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不同针头设计的预灌封注射器用于预防接种的对比研究

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中华全科医学 2019年第11期17卷 1929-1932页

作者：吕敏白霜高培王怀富继业史如晶董琳 Florence Schwarzenbach cecile Berteau 吴疆北京市疾病预防控制中心免疫预防所北京市预防医学研究中心北京100013 北京市海淀区疾病预防控制中心计划免疫科北京100094 BD中国医学事务部上海200040 BD法国医学事务部法国勒蓬德克莱38801

目的探讨5切面27G与3切面25G两种针头设计的预灌封注射器在受试者的疼痛感、接种护士的穿刺阻力以及注射部位不良事件等预防接种实践中的差异。方法采用随机双盲平行对照临床试验。将604例受试者随机分为2组,试验组299例使用5切面27G预... 详细信息

目的探讨5切面27G与3切面25G两种针头设计的预灌封注射器在受试者的疼痛感、接种护士的穿刺阻力以及注射部位不良事件等预防接种实践中的差异。方法采用随机双盲平行对照临床试验。将604例受试者随机分为2组,试验组299例使用5切面27G预灌封注射器,对照组305例使用3切面25G预灌封注射器接种甲肝疫苗,同时2组均使用3切面25G预灌封注射器接种乙肝疫苗作为自身对照。比较受试者疼痛与穿刺阻力,并比较受试者注射部位皮肤不良反应情况。结果采用视觉模拟量表(VAS)和疼痛程度语言等级量表中文版(C-PIVRS)评分法对甲肝疫苗穿刺时的疼痛感进行分级评价,试验组中等及以上疼痛比例分别为7.02%、16.55%;对照组分别为15.73%、20.32%,组间差异有统计学意义(均P≤0.001)。对照组注射甲肝时穿刺皮肤阻力VAS评分显著高于试验组(P<0.001)。试验组注射部位皮肤不良反应发生率低于对照组,分别为47.49%和65.25%(P<0.001)。结论5切面27G预灌封注射器用于疫苗接种时,受试者的疼痛度、针头的穿刺阻力以及注射部位不良事件发生率显著低于3切面25G针头设计的预灌封注射器。

关键词：预灌封注射器切面预防接种疼痛程度语言等级量表中文版视觉模拟量表

VERNAUZATION1 Modulates Root System Architecture in Wheat and Barley

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Molecular Plant 2018年第1期11卷 226-229页

作者： Kai P. Voss-Fels Hannah Robinson Stephen R. Mudge cecile Richard Saul Newman Benjamin Wittkop Andreas Stahl Wolfgang Friedt Matthias Frisch lulian Gabur Anika Miller-Cooper Bradley C. Campbell Alison Kelly Glen Fox Jack Christopher Mandy Christopher Karine Chenu Jerome Franckowiak Emma S. Mace Andrew K. Borrell Howard Eagles David R. Jordan Jose R. Botella Graeme Hammer lan D. Godwin Ben Trevaskis Rod J. Snowdon Lee T. Hickey Department of Plant Breeding IFZ Research Centre for Biosystems Land Use and Nutrition Justus Uebig University Heinrich-Buff-Ring 26-32 35392 Giessen Germany Queensland Alliance for Agriculture and Food Innovation The University of Queensland St Lucia QLD 4072 Australia School of Agriculture and Food Sciences The University of Queensland Brisbane QLD 4072 Australia CSIRO Agriculture Canberra ACT 2601 Australia Department of Biometry and Population Genetics IFZ Research Centre for Biosystems Land Use and Nutrition Justus Liebig University Heinrich-Buff-Ring 26-32 35392 Giessen Germany Department of Agriculture and Fisheries Leslie Research FacilRy Toowoomba QLD 4350 Australia Queensland Alliance for Agriculture and Food Innovation The University of Queensland roowoomba QLD 4350 Australia Department of Agronomy and Plant Genetics University of Minnesota St Paul MN USA Department of Agriculture and Fisheries Hermitage Research Facility Warwick QLD 4370 Australia Queensland Alliance for Agriculture and Food Innovation Hermitage Research Facility The University of Queensland Warwick QLD 4370 Australia These authors contributed equally to this article.

Dear Editor Roots play a key role in plant growth regulation. It is well described that the below-ground plant architecture has a significant impact on plant performance under abiotic constraints and maintains stabili... 详细信息

关键词： TRAITS RESPONDS

Phenotypic Characterization of Carbapenemase-Producing Enterobacteriaceae Strains in a Referral Teaching Hospital in Yaoundé, Cameroon

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Open Journal of Medical Microbiology 2023年第1期13卷 52-67页

作者： cecile Ingrid Djuikoue Paule Dana Djouela Djoulako Rodrigue Kamga Wouambo Charlène Nkouankou Tomi Christiane Possi Kiyang Murielle Chantale Tchitchoua Vynnie Manuella Nyatchoutou Blondelle Kitio Messeu Herman Koyouo Tagne Cedric Dylan Seugnou Nana Nadjia Benhamed Hortense Gonsu Kamga Benjamin D. Thumamo Pokam Faculty of Health Sciences Université des Montagnes Bangangté Cameroon Faculty of Medicine Sorbonne Université Paris France Division of Hepatology Department of Medecine II Leipzig University Medical Center Leipzig Germany University of Sciences and Technology Oran Algeria Bacteriology Unit University Teaching Hospital Yaounde Cameroon Department of Medical Laboratory Science Faculty of Health Sciences University of Buea Buea Cameroon

Background: Carbapenemase-producing Enterobacteriaceae (CPE) are an important and increasing threat to global health. They are nowadays more encountered routinely in hospitals and cause high morbidity and mortality due to limited therapeutic alternatives. This study sought to determine the prevalence of CPE in Yaoundé teaching hospital, Cameroon, and the associated risk factors. Materials and Method: To achieve this goal, a descriptive cross-sectional study coupled to an analytical component with consecutive collection of Enterobacteria strains was carried out during a three-month period (from 27th July to 24th October 2018) in the University Teaching Hospital of Yaoundé, Cameroon. The oxidase and biochemical identification tests using a miniaturized Api 20 E system were performed on colonies grown on Eosin Methylene Blue (EMB) medium and subcultured on nutrient agar. Drug susceptibility testing was carried out according to the Antibiogram Committee of the French Society of Microbiology (CA-SFM 2018.V.2.0). The detection of carbapenemase production was performed by the CA-SFM 2018 algorithm for the screening of carbapenemase-producing enterobacteriaceae and its classification by inhibitory synergy tests. Results: Out of the 104 isolates, Escherichia coli (50%) was the most prevalent species, followed by Klebsiella pneumoniae (37.5%) and Citrobacter frendii (12.5%). Drugs susceptibility patterns showed a high resistance to penicillins group (97.4% to amoxicillin), cephalosporins (68.4% to cefotaxim, 58.1% to cefixim, 60.7% to ceftazidim, 57.1% of cefoxitin) and aztreonam (55.7%). However, 11.9% carbapenems related resistance was noticed: 14.4% to imipenem, 13.8% to ertapenem and 7.5% to meropenem. Numerous co-resistance to quinolones (65.8%), fluoroquinolones (49.6%), aminoglycosides (49.6%) and cotrimoxazole (71.8%) were also observed. From 104 isolates, AmpC production represented 23.08% (25/104) and 36.54% (38/104) were ESBL-isolates. The ove

关键词： Enterobacteriaceae Antibiotics Carbapenemase Resistance

The safety and efficacy of palbociclib in older patients with advanced breast cancer in a real-world setting

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Journal of Cancer Metastasis and Treatment 2022年第1期8卷 15-27页

作者： Etienne Gouton Louis Tassy Joëlle Micallef Amir Meskine Renaud Sabatier Maud cecile-Herry Cécile Braticevic Anthony Goncalves Frederic Viret Alexandre de Nonneville Coline Montegut Franck Rouby Frederique Rousseau Department of Medical Oncology Institut Paoli-CalmettesMarseille 13009France Aix-Marseille Univ CNRS U7258INSERM U1068Institut Paoli-CalmettesCRCMMarseille 13009France Department of Clinical Pharmacology Régional Center of Pharmacovigilance Marseille-Provence-CorseAssistance Publique-Hôpitaux de MarseilleAix-Marseille Univ.Neurosciences InstituteMarseille 13005France

Aims:Palbociclib has been approved in combination with endocrine therapy(ET)for hormone receptor-positive(HR+)/human epidermal growth factor receptor 2-negative(HER2-)advanced breast cancer(ABC),regardless of *** though ABC is one of the most prevalent cancers in older patients,very few patients≥65 years old were included in pivotal ***,the current study evaluated the safety and efficacy of palbociclib in“real-world”routine treatment of unselected older patients with HR+/***:Data were collected on patients>70 years old who were treated with palbociclib plus ET for HR+/HER2-ABC in our *** analyzed safety data(CTCAE v4.0 criteria)and outcomes,such as progression-free survival(PFS)and overall survival(OS),as well as any associations between main geriatric characteristics and our ***,we assessed safety at a national level by analyzing all palbociclib-related adverse events(AEs)reported in the French Pharmacovigilance Database(FPVD)during the same ***:From February 2016 to July 2019,52 patients were identified with a median age of 80.9 years,of whom 88%presented an *** most common grade 3-4 AE was neutropenia(64%).Median PFS and OS were nine months and not reached,*** FPVD reports 227 cases of palbociclib-related AEs,with older and younger patients sharing similar ***:Palbociclib is well tolerated in older patients with efficacy comparable to that in younger ***,the addition of palbociclib to ET should be evaluated individually in this older and frailer subgroup.

关键词： Advanced breast cancer palbociclib older patients tolerance efficacy pharmacovigilance

Stachytarpheta cayennensis Aqueous Extract,a New Bioreactor towards Silver Nanoparticles for Biomedical Applications

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Journal of Biomaterials and Nanobiotechnology 2019年第2期10卷 102-119页

作者： Francois Eya’ane Meva Joel Olivier Avom Mbeng cecile Okalla Ebongue Carsten Schlusener Ulku Kokcam-Demir Agnes Antoinette Ntoumba Phillipe Belle Ebanda Kedi Etienne Elanga Evrard-Rudy Njike Loudang Moise Henri Julien Nko’o Edmond Tchoumbi Vandi Deli Christian Chick Nanga Emmanuel Albert Mpondo Mpondo Christoph Janiak Department of Pharmaceutical Sciences Faculty of Medicine and Pharmaceutical SciencesUniversity of DoualaDoualaCameroon Institute for Inorganic Chemistry and Structural Chemistry Heinrich-Heine-University DusseldorfDusseldorfGermany Clinical Biology Laboratory General Hospital of DoualaDoualaCameroon Department of Animal Biology and Physiology Faculty of ScienceUniversity of DoualaDoualaCameroon

This study reports the preparation and characterization of silver nanoparticles synthesized by the mediation of the plant weed Stachytarpheta cayennensis through solution method. Ultraviolet visible spectroscopy (UV-Vis) determines the presence of nanoparticles in the solution. Infrared spectroscopy (IR) proves organic molecules at the particles interface. Powder X-ray diffraction (PXRD) provides phase composition and crystallinity. Shape was showed by scanning electron microscopy (SEM), and energy dispersive X-ray spectroscopy (EDX) demonstrated the elemental mapping of the silver nanoparticles. Hydrogen peroxide scavenging and phosphomolybdenum antioxidant assays, egg albumin denaturation anti-inflammation study, and the formation mechanism complete the study. The particles have been found composed of pure silver Ag and silver chloride AgCl nanocrystallites. The average crystallite sizes were found to be 13 nm and 20 nm for Ag and AgCl respectively. A Rietveld refinement based XRD pattern data followed by Williamson-Hall plot allows a size and strain analysis. Based on SEM, spherical agglomerates materials were formed and EDX proved the presence of Cl- ions. The reaction formation mechanism of Ag and AgCl is proposed to be simultaneous and competitive. The silver nanoparticles moderately inhibit the denaturation of egg albumin and exhibit antioxidant action;hence, the nanoparticles could be considered as a potential source for biomedical applications.

关键词： Silver Nanoparticles Stachytarpheta cayennensis Size and Strain Anti-Oxidant Anti-Inflammation

Epidemiology of onchocerciasis-associated epilepsy in the Mbam and Sanaga river valleys of Cameroon:impact of more than 13 years of ivermectin

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Infectious Diseases of Poverty 2018年第1期7卷 1191-1201页

作者： Joseph Nelson Siewe Fodjo Godwin Tatah Earnest Njih Tabah Leonard Ngarka Leonard Njamnshi Nfor Samuel Eric Chokote Michel KMengnjo Fidele Dema Aurelien Tele Sitouok Grace Nkoro Felicien ENtone Anne-cecile Zoung-Kanyi Bissek Cedric BChesnais Michel Boussinesq Robert Colebunders Alfred K.Njamnshi Global Health Institute University of AntwerpAntwerpBelgium Neurology Department YaoundeCentral HospitalYaoundeCameroon Neurology Department CH Saint-NazaireSaint-NazaireFrance Neuroscience Laboratory FMBSThe University of YaoundeIYaoundeCameroon Ministry of Public Health YaoundeCameroon Neurology Department CHU BrugmanBrusselsBelgium Yoko District Hospital YaoundeCameroon UMI 233 Institut de Recherche pour le Developpement(IRD)MontpellierFrance UniversiteMontpellier MontpellierFrance INSERM Unite1175 MontpellierFrance Brain Research Africa Initiative(BRAIN) YaoundeCameroon.

Background:A high epilepsy prevalence has been reported in several onchocerciasis-endemic villages along the Mbam and Sanaga river valleys in Cameroon,including Bilomo and *** sought to determine the prevalence of epilepsy in these two villages following more than 13 years of community-directed treatment with ivermectin(CDTI).Methods:Door-to-door surveys were performed on the entire resident population in the villages in August 2017 and January *** was diagnosed using a 2-step approach:administration of a standardized 5-item questionnaire followed by confirmation by a *** published diagnostic criteria for onchocerciasis-associated epilepsy(OAE)were ***16 serology was done for children aged 7-10 years to assess onchocerciasis *** were compared with previous data from these two ***:A total of 1525 individuals(1321 in Bilomo and 204 in Kelleng)in 233 households were surveyed in both *** crude prevalence of epilepsy was 4.6%in Bilomo(2017)and 7.8%in Kelleng(2018),including 12(15.6%of cases)persons with epilepsy(PWE)with nodding *** age and sex-standardized prevalence in Kelleng decreased from 13.5%in 2004 to 9.3%in 2018(P<0.001).The median age of PWE shifted from 17(IQR:12-22)years to 24(IQR:20-30)years in Bilomo(P<0.001);and slightly from 24(IQR:14-34)years to 28(IQR:21.25-36.75)years in Kelleng(P=0.112).Furthermore,47.6%of all tested children between 7 and 10 years had Ov16 ***:There is a decrease in epilepsy prevalence after 13 years and more of CDTI in both *** age-shift observed in PWE suggests that ivermectin may prevent OAE in younger ***16 seropositivity in children indicates ongoing onchocerciasis transmission possibly due to suboptimal control *** findings support the existence of OAE in Cameroon and highlight the need to strengthen onchocerciasis elimination programs.

关键词： Onchocerciasis Epilepsy Nodding syndrome Ov16 rapid diagnostic test Ivermectin Cameroon

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世博口语跟我学

英语角（英文小读者）（红版） 2009年第4期 11-11页

作者： cecile 小民(画稿)

在日常对话中，我们常常会和朋友聊到自己的兴趣爱好。当别人问你，“你有什么爱好？”，或当你想询问对方，“你平时喜欢做什么？”时，你该怎样用英语表达呢？今天，秋天姐姐就来告诉你们吧！

关键词：口语兴趣爱好日常对话英语表达

PET放射化学概述第1部分:共价标记18F、11C和13N

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中华核医学与分子影像杂志 2020年第5期40卷 316-320页

作者：杜帅樊(译) 史继云(审校) 北京大学医学同位素研究中心、北京大学基础医学院放射医学系 100191 中国科学院生物物理研究所北京100101

该篇继续教育的文章介绍了与核素11C、13N和18F共价结合的放射性标记PET示踪剂的放射化学。从回旋加速器中放射性核素的生产入手,阐述了PET示踪剂生产的全过程;之后是放射合成的自动化过程,包括相应合成的必要步骤;并最终确定了质量控... 详细信息

该篇继续教育的文章介绍了与核素11C、13N和18F共价结合的放射性标记PET示踪剂的放射化学。从回旋加速器中放射性核素的生产入手,阐述了PET示踪剂生产的全过程;之后是放射合成的自动化过程,包括相应合成的必要步骤;并最终确定了质量控制要求。

关键词：共价结合放射化学放射性标记质量控制要求自动化过程放射性核素示踪剂 18F

GPS和InSAR数据反演的2001年可可西里地震的同震破裂分布

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GPS和InSAR数据反演的2001年可可西里地震的同震破裂分布