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Neural Regeneration Research 2024年第10期19卷 2240-2248页

作者： Meng Yuan Yao Tang Tianwen Huang Lining Ke en Huang Key Laboratory of Brain Aging and Neurodegenerative Diseases of Fujian Province Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Human Anatomy School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Scientific Research Center School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurology Fujian Medical University Union HospitalFuzhouFujian ProvinceChina Fujian Key Laboratory of Vascular Aging Fujian Medical UniversityFuzhouFujian ProvinceChina

In situ direct reprogramming technology can directly convert endogenous glial cells into functional neurons in vivo for central nervous system repair. Polypyrimidine tract-binding protein 1(PTB) knockdown has been shown to reprogram astrocytes to functional neurons in situ. In this study, we used AAV-PHP.e B-GFAP-sh PTB to knockdown PTB in a mouse model of ischemic stroke induced by endothelin-1, and investigated the effects of GFAP-sh PTB-mediated direct reprogramming to neurons. Our results showed that in the mouse model of ischemic stroke, PTB knockdown effectively reprogrammed GFAP-positive cells to neurons in ischemic foci, restored neural tissue structure, reduced inflammatory response, and improved behavioral function. These findings validate the effectiveness of in situ transdifferentiation of astrocytes, and suggest that the approach may be a promising strategy for stroke treatment.

关键词： astrocyte in situ direct reprogramming ischemic stroke miR-30 based shRNA neuron polypyrimidine tract-binding protein 1 transdifferentiation

Improving modeling of low-altitude particulate matter emission and dispersion:A cotton gin case study

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journal of environmental Sciences 2023年第11期133卷 8-22页

作者： Zijiang Yang Michael N.Evans Michael D.Buser cathl.en j.hapeman Alba Torrents Derek P.Whitelock Department of Civil and environmental engineering University of Maryland College Park1173 Glenn L.Martin HallCollege ParkMaryland 20742United States Department of Geology University of Maryland College Park1212B Chemistry BuildingCollege ParkMaryland 20742United States Earth System Science Interdisciplinary Center 1120 Geology BuildingUniversity of MarylandCollege ParkMaryland 20742United States United States Department of Agriculture Agricultural Research ServiceOffice of National Programs5601 Sunnyside Ave(GWCC 4–2282)BeltsvilleMaryland 20705United States United States Department of Agriculture Agricultural Research ServiceHenry A.Wallace Beltsville Agricultural Research Center10300 Baltimore AvenueBeltsvilleMaryland 20705United States United States Department of Agriculture Agricultural Research ServiceSouthwestern Cotton Ginning Research LaboratoryPO Box 578Mesilla ParkNew Mexico 88047United States

Monitoring and modeling of airborne particulate matter(PM)from low-altitude sources is becoming an important regulatory target as the adverse health consequences of PM become better ***,application of models not specifically designed for simulation of PM from low-altitude emissions may bias *** address this problem,we describe the modification and validation of an air dispersion model for the simulation of lowaltitude PM dispersion from a typical cotton ginning *** found that the regulatory recommended model(AERMOD)overestimated pollutant concentrations by factors of 64.7,6.97 and 7.44 on average for PM 2.5,PM 10,and TSP,*** concentrations were negatively correlated with height(pendent observations,reducing overestimation factors to 3.75,1.52 and 1.44 for PM 2.5,PM 10 and TSP,*** reductions in model error may be obtained from use of additional observations and refinement of dispersive correction *** generally,the correction permits the validated adjustment and application of pre-existing models for risk assessment and development of remediation *** same approach may also be applied to improve simulations of other air pollutants and environmental conditions of concern.

关键词： Air quality Particulate matter Air dispersion modelling Cotton gin

Copper-catalyzed enantioselective desymmetrizing C（sp2）–H functionalization of azide-ynamides via α-imino copper carbenes

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Science China Chemistry 2024年第9期67卷 2982-2988页

作者： en-He Huang Li-Gao Liu You-Wei Yin Hao-Xuan Dong ji-jia Zhou Xin Lu Bo Zhou Long-Wu Ye Key Laboratory for Chemical Biology of Fujian Province and State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical Engineering Xiamen University State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences

α-Imino metal carbenes are versatile intermediates in organic synthesis, and have broad applications in the assembly of divergent N-heterocycles. However, the catalytic enantioselective desymmetrization based on α-imino metal carbenes has not been developed to date. Herein, we disclose an enantioselective desymmetrizing C（sp2）–H functionalization of azide-ynamides via α-imino copper carbenes, leading to the efficient assembly of divergent chiral indoloazepines in generally moderate to excellent yields with high enantioselectivities. Notably, this reaction represents the first enantioselective desymmetrization based on α-imino metal carbenes. Further synthetic transformations and biological tests show the potential utility of this method. Moreover,computational studies are employed to elucidate the reaction mechanism and the origin of enantioselectivity.

关键词： enantioselective desymmetrization metal carbenes copper catalysis nitrene transfer alkynes

Multi-omics analysis of adamantinomatous craniopharyngiomas reveals distinct molecular subgroups with prognostic and treatment response significance

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Chinese Medical journal 2024年第7期137卷 859-870页

作者： Xianlong Wang Chuan Zhao jincheng Lin Hongxing Liu Qiuhong Zeng Huadong Chen Ye Wang Dapeng Xu Wen Chen Moping Xu en Zhang Da Lin Zhixiong Lin Department of Bioinformatics School of Medical Technology and EngineeringKey Laboratory of Medical BioinformaticsKey Laboratory of Ministry of Education for Gastrointestinal CancerFujian Medical UniversityFuzhouFujian 350122China Department of Neurosurgery Sanbo Brain HospitalCapital Medical UniversityBeijing 100093China

Background:Adamantinomatous craniopharyngioma(ACP)is the commonest pediatric sellar *** effective drug is available and interpatient heterogeneity is *** study aimed to identify distinct molecular subgroups of ACP based on the multi-omics profiles,imaging findings,and histological features,in order to predict the response to anti-inflammatory treatment and ***:Totally 142 Chinese cases diagnosed with craniopharyngiomas were profiled,including 119 ACPs and 23 papillary ***-exome sequencing(151 tumors,including recurrent ones),RNA sequencing(84 tumors),and DNA methylome profiling(95 tumors)were *** clustering and non-negative matrix factorization were used for subgrouping,and Cox regression were utilized for prognostic evaluation,***:Three distinct molecular subgroups were identified:WNT,ImA,and *** WNT subgroup showed higher Wnt/β-catenin pathway activity,with a greater number of epithelial cells and more predominantly solid *** ImA and ImB subgroups had activated inflammatory and interferon response pathways,with enhanced immune cell infiltration and more predominantly cystic ***-activated protein kinases(MEK/MAPK)signaling was activated only in ImA samples,while IL-6 and epithelial-mesenchymal transition biomarkers were highly expressed in the ImB group,mostly consisting of *** degree of astrogliosis was significantly elevated in the ImA group,with severe finger-like protrusions at the invasive front of the *** molecular subgrouping was an independent prognostic factor,with the WNT group having longer event-free survival than ImB(Cox,P=0.04).ImA/ImB cases were more likely to respond to immune checkpoint blockade(ICB)therapy than the WNT group(Pening of subtyping markers,CD38 was significantly downregulated in WNT compared with ImA and ImB(P=0.01).Conclusions:ACP comprises three molecular subtypes with distinct

关键词： Craniopharyngioma Central nervous system tumor Precision medicine beta Catenin Proto-Oncogene Proteins B-raf

Modulating p-type doping of two-dimensional material palladium diselenide

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Nano Research 2024年第4期17卷 3232-3244页

作者： jiali Yang Yu Liu en-Yang Wang jinbo Pang Shirong Huang Thomas Gemming jinshun Bi Alicja Bachmatiuk Hao jia Shu-Xian Hu Chongyun jiang Hong Liu Gianaurelio Cuniberti Weijia Zhou Mark H Rümmeli Institute for Advanced Interdisciplinary Research(iAIR) University of JinanJinan 250022China Institute for Materials Chemistry Leibniz Institute for Solid State and Materials Research Dresden(IFW Dresden)20 Helmholtz StrasseDresden 01069Germany State Key Lab of Transducer Technology Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050China College of energy Soochow Institute for Energy and Materials Innovations Soochow UniversitySuzhou 215006China Key Laboratory of Advanced Carbon Materials and Wearable energy Technologies of jiangsu Province Soochow UniversitySuzhou 215006China School of Integrated Circuits University of Chinese Academy of SciencesBeijing 101408China Institute of Microelectronics of Tianjin Binhai New Area Tianjin 300451China Institute of Microelectronics Chinese Academy of SciencesBeijing 100029China Lukasiewicz Research Network PORT Polish Center for Technology DevelopmentStablowicka 147Wroclaw 54-066Poland School of Mathematics and Physics University of Science and Technology BeijingBeijing 100083China College of electronic information and optical engineering Nankai UniversityTianjin 300350China Centre of Polymer and Carbon Materials Polish Academy of SciencesM.Curie Sklodowskiej 34Zabrze 41-819Poland Center for energy and environmental Technologies VŠB-Technical University of Ostrava17.Listopadu 15Ostrava 70833Czech Republic State Key Laboratory of Crystal Materials Center of Bio&Micro/Nano Functional MaterialsShandong UniversityJinan 250100China Dresden Center for Computational Materials Science Technische Universität DresdenDresden 01062Germany Dresden Center for Intelligent Materials(GCL DCIM) Technische Universität DresdenDresden 01062Germany Institute for Materials Science and Max Bergmann Center of Biomaterials Technische Universität DresdenDresden 01069Germany Center for Advancing Electronics Dresden Technische Universität DresdenDresden 01069Germany

The van der Waals heterostructures have evolved as novel materials for complementing the Si-based semiconductor ***-10 noble metal dichalcogenides(e.g.,PtS_(2),PtSe_(2),PdS_(2),and PdSe_(2))have been listed into two-dimensional(2D)materials toolkit to assemble van der Waals *** them,PdSe_(2) demonstrates advantages of high stability in air,high mobility,and wide tunable ***,the regulation of p-type doping of PdSe_(2) remains unsolved problem prior to fabricating p–n junction as a fundamental platform of semiconductor ***,a quantitative method for the controllable doping of PdSe_(2) is yet to be *** this study,the doping level of PdSe_(2) was correlated with the concentration of Lewis acids,for example,SnCl_(4),used for *** the transfer characteristics,the threshold voltage(the gate voltage corresponding to the minimum drain current)increased after SnCl_(4) soaking ***_(2) transistors were soaked in SnCl_(4) solutions with five different *** threshold voltages from the as-obtained transfer curves were extracted for linear fitting to the threshold voltage versus doping concentration correlation *** study provides in-depth insights into the controllable p-type doping of PdSe_(2).It may also push forward the research of the regulation of conductivity behaviors of 2D materials.

关键词： two-dimensional(2D)materials Lewis acid treatment p-type doping field-effect transistors transfer characteristic

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结合数字孪生的斜拉桥系统更新和响应预测

振动．测试与诊断 2024年第1期44卷 11-17,193页

作者：方圣恩郭新宇福州大学土木工程学院福州350108 福州大学土木工程防震减灾信息化国家地方联合工程研究中心福州350108

由于传统建模方法难以反馈桥梁系统参数和响应的细微变化,为此提出了以数字孪生体作为结构系统的高保真映射模型。首先,定义数字孪生体包含物理孪生层、数字孪生层和信息交互媒介3部分,数字孪生层的孪生模型是对斜拉桥物理实体的虚拟映... 详细信息

由于传统建模方法难以反馈桥梁系统参数和响应的细微变化,为此提出了以数字孪生体作为结构系统的高保真映射模型。首先,定义数字孪生体包含物理孪生层、数字孪生层和信息交互媒介3部分,数字孪生层的孪生模型是对斜拉桥物理实体的虚拟映射,通过信息交互媒介实现不同层间信息的实时传递;其次,针对具体应用提出了结构信息化、信息数据化和数据模型化3条建模准则,实现对斜拉桥物理实体的信息勾勒和可视化过程,建立高保真的斜拉桥数字孪生模型;最后,以一座实桥端锚索的监测数据为感知信息,将变化的索参数实时反馈给孪生模型,实现模型更新和响应预测。研究结果表明,所提出的数字孪生建模方法能及时反馈实桥的参数变化,并预测由此造成的索力、塔顶偏位及主梁跨中挠度的细微改变。

关键词：斜拉桥数字孪生体建模框架和准则孪生模型更新信息交互媒介

Copper-catalyzed enantioselective desymmetrizing C（sp）–H functionalization of azide-ynamides via α-imino copper carbenes

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Science China Chemistry 2024年

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Global research trends and hotspots in overweight/obese comorbid with depression among children and adolescents: A bibliometric analysis

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World journal of Psychiatry 2024年第8期14卷 1267-1284页

作者： Ya-Qi Wang Tao-Tao Wu Yan Li Shi-en Cui Ying-Shuai Li College of Basic Medical Sciences Zhejiang Chinese Medical UniversityHangzhou 310051Zhejiang ProvinceChina National Institute of Traditional Chinese Medicine Constitution and Preventive Treatment of Diseases Beijing University of Chinese MedicineBeijing 100029China

BACKGROUND Overweight/obesity combined with depression among children and adolescents(ODCA)is a global *** bidirectional relationship between depression and overweight/obesity often leads to their *** and adolescence represent critical periods for physical and psychological development,during which the comorbidity of overweight/obesity and depression may increase the risk of adverse health *** To evaluate the relationship between ODCA,we conduct a bibliometric analysis to aid in formulating prevention and treatment *** From 2004 to 2023,articles related to ODCA were selected using the Science Citation Index Expanded from the Web of Science Core *** analysis of relevant publications,including countries/regions,institutions,authors,journals,references,and keywords,was conducted using the online bibliometric analysis platforms,CiteSpace,VOSviewer,and *** Between 2004 and 2023,a total of 1573 articles were published on *** United States has made leading contributions in this field,with Harvard University emerging as the leading contributor in terms of research output,and Tanofsky being the most prolific *** j Adolescent Health has shown significant activity in this *** on the results of the keyword and reference analyses,inequality,adverse childhood experiences,and comorbidities have become hot topics in ***,the impact of balancedrelated behavior and exploration of the biological mechanisms,including the potential role of key adipocytokines and lipokines,as well as inflammation in ODCA,have emerged as frontier *** The trend of a significant increase in ODCA publications is expected to *** research findings will contribute to elucidating the pathogenic mechanisms of ODCA and its prevention and treatment.

关键词： Children Adolescents Overweight Obesity Depression Bibliometric analysis Research trends

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联合语义分割和深度估计的交通场景感知算法

浙江大学学报（工学版） 2024年第4期58卷 684-695页

作者：范康钟铭恩谭佳威詹泽辉冯妍厦门理工学院福建省客车先进设计与制造重点实验室福建厦门361024 厦门大学航空航天学院福建厦门361102

受不同像素级视觉任务间的特征信息能够相互指导和优化的思路启发,基于多任务学习理论提出联合语义分割和深度估计的交通场景感知算法.提出双向跨任务注意力机制,实现任务间的全局相关性显式建模,引导网络充分挖掘和利用任务间互补模式... 详细信息

受不同像素级视觉任务间的特征信息能够相互指导和优化的思路启发,基于多任务学习理论提出联合语义分割和深度估计的交通场景感知算法.提出双向跨任务注意力机制,实现任务间的全局相关性显式建模,引导网络充分挖掘和利用任务间互补模式信息.构建多任务Transformer,增强特定任务特征的空间全局表示,实现跨任务全局上下文关系的隐式建模,促进任务间互补模式信息的融合.设计编-解码融合上采样模块来有效融合编码器蕴含的空间细节信息,生成精细的高分辨率特定任务特征.在Cityscapes数据集上的实验结果表明,所提算法的语义分割平均交并比达到79.2%,深度估计均方根误差为4.485,针对5类典型交通参与者的距离估计平均相对误差为6.1%,能够以比现有主流算法更低的计算复杂度获得更优的综合性能.

关键词：交通环境感知多任务学习语义分割深度估计 Transformer

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Dynamics of lattice disorder in perovskite materials, polarization nanoclusters and ferroelectric domain wall structures

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npj Computational Materials 2023年第1期9卷 1137-1149页

作者： jan Očenášek ján Minár jorge Alcalá New Technologies Research Centre University of West Bohemia in Pilsen30614 PlzeňCzech Republic Department of Materials Science and Metallurgical engineering InSupETSEIBUniversitat Politècnica de Catalunya08028 BarcelonaSpain

The nexus between classic ferroelectricity and the structure of perovskite materials hinges on the concept of lattice *** the ordered perovskites display short-range displacements of the central cations around their equilibrium points,the lattice disorder dynamically unfolds to generate a myriad of distorted rhombohedral lattices characterized by the hopping of the central cations across*** is discovered that the lattice disorder correlates with the emergence of minimum configuration energypathways for the central cations,resulting in spatially modulated ultrafast polarization nanocluster arrangements that are stabilized by the electric charge defects in the *** high-resolution phonon dispersion analyses encompassing molecular dynamics(MD)and density functional theory(DFT)simulations,we provide unequivocal evidence linking the hopping of central cations to the development of diffuse soft phonon modes observed throughout the phase transitions of the *** massive MD simulations,we unveil the impact of lattice disorder on the structures of domain walls at finite-temperature vis-à-vis collective activation and deactivation of***,our simulations demonstrate the development of hierarchical morphotropic phase boundary(MPB)nanostructures under the combined influence of externally applied pressure and stress relaxation,characterized by sudden emergence of zig-zagged monoclinic arrangements that involve dualshifts of the central *** findings have implications for tailoring MPBs in thin-film structures and for the light-induced mobilization of *** are finally uncovered to the exploration of lattice disorder through gradual shear strain application.

关键词： perovskite lattice ferroelectric