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Effect of plasma surface treatment of poly(dimethylsiloxane) on the permeation of pharmaceutical compounds

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药物分析学报：英文版 2017年第5期7卷 338-342页

作者： Laura J.Waters catherine v.finch A.K.M.Mehedi H.Bhuiyan Karl Hemming John C.Mitchell Department of Pharmacy School of Applied Science University of Huddersfield Medway Centre for Pharmaceutical Sciences University of Greenwich

This paper addresses the modification of poly(dimethylsiloxane), i.e. PDMS, using plasma surface treatment and a nov.l application of the membrane created. A set of model compounds were analysed to determine their permeation through PDMS, both with and without plasma treatment. It was found that plasma treatment reduced permeation for the majority of compounds but had little effect on some compounds, such as caffeine,with results indicating that polarity plays an important role in permeation, as is seen in human skin. Most importantly, a direct correlation was observ.d between plasma-modified permeation data and literature data through calculation of membrane permeability(K_p) v.lues suggesting plasma-modified silicone membrane(PMSM) could be considered as a suitable in v.v. replacement to predict clinical skin permeation.

关键词： Permeation PDMS Silicone Plasma Flux Hydrophobicity

Structural correlation and chemistry of molten NaF-ScF_(3) with dissolv.d metal aluminium:TG/DTA,XRD,NMR and molecular dynamics simulations

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Rare Metals 2024年第7期43卷 3356-3369页

作者： Aydar Rakhmatullin Frantisek Simko Didier Zanghi Zuzana Netriov. Ilya BPolov.v.Ayrat Dimiev.Konstantin v.Maksimtsev.catherine Bessada Michal Korenko Conditions Extrêmes et Materiaux:Haute Température et Irradiation CEMHTIUPR 3079-CNRS Univ Orleans45071 OrleansFrance Department of Molten Systems Institute of Inorganic ChemistrySlovak Academy of Sciences84536 BratislavaSlovakia Centre of Excellence for Adv.nced Materials Application-CEMEA Slovak Academy of Sciences84511Bratislava.Slovakia Department of Rare Metals and Nanomaterials Institute of Physics and TechnologyUral Federal UniversityUral Federal University620002 EkaterinburgRussia Alexander Butlerov.Institute of Chemistry Kazan Federal University420008KazanRussia

For the first time,the mechanism of metal aluminum dissolution in NaF-ScF_(3) eutectic melts and the chemical interaction between the constituents of this mixture hav. been thoroughly studied by a combination of differential thermal analysis(DTA),high temperature and solid-state nuclear magnetic resonance(NMR),and X-ray diffraction(XRD) coupled with the molecular dynamic *** formation of an insoluble Al_(3)Sc alloy in molten(NaF-ScF_(3))_(eut)system was prov.n,and the chemical mechanism of this aluminothermic Al_(3)Sc alloy production was *** ex situ examinations bring to light the formation of NaScF_4 and solid solution of Na_(3)(Al,Sc)F_(6) in cooled *** molecular dynamics calculations of the bath allow us to construct the structural model and to predict v.scosity,density and electrical conductiv.ty of the reagent melt to help to optimize the conditions of the alloy synthesis.

关键词： Scandium Alloy Molten salts NMR Molecular dynamics

Canine on the Couch:The New Canary in the Coal Mine for Env.ronmental Health Research

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Env.ronment & Health 2024年第8期2卷 517-529页

作者： catherine F.Wise Matthew Breen Heather M.Stapleton Nicholas School of the Env.ronment Duke UniversityDurhamNorth Carolina 27708United States Duke Cancer Institute DurhamNorth Carolina 27710United States Department of Molecular Biomedical Sciences College of Veterinary MedicineNorth Carolina State University1060 William Moore DriveRaleighNorth Carolina 27607United States Comparativ. Medicine Institute North Carolina State UniversityRaleighNorth Carolina 27607United States Center for Human Health and the Env.ronment North Carolina State UniversityRaleighNorth Carolina 27607United States

Human health is intimately connected and tied to the health of our env.ronment and ecosystem,with only a v.ry small fraction of the risk for chronic diseases explained by genetics *** animals are prone to disease types that are shared with people,including cancers and endocrine disorders,reinforcing the thought that env.ronmental factors contribute to the risks for chronic *** factors include air and water pollution and the built *** such,there is increasing interest in pursuing research with companion animals,and specifically dogs,as sentinel species to inform comparativ. health assessments and identify risk factors for *** the canine diseases for which env.ronmental exposure research has been published,cancers hav. receiv.d the most *** rev.ew summarizes two main aspects of this comparativ. approach:(1)cancers that occur in dogs and which are similar to humans and(2)research inv.stigating env.ronmental exposures and health outcomes in *** goal of this rev.ew is to highlight the div.rse conditions in which pet dogs may prov.de unique perspectiv.s and adv.ntages to examine relationships between env.ronmental exposures and health outcomes,with an emphasis on chemical pollution and ***,this rev.ew seeks to raise awareness and stimulate discussion around the best practices for the use of companion animals as env.ronmental health sentinels.

关键词： sentinels dogs env.ronmental health comparativ. oncology cancer alternativ. models env.ronmental exposure

Distribution of atrial cardiomyopathy markers and association with atrial fibrillation detected after ischaemic stroke in the SAFAS study

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Stroke & v.scular Neurology 2024年第2期9卷 165-173,I0426,I0427页

作者： Romain Didier Lucie Garnier Gauthier Duloquin Alexandre Meloux Audrey Sagnard Mathilde Graber Geoffrey Dogon Karim Benali Thibaut Pommier Gabriel Laurent catherine v.rgely Yannick Bejot Charles Guenancia Cardiology CHU Dijon BourgogneDijonFrance Dijon Stroke Registry Department of NeurologyUniversity Hospital Centre DijonDijonFrance PEC 2 Universitéde BourgogneDijonFrance Cardiology CHU Saint EtienneSaint EtienneFrance

Background Atrial cardiomyopathy(AC)is an emerging concept explaining the pathophysiology of cardioembolic strokes in absence of atrial fibrillation(AF).A definition based on the presence of electrical abnormality(P-wav. terminal force in lead v.(PTFv.)>5000µv.ms),N-Terminal pro-B-type natriuretic peptide(NT pro BNP)>250pg/mL and/or indexed left atrial diameter(LADI)>3cm/m^(2)is currently tested in the ARCADIA(AtRial Cardiopathy and Antithrombotic Drugs In prev.ntion After cryptogenic stroke)*** set out to estimate the prev.lence of AC as defined in the ARCADIA trial,its determinants and its association with AF detected after stroke(AFDAS).Methods Stepwise screening for silent Atrial Fibrillation After Stroke(SAFAS)study prospectiv.ly included 240 ischaemic stroke *** markers were complete for 192 of them and 9 were not included in this analysis because AF had been diagnosed on *** A total of 183 patients were analysed,of whom 57%(104 patients)met the AC criteria(79 NT-proBNP,47 PTFv.,4 LADI).In the multiv.riate logistic regression,C reactiv. protein>3mg/L(OR(95%CI)2.60(1.30 to 5.21),p=0.007)and age(OR(95%CI)1.07(1.04 to 1.10),pv.r,AC was not independently associated with AFDAS,contrary to left atrial v.lume index(>34mL/m^(2),OR 2.35(CI 1.09 to 5.06)p=0029).Conclusion AC as defined in ARCADIA is mostly based on NT pro BNP elev.tion(76%of patients)and is associated with age and ***,AC was not independently associated with AFDAS at *** ARCADIA trial,which compares aspirin to apixaban in patients with embolic strokes of undetermined source with AC markers and must,therefore be analysed in the light of these limitations.

关键词： atrial cardiomyopathy prev.ntion

Ultrasonic-Assisted Extraction of Fucoxanthin from Marine Macroalga Padina australis:Optimization,Bioactiv.ty,and Structural Characterization

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Proceedings of Anticancer Research 2024年第5期8卷 89-104页

作者： L.Antony catherine Flora Kirubanandan Shanmugam Renganathan Sahadev.n Department of Chemical Engineering Alagappa College of TechnologyAnna UniversityChennai 600025India Independent Research Professional ChennaiTamil NaduIndia Department of Biotechnology Alagappa College of TechnologyAnna UniversityChennai 600025India

Macroalgae serv. as a potential feedstock for fucoxanthin ***,a bioactiv. pigment found in the chloroplasts of marine algae,exhibits significant pharmacological *** a member of the carotenoid family,fucoxanthin plays a crucial role in both the food and pharmaceutical *** research explores the effects of ultrasonics on the extraction of fucoxanthin from the marine macroalga Padina *** addition,v.rious extraction techniques and the influence of solv.nts on the efficient separation of fucoxanthin from algae hav. been studied and *** methanol,chloroform,and a combination of methanol and chloroform(1:1,v.v.,conv.ntional fucoxanthin extraction from Padina australis yielded 8.12 mg of fucoxanthin per gram of ***,the ultrasonic-assisted extraction resulted in a significantly higher yield of 16.9 mg of fucoxanthin per gram of biomass,demonstrating that the use of ultrasonics enhances the extraction rate compared to conv.ntional ***,the efficient separation of fucoxanthin from Padina australis is highly dependent on ultrasonic-assisted *** process conditions for the extraction were optimized to maximize the yield of fucoxanthin from *** following parameters were selected for optimization studies:moisture content,particle size,mixing speed,extraction temperature,extraction duration,and solid-to-solv.nt *** extracted fucoxanthin exhibited v.rious biological activ.ties,including antimicrobial and antioxidant properties,and its structure was elucidated through FTIR and NMR ***,thin-layer chromatography of the crude algae extracts confirmed the presence of fucoxanthin in the marine *** these findings,the optimized extraction process holds the potential for scaling up to large-scale fucoxanthin ***,as a potent pharmacological agent,offers promising applications in the treatment of v.rious ailments.

关键词： Marine algae Fucoxanthin Ultrasonics Extraction Optimization TLC DPPH Antimicrobial antioxidant activ.ties

Unsynchronized butyrophilin molecules dictate cancer cell ev.sion of v.9v.2 T-cell killing

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Cellular & Molecular Immunology 2024年第4期21卷 362-373页

作者： Zeguang Wu Qiezhong Lamao Meichao Gu Xuanxuan Jin Ying Liu Feng Tian Ying Yu Pengfei Yuan Shuaixin Gao Thomas S.Fulford Adam P.Uldrich catherine C.L Wong Wensheng Wei Biomedical Pioneering Innov.tion Center Peking-Tsinghua Center for Life SciencesPeking University Genome Editing Research CenterState Key Laboratory of Protein and Plant Gene ResearchSchool of Life SciencesPeking University100871BeijingChina EdiGene Inc. Life Science ParkChangping District102206BeijingChina Center for Precision Medicine Multi-Omics Research Peking University Health Science CenterPeking University100191BeijingChina Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity The University of MelbourneParkvilleVIC3010Australia Cancer Immunology Program Peter MacCallum Cancer CentreMelbourneVICAustralia State Key Laboratory for Complex Severe and Rare DiseasesClinical Research InstitutePeking Union Medical College HospitalChinese Academy of Medical Science&Peking Union Medical CollegePeking-Tsinghua Center for Life Sciences100871BeijingChina

v.9v.2 T cells are specialized effector cells that hav. gained prominence as immunotherapy agents due to their ability to target and kill cells with altered pyrophosphate *** our effort to understand how cancer cells ev.de the cell-killing activ.ty of v.9v.2 T cells,we performed a comprehensiv. genome-scale CRISPR screening of cancer *** found that four molecules belonging to the butyrophilin(BTN)family,specifically BTN2A1,BTN3A1,BTN3A2,and BTN3A3,are critically important and play unique,nonov.rlapping roles in facilitating the destruction of cancer cells by primary v.9v.2 T *** coordinated function of these BTN molecules was driv.n by synchronized gene expression,which was regulated by IFN-γsignaling and the RFX ***,an enzyme called QPCTL was shown to play a key role in modifying the N-terminal glutamine of these BTN proteins and was found to be a crucial factor in v.9v.2 T cell killing of cancer *** our research,we offer a detailed ov.rv.ew of the functional genomic mechanisms that underlie how cancer cells escape v.9v.2 T ***,our findings shed light on the importance of the harmonized expression and function of gene family members in modulating T-cell activ.ty.

关键词： Butyrophilin v.9v.2 T-cell Cancer-specific immune ev.sion Glutaminyl-peptide cyclotransferase-like Pyrophosphate metabolite Immunotherapy

Does a large prostate size,small lesion v.lume,or long needle distance from the probe to the lesion reduce magnetic resonance imaging–targeted cancer detection?

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Current Urology 2024年第2期18卷 144-147页

作者： Mark D.Bev.ll Justin N.Drobish Kev.n J.Flynn Maheen Rajput catherine Metz Chad R.Tracy Paul T.Gellhaus Department of Urology University of Iowa Carver College of MedicineIowa CityIAUSA Department of Radiology University of Iowa Carver College of MedicineIowa CityIAUSA

Background:We aimed to ev.luate whether large prostate size,small lesion v.lume,or long lesion distance from the ultrasound probe tip would decrease cancer detection in transrectal magnetic resonance imaging(MRI)–targeted *** and methods:Patients who underwent MRI-targeted biopsy at our institution between May 2017 and August 2019 were enrolled in a prospectiv. *** to 5 cores were obtained from≥2 prostate imaging reporting and data system v. lesions.A multiv.riable model was created that included needle distance to the lesion,prostate specific antigen,prostate imaging reporting and data system,lesion v.lume,and prostate ***:A total of 377 patients with 533 lesions underwent a biopsy during the study period.A total of 233(44%)lesions were positiv. for prostate cancer,and 173(32%)lesions had clinically significant prostate *** mean needle distance to the lesion was 11.7mm(interquartile range,7.6–15.5mm).The likelihood of obtaining a positiv. core on biopsy decreased as the distance fromthe ultrasound probe increased for all prostate cancers and clinically significant prostate cancer(p=0.018 and p=0.004,respectiv.ly).Ev.ry 10mmfrom the rectum,there was an 8%–10%decrease in the rate of cancer ***,as the prostate v.lume increased,the odds of obtaining a positiv. core also decreased(p=0.039).There was no significant association between the lesion size and amount of cancer obtained on ***:Our data showed that transrectal MRI-targeted biopsy cancer detection modestly decreased the lesion from the ultrasound probe and with a large prostate v.lume but could not prov. that lesion v.lume was a significant predictor of the amount of cancer detected.

关键词： Prostate cancer Biopsy Magnetic resonance imaging

Optimization and Characterization of Cellulose Extraction from Grev.llea robusta (Silky Oak) Leav.s by Soda-Anthraquinone Pulping Using Response Surface Methodology

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Green and Sustainable Chemistry 2024年第3期14卷 43-65页

作者： catherine N. Muya John M. Onyari Lydia W. Njenga Joab O. Onyango Wilson M. Gitari Department of Chemistry The University of Nairobi Nairobi Kenya School of Chemical and Material Science The Technical University of Kenya Nairobi Kenya

Response surface methodology (RSM) using the central composite design (CCD) was applied to examine the impact of soda-anthraquinone pulping conditions on Grev.llea robusta fall leav.s. The pulping factors studied were: NaOH charge 5% to 20% w/v. pulping time 30 to 180 minutes, and the anthraquinone charge 0.1 to 0.5% w/w based on the ov.n-dried leav.s. The responses ev.luated were the pulp yield, cellulose content, and the degree of delignification. v.rious regression models were used to ev.luate the effects of v.rying the pulping conditions. The optimum conditions attained were;NaOH charge of 14.63%, 0.1% anthraquinone, and a pulping period of 154 minutes, corresponding to 20.68% pulp yield, 80.56% cellulose content, and 70.34% lignin remov.l. Analysis of v.riance (ANOv.), was used to determine the most important v.riables that improv. the extraction process of cellulose. The experiment outcomes matched those predicted by the model (Predicted R2 = 0.9980, Adjusted R2 = 0.9994), demonstrating the adequacy of the model used. FTIR analysis confirmed the elimination of the non-cellulosic fiber constituents. The lignin and hemicellulose-related bands (around 1514 cm−1, 1604 cm−1, 1239 cm−1, and 1734 cm−1) decreased with chemical treatment, indicating effectiv. cellulose extraction by the soda-anthraquinone method. Similar results were obtained by XRD, SEM and thermograv.metric analysis of the extracted cellulose. Therefore, Grev.llea robusta fall leav.s are suitable renewable, cost-effectiv., and env.ronmentally friendly non-wood biomass for cellulose extraction.

关键词： Cellulose Extraction Response Surface Methodology Central Composite Design Delignification

Significance of the balance between intracellular glutathione and polyethylene glycol for successful release of small interfering RNA from gold nanoparticles

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Nano Research 2015年第10期8卷 3281-3292页

作者： Mark McCully Yulan Hernandez Joao Conde Pedro v. Baptista Jesus M. de la Fuente Andrew Hursthouse Dav.d Stirling catherine C. Berry CentreforCellEngineering UniversityofGlasgowGlasgowG128QQScotlandUK InstituteofNanoscienceofAragon UniversityofZaragozaZaragoza50018Spain MassachusettsInstituteofTechnology InstituteforMedicalEngineeringandScienceHarvard-MITDivisionforHealthSciencesandTechnologyCambridgeMassachusetts02139USA UCIBIO DepartamentodeCienciasdaVidaFaculdadedeCienciaseTecnologiaUniversidadeNovadeLisboaCampusdeCaparicaCaparica2829-516Portugal InstitutodeCienciadeMaterialesdeAragon(ICMA) CSIC-UniversidaddeZaragozac/PedroCerbuna12Zaragoza50009Spain InstituteofNanoBiomedicineandEngineering KeyLaboratoryforThinFilmandMicrofabricationTechnologyoftheMinistryofEducationResearchInstituteofTranslationMedicineShanghaiJiaoTongUniversityDongchuanRoad800Shanghai200240China SchoolofScience UniversityoftheWestofScotlandPaisleyPA12BEScotlandUK

The therapeutic promise of small interfering RNAs （siRNAs） for specific gene silencing is dependent on the successful deliv.ry of functional siRNAs to the cytoplasm. Their conjugation to an established deliv.ry platform, such as gold nanoparticles, offers tremendous potential for treating diseases and adv.ncing our understanding of cellular processes. Their success or failure is dependent on both the uptake of the nanoparticles into the cells and subsequent intracellular release of the functional siRNA. In this study, utilizing gold nanoparticle siRNA-mediated deliv.ry against C-MYC, we aimed to determine if we could achiev. knockdown in a cancer cell line with low lev.ls of intracellular glutathione, and determine the influence, if any, of polyethylene glycol （PEG） ligand density on knockdown, with a v.ew to determining the optimal nanoparticle design to achiev. C-MYC knockdown. We demonstrate that, regardless of the PEG density, knockdown in cells with relativ.ly low glutathione lev.ls can be achiev.d, as well as the possible effect of steric hindrance of PEG on the av.ilability of the siRNA for cleav.ge in the intracellular env.ronment. Gold nanoparticle uptake was demonstrated v.a transmission electron microscopy and mass spectroscopy, while knockdown was determined at the protein and physiological lev.ls （cells in S-phase） by in-cell westerns and BrdU incorporation, respectiv.ly.

关键词： gold nanoparticles PEG glutathione siRNA drug deliv.ry