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Divergent trajectories of lean vs obese non-alcoholic steatohepatitis patients from listing to post-transplant:A retrospective cohort study

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World Journal of Gastroenterology 2022年第26期28卷 3218-3231页

作者： Fakhar Ali Qazi-Arisar Raj Uchila Catherine chen cathy yang.shi-yi chen Ravikiran Sindhuvalada Karnam Amirhossein Azhie Wei Xu Zita Galvin Nazia Selzner Leslie Lilly Mamatha Bhat Ajmera Transplant Program Toronto General HospitalUniversity Health NetworkToronto M5G 2N2OntarioCanada Division of Gastroenterology and Hepatology Department of MedicineUniversity of TorontoToronto M5G 2N2OntarioCanada National Institute of Liver and GI Diseases Dow University of Health SciencesKarachi 75330Pakistan Department of Biostatistics Princess Margaret Cancer CenterUniversity Health NetworkToronto M5G 2C1OntarioCanada Division of Biostatistics Dalla Lana School of Public HealthUniversity of TorontoToronto M5G 2C1OntarioCanada

BACKGROUND Non-alcoholic steatohepatitis(NASH)cirrhosis is the second most common indication for liver transplantation(LT).The role of body mass index(BMI)on outcomes of NASH cirrhosis has been *** To compare the longitudinal trajectories of patients with lean vs obese NASH cirrhosis,from listing up to post-transplant,having adjusted their BMI for *** We retrospectively reviewed all adult NASH patients listed for LT in our program from 2012 to ***-Gray Competing Risk analyses and Cox Proportional-Hazard Models were performed to examine the cumulative incidence of transplant and survival outcomes *** Out of 265 NASH cirrhosis listed patients,176 were *** age was 61.0 years;46%were females.111 patients underwent *** robust patients had better waitlist survival[hazard ratio(HR):0.12;95%CI:0.05–0.29,P<0.0001]with higher instantaneous rate of transplant(HR:5.71;95%CI:1.26–25.9,P=0.02).Lean NASH patients had a substantially higher risk of graft loss within 90 d post-LT(1.2%vs 13.8%,P=0.032)and death post-LT(2.4%vs 17.2%,P=0.029).1-3-and 5-year graft survival was poor for lean NASH(78.6%,77.3%and 41.7%vs 98.6%,96%and 85%respectively).Overall patient survival post-LT was significantly worse in lean NASH(HR:0.17;95%CI:0.03–0.86,P=0.0142)with 83%lower instantaneous rate of death in obese *** Although lean NASH is considered to be more benign than obese NASH,our study suggests a paradoxical correlation of lean NASH with waitlist outcomes,and graft and patient survival post-LT.

关键词： Outcomes Frailty Waitlist Liver transplant Survival

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Effects of sex and generation on hepatitis B viral load in families with hepatocellular carcinoma

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World Journal of Gastroenterology 2017年第5期23卷 876-884页

作者： Ai-Ru Hsieh cathy SJ Fann Chau-Ting Yeh Hung-Chun Lin Shy-yi Wan yi-cheng chen Chia-Lin Hsu Jennifer Tai shi-Ming Lin Dar-In Tai Graduate Institute of Biostatistics China Medical University Institute of Biomedical Sciences Academia Sinica Division of Hepatology Department of Gastroenterology and Hepatology Chang Gung Memorial Hospital Kaohsiung Medical University College of Medicine

AIM To explore factors associated with persistent hepatitis B virus(HBV) infection in a cohort of hepatocellular carcinoma(HCC)-affected families and then investigate factors that correlate with individual viral load among hepatitis B surface antigen(HBsA g)-positive relatives. METHODS We evaluated non-genetic factors associated with HBV replication in relatives of patients with HCC. Relatives of 355 HCC cases were interviewed using a structuredquestionnaire. Demographics, relationship to index case, HBs Ag status of mothers and index cases were evaluated for association with the HBV persistent infection or viral load by generalized estimating equation analysis. RESULTS Among 729 relatives enrolled, parent generation(P = 0.0076), index generation(P = 0.0044), mothers positive for HBs Ag(P = 0.0007), and HBs Ag-positive index cases(P = 5.98 × 10-8) were associated with persistent HBV infection. Factors associated with HBV viral load were evaluated among 303 HBs Ag-positive relatives. Parent generation(P = 0.0359) and sex(P = 0.0007) were independent factors associated with HBV viral load. The intra-family HBV viral load was evaluated in families clustered with HBs Ag-positive siblings. An intra-family trend of similar HBV viral load was found for 27 of 46(58.7%) families. Male offspring of HBsA gpositive mothers(P = 0.024) and older siblings were associated with high viral *** Sex and generation play important roles on HBV viral load. Maternal birth age and nutritional changes could be the reasons of viral load difference between generations.

关键词：家庭产生性肝炎 B 病毒 Perinatal 感染病毒的复制

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Metabolite variation in hybrid corn grain from a large-scale multisite study

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The Crop Journal 2016年第3期4卷 177-187页

作者： Mingjie chen R.Shyama Prasad Rao yiming Zhang cathy Zhong Jay J.Thelen Haixia Institute of Science and Technology Horticulture Biology and Metabolomics CenterFujian Agriculture and Forestry University Department of Biochemistry Christopher S.Bond Life Science CenterUniversity of Missouri Biostatistics and Bioinformatics Division Yenepoya Research CenterYenepoya University Regulatory Group Du Pont Experimental Station

Metabolite composition is strongly affected by genotype,environment,and interactions between genotype and environment,although the extent of variation caused by these factors may depend upon the type of *** characterize the complexity of genotype,environment,and their interaction in hybrid seeds,50 genetically diverse non-genetically modified(GM) maize hybrids were grown in six geographically diverse locations in North *** metabolites from 553 harvested corn grain samples were isolated and analyzed by gas chromatography–mass spectrometry and 45 metabolites detected in all samples were used to generate a data matrix for statistical *** was moderate variation among biological replicates and across genotypes and test *** genotype effects were detected by univariate and Hierarchical clustering analyses(HCA) when environmental effects were ***,environment exerted larger effects than genotype,and polar metabolite accumulation showed a geographic *** conclude that it is possible to increase seed polar metabolite content in hybrid corn by selection of appropriate inbred lines and growing regions.

关键词： Corn grain Genotype Environment GC–MS Metabolomics

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Improving genomic tools for outcrossing crops

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Molecular Plant 2021年第4期14卷 538-540页

作者： cathy Jubin Stefanie Griebel Timothy Beissinger Division of Plant Breeding Methodology&Center for Integrated Breeding Research Department of Crop ScienceUniversity of Gottingen37075

For decades,practical limitations and cost have created a bias in plant genetic studies toward species that tolerate self *** important work by chen et al.(2021)in this issue provides key tools to overcome this bias a... 详细信息

关键词： crops breeding overcome

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论视觉化思维对儿童数学学习的重要性

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创新人才教育 2019年第3期 24-28页

作者： Jo Boaler Lang chen cathy Williams Montserrat Lordero 江冰冰(编译) 斯坦福大学 youcubed 斯坦福大学认知与系统神经科学实验室不详

儿童的思维发展、学习方式与学习效果密切相关。在数学学习中,儿童习惯的手指表达、视觉化表达等方式与其大脑运作机制相关。相关研究表明,基于视觉化思维的数学学习对于儿童具有重要意义。教育工作者和家长需要重视这一点,并鼓励儿童... 详细信息

儿童的思维发展、学习方式与学习效果密切相关。在数学学习中,儿童习惯的手指表达、视觉化表达等方式与其大脑运作机制相关。相关研究表明,基于视觉化思维的数学学习对于儿童具有重要意义。教育工作者和家长需要重视这一点,并鼓励儿童发展视觉化思维能力。

关键词：视觉思维数学学习大脑研究

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比较蛋白质组学的生物信息学(影印版)

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农药学学报 2013年第4期 380-380页

作者： cathy H.Wu Chuming chen

内容简介:随着生命科学和临床应用蛋白质组学技术的快速发展,许多生物信息学的研究方法、数据库、软件工具已经可以用于支持比较蛋白质组学的研究。《比较蛋白质组学的生物信息学(影印版)》分为3个主要部分,包括与比较蛋白质组学相关的... 详细信息

内容简介:随着生命科学和临床应用蛋白质组学技术的快速发展,许多生物信息学的研究方法、数据库、软件工具已经可以用于支持比较蛋白质组学的研究。《比较蛋白质组学的生物信息学(影印版)》分为3个主要部分,包括与比较蛋白质组学相关的基础生物信息学框架、蛋白质组学数据分析的生物信息学数据库和工具,以及在系统生物学背景下的比较蛋白质组学关于整合生物信息的系统学和研究方法。本书提供了详细的操作建议,逐步地描述操作过程,务求让使用者在实验室获得最佳的实验结果。

关键词：比较蛋白质组系统生物学蛋白质组学数据库数据库系统影印版生物信息学

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壳聚糖护肤液保湿和抗菌作用的研究

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材料导报 2013年第2期27卷 52-56,71页

作者：张利云丁仕力陈璋杨虎张梦媛谈伟强宣贵达浙江大学医学院附属儿童医院杭州310003 浙江大学医学院附属第一医院整形外科杭州310003 浙江大学城市学院医学与生命科学学院杭州310015

将不同分子量的壳聚糖混合后溶于1%(质量分数,下同)稀醋酸中制备壳聚糖护肤液。以15%(质量分数,下同)甘油和佳雪芦荟保湿乳液为阳性对照,以95%(体积分数,下同)酒精为阴性对照,以生理盐水为空白对照,用干燥器法测定壳聚糖护肤液的保湿率... 详细信息

将不同分子量的壳聚糖混合后溶于1%(质量分数,下同)稀醋酸中制备壳聚糖护肤液。以15%(质量分数,下同)甘油和佳雪芦荟保湿乳液为阳性对照,以95%(体积分数,下同)酒精为阴性对照,以生理盐水为空白对照,用干燥器法测定壳聚糖护肤液的保湿率,并用数字皮肤水分检测仪检测壳聚糖护肤液对人体皮肤的保湿性能;以15%甘油和佳雪芦荟保湿乳液为阳性对照,以维生素E和95%酒精为阴性对照,以生理盐水为空白对照,采用数字皮肤水分检测仪检测壳聚糖护肤液对大鼠背部皮肤的即时和长期保湿性能。以青霉素为阳性对照、未消毒壳聚糖和生理盐水为阴性对照,采用琼脂扩散纸片法检测已消毒壳聚糖护肤液对金黄色葡萄球菌的抑菌圈直径,比较其抗菌作用。结果表明,壳聚糖护肤液除了具有良好的保湿性能外,还同时具有抗金黄色葡萄球菌的能力,此为一般护肤液所不具备,因而具有独特的潜在应用价值。

关键词：壳聚糖护肤液保湿抗菌

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Abstracts from the 15th International Myopia Conference

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Eye and Vision 2016年第1期3卷 211-221页

作者： Alexandra Benavente-Perez Ann Nour Tobin Ansel Kathleen Abarr Luying Yan Keisha Roden David Troilo Chanyi Lu Miaozhen Pan Min Zheng Jia Qu Xiangtian Zhou Christine F. Wildsoet Fan Lu Jie chen Jinhua Bao Liang Hu Qinmei Wang Zibing Jin Frances Rucker Stephanie Britton Stephan Hanowsky Molly Spatcher Hui-ying Kuo Ching-Hsiu Ke I-Hsin Kuo Chien-Chun Peng Han-yin Sun Ian G. Morgan Jeremy A. Guggenheim Rupal L. Shah cathy Williams Jinglei yang Peter S. Reinach Sen Zhang Wenfeng Sun Bo Liu Fen Li Xiaoqing Li Aihua Zhao Tianlu chen Wei Jia Jun Jiang Haoran Wu Kazuo Tsubota Hiroko Ozawa Hidemasa Torii shigemasa Takamizawa Toshihide Kurihara Kazuno Negishi Klaus Graef Daniel Rathbun Frank Schaeffel Ladan Ghodsi William K. Stell Machelle T. Pardue Ranjay Chakraborty Han na Park Curran S. Sidhu P. Michael Iuvone Michael J Collins Nethrajeith Srinvasalu Sally A. McFadden Paul N. Baird Pablo Artal Pauline Cho SW Cheung Pei-Chang Wu Quan V. Hoang Duk C. Lee Erica G. Landis Michael A. Bergen Curran Sidhu Samer Hattar Richard A. Stone Ravi Metlapally Ruiqin Li Qinglin Xu Hong Zhong chenglin Pan Weizhong Lan Xiaoning Li Ling chen Zhikuan yang Scott A. Read Seang-Mei Saw shi-Jun Weng Xiao-Hua Wu Kang-Wei Qian Yun-Yun Li Guo-Zhong Xu Furong Huang Xiong-Li yang Yong-Mei Zhong Earl L Smith, III Baskar Arumugam Li-Fang Hung Lisa A. Ostrin Klaus Trier Monica Jong Brien A. Holden Thomas Chuen Lam Samantha Shan Bing Zuo Dennis Yan-yin Tse Jingfang Bian King-Kit Li Quan Liu Chi-ho To Timothy J. Gawne John T. Siegwart, Jr. Alexander H. Ward Thomas T. Norton Yan Zhang Yue Liu Carol Ho Eileen Phan Abraham Hang Emily Eng Christine Wildsoet Department of Biological Sciences SUNY College of Optometry New York NY 10036 USA School of Optometry and Ophthalmology and Eye Hospital Wenzhou Medical University Wenzhou Zhejiang 325027 China Center for Eye Disease & Development School of Optometry & Vision Science Program University of California Berkeley Berkeley CA 94720-2020 USA Wenzhou Medical University Wenzhou Zhejiang 325027 China Biomedical Science and Disease New England College of Optom Boston MA USA School of Optometry Chung Shan Medical University Taichung City 402 Taiwan Institute of Medicine Chung Shan Medical University Taichung City 402 Taiwan Division of Biochemistry and Molecular Biology Research School of Biology Australian National University Canberra Australia State Key Laboratory of Ophthalmology and Division of Preventive Ophthalmology Zhongshan Ophthalmic Center Sun Yat-Sen University Guangzhou China School of Optometry & Vision Sciences Cardiff University Cardiff UK School of Social and Community Medicine University of Bristol Bristol UK School of and Eye Hospital Wenzhou Medical University Wenzhou Zhejiang 325027 China State Key Laboratory Cultivation Base and Key Laboratory of Vision Science Ministry of Health and Zhejiang Provincial Key Laboratory of Ophthalmology and Optometry Wenzhou Zhejiang 325027 People’s Republic of China Shanghai Key Laboratory of Diabetes Mellitus and Center for Translational Medicine Shanghai Jiao Tong University Affiliated Sixth People’s Hospital Shanghai 200233 China Eye Hospital of Wenzhou Medical University Wenzhou Zhejiang 325027 China Department of Ophthalmology Keio University School of Medicine Shinjuku-ku Tokyo 160-8582 Japan General Medicine Ichikawa Medical Center Urayasu City Chiba 279-0001 Japan Ophthalmic Research Institute University of Tuebingen 72076 Tuebingen Germany Bernstein Center for Computational Neuroscience Tuebingen 72076 Tuebingen Germany Werner Reichardt Centre for Integrative Neuroscience Otfried-Mueller-Straße 25 Tueb

To assess the peripheral refractive changes that occur when eye growth decelerates in *** We measured peripheral refraction and on-axis vitreous chamber depth on a total of 53 marmosets;36 treated monocularly for 12 weeks 9 hrs/day(26 with-5 D contact lenses,10 with+5 D)and 17 untreated *** the 26 marmosets treated with-5 D,10 wore contact lenses 9 hrs/day without interruptions and were mea-sured at the end of 10 weeks of treatment(T10)and after 4 weeks of recovery(R14).Eight had both contact lenses removed for 30 mins twice/day(mid-morning and mid-afternoon)during the first four weeks of treatment(early interruption group)and eight had the lenses removed during the second four weeks of treatment(late interruption group).The two interruption groups were measured after 4,8 and 12 weeks of treatment only(T4,T8,T12).

关键词： removed treatment untreated

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A world of phones

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校园英语 2018年第47期 256-256页

作者： chen Yaqi Shandong Weifang No.1 Middle School Level 70 Class 21

It was a sunny ***,I walked into a restaurant tomeet my old friend,*** has been five years since we met lasttime."Hey,cathy!"Jim has already been there and orderedsome food looking delicious."Hey,Jim!"I greeted him with a bright *** that time,my phone ***,I saw there was somefunny messages being pushed in Weibo.I could’t wait to *** first just looked at me and *** I totally immersedmyself in the phone.I was so concentrated in it that I didn’t

关键词： A world of phones

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O型口蹄疫病毒VP1基因区序列系统发育树分型

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动物医学进展 2007年第3期28卷 8-13页

作者：相磊章振华胡国良陈小玲梁之昶徐福洲石岗江西农业大学动物科技学院江西南昌330045 北京市农林科学院畜牧兽医研究所北京100097 新疆农业大学动物科技学院新疆乌鲁木齐830052

从GenBank和世界口蹄疫参考实验室基因库(WRLFMD)下载O型FMDV全VP1序列共210条,其中23条为已知基因型序列,其他为未知基因型序列。利用分子生物学软件DNA Star中的Clust-alW和Tree View工具,以已知基因型的VP1区序列构建系统发育树,验... 详细信息

从GenBank和世界口蹄疫参考实验室基因库(WRLFMD)下载O型FMDV全VP1序列共210条,其中23条为已知基因型序列,其他为未知基因型序列。利用分子生物学软件DNA Star中的Clust-alW和Tree View工具,以已知基因型的VP1区序列构建系统发育树,验证分型结果与已知基因型是否一致。然后以已知基因型序列作为参照,将未知基因型序列与已知基因型序列一起构建系统发育树,以已知基因型序列在系统发育树中所处的位置,来判断未知基因型序列的归属,从而明确它们归属于何种基因型。结果表明,采用此种分型方法获得Cathay型74条、SEA型24条、EA型4条、WA型4条、Euro-SA型21条、ME-SA型68条、ISA-1型3条、ISA-2型2条,未能分型序列10条。

关键词： O型口蹄疫病毒基因型/拓扑型系统发育树 VP1基因

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