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Surveillance tools for detection of recurrent nasopharyngeal carcinoma: An evidence-based review and recommendations

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2022年第3期8卷 187-204页

作者： Andrew Thamboo Kim H.Tran Annette X.Ye Issraa Shoucair Basel Jabarin Eitan Prisman cathie garnis St.Paul's Sinus Centre Otolaryngology Head and Neck Surgery1081Burrard StVancouverV6Z 1Y6BCCanada Department of Biomedical Physiology and Kinesiology SimonFraserUniversity8888 University DrBurnabyV5A1S6BCCanada The University of British Columbia Faculty of Medicine MDProgram317-2194Health SciencesMallVancouverV6T1Z3BCCanada British Columbia Cancer Research Centre Cancer Genetics and Developmental Biology675 W 10th AveVancouverV5Z 1L3BCCanada VancouverGeneral Hospital Otolaryngology HeadandNeckSurgery899W12thAveVancouverV5Z 1M9BCCanada

Objective: Nasopharyngeal carcinomas (NPC) are tumors arising from epithelium of the nasopharynx. The 5-year survival rate of primary NPC is 80% with significant risks of recurrence. The objective here is to provide an evidence-based systemic review of the diagnostic value of different modalities in detecting local, regional, and distal recurrent NPC, as well as the associated costs with these ***: MEDLINE, EMBASE, and the Cochrane review database were queried. Two hundred and twenty-three abstracts were generated using the inclusion criteria: patients >18 years of age;histopathological reference standard;and modalities pertaining to imaging or ***: Twenty-four manuscripts fulfilled the inclusion criteria and 5 surveillance tools identified: endoscopy, MR, FDG-PET, Tc-99m MIBI and201TI SPECT, and EBV ***: For local surveillance, endoscopy is the gold standard recommendation, with increased efficacy if Narrow Band Imaging or contact endoscopy are utilized. MRI and FDG-PET is also recommended to help with local to distal spread;however, Tc-99m MIBI and201TI SPECT are options as well. EBV DNA is recommended as a cheap and accessible adjunct surveillance tool if an available as an option.

关键词： EBV DNA FDG-PET Imaging MR Endoscopy Recurrent Nasopharyngeal Carcinoma

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The association of Leptospermum honey with cytokine expression in the sinonasal epithelium of chronic rhinosinusitis patients

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2019年第1期5卷 19-25页

作者： Jamil Manji Andrew Thamboo Vishnu Sunkaraneni Amrit Singh Scott Tebbutt cathie garnis Amin Javer St.Paul's Sinus Centre Division of OtolaryngologyDepartment of SurgerySt.Paul's Sinus CentreVancouverBCCanada BC Cancer Research Centre Division of OtolaryngologyDepartment of SurgeryVancouverBCCanada Royal Surrey County Hospital Eserton RoadGuildfordUK PROOF Centre of Excellence St.Paul’s HospitalVancouverBCCanada James Hogs Research Centre St.Paul’s HospitalUniversity of British ColumbiaVancouverBCCanada

Objective:To identify the differences in cytokine expression between sinonasal tissue from patients treated with Leptospermum (Manuka) honey (LH) irrigation versus normal saline irrigation twice-daily for twelve weeks following sinus surgery (FESS).Methods:Forty-six CRS patients were *** tissue biopsies were collected during FESS and then at 5 and 12 weeks postoperatively during the course of treatment.A multiplex cytokine assay quantified the abundance of 17 cytokines in biopsied *** expression fold-change was analyzed between each time point using a robust linear regression model and compared between the two treatment ***:Compared to the saline irrigation group,five cytokines were differently expressed (CI =95%) in sinonasal tissue obtained from subjects in the LH irrigation group during the 12-week treatment *** IL-6 (P =0.0400),IL-8 (P =0.0398),MCP-1 (P =0.0284),and MIP-1β (P =0.016) were significantly increased in the LH irrigation group compared to the saline irrigation ***-13 was significantly increased in the saline irrigation group compared to the LH group (P =0.0086).Conclusion:LH may potentially act to modulate the expression of IL-6,IL-8,IL-13,MCP-1 and MIP-1β in sinonasal tissue.

关键词： Leptospermum honey Sinusitis Inflammation Postoperative care Irrigation

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