.5 Ma(mineralization host rock)and 189.5±2.6 Ma(overlying lava).Marifil volcanic complex is the host rock for these veins,veinlets and *** particular small deposit has developed low to intermediate sulphidation characteristics,with gangue mineral textures associated with several ore *** probe microanalysis determines electrum,silver minerals such as acanthite,and tetrahedrite,related Ag-Cu minerals like jalpaite,mckinstryite,stromeyerite,and base metals like chalcopyrite,sphalerite,galena and *** inclusions in quartz of two out of five events indicate that these Low Jurassic veins were formed due to subtle boiling and dilution mechanisms and by low-salinity(3.4 wt.%to 6.7 wt.%NaCl Eq)magmatic-hydrothermal fluid at 225 to 310℃.The fluid inclusion measurements that indicate boiling(Event 3)were plotted,and based on this data,we interpret that the Arroyo Verde deposit has been eroded between 550 and 700 *** particular character has not been previously recorded for other sectors of the eastern north Patagonian region.

关键词： epithermal deposit Ag minerals mineral geochemistry fluid inclusions Chon Aike geochronology

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Multifaceted superoxide dismutase 1 expression in amyotrophic lateral sclerosis patients:a rare occurrence?

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Neural Regeneration Research 2025年第1期20卷 130-138页

作者： Ilaria Martinelli Jessica Mandrioli Andrea Ghezzi Elisabetta Zucchi Giulia Gianferrari cecilia Simonini Francesco Cavallieri Franco Valzania Department of Neurosciences Azienda Ospedaliero Universitaria di ModenaModenaItaly Clinical and Experimental Medicine Ph.D.Program University of Modena and Reggio EmiliaModenaItaly Department of Biomedical Metabolic and Neural SciencesUniversity of Modena and Reggio EmiliaModenaItaly Neurology Unit Neuromotor&Rehabilitation DepartmentAzienda USL-IRCCS di Reggio EmiliaReggio EmiliaItaly

Amyotrophic lateral sclerosis(ALS)is a neuromuscular condition resulting from the progressive degeneration of motor neurons in the cortex,brainstem,and spinal *** the typical clinical phenotype of ALS involves both upper and lower motor neurons,human and animal studies over the years have highlighted the potential spread to other motor and non-motor regions,expanding the phenotype of *** superoxide dismutase 1(SOD1)mutations represent a minority of ALS cases,the SOD1 gene remains a milestone in ALS research as it represents the first genetic target for personalized *** numerous single case reports or case series exhibiting extramotor symptoms in patients with ALS mutations in SOD1(SOD1-ALS),no studies have comprehensively explored the full spectrum of extramotor neurological manifestations in this *** this narrative review,we analyze and discuss the available literature on extrapyramidal and non-motor features during *** multifaceted expression of SOD1 could deepen our understanding of the pathogenic mechanisms,pointing towards a multidisciplinary approach for affected patients in light of new therapeutic strategies for SOD1-ALS.

关键词： amyotrophic lateral sclerosis(ALS) autonomic extramotor genotype-phenotype multisystem involvement Parkinson’s disease sensory SOD1 superoxide dismutase 1 urinary vocal cord palsy

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