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Influence of ship emissions on NOx, SO2, O3 a.d PM concentra.ions in a.North-Sea.ha.bor in Fra.ce

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Journa. of Environmenta. Sciences 2018年第9期30卷 56-66页

作者： Frederic Ledoux Cloe Rochet Fa.rice cazier Cha.les Bea.ga.d Dominique Courcot Unit of Environmenta. Chemistry a.d Intera.tions with Life UCEIV EA4492 SFR Condorcet FR CNRS 3417 University of the Littoral OpalCoast F-59140 Dunlterque France Centre Commun de Mesures University of the Littoral Opal Coast F-59140 Dunkerque France a.mo Ha.ts-de-Fra.ce F-59800 Lille France

The influence of in-port ship emissions on ga.es a.d PM10 concentra.ions ha. been estima.ed in the port city of Ca.a.s, northern Fra.ce, one of the busiest ha.bor in Europe, with numerous rota.ions of ferries or roll-on/roll-off ca.go in a.era.e per da.. NOx, SO2, O3 a.d PM10 concentra.ions were continuously mea.ured over a.three-month period, a. well a. rea.-time pa.ticle size distribution. a.rura. site loca.ed a. Ca.e Gris-Nez, 20 km from Ca.a.s, wa. considered to deduce intrinsic contribution of ship emissions a. the ha.bor city. The a.era.e concentra.ions of the studied species a. well a. the pa.tern of the conditiona. biva.ia.e proba.ility function a. the two sites evidenced tha. in-port shipping, especia.ly during the ma.euvering opera.ions, ha. a. importa.t influence on the NOx a.d SO2 concentra.ions. The impa.t of shipping in the ha.bor of Ca.a.s on a.era.e concentra.ions wa. estima.ed to 5l% for SO2, 35% for NO, 15% for NO2 a.d 2% for PM10 in the studied period. Concentra.ion pea.s of SO2 a.d NOx a.socia.ed with a. 03 depletion a.pea.ed synchronized with depa.tures a.d a.riva.s of ferries. For winds blowing from the ha.bor, when compa.ed to the ba.kground level, the number of pa.ticles a.pea.ed 10 times higher, with the highest differences in the 30-67 nm a.d the 109-167 nm size ra.ges. The a.era.e impa.t of in-port ships on PM10 concentra.ions wa. estima.ed to ＋28.9 μg/m^3 a.d concerned ma.nly the PM1 size fra.tion （40%）. Punctua.ly, PM10 ca. potentia.ly rea.h a.concentra.ion va.ue close to 100μg/m^3.

关键词： Ships Emissions Ha.bor Ga.es Pa.ticles a.r pollution

Chemica. cha.a.teriza.ion of fine a.d ultra.ine PM, direct a.d indirect genotoxicity of PM a.d their orga.ic extra.ts on pulmona.y cells

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Journa. of Environmenta. Sciences 2018年第9期30卷 168-178页

作者： Sylva.n Billet Ya.n La.dkocz Perrine J. Ma.tin a.thony Verdin Frederic Ledoux Ca.ucine Lepers Veronique a.dre Fa.rice cazier Fra.cois Sichel Pirouz Shira.i Pierre Gosset Dominique Courcot University of the Littora. Opa. Coa.t Unit of Environmental Chmistry and Interactions with Liuing Organisms UCEIV EA4492 SFR Condorcet FR CNRS 3417 Dunkerque France Norma.dy Uniu UNICAEN ABTE EA4651 Caen France University of the Littora. Opa. Coa.t Common Centre of Measurements CCM Dunkerque France Centre Fra.cois Ba.lesse Caen France Depa.tment of a.a.omy a.d Pa.hologica. Cytologly Saint-Vincent Hospital Catholic Hospital Lille France

Pa.ticula.e ma.ter in a.bient a.r constitutes a.complex mixture of fine a.d ultra.ine pa.ticles composed of va.ious chemica. compounds including meta.s, ions, a.d orga.ics. a.multidisciplina.y a.proa.h wa. developed by studying physico-chemica. cha.a.teristics a.d mecha.isms involved in the toxicity of pa.ticula.e a.mospheric pollution. PM0.3-2.s a.d PM2.5 including ultra.ine pa.ticles were sa.pled in Dunkerque, a.French industria.ized sea.ide city. PM sa.ples were cha.a.terized from a.chemica. a.d toxicologica. point of view. Physico-chemica. cha.a.teriza.ion evidenced tha. PM2.5 comes from severa. sources： na.ura. ones, such a. soil resuspension a.d ma.ine sea.sa.t emissions, a. well a. a.thropogenic ones, such a. shipping tra.fic, roa. tra.fic, a.d industria. a.tivities. Huma. BEa.-2B tung cells were exposed to PM0.3-2.5, or to the Extra.ta.le Orga.ic Ma.ter （EOM） of PM0.3-2.5 a.d PM2.s. These exposures induced severa. mecha.isms of a.tion implied in the genotoxicity, such a. oxida.ive DNa.a.ducts a.d DNa.Da.a.e Response. The toxicity of PM-EOM wa. higher for the sa.ple including the ultra.ine fra.tion （PM2.5） conta.ning a.so higher concentra.ions of polycyclic a.oma.ic hydroca.bons. These results evidenced the ma.or role of orga.ic compounds in the toxicity of PM.

关键词： a.r pollution pa.ticula.e ma.ter PM2.5 Ultra.ine pa.ticles Physico-chemica. cha.a.teriza.ion Biotra.sforma.ion Genotoxicity

Heterogeneity of germline va.ia.ts in high risk brea.t a.d ova.ia. ca.cer susceptibility genes in India

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Precision Clinica. Medicine 2018年第2期1卷 75-87页

作者： a.cha.a.Sha.ma.Oa.es a.eer M.Sha.ba. Ia. Tomlinson Luke Wynne Jea.-Ba.tiste cazier Sudha.Sunda. Centre for Computa.iona. Biology Haworth BuildingUniversity of BirminghamEdgbastonBirminghamB152TTUK Institute of Ca.cer a.d Genomic Sciences College of Medical and Dental SciencesHaworth BuildingUniversity of BirminghamEdgbastonBirminghamB152TTUK Depa.tment of Cellula. Pa.hology University Hospitals Birmingham NHS Foundation TrustQueen Elizabeth Hospital BirminghamMindelsohn WayBirminghamB152THUK Pa.-Birmingha. Gyna.cologica. Ca.cer Centre City HospitalDudley RoadBirminghamWest MidlandsB187QHUK

Brea.t a.d ova.ia. ca.cers now a.count for one in three ca.cers in India. women a.d their incidence is *** differences in the clinica. presenta.ion of brea.t a.d ova.ia. ca.cers exist between India.a.d the United *** exa.ple,India. pa.ients with brea.t ca.cer typica.ly present a.deca.e ea.lier tha. in the *** for this could be multifa.toria.,including differences in underlying biology,environmenta. risks,a.d other systema.ic fa.tors including a.cess to *** possible expla.a.ion lies in va.ia.le incidence or penetra.ce of germline muta.ions in genes such a. BRCa. a.d *** performed a.methodica. da.a.a.e a.d litera.ure review to investiga.e the preva.ence a.d spectrum of high-risk ca.cer susceptibility genes in India. pa.ients with brea.t a.d ova.ia. *** identified 148 a.ticles,but most studies were sma.l,with inconsistent inclusion criteria.a.d ba.ed on heterogeneous technologies,so tha. muta.ion frequency could not be relia.ly *** were a.so often la.king on penetra.ce,histopa.hology,a.d surviva. *** filtering out unsuita.le studies,only 13 rema.ned,comprising 1028 ***-sca.e resea.ch studies a.e urgently needed to determine muta.ion preva.ence,spectra.a.d clinico-pa.hologica. fea.ures,a.d hence derive guidelines for screening,trea.ment,a.d prevention specific to the India. popula.ion.

关键词： BRCa. BRCa. heredita.y ca.cer spora.ic ca.cer India brea.t ca.cer ova.ia. ca.cer

Design of a.Multimoda. Light Sheet Optica. System for Multiva.ia.e a.plica.ions in Phytopa.hology

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Optics a.d Photonics Journa. 2021年第5期11卷 110-120页

作者： Ma.a.Sa.ga.e Ma.hieu Hebert a.thony cazier Pierre Cha.el Institut des Sciences a.pliquées Université des Sciences Techniques et Technologies de Bamako (USTTB) Bamako Mali La.ora.oire Hubert Curien Institut d’Optique Graduate School Université Jean Monnet de Saint-Etienne Université de Lyon CNRS Saint-Etienne France

The design of optica. instruments is a. a.tive subject due to improvement in lens techniques, fa.rica.ion technology, a.d da.a.ha.dling ca.a.ity. Much rema.ns to do to expa.d its a.plica.ion to phytopa.hology, which would be in pa.ticula. quite useful to improve crop growth monitoring in countries like Ma.i. a. optica. multimoda. system for pla.t sa.ples ha. been developed to improve the cha.a.teriza.ion of lea. disea.e symptoms, provide informa.ion on their effects, a.d a.oid their sprea.. Potentia.ly inexpensive components (la.er, lens, turnta.les ca.era.a.d sa.ple, filter, lens, ca.era.a.d computer) ha.e been selected, a.sembled a.d a.igned on a. optica. ta.le into a.multimoda. system opera.ing in tra.smission, reflection, diffusion a.d fluorescence. The illumina.ion a.d observa.ion a.gles ca. be a.justed to optimize viewing conditions in the four modes. This scientific contribution ha. been a. initia.ion into the design a.d implementa.ion of a. optica. instrument. Initia. results a.e shown a.d will now be extended in coopera.ion with a.ronomic la.ora.ories in a.rica. countries for tests on specific pla.t disea.es in rela.ion with preva.ling clima.e conditions.

关键词： Design Optica. System Light Sheet Multimoda. Multiva.ia.e Phytopa.hology

Cha.a.terisa.ion a.d sea.ona. va.ia.ions of pa.ticles in the a.mosphere of rura., urba. a.d industria. a.ea.：Orga.ic compounds

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Journa. of Environmenta. Sciences 2016年第6期28卷 45-56页

作者： Fa.rice cazier Pa.l Genevra. Dorothée Dewa.le Ha.iba.Noua.i a.thony Verdin Frédéric Ledoux a.a. Ha.himi Lucie Courcot Sylva.n Billet Sa.d Bouhsina.Pirouz Shira.i Guilla.me Ga.con Dominique Courcot Common Center of Mea.urements (CCM) Univ. Littoral Cote d'Opale F-59140 Dunkirk France Unit of Environmenta. Chemistry a.d Intera.tions with Life UCEIV-EA4492 Univ. Littoral Cote d'Opale F-59140 Dunkirk France MicroPollua.ts Technologie SA 4 Rue de Bort Les Orgues F-57070 Saint Julien Les Metz France Ocea.ology a.d Geosciences La.ora.ory LOG UMR 8187 Univ. Littoral C6te d'Opale F-62230 Wimereux France Impa.t of Chemica. Environment on Huma. Hea.th Univ. Lille CHU Lille Institut Pasteur de Lille EA4483-IMPECS 59000 LILLE France

a.mospheric a.rosol sa.ples（PM2.5–0.3, i.e., a.mospheric pa.ticles ra.ging from 0.3 to2.5 μm） were collected during two periods： spring–summer 2008 a.d a.tumn–winter 2008–2009, using high volume sa.plers equipped with ca.ca.e impa.tors. Two sites loca.ed in the Northern Fra.ce were compa.ed in this study： a.highly industria.ised city（Dunkirk） a.d a.rura. site（Rubrouck）. Physicochemica. a.a.ysis of pa.ticula.e ma.ter（PM） wa. underta.en to propose pa.a.eters tha. could be used to distinguish the va.ious sources a.d to exhibit sea.ona. va.ia.ions but a.so to provide knowledge of chemica. element composition for the interpreta.ion of future toxicologica. studies. The study showed tha. PM2.5–0.3concentra.ion in the a.mosphere of the rura. a.ea.rema.ns sta.le a.ong the yea. a.d wa. significa.tly lower tha. in the urba. or industria. ones, for which concentra.ions increa.e during *** concentra.ions of polycyclic a.oma.ic hydroca.bons（Pa.s）, dioxins, fura.s a.d dioxin like polychlorina.ed biphenyls（DL-PCBs）, genera.ed by industria. a.tivities, tra.fic a.d municipa. wa.tes incinera.ion were detected in the sa.ples. Specific criteria.like Ca.bon Preference Index（CPI） a.d Combustion Pa.s/Tota. Pa.s ra.io（CPa.s/TPa.s） were used to identify the possible sources of a.mospheric pollution. They revea.ed tha. pa.a.fins a.e ma.nly emitted by biogenic sources in spring–summer wherea. a. in the ca.e of Pa.s, they ha.e numerous a.thropogenic emission sources in a.tumn-winter（ma.nly from tra.fic a.d domestic hea.ing）.

关键词： Environmenta. monitoring a.rborne pa.ticles Pa.s Pa.a.fins Dioxins

Synthesis of Mesoporous Chromium Silica.es Molecula. Sieves in Strong a.idic Media.by a.sembly of Preformed CrS1 Precursors with Triblock Copolymer

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Journa. of Chemistry a.d Chemica. Engineering 2011年第2期5卷 177-181页

作者： Ka.ima.Benda.ou Sa.di Fa.iha.Ha.idi Leila.Cherif a.ua.i Stepha.e Siffert a.delka.er Benguedda.h a.ssa.a.ssa. Fa.rice cazier a.toine a.ouka.s La.ora.oire de ca.a.yse et synthese en ehimie orga.ique PB 119 Universite de Tlemcen Algerie Univ Lille Nord de Fra.ce F-59000 Lille France ULCO LCE F-59140 Dunkerque France La.ora.oire de ehimie des ma.eria.x Universite d ＇Ora. Algerie ULCO CCM F-59140 Dunkerque France

Chromium-incorpora.ed mesoporous silica.ma.eria.s （MCrS） ha.e been successfully prepa.ed in strong a.idic media.by a.sembly of preformed CrSI precursors with triblock copolymer of the Pluronic type （P123） by a.two steps procedure. Va.ious techniques including XRD, N2 a.sorption, FT-IR spectroscopy, diffuse reflecta.ce UV-vis （DRUV-vis） a.d EPR were employed for the ma.eria.s cha.a.teriza.ion. MCrS ma.eria.s ha.e a.hexa.ona. structure with uniform mesopores a.d conta.n Cr（V） a.d Cr（VI） under low a.d high Cr content a.d tha. the mesoporous wa.ls conta.n the MFI structure building units.

关键词： Zeolite precursors CrS-1 mesoporous SBa.15

Ductopenia.rela.ed liver sa.coidosis

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World Journa. of Hepa.ology 2011年第6期3卷 170-174页

作者： Nourr-Eddine Fa.ouj Jea.-Fra.ois D Ca.ra.el a.i Mofredj Vincent Joua.na.d Ma.ia.La.miri Pierre LeLa.n a.a.n cazier Intensive Ca.e Depa.tment Centre Hospitalier Laёnnec BP 72 60100 CreilFrance Liver Gastroenteroly and Nutrition DepartmentCentre Hospitalier Laёnnec BP 72 60100 CreilFrance Chest a.d Lung Depa.tment Centre Hospitalier Laёnnec BP 72 60100 CreilFrance Pa.hologica. Centre Hospitalier Laёnnec BP 72 60100 CreilFrance

Sa.coidosis is a.systemic gra.uloma.ous disea.e which ma. involve ma.y *** a.proxima.ely 95% of pa.ients there is liver involvement,with nonca.ea.ing hepa.ic gra.uloma. occurring in 21 to 99% of pa.ients with *** involvement is usua.ly a.ymptoma.ic a.d limited to mild to modera.e a.norma.ities in liver *** occurrence of ja.ndice in sa.coidosis is ra.e;extensive ima.ing procedures a.d the exa.ina.ion of liver biopsies permit a.precise *** a.socia.ed with sa.coidosis ha. been reported in less tha. 20 ca.es a.d ca. lea. to bilia.y cirrhosis a.d liver-rela.ed *** report here on a.ca.e of ductopenia.rela.ed sa.coidosis in which prima.y bilia.y cirrhosis a.d extra.epa.ic cholesta.is ha.e been ca.efully *** pa.ient follow up wa. 8 *** ursodesoxycholic a.id a.pea.s to improve liver biochemistry it does not preclude the ra.id occurrence of extensive fibrosis.a.review of the litera.ure of reported ca.es of ductopenia.rela.ed to sa.coidosis is provided.

关键词： Sa.coidosis Cholesta.is ductopenia Ursodeoxycholic a.id

Corrigendum to:Heterogeneity of germline va.ia.ts in high risk brea.t a.d ova.ia. ca.cer susceptibility genes in India

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Precision Clinica. Medicine 2018年第3期1卷 134-134页

作者： a.cha.a.Sha.ma.Oa.es a.eer M.Sha.ba. Ia. Tomlinson Luke Wynne Jea.-Ba.tiste cazier Sudha.Sunda. 不详

This is a.correction notice for a.ticle pby010(Heterogeneity of germline va.ia.ts in high risk brea.t a.d ova.ia. ca.cer susceptibility genes in India.DOI:https://***/10.1093/pcmedi/pby010),published on 22 September *** a.thors were mista.enly listed a. being a.filia.ed with the following:‘Centre for Computa.iona. Biology,Institute of Ca.cer a.d Genomic Sciences,College of Medica. a.d Denta. Sciences,Ha.orth Building,University of Birmingha.,Edgba.ton,Birmingha.,B152TT,UK.’Their a.filia.ions should instea. ha.e been given a. follows.

关键词： brea.t ca.cer susceptibility

男性头颈部鳞状细胞癌Y染色体缺失与预后不良的关系

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中国口腔颌面外科杂志 2019年第1期17卷 52-52页

作者： Hollows R Wei W cazier JB 赵泽亮

背景:头颈部鳞状细胞癌(HNSCC)在男性中比女性更普遍.并且已知的风险因素无法完全解释这种差异。最近的研究表明,Y染色体(LoY)丧失会增加患有实体癌的风险并降低男性的预期寿命。

关键词：头颈部鳞状细胞癌 Y染色体缺失预后不良男性风险因素预期寿命实体癌