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A One Health approach to fight antimicrobial resistance in Uganda: Implementation experience, results, and lessons learned

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Biosafety and Health 2024年第2期6卷 125-132页

作者： Reuben Kiggundu J.P.Waswa Niranjan Konduri Hassan Kasuja Marion Murungi Patrick Vudriko Harriet Akello Eric Lugada cecilia Muiva Esther Were Dinah Tjipura Henry Kajumbula Kate Kikule Emmanuel Nfor Mohan P.Joshi USAID Medicines Technologiesand Pharmaceutical Services ProgramManagement Sciences for HealthKampala 256Uganda USAID Medicines Technologiesand Pharmaceutical Services ProgramManagement Sciences for HealthArlingtonVA 22203USA College of Veterinary Medicine Animal Resources and BiosecurityMakerere UniversityKampala 256Uganda Ministry of Health Uganda Kampala 256Uganda USAID Strengthening Supply Chain Systems Activity Management Sciences for HealthKampala 256Uganda USAID Medicines Technologiesand Pharmaceutical Services ProgramManagement Sciences for HealthNairobi 254Kenya Department of Microbiology College of Health SciencesMakerere UniversityKampala 256Uganda

Uganda has been implementing the Global Health Security Agenda(GHSA)since 2015 to build its capacity according to World Health Organization(WHO)Benchmarks on International Health Regulations *** country remains prone to outbreaks,with more than 20 disease outbreaks reported in the past five years,including Ebola virus disease,Crimean-Congo haemorrhagic fever,Marburg haemorrhagic fever,measles,yellow fever,coronavirus disease 2019(COVID-19),and *** resistance(AMR)is an ongoing *** scored capacity level 3 on infection prevention and control(IPC)and antimicrobial stewardship(AMS)in the 2017 Joint External Evaluation(JEE)*** gaps were being addressed after a self-assessment in *** paper describes the technical assistance approaches provided to Uganda by the Medicines,Technologies,and Pharmaceutical Services Program,funded by the United States(U.S.)Agency for International Development,and implemented by Management Sciences for *** program,through a One Health approach,supported systematic capacity strengthening based on the JEE's capacity advancement framework for global health security,specifically relating to *** program's interventions impacted 32 WHO benchmark actions(7 for AMR multisectoral coordination,16 for IPC,and 9 for AMS),contributing to Uganda's strengthened GHSA *** success built on the AMR platform,the program trained 745 health workers in IPC for the Ebola virus and provided support for simulation exercises by eight district IPC *** program also worked with the Ministry of Health to coordinate IPC for the COVID-19 response in five health regions,covering 45 districts and reaching 5,452 health workers at 858 health facilities.

关键词： One health Antimicrobial resistance Antibiotic resistance Jointexternal evaluation Global health security Uganda Africa WHO Benchmarks for International Health Regulations Capacities

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办公室的午后时光Media Arts Lab上海办公室

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室内设计与装修 2016年第7期 10-11页

作者： lim chan(设计/摄影) 小麦(整理) Yummy Yu cecilia Jiang Danny Deng Steven Wang Vincent Xie 无不详 CDnA deisgn

在静安区胶州路武定路路口有一座上世纪的红色砖瓦老建筑,在茂密的梧桐树掩映下愈显其独特的老上海风情.本案就位于这栋老建筑的4楼.作为Apple唯一的广告合作公司,Media Arts Lab（以下简称Mal）对于办公空间设计的要求,跟Ap-ple产品的... 详细信息

在静安区胶州路武定路路口有一座上世纪的红色砖瓦老建筑,在茂密的梧桐树掩映下愈显其独特的老上海风情.本案就位于这栋老建筑的4楼.作为Apple唯一的广告合作公司,Media Arts Lab（以下简称Mal）对于办公空间设计的要求,跟Ap-ple产品的精神一样：“我要做得更好.”

关键词： Media Arts Lab 办公室上海空间设计老建筑静安区

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Characterization of the Ear Canal Bacterial Flora Present in Hearing Aids (HA) Wearing Subjects

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Advances in Microbiology 2019年第7期9卷 616-628页

作者： Marta Aleandri cecilia Ambrosi Maria Stefania Lepanto Antonietta Lucia Conte Massimiliano Marazzato Catia Longhi Mauro Nicoletti Carlo Zagaglia Paola Goldoni Francesco Bussu Roberta Anzivino Roberto Gallus Maria Pina Battista Maria Pia Conte Anna Teresa Palamara Department of Public Health and Infectious Diseases “Sapienza” University of Rome Rome Italy Dani Di Giò Foundation-Onlus Rome Italy Department of Medical Oral and Biotechnological Sciences University “G. D’Annunzio” Chieti Italy Institute of Otolaryngology “Cattolica del Sacro Cuore” University Agostino Gemelli Polyclinic Rome Italy Otolaryngology Mater Olbia Hospital Olbia Italy Department of Public Health and Infectious Diseases “Sapienza” University of Rome Laboratory Affiliated to Institute Pasteur Italia Cenci-Bolognetti Foundation Rome Italy San Raffaele Pisana IRCCS Telematic University Rome Italy

The use of hearing aids (HA) is considered a predisposing factor for ear microbial infections. We undertook this study to compare the presence and nature of the microbial flora inhabiting of ears of HA and non-HA (nHA) users. Swab samples of the ears of HA and nHA users were collected from the Institute of Otolaryngology, “Cattolica del Sacro Cuore” University “Agostino Gemelli”, Rome, Italy. Swab samples were taken from the ear canal of 57 HA and 33 nHA users. The components of the microbial flora present on each swab sample were identified and characterized at the level of species. A total of 41 different bacterial species were identified. A statistically significant prevalence of polymicrobial communities was found in ears presenting signs of inflammation (2.5 ± 1.7 vs 2.1 ± 1.3;P = 0.02) and in HA users (2.3 ± 1.2 vs 1.7 ± 1.0;P = 0.002). Few putative pathogens were detected. Candida albicans spp. was not isolated in our study. A small number of swab samples presented no microbial growth. Bacterial species isolated from HA users with and without inflammation were assayed for the ability to form biofilm. Among gram-positive and gram-negative bacteria, S. aureus, CoNS, P. aeruginosa and K. pneumoniae were found to be strong biofilm producers. S. aureus and P. aeruginosa, isolated only from the ears of HA and nHA users presenting signs of inflammation, were further analyzed for their antibiotic-resistance profile and characterized by the Multilocus Sequence Typing (MLST) assay. The highest rates of antibacterial resistance were in S. aureus to penicillin (75.5%) and in P. aeruginosa, to amoxicillin-clavulanic acid, cefotaxime, ertapenem, tigecycline and trime-thoprim-sulfamethoxazole (100%). Moreover, three S. aureus strains (37.5%) were methicillin-resistant (MRSA). Of the eight S. aureus isolates, we identified six sequence types (ST) indicating that 75% are likely independent clones. For what it concerned P. aeruginosa, six different STs were assigned. Interesti

关键词： Ear Bacterial Flora Hearing Aids Acute Otitis Externa

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指标的抉择:概念、方法与应用

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国际城市规划 2012年第2期27卷 4-15页

作者：黄燕玲袁媛张家睿骆逸玲英国曼彻斯特大学城市规划系都市政策研究中心中山大学地理科学与规划学院广东工业大学

本文概述了指标的发展历程,着重介绍了英国城市与区域规划背景下指标的发展情况,并为未来的指标研究和深入发展提供了线索。本文的观点和建议是对经济与社会研究理事会(ESRC:Economic and Social Research Council)所资助的一项研究项... 详细信息

本文概述了指标的发展历程,着重介绍了英国城市与区域规划背景下指标的发展情况,并为未来的指标研究和深入发展提供了线索。本文的观点和建议是对经济与社会研究理事会(ESRC:Economic and Social Research Council)所资助的一项研究项目成果的阐释,该研究项目旨在识别出用于衡量地方经济发展潜力的指标,以及用于建立一个城镇指标数据库的方法,这一数据库用来帮助副首相办公室(ODPM:the Office of DeputyPrime Minister)监测城市白皮书(Urban White Paper)执行的力度。文章讨论的内容主要围绕五大问题:城市与区域规划评价指标发展的理论、概念与度量之间的关系;政策背景的重要性与指标研究的价值;社会科学家在指标演化过程中所扮演的角色;指标在为政策制定以及数据建设提供信息上的作用;最后综合评价了不同分析方法的优缺点。

关键词：应用 Office 区域规划社会研究地方经济 White 发展潜力评价指标

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短链脂肪酸(SCFA)对新生鼠肠粘膜屏障的作用机制研究

短链脂肪酸(SCFA)对新生鼠肠粘膜屏障的作用机制研究

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2011年浙江省小儿外科学术年会

作者：朱利斌李仲荣林锦 cecilia M Berin 包苏谨温州医学院附属育英儿童医院小儿外科纽约西奈山医学院儿科

目的正常菌群的定植对于出生后胃肠道适应环境的变化和肠粘膜屏障的成熟起非常重要的作用。我们观察到早期应用广谱抗生素和延迟喂养,会损伤肠粘膜屏障的发育。短链脂肪酸(SCFA)是肠腔内细菌发酵终产物,可能具有调节肠粘膜屏障功能。我... 详细信息

目的正常菌群的定植对于出生后胃肠道适应环境的变化和肠粘膜屏障的成熟起非常重要的作用。我们观察到早期应用广谱抗生素和延迟喂养,会损伤肠粘膜屏障的发育。短链脂肪酸(SCFA)是肠腔内细菌发酵终产物,可能具有调节肠粘膜屏障功能。我们通过在体外检测生理浓度SCFA作用下的新生鼠肠粘膜,推测SCFA对于维持正常肠粘膜屏障的功能起重要作用。方法取SD大鼠近端结肠组织,分断奶前组(n=8,日龄13-17d),断奶后组(n=8,日龄

关键词：短链脂肪酸肠粘膜屏障新生儿

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砂岩中的孔隙块和应变局部化

砂岩中的孔隙块和应变局部化

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2015中国地球科学联合学术年会

作者：汲云涛 Patrick Baud Thierry Reuschlé cecilia S.N.Cheung 黄庭芳中国地震局地质研究所 Institut de Physique du Globe de Strasbourg(UMR 7516 CNRS Université de Strasbourg/EOST) StrasbourgFrance Department of Geosciences State University of New York Stony Brook Earth System Science Programme Faculty of ScienceThe Chinese University of Hong Kong

＜正＞近些年的研究发现,在高围压条件下,某些特定的砂岩呈现出不一样的破坏模式。这是一种介于脆性和韧性的最终破坏模式,叫做局部化离散压缩带。这是一种平面结构压缩带,垂直于平面方向的缩短导致了平面内的碎裂压缩,伴随着非常少量...

＜正＞近些年的研究发现,在高围压条件下,某些特定的砂岩呈现出不一样的破坏模式。这是一种介于脆性和韧性的最终破坏模式,叫做局部化离散压缩带。这是一种平面结构压缩带,垂直于平面方向的缩短导致了平面内的碎裂压缩,伴随着非常少量的剪切。这种压缩带的首次报道见于野外研究中（Hill,1989;Sternlof et al.,2005;Eichhubl et al.,2010）,后来在实验室得到了系统的研究（Baud et al.,2004）。研究指出这种现象至少在三种岩石中存在,分别是Bleurswiller砂岩、Diemelstadt砂岩和

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Comparison on the Pharmacokinetics and Weight Reduction of Clobenzorex Slow Release and Immediate Release Formulations in Obese Patients

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Pharmacology & Pharmacy 2013年第2期4卷 218-221页

作者： Federico Argüelles-Tello Miriam del C.Carrasco-Portugal Norma A.Carrasco-Portugal Jose Carlos Aguilar-Carrasco Selene I.Patino-Camacho cecilia Fernandez del Valle Gerardo Reyes-Garcia Francisco J.Flores-Murrieta Sección de Estudios de Posgrado e Investigación Escuela Superior de Medicina del Instituto Politecnico NacionalMexico CityMexico Unidad de Investigación en Farmacología Instituto Nacional de Enfermedades Respiratorias Ismael Cosío VillegasMexico CityMexico Centro de Estudios Biofarmaceuticos Mexico CityMexico Instituto Nacional de Perinatología Mexico CityMexico

Clobenzorex is an anorexigenic drug that is widely used in Mexicofor the treatment of obesity, since it helps to reduce body weight. This drug is available as immediate release capsules. To improve compliance to treatment, it was developed a new slow release formulation. In order to establish its usefulness, oral pharmacokinetics and weight reduction of slow release and immediate release formulations of clobenzorex in obese patients were compared. Sixty patients with a BMI higher than 27 kg/m2 were included in the study. Two groups of 30 patients were formed, one of them received 30 mg immediate release formulation b.i.d. and the other group received one 60 mg slow release formulation once a day, since under this scheme these formulations are prescribed. Blood samples were obtained at selected times during the first day and once weekly during 4 weeks. After the last dose, samples were obtained at selected times during 48 h. Plasma levels were determined by HPLC-MS/MS and pharmacokinetic parameters were obtained. Reduction in Cmax due to increased tmax, as well as, increased half-life were observed with the slow release formulation in comparison with immediate release formulation. Although lower plasma levels of clobenzorex were reached with the slow release formulation, reduction of body weight was similar with both products. Based on the results, it was concluded that slow release formulation of clobenzorex is an adequate formulation of clobenzorex, since pharmacokinetics and effects observed are compatible with a once a day administration.

关键词： Clobenzorex Pharmacokinetics Slow Release Formulation

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Detection of Delayed Hypersensitivity to Fonsecaea pedrosoi Metabolic Antigen （Chromomycin）in Healthy People in an Endemic Area

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Journal of Life Sciences 2013年第3期7卷 267-275页

作者： Conceiao de Maria Pedrozo e Silva de Azevedo Antonio Augusto Moura da Silva Sirlei Garcia Marques Oscar Brufia-Romero Gilnara Fontinelle Silval cecilia Silva de Lima Flaivia Raquel Femandes do Nascimento Maria Aparecida de Resende Stoianoff Department of Medicine Federal University of Maranh6o S6o Luis City 65604010 Maranh6o Brazil Department of Microbiology Federal University of Minas Gerais Belo Horizonte 31270901 Minas Gerais Brazil

The CBM （chromoblastomycosis） is a disease caused by dematiaceous fungi, which has the species Fonsecaea pedrosoi as main agent. This fungus is found in warm and moist climates, characteristically found in the amazonic lands of the region, where its environmental isolation was once described. This research aimed to identify the healthy population exposed to agent F. pedrosoi in four villages located in the Legal Amazon. In order to clarify the risk factors for allergic immune exposure, a survey was conducted by the technique of delayed skin reaction （IDR） with the metabolic antigen （chromomycin） in 449 healthy individuals. The results showed that 14.9% （67 subjects） were IDR positive, with induration 〉 5 mm. Multivariate analysis with logistic regression for risk factors： living in the village of Z6 Pedro （municipality of Bacabeira in the state of Maranhao, Brazil）,

关键词： Fonsecaeapedrosoi chromomycin risk factor.

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TEACHING ACUPUNCTURE TO MEDICAL STUDENTS:THE EXPERIENCE OF RIO PRETO MEDICAL SCHOOL(FAMERP), BRAZIL

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Journal of Integrative Medicine 2014年第3期 313-313页

作者： Joao Bosco Silva Rassen Saidah cecilia Megid Neil Ramos Rio Preto Medical School

Complementary and alternative medicine(CAM), in particular acupuncture, has been practiced and taught in recent years in many universities in the Western ***, we relate our experience since 1997 in teaching acupuncture to medical students in Rio Preto Medical School(Famerp), *** are given in the third and fifth *** main goals of understanding the mechanisms of action and being able to recognize patients who may benefit from treatment and referring them have been well achieved, scoring 3.6 and 4.1 respectively, on a scale from *** using that scale, medical students believe that acupuncture is important in the curriculum(4.6), course time is not sufficient(2.7) and they would like more information(4.6).To overcome these concerns, many students join the undergraduate study groups(Acupuncture League) where they have more time to *** also describe the presence of foreign medical students who, since 2000, have enrolled in a course of 150 h in an exchange program.

关键词： TEACHING ACUPUNCTURE TO MEDICAL STUDENTS FAMERP BRAZIL

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The Children’s Faecal Matter Structure Is Built by Their Parents

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Open Journal of Epidemiology 2019年第1期9卷 64-74页

作者： Eduard Cueto Rua Ricardo Wright cecilia Zubiri Luciana Guzmán Claudia Losada M. Inés Urrutia María T. Gonzalez Ricardo Drut Mariela Espósito Norberto Recalde Jorge Fiad Ignacio Goni Natalia Belén María Cristina Arregui Facultad de Ciencias Médicas Universidad Nacional de La Plata La Plata Argentina Comisión de Investigación Científica de la Provincia de Buenos Aires Buenos Aires Argentina Pediatric Hospital “Sor María Ludovica” La Plata Argentina Universidad Nacional de La Plata La Plata Argentina Consultant in Pediatrics Mar del Plata City Argentina Dolores City Argentina

Introduction: Humans have gone through physical changes over the last 4 million years. The mouth, however, has not changed teeth quantity or quality. Eight incisors for fruits, vegetables and tubers;four little canines for little animals;eight premolars and twelve flat molars are used for crushing these foods, especially whole grains and legumes. The teeth crushing foods are the first step in the building of faecal matter. Foods are selected mostly according to cultural guidelines than to biological needs. The patterns of consumption are induced by the publicity of industrialized or processed foods. Material and Methods: This study design was observational, analytical, correlational, transversal and prospective. One thousand children (0 - 12 years old) were questioned in order to learn about the relationship between Weekly Eating Frequency (WEF) and Faecal Matter (FM) characteristics. The FM was classified as soft, normal or hard and the outcome was expressed as Dry Faecal Residue (DFR). The WEF and Weekly Bowel Movement Frequency (WBMF) were determined and tabulated according to times per week. Environmental factors, parents’ education level and children’s birth order were examined. Results: There was a strong association between DFR, WBMF and WEF. Environment and education level did not play a key role although birth order did matter. Conclusions: Fibre-free foods (dairies, meats, flours and sweeties or sodas) increased DFR. Foods containing fibre from vegetables decreased DFR, which in turn contributed to the WBMF. Lowest DFR was observed in children under Exclusive Breastfeeding (EB). Distant last-born children had higher DFR. Comments: Daily examples support these results and it is clear that children’s FM is built by their parents. We encourage parents to follow the “mouth nature” rather than the “advertisements nature”.

关键词： Bowel Movement Frequency Constipation Culture Faecal Matter Foods

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