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Responses to oral glucose challenge differ by physical activity volume and intensity: A pilot study

Journal of Sport and Health Science 2020年第6期9卷 645-650页

作者： Trevor N.Simper cecile morris Anthony Lynn Ciara O’Hagan Karen Kilner Food Group Sheffield Business School Sheffield Hallam UniversitySheffield S11WBUK Academy of Sport and Physical Activity Sheffield Hallam UniversitySheffield S102BPUK Department for Health and Social Care Research Sheffield Hallam UniversitySheffield S102BPUK

Background:One-hour postprandial hyperglycemia is associated with increased risk of type 2 diabetes and cardiovascular *** activity(PA)has short-term beneficial effects on post-meal glucose *** study compared the oral glucose tolerance test results of 3 groups of people with habitually different levels of ***:Thirty-one adults without diabetes(age 25.9±6.6 years;body mass index 23.8±3.8 kg/m^2;mean±SD)were recruited and divided into 3 groups based on self-reported PA volume and intensity:low activity0.05).The groups were significantly different in terms of baseline glucose level(p=0.003)and,marginally,for gender(p=0.053)and BMI(p=0.050).There was a statistically significant effect of PA on the 1-h postprandial glucose results(p=0.029),with differences between very active and low activity groups(p=0.008)but not between the moderately active and low activity groups(p=0.360),even when baseline glucose level and gender differences were accounted *** incremental area under the curve there was no significant effect of activity group once gender and body fat percentage had been accounted for(p=0.401).Those in the low activity group took 15 min longer to reach peak glucose level than those in the very active group(p=0.012).Conclusion:The results suggest that high levels of PA have a beneficial effect on postprandial blood glucose profiles when compared to low and moderate levels of activity.

关键词： Blood glucose response Incremental area under the curve Oral glucose tolerance test Physical activity Time to peak Type 2 diabetes

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High frequency of severe liver dysfunction in critically ill Dengue patients in the French West Indies

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Journal of Intensive Medicine 2024年第3期4卷 403-404页

作者： Laurent Camous Samuel Markowicz cecile Loraux Julien Jabot Jean David Pommier Réanimation Médicale et Chirurgicale CHU de GuadeloupeChemin ChauvelLes Abymes97139 GuadeloupeFrance Service de Maladies infectieuses et tropicales CHU de GuadeloupeChemin ChauvelLes Abymes97139 GuadeloupeFrance Service de Microbiologie CHU de GuadeloupeChemin ChauvelLes Abymes97139 GuadeloupeFrance Médecine Intensive et Réanimation Centre hospitalier universitaire de la Réunion 97460 Saint-PaulFrance Institut Pasteur de la Guadeloupe Morne Jolivière97183 AbymesFrance

Dear Editor,Dengue is a worldwide zoonosis,transmitted by mosquitoes and highly prevalent in tropical and subtropical *** recent years,its incidence has increased with a massive healthcare burden worldwide[1]and recent climatic changes have expanded the geographic range of the insect vector with described outbreaks in Europe.[2]Most patients present pauci-symptomatic infections,but some patients could present severe manifestations with high reported mortality[[3],[4],[5]]and no specific *** bleeding,hemodynamic failure and various organ damage(cardiac,renal,neurological,and hepatic)are described in severe dengue(SD)patients.[5]In the future,intensivists worldwide will be increasingly treating SD and the spectrum of severe organ impairment should be well known.

关键词： patients mortality expanded

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Rare dentin defects:Understanding the pathophysiological mechanisms of COLXVA1 mutations

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Genes & Diseases 2024年第5期11卷 1-5页

作者： Isaac Maximiliano Bugueno Tristan Rey Alexandra Jimenez-Armijo Marzena Kawczynski Naji Kharouf Marie-cecile Maniere Yann Herault Agnes Bloch-Zupan Virginie HaushalterLaugel Institute of Genetics and Molecular and Cellular Biology(IGBMC) CNRS-UMR7104INSERM U1258Universitede StrasbourgIllkirch 67400France Faculty of Dentistry Universitede StrasbourgStrasbourg 67000France Institute of Advanced Studies(USIAS) Universitede StrasbourgStrasbourg 67045France Reference Center for Rare Oral and Dental Diseases(CRMR-O-Rares) Oral Medicine and Surgery DepartmentHopitaux Universitaires de Strasbourg(HUS)Strasbourg 67000France Rare Diseases Health Network“TETE COU”&European Reference Network ERN CRANIO Strasbourg 67000France “Institut de Genetique Medicale d’Alsace” Laboratory of Genetic DiagnosticHopitaux Universitaires de Strasbourg(HUS)Strasbourg 67000France Biomaterials and Bioengineering Laboratory Inserm UMR_S 1121Strasbourg 67000France Orofacial Development and Regeneration Faculty of MedicineInstitute of Oral BiologyCentre of Dental MedicineUniversity of ZurichZurich 8032Switzerland

Dentin is a mineralized tissue with a chemical composition similar to bone but with a higher mineralized density and *** constitutes the central structure of the tooth between the internal pulp and external enamel toward the oral cavity or cementum toward the underlying *** dentin defects occur in a variety of rare genetic *** can manifest as“isolated”occurrences such as in dentinogenesis imperfecta(DI)or dentin dysplasia(DD)or can be associated with other symptoms in diseases such as osteogenesis imperfecta,Goldblatt syndrome,microcephalic osteodysplastic primordial dwarfism type II,among others.

关键词： diseases den rigidity

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廉价债券到期押注企业破产小心为上

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商业周刊（中文版） 2024年第3期 24-25页

作者： Natasha Doff cecile Gutscher 永年(译) 不详

金融家正用自己的钱来押注超廉价债券到期后的违约潮,但并一定能获得丰厚回报,2020年,对冲基金经理亚当·施瓦茨(Adam Schwartz)因预测公司债券市场的大起大落而大赚了一把。现在,他把所管理基金的大部分资金和自己的钱都用来再次下注,... 详细信息

金融家正用自己的钱来押注超廉价债券到期后的违约潮,但并一定能获得丰厚回报,2020年,对冲基金经理亚当·施瓦茨(Adam Schwartz)因预测公司债券市场的大起大落而大赚了一把。现在,他把所管理基金的大部分资金和自己的钱都用来再次下注,赌那些面临创纪录债务到期潮的公司将出现一波违约潮。

关键词：企业破产对冲基金公司债券市场施瓦茨债券到期大起大落债务

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The code of light:do neurons generate light to communicate and repair?

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Neural Regeneration Research 2022年第6期17卷 1251-1252页

作者： cecile Moro Ann Liebert Catherine Hamilton Nicolas Pasqual Glen Jeffery Jonathan Stone John Mitrofanis Universite Grenoble Alpes CEALETIClinatecGrenobleFrance Department of Anatomy University of SydneySydneyAustralia Vie Integrative GrenobleFrance Institute of Ophthalmology University College LondonLondonUK Department of Physiology University of SydneySydneyAustralia

A great challenge in neuroscience has been to understand how neurons *** neuroanatomists of the 19th Century could see neurons stretching processes to contact other neurons,but could not see the detail of the *** thought that neurons formed a syncytium,with continuity of membranes from one to the *** the ensuing two hundred years or so,we have come to understand that the circuity of the brain is not formed by a syncytium of neurons;rather,individual neurons communicate with each other with a range of biological *** are highly active cells,with their activity being electrical and their communication being either chemical,electrical or gaseous.

关键词： communicate stretching electrical

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CD36： linking lipids to the NLRP3 inflammasome, atherogenesis and atherothrombosis

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Cellular & Molecular Immunology 2014年第1期11卷 8-10页

作者： cecile Oury GIGA-Research Human Genetics Unit Laboratoryof Thrombosis and Hemostasis University of LiegeLiege Belgium

Arecent study published in Nature Immunology by Sheedy et al.1 indicates that uptake of modified low-den- sity lipoprotein （LDL） by the scavenger receptor CD36 primes and activates the NLRP3 inflammasome, providing an early pathogenic pathway that links cho- lesterol accumulation to the chronic inflammatory process of atherosclero- sis.1 Atherosclerosis arises from chronic vascular inflammation elicited by lipids.

关键词： STERILE INFLAMMATION ACTIVATION DEUBIQUITINATION LIGANDS MICE

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When parasitoids deal with the spatial distribution of their hosts: consequences for both partners

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Insect Science 2019年第5期26卷 923-931页

作者： Philippe Louapre cecile Le Lann Thierry Hance Earth and Life Institue Universite Catholique de LouvainLouvain-la-NeuveBelgium CNRS Biogeosciences UMR 6282Universite Bourgogne Franche-ComteDijonFrance UMR CNRS 6553 Ecobio University of Rennes 1Rennes CedexFrance

Insect parasitoids developing inside hosts face a true challenge: hosts are scattered in the field and their localization and selection require the use of complex and sometime confusing information. It was assumed for a long time that small-brained organisms like parasitoids have evolved simple and efficient behavioral mechanisms, leading them to be adapted to a given ecological situation, for example, the spatial distribution o f hosts in the habitat. However, hosts are not static and their distribution may also vary through generations and within the life of parasitoid individuals. We investigated if and how parasitoids deal with such a spatial com plexity in a m esocosm experiment. We used the Aphidius rhopalosiphi/Sitobion avenae parasitoid/host system to investigate if parasitoid females experiencing different host aggregation levels exhibit different foraging behaviors independently of the number of hosts in the environment. We showed that A. rhopalosiphi females exploited hosts more intensively both within and among patches at higher host aggregation levels. We discussed the adaptiveness of such behaviors in the light of evolution and biological control.

关键词： Aphidius rhopalosiphi foraging behavior parasitoid sequential adjustment Sitobion avenae spatial distribution

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The SlSHN2 transcription factor contributes to cuticle formation and epidermal patterning in tomato fruit

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Molecular Horticulture 2022年第1期2卷 186-205页

作者： cecile Bres Johann Petit Nicolas Reynoud Lysiane Brocard Didier Marion Marc Lahaye Benedicte Bakan Christophe Rothan UMR 1332 BFP INRAEUniversite de Bordeaux33140 Villenave d’OrnonFrance Unite Biopolymeres InteractionsAssemblagesINRAEBP7162744316 Nantes Cedex 3France Univ.Bordeaux CNRSINSERMBordeaux Imaging CenterBICUMS 3420US 433000 BordeauxFrance INRA UMR1332 Biologie du Fruit Et Pathologie71 Av Edouard Bourlaux33140 Villenave d’OrnonFrance

Tomato(Solanum lycopersicum)is an established model for studying plant cuticle because of its thick cuticle covering and embedding the epidermal cells of the *** this study,we screened an EMS mutant collection of the miniature tomato cultivar Micro-Tom for fruit cracking mutants and found a mutant displaying a glossy fruit *** using an established mapping-by-sequencing strategy,we identified the causal mutation in the SlSHN2 transcription factor that is specifically expressed in outer epidermis of growing *** point mutation in the shn2 mutant intro-duces a K to N amino acid change in the highly conserved‘mm’domain of SHN *** cuticle from shn2 fruit showed a~fivefold reduction in cutin while abundance and composition of waxes were barely *** addition to alterations in cuticle thickness and properties,epidermal patterning and polysaccharide composition of the cuticle were *** analysis further highlighted the altered expression of hundreds of genes in the fruit exocarp of shn2,including genes associated with cuticle and cell wall formation,hormone signaling and response,and transcrip-tional *** conclusion,we showed that a point mutation in the transcriptional regulator SlSHN2 causes major changes in fruit cuticle formation and its coordination with epidermal patterning.

关键词： Mutant SHINE Cuticle Epidermis Cell wall Ethylene

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Optimal Low-voltage Distribution Topology with Integration of PV and Storage for Rural Electrification in Developing Countries:A Case Study of Cambodia

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Journal of Modern Power Systems and Clean Energy 2020年第3期8卷 531-539页

作者： Vannak Vai Marie-cecile Alvarez-Herault Bertrand Raison Long Bun Department of Electrical and Energy Engineering(GEE) Institute of Technology of Cambodia(ITC)Phnom Penh 12150Cambodia Institute of Engineering UniversitéGrenoble Alpes38000 GrenobleFrance

This paper addresses an optimal design of low-voltage(LV)distribution network for rural electrification considering photovoltaic(PV)and battery energy storage(BES).It aims at searching for an optimal topology of an LV distribution system as well as the siting and sizing of PV and storage over a time horizon of 30 ***,the shortest-path algorithm(SPA)and first-fit bin-packing algorithm(FFBPA)are used to search for the optimal radial topology that minimizes the total length of the distribution line and improves the load ***,the optimal siting of decentralized BES(DeBES)is determined using a genetic algorithm(GA)to eliminate the undervoltage constraints due to the load *** iterative techniques are elaborated to size the maximum peak power of PV and the minimum number of DeBES that can be connected to an LV network without violating the voltage and current ***,the sizing strategy of centralized BES(CeBES)is developed to avoid reverse power flows into the medium-voltage(MV)***,a Monte Carlo approach is used to study the impact of load profile uncertainties on the topology.A non-electrified village in Cambodia has been chosen as a case study.

关键词： Battery energy storage(BES) low-voltage(LV)distribution network Monte Carlo photovoltaic(PV) electrification planning

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Population genetic structure of the biological control agent Macrolophus pygmaeus in Mediterranean agroecosystems

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Insect Science 2017年第5期24卷 859-876页

作者： Jean-Claude Streito cecile Clouett Faten Hamdi Nathalie Gauthier IRD UMR (INRA/IRDICiradlMontpellier SupAgro) Centre de Biologie pour la Gestion des Populations INRA UMR (INRA/IRDI CiradlMontpellier SupAgro) Centre de Biologie pour la Gestion des Populations 755 avenue du Campus Agropolis CS 30016 34988Montferrier-sur-Lez France

Biological control of agricultural pests relies on knowledge of agroecosystem functionality, particularly when affected by the use of mass-produced biological agents. Incorporating pre- and/or post-release information such as genetic diversity and struc- ture on these agents using molecular-based approaches could advance our knowledge of how they perform in agroecosystems. We evaluated the population genetics of Macrolo- phus pygmaeus, the most widely used predatory mirid against many arthropod pests of greenhouse crops in the Mediterranean region, using the mitochondrial Cytb sequence and microsatellite data, and population genetics and phylogeny approaches. We investigated commercially mass-produced insects （i.e., commercial insects either mass-reared in the laboratory for many generations, or purchased by farmers and released in the greenhouses） and ＂wild＂ insects （i.e., that occur naturally outside or are collected in nature for release in the greenhouses）. The mirids were mainly collected in agroecosystems in which solana- ceous plants are grown in northern Spain, southern France and Greece. Both molecular markers and approaches distinguished 2 genetically differentiated populations. The less genetically diverse population, hereafter named the ＂commercial＂ strain included all indi- viduals from laboratory mass-rearings and most releases of commercially bred individuals. The most genetically diverse population mainly comprised individuals originating from noncultivated environments, or from releases of＂wild＂ individuals. Rare examples of hy- bridization between M. pygmaeus from the 2 populations were observed and asymmetric gene flow was revealed. These findings provide new insights into what happens to M. pyg- maeus released in the agroecosystems we studied, and show that it is possible to monitor some commercial strains.

关键词： biological control commercial vs. wild strains Macrolophus pygmaeus microsatellites mtCytb population genetics

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