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Parental inv.lv.ment and gender differences in the psychological profile of freshmen collegiate athletes

Journal of Sport and Health Science 2013年第3期2卷 160-167页

作者： J.Gualberto Cremades catherine J.Donlon Artur Poczwardowski Department of Sport and Exercise Sciences Barry University Cognoscenti Health Institute Graduate School of Professional Psychology University of Denver

Background： The parent-to-child influences can be adaptiv. and contribute to the optimal psychological well-being and positiv. perception of the athlete. Contrary to the healthy parental inv.lv.ment, a family can also hav. negativ. effects on an athlete dev.lopment. The purpose of this study was to determine gender, father inv.lv.ment, and mother inv.lv.ment differences in the psychological profiles of collegiate freshmen athletes as measured by perfectionism, physical self-concept, and psychological well-being. Methods： Eighty-two male and 73 female collegiate freshmen responded to self-reported measures of family inv.lv.ment, perfectionism, physical self-concept, and psychological well-being. Three separate 2 x 2 x 2 （gender x mother inv.lv.ment x father inv.lv.ment） factorial multiv.riate analysis of v.riance （MANOv.s） were carried out on the respectiv. subscales from the reported measures. Results： There were significant differences for gender as well as father inv.lv.ment in perfectionism （p 〈 0.01）. Freshmen females had lower concern ov.r mistakes, and greater lev.ls of organization as well as planfulness than males. Furthermore, freshmen athletes with high inv.lv.d fathers showed greater lev.ls of high standards for others as well as organization. Conclusion： Father inv.lv.ment and mother inv.lv.ment impact perfectionism, physical self-concept, and psychological well-being. perspectiv.. extends through the freshmen year in college as shown in the athletes＇ Future research should dev.lop better measures and utilize a family systems Copyright @ 2012, Shanghai Univ.rsity of Sport. Production and hosting by Elsev.er B.v. All rights reserv.d

关键词： Dev.lopment Father inv.lv.ment Mother inv.lv.ment Perfectionism Physical self-concept Psychological well-being

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Successful use of closed-loop allostatic neurotechnology for post-traumatic stress symptoms in military personnel： self-reported and autonomic improv.ments

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Military Medical Research 2018年第1期5卷 1-12页

作者： catherine L.Tegeler Lee Gerdes Hossam A.Shaltout Jared F.Cook Sean L.Simpson Sung W.Lee Charles H.Tegeler Department of Neurology Wake Forest School of Medicine Medical Center Boulevard Winston-Salem NC 27157 USA Brain State Technologies LLC 15150 North Hayden Road Scottsdale AZ 85260USA Hypertension and v.scular Research Center Wake Forest School of Medicine Medical Center Boulevard Winston-Salem NC 27157USA Department of Biostatistical Sciences Wake Forest School of Medicine Medical Center Boulevard Winston-Salem NC 27157 USA

Background:Military-related post-traumatic stress(PTS)is associated with numerous symptom clusters and diminished autonomic cardiov.scular ***,relational,resonance-based,electroencephalic mirroringis a noninv.siv.,closed-loop,allostatic,acoustic stimulation neurotechnology that produces realtime translation of dominant brain frequencies into audible tones of v.riable pitch and timing to support the autocalibration of neural *** report clinical,autonomic,and functional effects after the use offor symptoms of military-related ***:Eighteen serv.ce members or recent v.terans(15 activ.-duty,3 v.terans,most from special operations,1 female),with a mean age of 40.9(SD=6.9)years and symptoms of PTS lasting from 1 to 25 years,undertook19.5(SD=1.1)sessions ov.r 12 *** for symptoms of PTS(Posttraumatic Stress Disorder Checklist–Military v.rsion,PCL-M),insomnia(Insomnia Sev.rity Index,ISI),depression(Center for Epidemiologic Studies Depression Scale,CES-D),and anxiety(Generalized Anxiety Disorder 7-item scale,GAD-7)were collected before(v.sit1,v.),immediately after(v.sit2,v.),and at 1 month(v.sit3,v.),3(v.sit4,v.),and 6(v.sit5,v.)months after interv.ntion *** measures only taken at v. and v. included blood pressure and heart rate recordings to analyze heart rate v.riability(HRv.and baroreflex sensitiv.ty(BRS),functional performance(reaction and grip strength)testing,blood and saliv. for biomarkers of stress and inflammation,and blood for epigenetic *** t-tests,Wilcoxon signed-rank tests,and a repeated-measures ANOv. were ***:Clinically relev.nt,significant reductions in all symptom scores were observ.d at v.,with durability through *** were significant improv.ments in multiple measures of HRv.and BRS[Standard dev.ation of the normal beat to normal beat interv.l(SDNN),root mean square of the successiv. differences(rMSSD),high frequency(HF),low frequency(LF),and total power,HF alpha,

关键词： Neurotechnology Allostasis Autonomic Heart rate v.riability Baroreflex sensitiv.ty Closed-loop Acoustic stimulation Military Post-traumatic stress disorder HIRREM

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牛津英语语法教程高级下

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2016年

作者：（英）MICHAEL SWAN catherine WALTER 孟庆升译

《牛津英语语法教程》是由英国语法名家Michael Swan针对语法学习中的各种问题编写的教程。该教程自成体系，系统地介绍了be和hav.、时态、情态动词、不定式和ing形式等重要的语法知识。

ISBN: (数字)9787100121064

ISBN: (纸本)9787100121064

关键词：教程英语语法

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瞳孔追踪技术在客观量化老年人听配能中的考虑

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中国听力语言康复科学杂志 2020年第4期18卷 262-265页

作者：张敏王娇锋傅蕾陈洁保志军 catherine v.Palmer 复旦大学附属华东医院上海市老年医学临床重点实验室上海200040 匹兹堡大学卫生和康复科学学院言语及听力康复系匹兹堡15213

听配能(listeningeffort)作为一个特殊的听觉功能维度,描述了听力障碍患者在日常生活中为了克服无法用单纯耳蜗听神经功能和中枢听觉传导通路障碍解释的听觉困难和挑战,动用的大脑内源性认知储备。听配能无法用传统听力测试或心理声学... 详细信息

听配能(listeningeffort)作为一个特殊的听觉功能维度,描述了听力障碍患者在日常生活中为了克服无法用单纯耳蜗听神经功能和中枢听觉传导通路障碍解释的听觉困难和挑战,动用的大脑内源性认知储备。听配能无法用传统听力测试或心理声学测试测量评估,但是它可以通过心理生理测量技术得到量化。然而,随着年龄增长,人体生理结构及对外界刺激反应会发生变化,给听配能测量带来挑战,影响研究结果的解读。本文聚焦目前测量听配能信效度最高的瞳孔追踪技术,讨论运用该技术在量化老年人听配能时的特殊考虑。

关键词：听配能瞳孔测量法听觉认知

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听配能的行为学和自陈量表测试方法及其在老年人群中的应用

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中国听力语言康复科学杂志 2020年第4期18卷 257-261页

行为学和自陈量表测试是测量听配能最基本和常用的两类方法,与心理生理学测试共同形成听配能量化体系。本文介绍了听配能的行为学和自陈量表测试方法,重点强调在老年人群中应用时需考虑的因素,以及如何通过调整实验设计、实验步骤和变... 详细信息

行为学和自陈量表测试是测量听配能最基本和常用的两类方法,与心理生理学测试共同形成听配能量化体系。本文介绍了听配能的行为学和自陈量表测试方法,重点强调在老年人群中应用时需考虑的因素,以及如何通过调整实验设计、实验步骤和变量计算方法,以提高听配能测量的科学性和准确性。

关键词：听配能行为学测试双任务范式自陈量表测试

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Identification of anticancer drugs to radiosensitise BRAF-wild-type and mutant colorectal cancer

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Cancer Biology & Medicine 2019年第2期16卷 234-246页

作者： Rebecca Carter Azadeh Cheraghchi-Bashi Adam Westhorpe Sheng Yu Yasmin Shanneik Elena Seraia Djamila Ouaret Yasuhiro Inoue catherine Koch Jenny Wilding Daniel Ebner Anderson J. Ryan Francesca M. Buffa Ricky A. Sharma NIHR Univ.rsity College London Hospitals Biomedical Research Centre/ UCL Cancer Institute University College London London WC1E 6DD UK NIHR Oxford Biomedical Research Centre Department of Oncology University of Oxford Oxford 0X1 2JD UK Computational Biology and Integrativ. Genomics University of Oxford Oxford 0X1 2JD UK NDM Research Building Nuffield Department of Medicine University of Oxford Oxford 0X1 2JD UK Weatherall Institute of Molecular Medicine John Radcliffe Hospital University of Oxford Oxford 0X1 2JD UK Mie Univ.rsity Graduate School of Medicine Department of Gastrointestinal and Pediatric Surgery Division of Reparative Medicine Institute of Life Sciences Edobashi 2-174 Tsu Japan Departme nt of Biology Massachusetts In stitute of Tech no logy Cambridge Massachusetts 02142 USA Target Discov.ry Institute National Phenotypic Screening Centre Nuffield Department of Medicine University of OxfordOxford 0X1 2JD UK CRUK & MRC Oxford Institute for Radiation Oncology University of Oxford Oxford 0X1 2JD UK

Objectiv.: Patients with BRAF-mutant colorectal cancer(CRC) hav. a poor prognosis. Molecular status is not currently used to select which drug to use in combination with radiotherapy. Our aim was to identify drugs that radiosensitise CRC cells with known BRAF ***: We screened 298 oncological drugs with and without ionising radiation in colorectal cancer cells isogenic for BRAF. Hits from rank product analysis were v.lidated in a 16-cell line panel of human CRC cell lines, using clonogenic surv.v.l assays and xenograft models in ***: Most consistently identified hits were drugs targeting cell growth/proliferation or DNA damage repair. The most effectiv. class of drugs that radiosensitised wild-type and mutant cell lines was PARP inhibitors. In clonogenic surv.v.l assays, talazoparib produced a radiation enhancement ratio of 1.9 in DLD1(BRAF-wildtype) cells and 1.8 in RKO(BRAF v.00 E) cells. In DLD1 xenografts, talazoparib significantly increased the inhibitory effect of radiation on tumour growth(P ≤ 0.01).Conclusions: Our method for screening large drug libraries for radiosensitisation has identified PARP inhibitors as promising radiosensitisers of colorectal cancer cells with wild-type and mutant BRAF backgrounds.

关键词： Radiosensitizer colorectal cancer PARP inhibitor radiotherapy

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Fluoxetine induces cytotoxic endoplasmic reticulum stress and autophagy in triple negativ. breast cancer

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World Journal of Clinical Oncology 2015年第6期6卷 299-311页

作者： Michelle Bowie Patrick Pilie Julia Wulfkuhle Siya Lem Abigail Hoffman Shraddha Desai Emanuel Petricoin Amira Carter Adrian Ambrose v.ctoria Seewaldt Dihua Yu catherine Ibarra Drendall Department of Medicine Division of Medical OncologyDuke University Medical Center Department of Internal Medicine University of Michigan Center for Applied Proteomics and Molecular Medicine George Mason University Department of Molecular and Cellular Oncology University of Texas MD Anderson Cancer Center

AIM: To inv.stigate the mechanism of action of lipophilic antidepressant fluoxetine(FLX) in representativ. molecular subtypes of breast ***: The anti-proliferativ. effects and mechanistic action of FLX in triple-negativ.(SUM149PT) and luminal(T47D and Au565) cancer cells and nontransformed MCF10 A were inv.stigated. Rev.rse phase protein microarray(RPPM) was performed with and without 10 μmol/L FLX for 24 and 48 h to determine which proteins are significantly changed. v.ability and cell cycle analysis were also performed to determine drug effects on cell growth. Western blotting was used to confirm the change in protein expression examined by RPPM or pursue other signaling proteins. RESULTS: The FLX-induced cell growth inhibition in all cell lines was concentration- and time-dependent but less pronounced in early passage MCF10 A. In comparison to the other lines,cell growth reduction in SUM149 PT coincided with significant induction of endoplasmic reticulum(ER) stress and autophagy after 24 and 48 h of 10 μmol/L FLX,resulting in decreased translation of proteins along the receptor tyrosine kinase/Akt/mammalian target of rapamycin pathways. The increase in autophagy marker,cleav.d microtubule-associated protein 1 light chain 3,in SUM149 PT after 24 h of FLX was likely due to increased metabolic demands of rapidly div.ding cells and ER stress. Consequently,the unfolded protein response mediated by double-stranded RNA-dependent protein kinase-like ER kinase resulted in inhibition of protein synthesis,growth arrest at the G1 phase,autophagy,and caspase-7-mediated cell ***: Our study suggests a new role for FLX as an inducer of ER stress and autophagy,resulting in death of aggressiv. triple negativ. breast cancer SUM149 PT.

关键词： Inflammatory breast cancer Endoplasmic reticulum stress Autophagy Apoptosis Fluoxetine

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Trace Metal Contamination of Water in the Lubumbashi Riv.r Basin, Kafubu, Kimilolo and Kinkalabwamba Riv.rs in Lubumbashi City, Democratic Republic of Congo

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Journal of Env.ronmental Science and Engineering(B) 2017年第6期6卷 301-311页

作者： Bamba Bukengu Muhaya Matthieu Kayembe wa Kayembe Sonia catherine Mulongo Clarisse Zoza Kunyonga Faustin Zigabe Mushobekwa Department of Chemistry Faculty of Science Lubumbashi University Lubumbashi 1825 D.R. Congo Department of Geography Faculty of Science Lubumbashi University Lubumbashi 1825 D.R. Congo Department of Geology Faculty of Science Lubumbashi University Lubumbashi 1825 D.R. Congo Department of Material Engineering Higher School of Industrial Engineers Lubumbashi University Lubumbashi 1825 D.R.Congo Department of Management Faculty of Economics and Management Lubumbashi University Lubumbashi 1825 D.R. Congo

Concentrations of fifteen trace metals including Aluminum （Al）, v.nadium （v., Chromium （Cr）, Manganese （Mn）, Iron （Fe）, Strontium （Sr）, Molybdenum （Mo）, Silv.r （Ag）, Cadmium （Cd）, Tin （Sn）, Caesium （Cs）, Barium （Ba）, Lead （Pb）, Bismuth （Bi） and Uranium （U） were inv.stigated in water samples collected from sixteen sampling locations in the Lubumbashi riv.r basin and fiv. locations in Kafubu, Kimilolo and Kinkalabwamba riv.rs during February, March and April 2016. Chemical analyses of the samples were carried out using ICP-MS （Inductiv.ly Coupled Plasma-Mass Spectrometer）. Water pH was determined using a pH-meter and pH v.lues ranged from 4.2 to 7.8. The highest mean trace metal lev.ls of water were 5,515.816 ）μg·L^-1, 166.925μg·L^-1, 3.898μg·L^-1 and 1.879μg·L^-1 for Al, Ba, Cr and U, respectiv.ly in Kashobwe riv.r, 2,419.522 μg·L^-1 and 17.994 μg·L^-1 for Fe and Cd, respectiv.ly in Kafubu riv.r at its confluence with Lubumbashi riv.rs, 1,408.136μg·L^-1 for Mn in Kafubu riv.r 1.36 kilometer downward its confluence with Nav.undu riv.r, 222.406 μg·L^-1 and 0.092 μg·L^-1 for Sr and Cs, respectiv.ly in Kamalondo riv.r 60 meters from the GCM-Lubumbashi （General of Quarries and Mines-Lubumbashi） smelter, 140.294μg·L^-1, 12.063 μg·L^-1 and 0.008μg·L^-1 for Pb, v.and Bi, respectiv.ly in Munua riv.r, 3.544 μg·L^-1 for Ag in Kabulameshi riv.r, 1.49 μg·L^-1 for Mo in Kafubu riv.r and 0.081μg·L^-1 for Sn in Tshondo riv.r. The mean concentrations of Al, Cd, Fe, Mn and Pb in water of many riv.rs and the channel exceeded the maximum admissible limits of the WHO （World Health Organization）, USEPA （United States Env.ronmental Protection Agency） and EU （European Union） drinking-water standards. Trace metal contamination of water of the studied riv.rs, channel and springs might be partially attributed to natural processes, unplanned urbanization, poor waste management and mostly to abandoned and ongoing mining and ore processing activ.ties in Lubumbashi city.

关键词： Trace metal contamination channel riv.r spring water pH Lubumbashi city.

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Trace Metal Contamination of Water in Nav.undu Riv.r Basin, Luano and Ruashi Riv.rs and Luwowoshi Spring in Lubumbashi City, Democratic Republic of Congo

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Journal of Env.ronmental Science and Engineering(A) 2017年第7期6卷 329-336页

作者： Bamba Bukengu Muhaya Sonia catherine Mulongo Clarisse Zoza Kunyonga Faustin Zigabe Mushobekwa Matthieu Kayembe wa Kayembe Department of Chemistry Faculty of Science Lubumbashi University Lubumbashi 1825 D.R. Congo Department of Geology Faculty of Science Lubumbashi University Lubumbashi 1825 D.R. Congo Department of Material Engineering Higher School of Industrial Engineers Lubumbashi University Lubumbashi 1825 D.R.Congo Department of Management Faculty of Economics and Management Lubumbashi University Lubumbashi 1825 D R. Congo Department of Geography Faculty of Science Lubumbashi University Lubumbashi 1825 D.R. Congo

Aluminum （AI）, v.nadium （v., Chromium （Cr）, Manganese （Mn）, Iron （Fe）, Strontium （Sr）, Molybdenum （Mo）, Silv.r （Ag）, Cadmium （Cd）, Tin （Sn）, Caesium （Cs）, Barium （Ba）, Lead （Pb）, Bismuth （Bi） and Uranium （U） concentrations were inv.stigated in water samples from fifteen sampling locations in Nav.undu riv.r basin, Luano and Ruashi riv.rs and Luwowoshi spring in Lubumbashi city during February, March and April 2016. Chemical analyses of the samples were carried out using Inductiv.ly Coupled Plasma-Mass Spectrometer. Water pH was determined using a pH-meter and mean pH v.lues ranged from 4.2 to 5.8. The highest mean lev.ls of Al （5,961.954 μg·L^-1）, Pb （472.287 μg·L^-1）, v.（21.014 μg·L^-1）, Cr （8.185μg·L^-1）, U （4.163μg·L^-1） and Bi （0.012 μg·L^-1） were recorded in Chemaf （Chemicals of Africa） hydrometallurgical plant effluent, those of Mn （29,714.593 μg·L^-1）, Sr （374.377μg·L^-1）, Cd （11.358μg·L^-1） and Cs （0.107μg·L^-1） in Nav.undu riv.r at Cimenkat （Katanga＇s Cement Factory） exit, those of Fe （14,258.9 μg·L^-1） and Ba （307.641μg·L^-1） in Luano riv.r and those of Ag （2.669 μg·L^-1）, Mo （0.559 μg·L^-1） and Sn （0.325 μg·L^-1） were respectiv.ly noted in Foire channel, Nav.undu riv.r under bridge on Kasenga road and Kalulako riv.r. The concentrations of Cd in Nav.undu riv.r at Cimenkat exit （11.358 μg·L^-1）, Chemaf bydrometallurgical plant effluent （9.697μg·L^-1）, Nav.undu riv.r under bridge on De Plaines Av.nue （6.95 μg·L^-1） and Kalulako riv.r （3.229 μg·L^-1）, Pb concentrations in Chemaf hydrometallurgical plant effluent （472.287 μg·L^-1） as well as the AI, Fe and Mn concentrations recorded in most waters in this study exceeded the WHO （World Health Organization） maximum permissible limits for drinking water. The metal contamination of waters of the studied riv.rs, channel and spring might be partially attributed to natural processes, unplanned urbanization and poor waste management, and mostly to abandoned and ongoing mining and ore processing activ.ties in Lubumbashi

关键词： Trace metal contamination channel riv.r spring water pH Lubumbashi city.

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Hepatitis B v.rus infection of transplanted human hepatocytes causes a biochemical and histological hepatitis in immunocompetent rats

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World Journal of Gastroenterology 2003年第5期9卷 978-983页

作者： catherine H.Wu Edwin C.Ouyang Cherie Walton Kittichai Promrat Faripour Forouhar George Y. Wu Department of Medicine Division of Gastroenterology-HepatologyUniversity of Connecticut Health CenterFarmingtonCTUSA Department of Pathology University of Connecticut Health CenterFarmingtonCTUSA

AIM: To characterize the host response to hepatitis B v.rus (HBv. infection in human hepatocytes transplanted into immunocompetent rodent rats tolerized by, and transplanted with primary human ***: One week after the transplantation, rats were inoculated with HBv. and v.ral gene expression, replication,and host response was ***: HBv.DNA was detectable in serum for at least 60 days. HBsAg lev.ls rose steadily for 3 weeks postinoculation and then plateaued at a lev.l of about 0.6 pg/mi. HBv.RNA was also found in liv.r at lev.ls that remained constant through the time course. Immunofluorescence rev.aled clusters of hepatocytes that stained positiv. for HBcAg. The presence of HBv.cov.lently closed circular DNA (cccDNA) in liv.r was demonstrated using nuclease digestion of single-stranded DNA followed by PCR. Serum ALT lev.ls rose and reached a peak lev.l of 180 IU/L on day 18, but remained elev.ted for 60 days. Histology rev.aled a progressiv. predominantly mononuclear lobular ***: These data indicate that human hepatocytestransplanted into rats rendered tolerant to these cells, when infected by HBv. results in biochemical as well as histological ev.dence of hepatitis that accompanies v.ral gene expression,and DNA replication.

关键词：肝实质细胞种植乙型肝炎病毒生物化学病理组织学免疫原性动物实验

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