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E-Cigarette Survey am.ng Student Pharm.cists Reveals Troubling Results

Pharm.cology & Pharm.cy 2020年第6期11卷 127-136页

作者： Jam.e L. m.Conaha Phillip Lunney Jan m. Kitzen Joseph V. Pergolizzi Jr. Robert taylor Jr. Robert B. Raffa Duquesne University School of Pharm.cy Pittsburgh PA USA Lachm.n Consultants Westbury NY USA Kitzen Pharm.ceutical Consulting Collegeville PA USA NEm. Research Naples FL USA University of Arizona College of Pharm.cy Tucson AZ USA Neum.ntum Inc. Palo Alto CA USA Tem.le University School of Pharm.cy Philadelphia PA USA

The rise in “vaping”-associated deaths in the United States raises serious concerns. A justification for som. level of risk is that e-cigarettes m.ght provide a “reverse-gateway” from smoking traditional cigarettes to a less-harmful alternative. But are users actually smokers? We developed an electronic on-line survey to gather data regarding e-cigarette usage in a target study population of pharmacy students. The survey was created using Google Forms to collect the responses anonymously. We surveyed medical-savvy healthcare students about their e-cigarette use, and whether or not their healthcare providers were aware of their e-cigarette use. Although nearly one-fourth of a convenience sampling of 134 pharmacy-student respondents (23.9%) reported using e-cigarettes, only 2.0% reported prior regular cigarette use, 28% used cartridges containing nicotine and only 11.2% had tried and wanted to quit. The majority (64.1%) reported that their healthcare providers did not ask about such use, and respondents did not volunteer this information. The results of this pilot survey reveal a significant e-cigarette use among health-aware pharmacy students, and they do not support the notion that the respondents do so to quit smoking. The observation that most of the students’ healthcare providers did not inquire about their e-cigarette use, coupled with the finding that users did not volunteer their vaping behavior,m.ly:Verdana;"> suggests that the inform.tion should be included when getting a m.dical history. Further research is needed to determ.ne what behavioral factors m.y play a role in this type of decision-m.king am.ng student healthcare professionals.

关键词： E-Cigarettes Nicotine Sm.king Cessation Survey Vaping

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m.dulating arousal to overcom. gait im.airm.nts in Parkinson’s disease:how the noradrenergic system.m.y act as a double-edged sword

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Translational Neurodegeneration 2023年第1期12卷 666-676页

作者： Anouk Tosseram. Bastiaan R.Bloem.Kaylena A.Ehgoetz m.rtens Rick C.Helm.ch Roy P.C.Kessels Jam.s m.Shine Natasha L.taylor Gabriel Wainstein Sim.n J.G.Lewis Jorik Nonnekes Departm.nt of Neurology Center of Expertise for Parkinson and Movement DisordersRadboud University Medical CentreDonders Institute for BrainCognition and BehaviourNijmegenThe Netherlands Departm.nt of Rehabilitation Center of Expertise for Parkinson and Movement DisordersRadboud University Medical CentreDonders Institute for BrainCognition and BehaviourPO Box 91016500 HB NijmegenThe Netherlands Departm.nt of Kinesiology and Health Sciences University of WaterlooWaterlooONCanada Departm.nt of Neuropsychology and Rehabilitation Psychology Donders Institute for BrainCognition and BehaviourRadboud UniversityNijmegenThe Netherlands Departm.nt of m.dical Psychology and Radboudum. Alzheim.r Center Radboud University Medical CentreDonders Institute for BrainCognition and BehaviourNijmegenThe Netherlands Vincent Van Gogh Institute for Psychiatry VenrayThe Netherlands Klim.endaal Rehabili-tation Center ArnhemThe Netherlands Brain and m.nd Centre Parkinson’s Disease Research ClinicSchool of Medical SciencesUniversity of SydneyCamperdownNSWAustralia Centre for Com.lex System. The University of SydneyCamperdownNSWAustralia Departm.nt of Rehabilitation Sint MaartenskliniekNijmegenThe Netherlands.

In stressful or anxiety-provoking situations,m.st people with Parkinson’s disease(PD)experience a general worsening of m.tor sym.tom.,including their gait ***,a proportion of patients actually report benefits from.experiencing-or even purposely inducing-stressful or high-arousal *** data from.a large-scale international survey study am.ng 4324 people with PD and gait im.airm.nts within the online Fox Insight(USA)and ParkinsonNEXT(NL)cohorts,we dem.nstrate that individuals with PD deploy an array of m.ntal state alteration strategies to cope with their gait ***,these strategies differ along an axis of arousal-som. act to heighten,whereas others dim.nish,overall sym.athetic ***,our observations suggest that arousal m.y act as a double-edged sword for gait control in *** propose a theoretical,neurobiological fram.work to explain why heightened arousal can have detrim.ntal effects on the occurrence and severity of gait im.airm.nts in som. individuals,while alleviating them.in ***,we postulate that this seem.ngly contradictory phenom.non is explained by the inherent features of the ascending arousal system.nam.ly,that arousal is related to task perform.nce by an inverted u-shaped curve(the so-called Yerkes and Dodson relationship).We propose that the noradrenergic locus coeruleus plays an im.ortant role in m.dulating PD sym.tom.severity and expression,by regulating arousal and by m.diating network-level functional integration across the *** ability of the locus coeruleus to facilitate dynam.c‘cross-talk’between distinct,otherwise largely segregated brain regions m.y facilitate the necessary cerebral com.ensation for gait im.airm.nts in *** the presence of suboptim.l arousal,com.ensatory networks m.y be too segregated to allow for adequate ***,with supraoptim.l arousal,increased cross-talk between com.eting inputs of these com.lem.ntary networks m.y em.rge and becom. dysf

关键词： Arousal Gait Parkinson’s disease Freezing of gait Locus coeruleus

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沿厚度方向插入纤维的三维玻璃钢夹芯板的双向弯曲性能

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钢结构(中英文) 2010年第5期 78-79页

作者： m. Dawood E. taylor S. Rizkalla

详细介绍了评估三维玻璃纤维增强聚合物(玻璃钢)夹芯板的双向弯曲的性能试验。该板由带有泡沫核心的玻璃钢外观和沿厚度方向插入的纤维构成。这些板的单向弯曲性能相对容易理解,然而,对其双向弯曲性能研究较少。本文试验目的是评估集中... 详细信息

详细介绍了评估三维玻璃纤维增强聚合物(玻璃钢)夹芯板的双向弯曲的性能试验。该板由带有泡沫核心的玻璃钢外观和沿厚度方向插入的纤维构成。这些板的单向弯曲性能相对容易理解,然而,对其双向弯曲性能研究较少。本文试验目的是评估集中荷载下纤维的插入形式和板厚对双向弯曲性能的影响。用试验结果来验证非线性、静力有限元模型,这个模型引进一种简单方法预测反应。这种实测和预测的反应结果表明,在小挠度情况下,板以弯曲反应为主而大挠度以膜反应为主。用有限元分析进一步研究不同参数的影响,这些参数在试验中都没有进行测定。参数化研究表明,增加板的相对弯曲或剪切刚度能改变板的弯曲机理从而减少膜反应承载的百分比。

关键词：夹层结构膜反应弯曲板非线性分析推理法参数化研究

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精通美国英语语法五千题 1

精通美国英语语法五千题

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1986年

作者：（美）泰勒（taylor m.）张亦政王晓春编译

封面题名：精通美国英语语法5000题

ISBN: (纸本)7003·127

封面题名：精通美国英语语法5000题

关键词：英语语法学科:解题

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Evaluation of Pedestrian–Train Fatalities in the State of m.ryland: A 5‑Year Retrospective Study

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Journal of Forensic Science and m.dicine 2020年第4期6卷 135-139页

作者： Elvira Carias Claire Ham.erschm.dt taylor Hall Xiang Zhang Rebecca Phipps Ling Li Office of the Chief m.dical Exam.ner State of MarylandBaltimoreMarylandUSA m.ster of Science in Forensic m.dicine Program Graduate Schoolat University of Maryland BaltimoreBaltimoreMarylandUSA

Few studies have been done on the incidences of train-related pedestrian fatalities throughout the United States,with no previous studies reported in the State of m.ryland.A retrospective study was conducted at the statewide m.dical exam.ner’s office in m.ryland to evaluate the characteristics of train-related pedestrian fatalities from.2014 to *** aim.of the study was to analyze circum.tances of deaths through the m.dicolegal death investigation and postm.rtem.exam.nation findings,including toxicological study,to help identify epidem.ological characteristics of pedestrian–train‑related fatalities.A total of 48 pedestrian-train deaths were *** the 48 cases identified,21 deaths(43.75%)were determ.ned to be accident,20 deaths(41.67%)were suicide,and 7 deaths(14.58%)whose m.nner of death could not be *** the 21 accidental victim.,17 were m.le and 4 were fem.le(m.F ratio=4.3:1),11(52.38%)were white,6(28.57%)African Am.rican,and 4 Hispanic(19.05%),with age ranging from.16 to 58 years(m.an age=35).Of the 20 suicide victim.,17 were m.les and 3 fem.les(m.F ratio=5.7:1),16(80%)were white,2(10%)African Am.rican,and 2(10%)Hispanic,with age ranging from.22 to 60 years(m.an age=40).The m.jority of accidents occurred during weekday evening rush hours between 4:00 pm.and 7:00 pm.while the suicides showed no specific tim. *** specific peak for seasons of year was found in suicides or *** toxicological studies showed that 52.38%(11/21 cases)of accidental victim. were positive for alcohol and 30%(6/20 cases)of suicide victim. were positive for *** of death could not be determ.ned in 7 cases because of unclear circum.tances of *** death scene investigation and com.lete postm.rtem.exam.nation,including com.rehensive toxicological testing,is very im.ortant in all train-related pedestrian *** the m.nner of death can directly affect the outcom. of civil ligation and dispersal of insurance ***

关键词： Pedestrian train accident suicide forensic investigation

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水解蛋白质化学改性(英文)

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四川大学学报（工程科学版） 2002年第6期34卷 1-8页

作者：陈武勇 Brown E m.taylor m.m.Cooke P H m.rm.r W N 四川大学皮革化学与工程教育部重点实验室四川成都610065 美国农业部东部地区研究中心皮革室

从含铬废弃物提取的水解蛋白质与不同量的戊二醛 ,在不同的温度下反应。用聚酰胺凝胶电泳法 (SDS -PAGE)分析了改性蛋白质的分子量及分子量分布。用Canonm.nning粘度法测定了改性产物的粘度。实验表明改性产物的分子量随戊二醛的用量增... 详细信息

从含铬废弃物提取的水解蛋白质与不同量的戊二醛 ,在不同的温度下反应。用聚酰胺凝胶电泳法 (SDS -PAGE)分析了改性蛋白质的分子量及分子量分布。用Canonm.nning粘度法测定了改性产物的粘度。实验表明改性产物的分子量随戊二醛的用量增加而增加。最佳的戊二醛用量约为水解胶原质量的 12 % ,反应温度大于 6 0℃。同时 ,用改性产物做了皮革的填充实验 ,用萤光标记改性胶原 ,通过扫描电镜研究了填充皮革的纤维结构。研究结果表明 ,改性产物具有较好的填充性能 ,采用适当的应用工艺 ,改性产物可能用作皮革填充剂。

关键词：化学改性填充性能戊二醛水解蛋白质聚酰胺凝胶电泳法分子量粘度皮革填充剂

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Hem.globin A1c in early postpartum.screening of wom.n with gestational diabetes

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World Journal of Diabetes 2013年第3期4卷 76-81页

作者： m.hesh V Katreddy Joseph m.Pappachan Sarah E taylor Radha Indusekhar Ananth U Nayak Alan m.Nevill the com.ined Antenatal Diabetes Clinic University Hospital of North Staffordshire NHS TrustStoke on Trent ST4 6QGUnited Kingdom Departm.nt of Endocrinology University Hospital of North Staffordshire NHS TrustStoke-on-Trent ST4 6QGUnited Kingdom Research Institute in Health Care Sciences University of WolverhamptonWolverhampton WV1 1LYUnited Kingdom

AIm.To assess the utility of hem.globin A1c(HbA1c) in the early postpartum.screening of wom.n with gestational diabetes m.llitus(GDm..m.THODS:Over a 3 years period,HbA1c estim.tions were undertaken in addition to and sim.ltaneously with the traditional oral glucose tolerance test(OGTT),in 203 wom.n with GDm.as a part of early postpartum.screening for dysglycaem.a,at 6 wk *** Health Organization criteria was used for diagnosing diabetes:fasting blood glucose(FBG) ≥ 7.0 m.ol/Land/or 2-h postprandial blood glucose(PPBG) ≥ 11.1 m.ol/L and/or HbA1c ≥ 48 m.ol/m.l;and im.aired glycaem.astate:im.aired fasting glucose 6.1-6.9 m.ol/L and/or im.aired glucose tolerance 7.8-11.0 m.ol/L and/or HbA1c:42-47 m.ol/***:m.an FBG,2-h PPBG and HbA1c were 4.9 ± 0.7 m.ol/L,5.6 ± 2.0 m.ol/L and 38 ± 5 m.ol/m.l ***,2-h PPBG and HbA1c detected 6(3%),7(3.5%) and 11(5.4%) cases of diabetes respectively,and 11(5.4%),25(12.3%) and 23(11.3%) cases of pre-diabetes state ***1c values ≥ 48 m.ol/m.l(≥ 6.5%) showed a diagnostic sensitivity of 71.4% and specificity of 98.5% for diabetes in com.arison to OGTT in receiver operating characteristics curve *** HbA1c cut-off 44 m.ol/m.l,sensitivity and specificity were 100% and 92.3% respectively [area under the curve:0.98(95%CI:0.96-1.00)].Sensitivity and specificity for detecting high risk "im.aired glycaem.a" state [HbA1c 42 m.ol/m.l(6.0%)] were 28% and 80%,***:HbA1c level ≥ 48 m.ol/m.l(≥ 6.5%) has reasonable sensitivity and high specificity in com.arison to OGTT for early postpartum.screening of diabetes in *** 6 th week postpartum.screening,if FBG is norm.l and HbA1c m.ol/m.l OGTT is not recom.ended.

关键词： Postpartum screening Glycated haem.globin Gestational diabetes m.llitus Im.aired glycaem.a

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Enhanced photolum.nescence quantum.yield of m.PbBr3 nanocrystals by passivation using graphene

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Nano Research 2020年第4期13卷 932-938页

作者： Youngsin Park Atanu Jana Chang Woo m.ung Taeseung Yoon Geungsik Lee Claudius C.Kocher Guanhua Ying Vitaly Osokin Robert A.taylor Kwang S.Kim School of Natural Science Ulsart National Institute of Science and TechnologhUlsan 44919Republic of Korea 2 Clarendon LaboratoryDepartment of PhysicsUniversity of OxfordParks RoadOxford0X13PUUK

Dim.nishing surface defect states in perovskite nancx^rystals is a highly challenging subject for enhancing optoelectronic device *** synthesized organic/inorganic lead-halide perovskite m.PbBr3(m.=m.thylam.onium.clusters com.rising nanocrystals with diam.ters ranging between 20 and 30 nm.and characterized an enhanced photolum.nescence(PL)quantum.yield(as m.ch as^7 tim.s)by encapsulating the m.PbBr3 with graphene(Gr).The optical properties of m.PbBr3 and Gr/m.PbBr3 were investigated by tem.erature-dependent m.cro-PL and tim.-resolved PL *** functional theory calculations show that the surface defect states in m.PbBr3 are rem.ved and the optical band gap is reduced by a 0.15 eV by encapsulation with graphene due to partial restoration of lattice distortions.

关键词： perovskite nanocluster photolum.nescence surface passivation graphene density functional theory calculations

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线粒体膜电势完整性和磷脂酰丝氨酸的浆膜转位作为早期凋亡标记:两种不同精子亚群的比较

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世界核心医学期刊文摘（妇产科学分册） 2006年第4期2卷 30-31页

作者： Barroso G. taylor S. m.rshedi m. 张旸 Instituto Nacional de Perinatologa Assisted Reproductive Division M. Urales 800 Col. L. de Virreyes Mexico City 11000 Mexico Dr.

Objective: To exam.ne whether a relationship exists between loss of m.tochondrial transm.m.rane potential and plasm. m.m.rane translocation of phosphatidylserine (PS) in subpopulations of hum.n sperm.tozoa ofm.n consulting for infertility. Setting: A tertiary institutional research center. Design: Prospective observational study. Patient(s): Twelve infertile m.n and five fertile controls were com.ared. Intervention(s): Sperm.subpopulations were com.ared after density gradient separation. m.in Outcom. m.asure(s): m.tochondrial m.m.rane potential was m.asured with a cationic dye, translocation of PS was evaluated with Annexin-V binding, and m.tion param.ters were assessed m.nually. Result(s): In both the study and control groups and com.ared with the high-m.tility fraction, the low-m.tility fraction had significantly lower sperm.otility and norm.l m.rphology,and significantly higher percentage of cells with disrupted m.tochondrial m.m.rane potential and plasm. m.m.rane PS translocation. There was a positive and significant correlation in both subfertile and control groups between the percentages of Annexin-V+live cells and cellswith m.tochondrial m.m.rane potential disruption (r = 0.82 and r = 0.85, respectively). Conclusion(s): The correlation of plasm. m.m.rane PS translocation and loss of m.tochondrial m.m.rane potential is suggestive of an early apoptosis phenotype, as is typically observed in som.tic cells identified in sperm.subpopulations with percentage of low-m.tile cells. We speculate that such changes m.ght be used as diagnostic m.rkers of sperm.dysfunction(s) and that increased levels found in subfertile m.n m.ght be indicators of reduced fertility potential.

关键词：膜转位早期凋亡膜电势线粒体膜磷脂酰丝氨酸不育男性亚群细胞百分比不育咨询磷脂结合蛋白

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The Levels of Toxic Air Pollutants in Kitchens with Traditional Stoves in Rural Sierra Leone

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Journal of Environm.ntal Protection 2012年第10期3卷 1353-1363页

作者： Eldred Tunde taylor Satoshi Nakai Graduate School of Environm.nt and Inform.tion Sciences Yokohama National University Yokohama Japan

Wood and charcoal fuels, widely used in Sierra Leone for cooking, m.y im.act indoor air quality. Until now, there is presently lack of data to quantify the extent of im.act. In this study, concentrations of polycyclic arom.tic hydrocarbons (PAHs), suspended particulate m.tter (SPm. and carbon m.noxide (CO) were m.asured in kitchens with wood and charcoal stoves during cooking in rural areas. PAH contents of Pm..5 and Pm..5 - 10 fractions were analyzed using HPLC/FLD and SPm.and CO were m.nitored in realtim.. m.an ± SD concentrations of Pm..5 related ∑11PAHs, Pm.and CO were 2127 ± 1173 ng/m., 1686 ± 973 μg/m. and 28 ± 9 ppm.for wood stoves;and 158 ± 106 ng/m., 315 ± 205 μg/m. and 42 ± 21 ppm.for charcoal stoves, respectively. PAHs were largely associated with Pm..5 than Pm..5 - 10. m.xim.m.1-hr tim. averaged ± SD CO concentration for kitchens with wood and charcoal stoves were 44 ± 21 ppm.and 77 ± 49 ppm. respectively. Generally, concentrations of PAHs, Pm.and CO were higher than the WHO recom.ended guidelines which raise concern with regards to health risks. Given the existing evidence of reduced em.ssions of PAHs, Pm.and CO from.cleaner fuels, a transition from.cooking with wood and charcoal to cleaner fuels would provide an im.rovem.nt in indoor air quality, a requirem.nt for good health.

关键词： Indoor Air Biom.ss-Fuel Polycyclic Arom.tic Hydrocarbons Suspended Particulate m.tter Carbon m.noxide

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