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现代生物医学进展 2017年第8期17卷 I0004-I0004页

作者： Lars Sivars MD David Landin MD Linnea Haeggblom MSci Nikolaos Tertipis phd Nathalie Gr uuml n phd Cinzia Bersani phd Linda Marklund MD, phd Mehran Ghaderi phd Anders N auml sman MD, phd Torbj ouml rn Ramqvist phd cecilia nordfors phd Eva Munck ndash Wikland MD, phd Edneia Tani MD, phd Tina Dalianis MD, phd Department of Oncology - Pathology Karolinska Institutet Stockholm Sweden Department of Oto-Rhino-Laryngology Head and Neck Surgery CLINTEC Karolinska Institutet Stockholm Sweden Department of Clinical Pathology Karolinska University Hospital Stockholm Sweden Department of Medical Biochemistry and Microbiology Microbiology - Immunology Uppsala University Uppsala Sweden

口咽鳞状细胞癌HPV16是指人乳头瘤病毒16型。HPV有多种类型，其中低危型HPV感染，主要引起生殖器疣（俗称菜花）。而高危型HPV感染则引起生殖器癌和子宫颈癌上皮细胞病变，此病毒为生殖器癌和子宫颈癌前细胞病毒的开端。

关键词： HPV16 人乳头瘤病毒16型鳞状细胞癌阳性诊断样品穿刺检测

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The landscape of cognitive impairment in superoxide dismutase 1-amyotrophic lateral sclerosis

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Neural Regeneration Research 2023年第7期18卷 1427-1433页

作者： Ilaria Martinelli Elisabetta Zucchi cecilia Simonini Giulia Gianferrari Giovanna Zamboni Marcello Pinti Jessica Mandrioli Clinical and Experimental Medicine phd Program University of Modena and Reggio EmiliaModenaItaly Department of Neurosciences Azienda Ospedaliero-Universitaria di ModenaModenaItaly Department of Biomedical Metabolic and Neural SciencesUniversity of Modena and Reggio EmiliaModenaItaly Department of Life Sciences University of Modena and Reggio EmiliaModenaItaly

Although mutations in the superoxide dismutase 1 gene account for only a minority of total amyotrophic lateral sclerosis cases,the discovery of this gene has been crucial for amyotrophic lateral sclerosis *** the identification of superoxide dismutase 1 in 1993,the field of amyotrophic lateral sclerosis genetics has considerably widened,improving our understanding of the diverse pathogenic basis of amyotrophic lateral *** this review,we focus on cognitive impairment in superoxide dismutase 1-amyotrophic lateral sclerosis *** has mostly reported that cognition remains intact in superoxide dismutase 1-amyotrophic lateral sclerosis patients,but recent reports highlight frontal lobe function frailty in patients carrying different superoxide dismutase 1-amyotrophic lateral sclerosis *** thoroughly reviewed all the various mutations reported in the literature to contribute to a comprehensive database of superoxide dismutase 1-amyotrophic lateral sclerosis genotype-phenotype *** a resource could ultimately improve our mechanistic understanding of amyotrophic lateral sclerosis,enabling a more robust assessment of how the amyotrophic lateral sclerosis phenotype responds to different variants across genes,which is important for the therapeutic strategy targeting genetic *** in superoxide dismutase 1-amyotrophic lateral sclerosis deserves further longitudinal research since this peculiar frailty in patients with similar mutations can be conditioned by external factors,including environment and other unidentified agents including modifier genes.

关键词： amyotrophic lateral sclerosis cognitive impairment genotype-phenotype correlation superoxide dismutase 1

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Saxicolous lichen communities in three basins associated with mining activity in northwestern Argentina

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Journal of Arid Land 2023年第8期15卷 989-1005页

作者： Juan M HERNÁNDEZ Renato A GARCÍA Edith R FILIPPINI cecilia ESTRABOU Martha S CAÑAS Juan M RODRÍGUEZ Faculty of Technology and Applied Sciences Regional Centre of Energy and Environment for Sustainable DevelopmentNational University of CatamarcaCatamarca 4700Argentina Laboratory of Biodiversity and Environmental Genetics National University of AvellanedaAvellaneda 1870Argentina Institute of Biological and Technological Research Centre for Ecology and Renewable Natural ResourcesFaculty of ExactPhysical and Natural SciencesNational University of CordobaCordoba 5000Argentina

Mining activity affects the vegetation and soils of the ***,the effects of mining activity on saxicolous lichen communities are less ***,the aim of this study was to characterize saxicolous lichen communities in three basins(Vis-Vis River basin,Poteros River basin,and Capillitas River basin)surrounding metalliferous mining projects of different types of operation and at different stages of exploitation.A large-scale mine(Bajo de la Alumbrera)with more than 25 a of open-pit mining located in the Vis-Vis River basin(CRV).A pre-exploitation mine(Agua Rica)located in the Poteros River basin(CRP),and a small-scale mine(Minas Capillitas)with more than 160 a of underground mining located in the Capillitas River basin(CAC).In each basin,species richness,cover,and frequency of lichen communities were measured on 40 rock ***,explanatory variables were recorded,i.e.,altitude,slope,aspect,vegetation cover,rock,and soil cover around the rocky area *** and total cover of lichen communities were analysed using linear models,and species composition was explored using multivariate ordination *** showed that a total of 118 lichen species were *** species richness differed among basins and the lichen composition present in areas close to mining sites responded mainly to basins,altitude,and microsite *** lichen cover showed no difference among basins,but it changed under different rock and vegetation *** was not possible to quantify the effects of mining activity on species richness and ***,the low richness values found in the downstream of Minera Alumbrera could be associated with the negative impact of open-pit ***,the effects of large-scale mining activity on lichen communities needs more investigation.

关键词： lichen community altitude microsite metalliferous mining vegetation

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