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Epidemiology of Cancer in Systemic Sclerosis—Systematic Review and meta-Analysis of Cancer Incidence, Predictors and mortality

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Open Journal of Rheumatology and Autoimmune Diseases 2013年第4期3卷 231-245页

作者： Tatiana Nevskaya Shelly Chandran Adrienne m. Roos Christopher R. Pasarikovski Amie Kron cathy Chau Sindhu R. Johnson Toronto Scleroderma Program Division of Rheumatology Mount Sinai and Toronto Western Hospitals University of Toronto Toronto Canada Toronto Scleroderma Program Division of Rheumatology Mount Sinai and Toronto Western Hospitals University of Toronto Toronto Canada

Objectives: The study was conducted to improve our understanding of the epidemiology of cancer in systemic sclerosis (SSc) by evaluating the incidence, prevalence, relative risk of overall and site-specific malignancies, predictors and cancer-attributable mortality. methods: mEDLINE, CINAHL, EmBASE and Cochrane Library (inception-may 2012) were searched. Estimates were combined using a random effects model. Consistency was evaluated using the I2 statistic. Results: 4876 citations were searched to identify 60 articles. The average incidence of malignancy in SSc was 14 cases/1000 person-years;the prevalence ranged between 4%-22%. Cancer was the leading cause of non-SSc related deaths with a mean of 38%. Overall SIR for all-site malignancy risk was 1.85 (95%CI 1.52, 2.25;I276%). There was a greater risk of lung (SIR 4.69, 95%CI 2.84, 7.75;I293%) and haematological (SIR 2.58, CI 95% 1.75, 3.81;I20%) malignancies, including non-Hodgkin’s lymphoma (SIR 2.55, 95%CI 1.40, 4.67;I20%). SSc patients were at a higher risk of leukemia (SIR 2.79, 95%CI 1.22, 6.37;I20%), malignant melanoma (SIR 2.92, 95%CI 1.76, 4.83;I235%), liver (SIR 4.75, 95%CI 3.09, 7.31;I20%), cervical (SIR 2.28, 95%CI 1.26, 4.09;I254%) and oropharyngeal (SIR 5.0, 95%CI 2.18, 11.47;I258%) cancers. Risk factors include a-RNAP I/III seropositivity, male sex, and late onset SSc. Smoking and longstanding interstitial lung disease increase the risk of lung cancer;Barrett’s esophagus and a positive family history of breast cancer, respectively, increase the risk of esophageal adenocarcinoma and breast cancer. Conclusions: SSc patients have a two-fold increase in all-site malignancy, and greater risk of lung and haematological malignancies that contribute significantly to mortality. Vigilance should be considered in SSc patients with risk factors for cancer.

关键词： Systemic Sclerosis Neoplasms Epidemiology Risk Factors mortality

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Solvation Structure and Dynamics of mg(TFSI)_(2) Aqueous Electrolyte

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Energy & Environmental materials 2022年第1期5卷 295-304页

作者： Zhou Yu Taylor R.Juran Xinyi Liu Kee Sung Han Hui Wang Karl T.mueller Lin ma Kang Xu Tao Li Larry A.Curtiss Lei Cheng materials Science Division Argonne National LaboratoryLemont IL 60439USA Joint Center for Energy Storage Research(JCESR) Lemont IL 60439USA Department of Physics Binghamton UniversityState University of New York4400 Vestal Parkway EastBinghamton NY 13902USA Department of Chemistry and Biochemistry Northern Illinois UniversityDeKalb IL 60115USA Physical and Computational Sciences Directorate Pacific Northwest National LaboratoryRichland WA 99352USA Energy&Environment Directorate Pacific Northwest National LaboratoryRichland WA 99352USA Energy Storage Branch Energy and Biotechnology DivisionSensor and Electronics DirectorateU.S.Army Research LaboratoryAdelphi MD 20783USA Department of Chemistry and Biochemistry Northern Illinois University DeKalb IL 60115 USA X-ray Science Division Argonne National Laboratory Lemont IL 60439 USA

Using ab initio molecular dynamics(AImD)simulations,classical molecular dynamics(CmD)simulations,small-angle X-ray scattering(SAXS),and pulsed-field gradient nuclear magnetic resonance(PFG-NmR),the solvation structure and ion dynamics of magnesium bis(trifluoromethanesulfonyl)imide(mg(TFSI)_(2))aqueous electrolyte at 1,2,and 3 m concentrations are *** AImD and CmD simulations,the first solvation shell of an mg;ion is found to be composed of six water molecules in an octahedral configuration and the solvation shell is rather *** TFSI^(-)ions prefer to stay in the second solvation shell and ***,the comparable diffusion coefficients of positive and negative ions in mg(TFSI)_(2)aqueous electrolytes have been observed,which is mainly due to the formation of the stable[mg(H_(2)O_(6))_(2)]^(+)complex,and,as a result,the increased effective mg ion ***,the calculated correlated transference numbers are lower than the uncorrelated ones even at the low concentration of 2 and 3 m,suggesting the enhanced correlations between ions in the multivalent *** work provides a molecular-level understanding of how the solvation structure and multivalency of the ion affect the dynamics and transport properties of the multivalent electrolyte,providing insight for rational designs of electrolytes for improved ion transport properties.

关键词： mg(TFSI)_(2)aqueous electrolyte molecular dynamics simulation pulsed-field gradient nuclear magnetic resonance small-angle X-ray scattering ion dynamics

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Visual C++ .NET开发人员指南 4

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2002年

作者： John Paul mueller 康博译

本书介绍了Visual C++ .NET的新增功能，如何使用这种语言创建线程、静态图形和动画，如何创建数据库应用程序、管理工具、帮助文档，如何使用SOAP开发分布式应用程序等内容。

ISBN: (纸本)7900643230

关键词： C语言程序设计

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Experimental salt cavern in offshore ultra-deep water and well designevaluation for CO_(2) abatement

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International Journal of mining Science and Technology 2019年第5期29卷 641-656页

作者： Alvaro maia da Costa Pedro V.m.Costa Antonio C.O.miranda mariana B.R.Goulart Okhiria D.Udebhulu Nelson F.F.Ebecken Ricardo C.Azevedo Sérgio m.de Eston Giorgio de Tomi Andre B.mendes Julio R.meneghini Kazuo Nishimoto Claudio mueller Sampaio Camila Brandao Alexandre Breda University of Sao Paulo(USP) Sao Paulo 01000-000Brazil modecom-Technology in Geomechanics and Computing modeling Rio de Janeiro 27570-000Brazil Department of Civil and Environment Engineering University of Brasília(UnB)Brasília 70000-000Brazil COPPE Federal University of Rio de JaneiroRio de Janeiro 27570-000Brazil Technology Division of Shell Shell BrazilRio de Janeiro 27570-000Brazil

This paper presents a proposal for an experimental salt cavern in offshore ultra-deep water for CO2 abatement,including the instrumentation plan and well conceptual design evaluated for carbon capture and storage(CCS)*** studies are based on applied computational mechanics associated with field experimentation that has contributed to the technical feasibility of the underground potash mine at the State of Sergipe in *** knowhow allowed the stability analysis of several salt caverns for brine production at the State of Alagoas in Brazil and to the drilling through stratified thick layers of salt of the pre-salt reservoirs in Santos ***,this knowledge has been applied in the design of onshore and offshore salt caverns opened by dissolution for storage of natural gas and *** geomechanical study,through the application of computational mechanics,of offshore giant salt caverns of 450 m high by 150 m in diameter,shows that one cavern can store about 4 billion Sm3 or 7.2 million tons of *** the construction of the giant cavern,which will be the first gas storage offshore in the world,it has been decided to develop an experimental one,with smaller size,to obtained field *** experimental cavern will allow the calibration of parameters to be used in the structural integrity analysis of the cavern and well for storage of natural gas which is rich in CO2 under high pressure.

关键词： Salt cavern Pre-salt reservoir Geomechanical study Carbon capture and storage

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Use of SWAT to model Impact of Climate Change on Sediment Yield and Agricultural Productivity in Western Oregon, USA

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Open Journal of modern Hydrology 2019年第2期9卷 54-88页

作者： G. W. mueller-Warrant C. L. Phillips K. m. Trippe USDA-Agricultural Research Service Forage Seed and Cereals Research Unit Corvallis OR USA

Climate change predictions for the Pacific Northwest region of the United States of America include increasing temperatures, intensification of winter precipitation, and a shift from mixed snow/rain to rain-dominant events, all of which may increase the risk of soil erosion and threaten agricultural and ecological productivity. Here we used the agricultural/environmental model SWAT with climate predictions from the Coupled model Intercomparison Project 5 (CmIP5) “high CO2 emissions” scenario (RCP8.5) to study the impact of altered temperature and precipitation patterns on soil erosion and crop productivity in the Willamette River Basin of western Oregon. An ensemble of 10 climate models representing the full range in temperature and precipitation predictions of CImP5 produced substantial increases in sediment yield, with differences between yearly averages for the final (2090-2099) and first (2010-2019) decades ranging from 3.9 to 15.2 mT·ha-1 among models. Sediment yield in the worst case model (CanESm2) corresponded to loss of 1.5 - 2.7 mm·soil·y-1, equivalent to potentially stripping productive topsoil from the landscape in under two centuries. most climate models predicted only small increases in precipitation (an average of 5.8% by the end of the 21st century) combined with large increases in temperature (an average of 0.05°C·y-1). We found a strong correlation between predicted temperature increases and sediment yield, with a regression model combining both temperature and precipitation effects describing 79% of the total variation in annual sediment yield. A critical component of response to increased temperature was reduced snowfall during high precipitation events in the wintertime. SWAT characterized years with less than basin-wide averages of 20 mm of precipitation falling as snow as likely to experience severe sediment loss for multiple crops/land uses. mid-elevation sub-basins that are projected to shift from rain-snow tr

关键词： Climate Change Sediment Yield Soil Water Assessment Tool SWAT Coupled model Intercomparison Project 5 CImP5 Nash-Sutcliffe Efficiency NSE

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PC升级与维修第1版

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2001年

作者：（美）Scott mueller等秦钢等译

本书介绍了PC硬件知识，包括BIOS、Intel最新的Socket 370设计和CPU信息、RDRAm、WTX主版规格，详细解释了为什么Celeron CPU以较低的成本获得接近PⅢ的性能，并教会读者解决PC系统的常见硬件问题等。

ISBN: (纸本)7115090343

关键词：微型计算机基本知识维修

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狭义小奥德蘑属(膨瑚菌科,蘑菇目)的一个新系统(英文)

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菌物学报 2009年第1期28卷 1-13页

作者：杨祝良张丽芳 Gregory m.mueller Gerhard W.KOST Karl-Heinz REXER 中国科学院昆明植物研究所生物多样性与生物地理学重点实验室昆明650204 美国芝加哥费尔德自然历史博物馆植物部芝加哥IL60605-2496 德国马尔堡大学生物学系系统植物学与真菌学实验室马尔堡35032

本文对狭义小奥德蘑属Oudemansiella ***.的概念做了修订,在修订后的属中,狭义干蘑属Xerula ***.的物种不纳入其中。在狭义小奥德蘑属下,提出了一个包含4个组***、mucidula、Dactylosporina和Radicatae的新系统。小奥德蘑组***包括热带... 详细信息

本文对狭义小奥德蘑属Oudemansiella ***.的概念做了修订,在修订后的属中,狭义干蘑属Xerula ***.的物种不纳入其中。在狭义小奥德蘑属下,提出了一个包含4个组***、mucidula、Dactylosporina和Radicatae的新系统。小奥德蘑组***包括热带至南温带的一些物种,如新热带小奥德蘑***、澳洲小奥德蘑***、旧热带小奥德蘑***和宽褶小奥德蘑***,这些物种的菌盖表皮为粘栅栏型,由菌丝组成,但其中常夹杂有链状排列的膨大细胞。粘蘑组***包含北半球温带至亚热带的一些物种,如粘小奥德蘑***、网褶小奥德蘑***和近粘小奥德蘑***,其菌盖表皮为粘子实层-栅栏型,由近棒状的顶端膨大细胞组成。小奥德蘑组和粘蘑组的物种,在外形和小生境上有相似之处,其担子果皆生于地表外的腐木上,菌柄上有或无菌环。刺孢组***包含中南美洲那些孢子表面有指状凸起的物种。长根组***由长根小奥德蘑***及其近缘种为代表,是该属中最大的组,包括该属其他三组之外的所有种。北美的***、欧洲的***和东亚的***曾被置于小奥德蘑属中的白毛组***或干蘑属的亮毛组***,在本系统中它们没有纳入小奥德蘑属,因为它们可能代表一个单独的属。本文还提出了1新等级、32个新组合和1个新名称。

关键词：担子菌新组合新名称命名法系统学分类学

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孕期暴露于大气颗粒物Pm2.5与儿童血压升高风险的关联性研究

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中华预防医学杂志 2019年第1期53卷 111-111页

作者： Zhang m mueller NT Wang H 米馨(编译) 不详中山大学公共卫生学院

以往研究表明,出生后暴露于大气污染物能够增加儿童血压升高的风险。而对于孕期暴露于大气污染物对儿童血压影响的研究仍然不足。Zhang等进行了一项前瞻性研究,包含波士顿出生队列(1998-2012年)的1293名母亲和孩子(在3~9岁间随访)。用... 详细信息

以往研究表明,出生后暴露于大气污染物能够增加儿童血压升高的风险。而对于孕期暴露于大气污染物对儿童血压影响的研究仍然不足。Zhang等进行了一项前瞻性研究,包含波士顿出生队列(1998-2012年)的1293名母亲和孩子(在3~9岁间随访)。用美国环境保护局的空气质量测试仪与母亲的居住地址相匹配来预测孕期暴露的Pm2.5水平。将儿童收缩压(SBP)升高定义为≥90百分位数。

关键词： Pm2.5 孕期暴露血压升高高风险大气颗粒物儿童大气污染物出生队列

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PC硬件金典 G

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2001年

作者：（美）Scott mueller 孙国盟等译

本书涉及系统的所有方面，包括主要元器件、主要部件、各种接口、各种外设以及相关软件等。除了阐明基本原理外，着重强调了组装、检测和维修PC系统的方法。

ISBN: (纸本)7505363077

关键词：微型计算机基本知识硬件

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matrix Extension with Fitness for Purpose and Stability Assessment of DHA and Additional Fatty Acids in Individual Whole Chicken Eggs

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Food and Nutrition Sciences 2019年第5期10卷 517-532页

作者： Gerald Patrick Dillon Alexandros Yiannikouris Walter Brandl cathy Cardinall Wendy Yuan Colm Anthony moran Regulatory Affairs Department Alltech Ireland Dunboyne Ireland Research Department Alltech Inc. Nicholasville USA Analytical Chemistry Department Mérieux NutriSciences Burnaby Canada Regulatory Affairs Department Alltech SARL Vire France

The consumption of long chain polyunsaturated fatty acids (LC-PUFA) is associated with several human health benefits. most notable of these LC-PUFA is docosahexaenoic acid (DHA C22:6) whose inclusion is considered essential for optimum human health. Biofortification of common foods such as eggs with DHA has emerged as a specific approach to increase the intake of DHA in human populations. This can be achieved by supplementing poultry rations with feeds like microalgae or fish oil that are rich in DHA, which results in an increased uptake in the egg. Gas chromatography with flame ionization detection (GC-FID) is the method of choice when analyzing food such as eggs for DHA and other fatty acids. For regulatory studies it is desirable to demonstrate that the method is specifically suitable for the analysis of DHA and fatty acids in eggs. The purpose of this paper is to further extend the scope of the AOAC 996.06 methodology examined in the paper by Dillon et al., and to demonstrate the fitness for purpose of the method by examining specific validation parameters. It is a further objective to investigate the stability of DHA and other fatty acids of short and long timepoints. A validation of the method for the determination of DHA and three other fatty acids in eggs is thus presented.

关键词： DHA GC-FID Fatty Acids Analytical method Fitness for Purpose Aurantiochytrium limacinum

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