检索结果-南通市图书馆

Glucose-6-Phosphate Dehydrogen.se Deficien.y: Difficulties in.Diagn.sis at the Souro San.u Un.versity Hospital, Burkin. Faso

引用

Open.Journ.l of Blood Diseases 2023年第1期13卷 24-32页

作者： Salifo Sawadogo Koumpin.n.n.n.bié Jerôme Kouldiati catherine Traoré Salam Sawadogo Aimée S. Kissou Eléon.re Kafan.o Souro San.u Un.versity Hospital Bobo-Dioulasso Burkina Faso n.tion.l Blood Tran.fusion.Cen.er Ouagadougou Burkina Faso Yalgado Ouédraogo Un.versity Hospital Ouagadougou Burkina Faso Charles De Gaule Un.versity Pediatric Hospital Ouagadougou Burkina Faso

Glucose-6-phosphate dehydrogen.se deficien.y is the most common.en.ymopathy worldwide. The precise prevalen.e of G6PD is un.n.wn.in.Burkin. Faso. The objective of the study was to describe the difficulties to diagn.se this disease at the Souro San.u Un.versity hospital (CHUSS) in.Bobo-Dioulasso. It in.olved five patien.s comprisin. on. child with homozygous SS sickle cell disease, on. adolescen. screen.d followin. a family in.estigation. an. three adults in.ludin. a man.an. two women. Blood smear stain.d with May Grun.ald Giemsa was performed to look for specific sign. of G6PD-deficien. red blood cell an. brillian. cresyl Blue for Hein. Bodies. A microscope Olympus BX53 equipped with a Camera (XC10) an. con.ected to a computer was used to read blood smears an. capture images. Gen.s sequen.in. by San.er method were performed in.a specialized laboratory in.molecular gen.tics. For each an.lysis, the protocol an. in.truction. of the equipmen. an. reagen. man.facturer were applied. Of the five patien.s, three had an.mia an. on.y on. had hyperreticulocytosis. Two patien.s had biological sign. of hemolysis an. on. patien. had an.elevated CRP. Blood smear stain.d with MGG an. cresyl blue showed specific sign. of G6PD-deficien. red blood cells an. Hein. bodies in.all patien.s. Biochemical an.lysis an. molecular typin. con.irmed G6PD deficien.y. The presen.e of G6PD-deficien. red blood cells in.the blood smear guides the diagn.sis of G6PD deficien.y. The diagn.sis is biochemical an. is based on.the combin.d measuremen. of G6PD plus pyruvate kin.se an./or hexokin.se.

关键词： G6PD Deficien.y G6PD-Deficien. Red Cell Diagn.sis Difficulties Burkin. Faso

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Den.al impact of an.i-fibroblast growth factor 23 therapy in.X-lin.ed hypophosphatemia

引用

In.ern.tion.l Journ.l of Oral Scien.e 2023年第4期15卷 691-700页

作者： Elis J.Lira dos San.os Ken.a n.kajima Julien.Po Ayako Han.i Volha Zhukouskaya Martin.Biosse Duplan.Agn.s Lin.lart Takashi Shimada catherine Chaussain.Claire Bardet Un.versitéParis Cité Institut des maladies musculo-squelettiquesLaboratory Orofacial PathologiesImaging and Biotherapies URP2496 and FHU-DDS-NetDental Schooland Plateforme d’Imagerie du Vivant(PIV)MontrougeFrance R&D Division Kyowa KirinCo.Ltd3-6-6 Asahi-machiMachida-shiTokyoJapan Un.versitéParis Cité Institut ImagineINSERM UMR 1163ParisFrance AP-HP Reference Center for Rare Disorders of the Calcium and Phosphate MetabolismDental Medicine DepartmentBretonneau HospitalGHN-UniversitéParis CitéParisFrance Paris-Saclay Un.versity AP-HPINSERM U1185DMU SEAEndocrinology and Diabetes for ChildrenReference Center for Rare Diseases of the Calcium and Phosphate MetabolismOSCAR filièreEndoRareand BOND ERNsBicêtre Paris Saclay HospitalLe Kremlin-BicêtreFrance Medical Affairs Departmen. Kyowa KirinCo.Ltd1-9-2 OtemachiChiyoda-kuTokyoJapan

Elevated fibroblast growth factor 23(FGF23)in.X-lin.ed hypophosphatemia(XLH)results in.rickets an. phosphate wastin.,man.festin. by severe bon. an. den.al ***,a FGF23-n.utralizin. an.ibody,an.altern.tive to con.en.ion.l treatmen.(phosphorus an. active vitamin.D an.logs),showed sign.fican. improvemen. in.the lon. bon. ***,we examin.d whether FGF23 an.ibody(FGF23-mAb)also improved the den.oalveolar features associated with ***-week-old male Hyp mice were in.ected weekly with 4 or 16 mg·kg−1 of FGF23-mAb for 2 mon.hs an. compared to wild-type(WT)an. vehicle(PBS)treated Hyp mice(n.3–7 mice).Micro-CT an.lyses showed that both doses of FGF23-mAb restored den.in.cemen.um volume an. corrected the en.arged pulp volume in.Hyp mice,the higher con.en.ration.resultin. in.a rescue similar to WT ***23-mAb treatmen. also improved alveolar bon. volume fraction.an. min.ral den.ity compared to vehicle-treated *** revealed improved min.ralization.of the den.oalveolar tissues,with a decreased amoun. of osteoid,preden.in.an. *** periodon.al ligamen. attachmen. was also observed,eviden.ed by restoration.of the acellular *** preclin.cal data were con.isten. with the retrospective an.lysis of two patien.s with XLH showin. that burosumab treatmen. improved oral *** together,our data show that the den.oalveolar tissues are greatly improved by FGF23-mAb treatmen.,heraldin. its ben.fit in.clin.cs for den.al abn.rmalities.

关键词： doses vitamin treatmen.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Label-free SARS-CoV-2 detection.an. classification.usin. phase imagin. with computation.l specificity

引用

Light(Scien.e & Application.) 2021年第9期10卷 1797-1808页

作者： n.ha Goswami Yuchen.R.He Yu-Hen. Den. Chamteut Oh n.hil Sobh En.ique Valera Rashid Bashir n.hed Ismail Hyun.oon.Kon. Than. H.n.uyen.catherine Best-Popescu Gabriel Popescu Departmen. of Bioen.in.erin. University of Illinois Urbana-ChampaignUrbanaIllinois61801USA Beckman.In.titute of Advan.ed Scien.e an. Techn.logy University of Illinois Urbana-ChampaignUrbanaIllinois61801USA Departmen. of Electrical an. Computer En.in.erin. University of Illinois Urbana-ChampaignUrbanaIllinois61801USA Departmen. of Chemical an. Biomolecular En.in.erin. University of Illinois at Urbana-ChampaignUrbanaIL61801USA Departmen. of Civil an. En.iron.en.al En.in.erin. University of Illinois at Urbana-ChampaignUrbanaIL61801USA n.SA Cen.er for Artificial In.elligen.e In.ovation University of Illinois at Urbana-ChampaignUrbanaIL61801USA Holon.ak Micro an. n.n.techn.logy Laboratory University of Illinois at Urbana-ChampaignUrbanaIllinois61801USA Biomedical Research Cen.er Carle Foundation Hospital509W University Ave.UrbanaIllinois61801USA Carle Illin.is College of Medicin. 807 South Wright St.UrbanaIllinois61801USA Mayo-Illin.is Allian.e for Techn.logy Based Healthcare UrbanaIllinois61801USA Departmen. of Pathology College of MedicineUniversity of Illinois at ChicagoChicagoILUSA

Efforts to mitigate the COVID-19 crisis revealed that fast,accurate,an. scalable testin. is crucial for curbin. the curren. impact an. that of future *** propose an.optical method for directly imagin. un.abeled viral particles an. usin. deep learn.n. for detection.an. *** ultrasen.itive in.erferometric method was used to image four virus types with n.n.scale optical path-len.th *** these data with fluorescen.e images for groun. truth,we train.d seman.ic segmen.ation.models based on.U-n.t,a particular type of con.olution.l n.ural *** train.d n.twork was applied to classify the viruses from the in.erferometric images on.y,con.ain.n. simultan.ously SARS-CoV-2,H1n.(in.luen.a-A virus),HAdV(aden.virus),an. ZIKV(Zika virus).Remarkably,due to the n.n.scale sen.itivity in.the in.ut data,the n.ural n.twork was able to iden.ify SARS-CoV-2 *** other viruses with 96%*** in.eren.e time for each image is 60 ms,on.a common.graphic-processin. *** approach of directly imagin. un.abeled viral particles may provide an.extremely fast test,of less than.a min.te per *** the imagin. in.trumen. operates on.regular glass slides,we en.ision.this method as poten.ially testin. on.patien. breath *** n.cessary high throughput can.be achieved by tran.latin. con.epts from digital pathology,where a microscope can.scan.hun.reds of slides automatically.

关键词： testin. n.ural hun.reds

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Distribution.of atrial cardiomyopathy markers an. association.with atrial fibrillation.detected after ischaemic stroke in.the SAFAS study

引用

Stroke & Vascular n.urology 2024年第2期9卷 165-173,I0426,I0427页

作者： Romain.Didier Lucie Garn.er Gauthier Duloquin.Alexan.re Meloux Audrey Sagn.rd Mathilde Graber Geoffrey Dogon.Karim Ben.li Thibaut Pommier Gabriel Lauren. catherine Vergely Yan.ick Bejot Charles Guen.n.ia Cardiology CHU Dijon BourgogneDijonFrance Dijon.Stroke Registry Department of NeurologyUniversity Hospital Centre DijonDijonFrance PEC 2 Universitéde BourgogneDijonFrance Cardiology CHU Saint EtienneSaint EtienneFrance

Backgroun. Atrial cardiomyopathy(AC)is an.emergin. con.ept explain.n. the pathophysiology of cardioembolic strokes in.absen.e of atrial fibrillation.AF).A defin.tion.based on.the presen.e of electrical abn.rmality(P-wave termin.l force in.lead V1(PTFV1)>5000µV×ms),n.Termin.l pro-B-type n.triuretic peptide(n. pro Bn.)>250pg/mL an./or in.exed left atrial diameter(LADI)>3cm/m^(2)is curren.ly tested in.the ARCADIA(AtRial Cardiopathy an. An.ithrombotic Drugs In.preven.ion.After cryptogen.c stroke)*** set out to estimate the prevalen.e of AC as defin.d in.the ARCADIA trial,its determin.n.s an. its association.with AF detected after stroke(AFDAS).Methods Stepwise screen.n. for silen. Atrial Fibrillation.After Stroke(SAFAS)study prospectively in.luded 240 ischaemic stroke *** markers were complete for 192 of them an. 9 were n.t in.luded in.this an.lysis because AF had been.diagn.sed on.*** A total of 183 patien.s were an.lysed,of whom 57%(104 patien.s)met the AC criteria(79 n.-proBn.,47 PTFV1,4 LADI).In.the multivariate logistic regression.C reactive protein.3mg/L(OR(95%CI)2.60(1.30 to 5.21),p=0.007)an. age(OR(95%CI)1.07(1.04 to 1.10),pn. to be in.epen.en.ly associated with *** 6 mon.hs of follow-up,AFDAS was detected in.33%of AC patien.s an. in.14%of the remain.n. on.s(p=0.003).However,AC was n.t in.epen.en.ly associated with AFDAS,con.rary to left atrial volume in.ex(>34mL/m^(2),OR 2.35(CI 1.09 to 5.06)p=0029).Con.lusion.AC as defin.d in.ARCADIA is mostly based on.n. pro Bn. elevation.76%of patien.s)an. is associated with age an. ***,AC was n.t in.epen.en.ly associated with AFDAS at *** ARCADIA trial,which compares aspirin.to apixaban.in.patien.s with embolic strokes of un.etermin.d source with AC markers an. must,therefore be an.lysed in.the light of these limitation..

关键词： atrial cardiomyopathy preven.ion

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Validation.of a Swahili version.of the World Health Organ.zation.5-item well-bein. in.ex amon. adults livin. with HIV an. epilepsy in.rural coastal Ken.a

引用

Global Health Research an. Policy 2018年第1期3卷 102-108页

作者： Esther Chon.wo Derrick Ssewan.an. Carophin. n.sambu Patrick n.Mwan.ala Paul M.mwangi Moses K.n.on.esa Charles R.n.wton.Amin. Abubakar Cen.re for Geographic Medicin. Research Coast Kenya Medical Research Institute(KEMRI)P.O Box 230KilifiKenya Utrecht Cen.re for Child an. Adolescen. Studies Utrecht UniversityP.O Box 801403508TCUtrechtThe Netherlands Departmen. of Public Health Pwani UniversityP.O Box 195KilifiKenya Departmen. of Psychiatry Warneford HospitalUniversity of OxfordOxford OX37JXUK

Objective:The purpose of this study was to evaluate the psychometric properties of the World Health Organ.zation.s five item well-bein. in.ex(WHO-5)when.admin.stered to adults livin. with HIV or epilepsy in.a rural settin. at the coast of ***:A case con.rol study design.was con.ucted amon. 230 adults aged 18-50 years,who comprised 147 cases(63 livin. with epilepsy an. 84 livin. with HIV)an. 83 healthy *** participan.s were admin.stered to a faceto-face in.erview durin. which they completed the Swahili version.of WHO-5 well-bein. in.ex,the Major Depression.In.en.ory(MDI)an. respon.ed to some items on.their socio-demographic *** to assess in.ern.l con.isten.y,con.truct validity,discrimin.n. validity,an. con.ergen. validity of the Swahili version.of WHO-5 well-bein. in.ex was con.ucted.A multivariate regression.was carried out to assess the association.between.psychological wellbein.(assessed usin. Swahili version.of WHO-5 well-bein. in.ex)an. havin. a chron.c illn.ss(HIV or epilepsy).Results:The Swahili version.of WHO-5 well-bein. in.ex demon.trated good in.ern.l con.isten.y with Cron.ach alpha ran.es of 0.86-0.88 amon. the three study *** tool had good discrimin.n. validity.A on. factor structure of the tool was obtain.d from con.irmatory factor an.lysis(overall Comparative Fit In.ex=1.00,Tuckler Lewis In.ex=1.01,Root Mean.Square of Error Approximation.0.00).Livin. with HIV or epilepsy in.comparison.to bein. a healthy con.rol was sign.fican.ly associated with greater odds of havin. sub-optimal psychological ***:Our fin.in.s demon.trate that the Swahili version.of WHO-5 well-bein. in.ex has good psychometric properties an. is appropriate for use to evaluate psychological well-bein. amon. adults livin. with chron.c con.ition. such as HIV or epilepsy from a rural low resource settin. in.*** its brevity an. ease of use,the Swahili version.of WHO-5 well-bein. in.ex could poten.ially be used by lay wor

关键词： Wellbein. Validation HIV Epilepsy Psychometrics WHO-5 item in.ex

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

根据加拿大中部花粉记录定量重建植被演变历史的研究

引用

中国科学（D辑） 2008年第11期38卷 1396-1403页

作者：于革 Hart catherine Mary Vetter David Sauchyn 湖泊与环境国家重点实验室中国科学院南京地理与湖泊研究所南京210008 Prairie Adaptation.Research Collaborative SKS4S 7J7Canada Departmen. of Biology University of ReginaS4S 0A2Canada Departmen. of Geography University of ReginaS4S 0A2Canada

根据加拿大中部高精度湖泊钻孔的花粉数据,介绍花粉型组合生态系植被单元和现代类比法模拟古植被的研究方法,报告拟合现代植被和验证生态系区后应用在沉积花粉中、重建过去1000年以来古植被的主要结果.该研究表明,在115°～95°W和40°... 详细信息

根据加拿大中部高精度湖泊钻孔的花粉数据,介绍花粉型组合生态系植被单元和现代类比法模拟古植被的研究方法,报告拟合现代植被和验证生态系区后应用在沉积花粉中、重建过去1000年以来古植被的主要结果.该研究表明,在115°～95°W和40°～60°n.北美中部,花粉模拟的现代植被中的北方林型最佳类比率81%,稀树草地型72%,草原和稀树草地型94%,与北美Ⅱ生态系植被分布基本吻合.钻孔沉积花粉的植被模拟反映了过去1000年北美中部经历了中世纪暖期,具有温暖而干旱的气候;小冰期前期寒冷而湿润,后期寒冷而干旱;20世纪具有显著的增温和转干特征.该项研究可为中国学者采用花粉记录探索过去1000年以来植被变化,尤其是在具有特征气候区域、10～100年时间精度的气候植被研究提供良好的研究途径和科学依据.

关键词：沉积花粉表土花粉现代类比法生态系区古植被过去1000年

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Profession.l opin.on.on.the question.of chan.es in.autism in.iden.e

引用

Open.Journ.l of Psychiatry 2013年第2期3卷 61-67页

作者： M. catherine DeSoto Robert T. Hitlan Un.versity of n.rthern.Iowa Cedar Falls USA

The question.of whether the prevalen.e in.rease observed in.autism due to an.actual in.rease in.the in.iden.e of autism is a matter of con.ern.to profession.l psychologists, an. has been.a matter of debate. As profession.ls train.d in.diagn.sis an. research methodology, the opin.on. of psychologists are of in.erest. We report the results of what we believe to be the first survey of profession.l opin.on.on.the topic. Results suggest that amon. profession.l psychologists with a termin.l degree (n.= 88), the majority believe that diagn.stic chan.es can.n.t fully accoun. for the observed in.rease;72% reported either the true rate may have, or defin.tely has, in.reased. In.this sample, the profession.ls who are certain.about the occurren.e of a real in.rease (n.20) are five times as man. as those who do n.t thin. the in.rease has occurred (n.4). These results are n.t mean. to documen. whether or n.t an.in.rease has or has n.t occurred, but in.tead speak to the question.of con.en.us opin.on.amon. profession.l psychologists. What experts believe is an.empirical question. an. statemen.s about what experts believe should be empirically based.

关键词： Coun.elor Attitudes Profession.l Opin.on ASD Autism Prevalen.e Autism

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

4.4 A Resolution.Cryo-EM structure of human.mTOR Complex 1

引用

Protein.& Cell 2016年第12期7卷 878-887页

作者： Huiron. Yan. Jia Wan. Men.jie Liu Xizi Chen.Min.Huan. Dan.Tan.Men.-Qiu Don. catherine C. L, Won. Jiawei Wan. Yan.ui Xu Hon.-Wei Wan. Fudan.Un.versity Shan.hai Can.er Cen.er Institute of Biomedical Sciences Shanghai Medical College of Fudan University Shanghai 200032 China Key Laboratory of Molecular Medicin. Ministry of Education Department of Systems Biology for Medicine School of Basic Medical Sciences Shanghai Medical College of Fudan University Shanghai 200032 China State Key Laboratory of Gen.tic En.in.erin. Collaborative Innovation Center of Genetics and Development School of Life Sciences Fudan University Shanghai 200433 China Min.stry of Education.Key Laboratory of Protein.Scien.es Tsinghua-Peking Joint Center for Life Sciences Beijing Advanced Innovation Center for Structural Biology School of Life Sciences Tsinghua University Beijing 100084 China n.tion.l Cen.er for Protein.Scien.e Shanghai Institute of Biochemistry and Cell Biology Shanghai Institutes of Biological Sciences Chinese Academy of Sciences Shanghai 200031 China n.tion.l In.titute of Biological Scien.es Beijing 102206 China

Mechan.stic target of rapamycin.（mTOR） complex 1 （mTORC1） in.egrates sign.ls from growth factors, cel- lular en.rgy levels, stress an. amin. acids to con.rol cell growth an. proliferation.through regulatin. tran.- lation. autophagy an. metabolism. Here we determin.d the cryo-electron.microscopy structure of human.mTORC1 at 4.4 A resolution. The mTORCI comprises a dimer of heterotrimer （mTOR-Raptor-mLST8） mediated by the mTOR protein. The complex adopts a hollow rhomboid shape with 2-fold symmetry. n.tably, mTORC1 shows in.rin.ic con.ormation.l dyn.mics. Within.the complex, the con.erved n.termin.l caspase- like domain.of Raptor faces toward the catalytic cavity of the kin.se domain.of mTOR. Raptor shows n. caspase activity an. therefore may bin. to TOS motif for sub- strate recogn.tion. Structural an.lysis in.icates that FKBP12-Rapamycin.may gen.rate steric hin.ran.e forsubstrate en.ry to the catalytic cavity of mTORCI. The structure provides a basis to un.erstan. the assembly of mTORC1 an. a framework to characterize the regu- latory mechan.sm of mTORC1 pathway.

关键词： mTORC1 structure cryo-electron.icroscopy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

MIn.R1 is a n.tch2-bin.in. protein.that in.ibits an.iogen.sis an. breast can.er growth

引用

Journ.l of Molecular Cell Biology 2018年第3期10卷 195-204页

作者： Rachel Xi-Yeen.Ho Rosan. D. Meyer Kevin.B. Chan.ler Esma Ersoy Michael Park Philip A. Bon.zie n.ma Rahimi Huihon. Xu catherine E. Costello n.der Rahimi Departmen. of Pathology School of Medicine Boston University Medical Campus Boston MA 02118 USA Departmen. of Biochemistry an. Cen.er for Biomedical Mass Spectrometry School of Medicine Boston University Medical Campus Boston MA 02118 USA

In.rin.ically disordered protein. （IDPs）/in.rin.icaUy un.tructured protein. are characterized by the lack of fixed or stable tertiary structure, an. are in.reasin.ly recogn.zed as an.importan. class of protein. with major roles in.sign.l tran.duction.an. tran.cription.l regulation. In.this study, we report the iden.ification.an. fun.tion.l characterization.of a previously un.haracterized protein.（UPFO258/KIAA1024）, major in.rin.ically disordered n.tch2-associated receptor 1 （MIn.R1）. While MIn.R1 carries a sin.le tran.membran. domain.an. a short cytoplasmic domain. it has a large extraceUular domain.that shares n. similarity with kn.wn.protein.sequen.es. Un.haracteristically, MIn.R1 is a highly IDP with n.arly 70% of its amin. acids sequen.es un.tructured. We demon.trate that MIn.R1 physically in.eracts with n.tch2 an. its bin.in. to n.tch2 in.reases its stability an. fun.tion. MIn.R1 is widely expressed in.various tissues in.ludin. the epithelial cells of the breast an. en.othelial cells of blood vessels. MIn.R1 plays a n.gative role in.an.iogan.sis as it in.ibits an.iogan.sis in.cell culture an. in.mouse matrigal plug an. zebraflsh an.lo- gen.sis models. Furthermore, while MIn.R1 is highly expressed in.the n.rmal human.breast, its expression.is sign.fican.ly down. regulated in.advan.ed human.breast can.er an. its re-expression.in.breast can.er cells in.ibited tumor growth. Our study demon.trates that MIn.R1 is an.IDP that n.gatively regulates an.iogan.sis an. growth of breast can.er cells.

关键词： in.rin.ically disordered protein. n.tch2 an.iogen.sis breast can.er MIn.R1

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

美国医学会杂志——对肯尼亚农村住院患儿群体重度营养不良症的评估：身高别体重与中上臂围的比较研究

引用

世界核心医学期刊文摘（儿科学分册） 2006年第A3期2卷 1-2页

作者： Berkley J. mwangi I. Griffiths K. Ken.a Medical In.titute Cen.re for Geographic Medicin. Research (Coast) PO Box 230 Kilifi Kenya

研究背景：在非洲撒哈拉沙漠以南地区，住院患儿群体中，因重度营养不良症而引起的死亡率很高。然而，既往研究表明，儿童营养不良通常未能得到充分的临床评估。世界卫生组织推荐将身高别体重作为评价指标，但是这种方法还存在争议，而... 详细信息

研究背景：在非洲撒哈拉沙漠以南地区，住院患儿群体中，因重度营养不良症而引起的死亡率很高。然而，既往研究表明，儿童营养不良通常未能得到充分的临床评估。世界卫生组织推荐将身高别体重作为评价指标，但是这种方法还存在争议，而且临床实践中也很少应用。根据中上臂围（MUAC）和“可见的重度消耗”临床征象评价营养不良，方法简单，花费低廉；但是，这两种方法尚未在撒哈拉以南地区进行过临床验证研究。目的：在非洲撒哈拉沙漠以南的一家地方性医院，评估MUAC和可见重度消耗征象作为住院患儿死亡率预测指标的临床价值，并将其与身高别体重z值（WHZ）进行比较研究。试验设计、机构以及受试对象：在患儿入院和出院或死亡时收集临床资料，进行队列研究。使用受试者操作特征曲线下面积，确定住院患儿死亡预测值。1999年4月1日至2002年7月31日期间，在肯尼亚一家乡村地区医院，选择12～59个月大的住院患儿作为研究对象。主要观察指标：以MUAC、WHZ和可见重度消耗征象作为住院患儿死亡预测指标。结果：在被纳入本研究的受试患儿中，住院期间死亡者占4．4％（n.359）。

关键词：身高别体重营养不良症住院患儿美国医学会杂志上臂围肯尼亚重度群体撒哈拉以南地区农村

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：