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Food Science and Human Wellness 2023年

作者： Xinqi chen Yang chen catherine Stanton R.Paul Ross Jianxin Zhao Bo Yang Wei chen National Engineering Research Center for Functional Food Jiangnan University School of Food Science and Technology Jiangnan University State Key Laboratory of Food Science and Technology Jiangnan University APC Microbiome Ireland University College Cork Teagasc Food Research Centre International Joint Research Center for Probiotics & Gut Health Jiangnan University

This study aimed to evaluate the effects of Bifidobacterium breve CCFM683 on psoriasis and to investigate the underlying mechanisms. Bifidobacterium breve CCFM683 significantly ameliorated psoriasis in mice as well as elevated the deoxycholic acid (DCA) and lithocholic acid (LCA) in the colon compared with those of the imiquimod-treated mice. Meanwhile， B. breve CCFM683 increased the relative abundance of DCA-producing Lachnoclostridium and diminished the harmful Desulfovibrio and Prevotellaceae UCG001. Additionally， the farnesoid X receptor (FXR) in the skin was activated and the expression of the TLR4/NF-κB pathway was inhibited， and the downstream IL-17 and TNF-α were downregulated whereas IL-10 was up-regulated . Moreover， the subsequent hyperproliferation of keratinocytes and the dysfunction of the epidermal barrier were improved. In conclusion， CCFM683 administration ameliorated IMQ-induced psoriasis via modulating gut microbiota， promoting the DCA production， regulating the FXR-TLR4/NF-κB pathway， diminishing proinflammatory cytokines， and regulating keratinocytes and epidermal barrier. These findings may be conducive to elucidating the mechanism for probiotics to ameliorate psoriasis and to promote its clinical trials in skin disease.

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Innovative chemistry research driven by medicine

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Fundamental Research 2023年第4期3卷 479-480页

作者： Hang Yin Chunhai Fan catherine Chiulan Wong Lanqun Mao Yanyi Huang Guo-Qiang chen School of Pharmaceutical Sciences Tsinghua UniversityBeijing 100084China School of Chemistry and Chemical Engineering New Cornerstone Science LaboratoryFrontiers Science Center for Transformative Molecules and National Center for Translational MedicineShanghai Jiao Tong UniversityShanghai 200240China Clinical Research Institute State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Science&Peking Union Medical CollegeBeijing 100730China College of Chemistry Beijing Normal UniversityBeijing 100875China College of Chemistry and Molecular Engineering Beijing National Laboratory for Molecular SciencesBiomedical Pioneering Innovation CenterPeking-Tsinghua Center for Life SciencesPeking UniversityBeijing 100871China Institute of Aging&Tissue Regeneration State Key Laboratory of Systems Medicine for Cancer and Chinese Academy of Medical Sciences Research Unit(No.2019RU043)Ren-Ji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China

Chemistry,a fundamental scientific discipline,plays a significant role in various fields,including medical *** ability to break down human cells into constituent biomolecules,such as nucleic acids,proteins,carbohydrates and lipids,has been a valuable resource for studying fundamental building blocks at the atomic *** studying the functions of these biomolecules,chemists can gain insights into the underlying mechanisms of various *** integration of chemistry and medical science has facilitated advancements in diagnostic,therapeutic and translational research,leading to fruitful collaborations between these two *** a result,this interdisciplinary approach has yielded cutting-edge research with implications for the improvement of human health.

关键词： insight chemistry advancement

Molecular catalysis for the steam reforming of ethanol

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Science China Chemistry 2015年第1期58卷 60-78页

作者： Jianyi Lin Luwei chen catherine Kai Shin Choong Ziyi Zhong Lin Huang Heterogeneous Catalysis Institute of Chemical and Engineering Sciences Agency for ScienceTechnology and Research

In this paper,the application of molecular catalysis for steam reforming of ethanol(SRE)is *** metals(Ni,Co,Cu,Pt,Rh,Pd,Ir and Ru)have shown high catalytic activity for *** them Ni and Rh are very promising because of high d character in the metal bond and low metal-oxygen bonding(***-carbon).They can effectively promote C–C bond cleavage in the rate-determining process during ***,Rh is weak in water-gas-shift so that CH4 and CO become the main by-products at low reaction temperatures,while Ni catalysts suffer from rapid deactivation due to coking and *** low-temperature CO-free catalysts have been developed in our lab,namely Rh-Fe/Ca-Al2O3 and carbonyl-derived Rh-Co/Ce O2,in which the presence of iron oxide or Co can promote water-gas-shift reaction and significantly improve the SRE *** the other hand,adding 3 wt%Ca O to Ni/Al2O3 can greatly improve the catalyst stability because the Ca modification not only increases Ni concentration on the Ni/Ca-Al2O3 surface and 3d valence electron density,but also facilitates the water adsorption and coke gasification via *** availability of abundant surface OH groups helps the formation and conversion of adsorbed formate ***,ethanol reaction on Ca-Al2O3-supported Ni,Pt,Pd and Rh catalysts are found to follow the formate-intermediated pathway,a new reaction pathway alternative to the traditional acetate-intermediated pathway.

关键词：蒸汽重整催化活性乙醇分子水煤气变换反应镍催化剂金属粘结价电子密度

A study on the in vitro degradation of poly（L-lactide）/chitosan microspheres scaffolds

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Frontiers of Materials Science 2013年第1期7卷 76-82页

作者： Ning ZHU David COOPER Xiong-Biao chen catherine Hui NIU Division of Biomedical Engineering University of Saskatchewan Saskatoon Saskatchewan Canada Department of Anatomy and Cell Biology University of Saskatchewan Saskatoon Saskatchewan Canada Department of Mechanical Engineering University of Saskatchewan Saskatoon Saskatchewan Canada Department of Chemical Engineering University of Saskatchewan Saskatoon Saskatchewan Canada

Recent research shows that the addition of chitosan microspheres (CMs) to poly(l-lactide) (PLLA) can result in a composite scaffold material with improved biocompatibility and mechanical properties for tissue engineering applications. However, research regarding the influence of CMs on scaffold degradation is absent in the literature. This paper presents a study on the in vitro degradation of scaffolds made from PLLA with CMs. In this study, the PLLA/CMs scaffolds with a 25% ratio of CMs to PLLA were immersed in phosphate-buffered saline (PBS) solution at 37°C for 8 weeks. The in vitro degradation of the scaffolds was investigated using microcomputed tomography (μCT), weight loss analysis, Raman spectroscopy, and differential scanning calorimetry (DSC). Microstructure changes during degradation were monitored using μCT. The μCT results were consistent with the results obtained from Raman spectra and DSC analysis, which reflected that adding CMs into PLLA can decrease the degradation rate compared with pure PLLA scaffolds. The results suggest that PLLA/CMs scaffold degradation can be regulated and controlled to meet requirements imposed a given tissue engineering application.

关键词： poly( l -lactide) (PLLA) chitosan scaffold degradation tissue engineering

Learners’motivational response to the Science,PE,&Me!curriculum:A situational interest perspective

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Journal of Sport and Health Science 2021年第2期10卷 243-251页

作者： Senlin chen Haichun Sun Xihe Zhu Ang chen catherine D.Ennis(Posthumous) School of Kinesiology Louisiana State UniversityBaton RougeLA 70803USA Department of Teaching and Learning University of South FloridaTampaFL 33620USA Department of Human Movement Sciences Old Dominion UniversityNorfolkVA 23529USA Department of Kinesiology University of North Carolina at GreensboroGreensboroNC 27402USA

Background:The Science,PE,&Me!(SPEM)curriculum is a concept-based physical education curriculum that offers students coherent educational experiences for constructing health-related fitness knowledge through movement *** purpose of this study was to evaluate students’motivational response to the SPEM curriculum from the situational interest ***:The study used a cluster randomized controlled design in which 30 elementary schools in one of the largest metropolitan areas in the eastern United States were randomly assigned to an experimental or comparison *** all students in the 3rd,4th,and 5th grades in the targeted schools were eligible to participate in the study,a random sample of students from the experimental(n=1749;15 schools)and comparison groups(n=1985;15 schools)provided ***’motivational response to the SPEM curriculum or comparison curriculum was measured using the previously validated Situational Interest *** were analyzed using structural mean ***:The results demonstrated that the experimental group(as reference group)showed significantly higher enjoyment(z=-2.01),challenge(z=-6.54),exploration(z=-12.195),novelty(z=-8.80),and attention demand(z=-7.90)than the comparison ***:The findings indicate that the SPEM curriculum created a more situationally interesting context for learning than the comparison physical education curriculum.

关键词： Constructivist learning theory Curriculum intervention Elementary physical education Learner motivation Structural mean modeling

Effect of rifampicin pre-and post-treatment on rotenone-induced dopaminergic neuronal apoptosis and alpha-synuclein expression

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Neural Regeneration Research 2010年第2期5卷 85-91页

作者： Yuanlin Sun Guohua Zhang Jie Xu Shiwen chen Enxiang Tao Changqing Xu M. catherine Bennett Department of Neurology Second Affifiated Hospital of Sun Yat-sen University Guangzhou 510120 Guangdong Province China Blanchette Rockefeller Neurosciences Institute Rockville MD 20850 USA

BACKGROUND： Rifampicin inhibits the formation of a-synuclein multimer and protects against 1-methyl-4-phenyl-1,2, 3, 6-tetrahydropyritine （MPTP）-induced PC12 cell apoptosis. OBJECTIVE： To compare the effect of rifampicin pre- and post-treatment on tyrosine hydroxylase and α-synuclein expression in substantia nigra pars compacta in a rat model of Parkinson＇s disease. DESIGN, TIME AND SE＇B＇ING： A randomized, controlled experiment was performed at the Experimental Animal Center of Sun Yat-sen University North Campus （China） from November 2006 to October 2008. MATERIALS： Rifampicin was purchased from MD, USA; rotenone was purchased from Sigma, USA; mouse anti-rat α-synuclein monoclonal antibody was purchased from B＆D, USA; and rabbit anti-rat tyrosine hydroxylase monoclonal antibody was purchased from Chemicon, USA. METHODS： A total of 72 male, Sprague Dawley rats, aged 8 weeks, were randomly assigned to 5 groups： blank control （n = 12）, rifampicin （n = 12）, rotenone （n = 16）, rifampicin pre-treatment （n = 16）, and rifampicin post-treatment （n = 16）. Parkinson＇s disease model rats were established via a subcutaneous injection of rotenone （1.5 mg/kg per day） in the three treatment groups, once a day for 3 successive weeks. Rifampicin （30 mg/kg per day） was intragastrically administered in the rifampicin pre-treatment group 3 days prior to rotenone induction and in the rifampicin post-treatment group 7 days after rotenone induction. Rats were treated with a subcutaneous injection of 1 mL/kg per day sunflower oil in the blank control group and an intragastric injection of 30 mg/kg per day rifampicin in the rifampicin group, once a day for 3 successive weeks in total. MAIN OUTCOME MEASURES： Prior to treatment and in the end of the 3^rd week after treatment, the rats were evaluated using the modified neurological severity score. The substantia nigra from the rats was extracted for hematoxylin-eosin staining. Western blot analysis was performed to determine tyrosine hydroxyla

关键词： rifampicin rotenone Parkinson's disease α-synuclein dopaminergic neurons

上肢康复机器人辅助训练对脑卒中后单侧空间忽略患者影响的Meta分析

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实用心脑肺血管病杂志 2024年第4期32卷 105-111页

作者：徐淑娴刘凡王芳陈璐江苏大学鼓楼临床医学院江苏省南京市210008 南京大学医学院附属鼓楼医院神经外科江苏省南京市210008

目的系统评价上肢康复机器人辅助训练对脑卒中后单侧空间忽略(USN)患者的影响。方法计算机检索中国生物医学文献数据库、中国知网、维普网、万方数据知识服务平台、中国临床试验注册中心、Web of Science、PubMed、Cochrane Library、Em... 详细信息

目的系统评价上肢康复机器人辅助训练对脑卒中后单侧空间忽略(USN)患者的影响。方法计算机检索中国生物医学文献数据库、中国知网、维普网、万方数据知识服务平台、中国临床试验注册中心、Web of Science、PubMed、Cochrane Library、Embase、CINAHL、Scopus和Clinical Trials数据库公开发表的关于上肢康复机器人辅助训练治疗脑卒中后USN患者的随机对照试验(对照组实施常规治疗/综合康复训练/低频重复经颅磁刺激,试验组实施上肢康复机器人辅助训练或在对照组基础上实施上肢康复机器人辅助训练)。检索时限为建库至2024年1月。提取纳入文献的资料,使用RevMan 5.4.1软件进行Meta分析。结果共纳入6篇文献,共188例脑卒中后USN患者。Meta分析结果显示,干预后试验组凯瑟林-波哥量表(CBS)评分低于对照组〔均数差(MD)=-1.67,95%CI(-3.06~-0.28),P=0.02〕。以干预时间进行亚组分析,结果显示,干预时间<4周时,干预后两组CBS评分比较,差异无统计学意义〔MD=-0.55,95%CI(-3.27~2.17),P=0.69〕;干预时间≥4周时,干预后试验组CBS评分低于对照组〔MD=-2.59,95%CI(-3.20~-1.98),P<0.00001〕。干预后两组二等分线段测验(LBT)评分比较,差异无统计学意义〔标准化均数差(SMD)=-1.22,95%CI(-2.54~0.10),P=0.07〕。干预后试验组肢体功能评分〔SMD=0.85,95%CI(0.43~1.28),P<0.0001〕和改良Barthel指数〔SMD=0.52,95%CI(0.21~0.82),P=0.0009〕均高于对照组。结论现有证据显示,上肢康复机器人辅助训练能够减轻脑卒中后USN患者USN严重程度,改善肢体功能和提高日常生活活动能力,但对患者视觉忽略效果尚不明确。

关键词：卒中单侧空间忽略上肢康复机器人 Meta分析

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The Chinese Political Novel： Migration of a World Genre

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Frontiers of Literary Studies in China-Selected Publications from Chinese Universities 2017年第2期11卷 401-406页

作者： Dandan chen Yeh, catherine Vance Farmingdale State College State University of New York 不详

In a lecture given at Peking University, the author highlighted several key questions addressed in this book： can a genre cross cultures？ If so, in its transcultural journey into various countries, would its basic cultural and social values be lost or kept？ How can this genre retain its original status of the political novel？ How can it interact with local genres？ Or, in other words, how can it be localized？ By criticizing the tendency to look down on the political novel as something that serves politics in mainstream academia （especially Western academia）, Yeh hopes to reexamine the relationship between politics and literature. Can political discourse encourage the development of new cultures and new literature？ Yeh believes the answer to be yes.

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Erythrocytic α-Synuclein as a potential biomarker for Parkinson’s disease

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Translational Neurodegeneration 2019年第1期8卷 171-182页

作者： chen Tian Genliang Liu Liyan Gao David Soltys catherine Pan Tessandra Stewart Min Shi Zhiying Xie Na Liu Tao Feng Jing Zhang Department of Pathology Peking University School of Basic Medical SciencesPeking UniversityBeijingChina Department of Pathology Peking University Third HospitalPeking UniversityBeijingChina Center for Neurodegenerative Disease Department of NeurologyBeijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina Parkinson’s Disease Center Beijing Institute for Brain DisordersCapital Medical UniversityBeijingChina Department of Pathology University of Washington School of MedicineSeattleWAUSA Beijing Key Laboratory of Research and Transformation on Neurodegenerative Diseases Biomarkers BeijingChina Department of neurology Qingdao Municipal HospitalQingdao UniversityQingdaoChina Department of Neurology Peking University Third HospitalPeking UniversityBeijingChina

Background:Erythrocytes are a major source of peripheralα-synuclein(α-Syn).The goal of the current investigation is to evaluate erythrocytic total,oligomeric/aggregated,and phosphorylatedα-Syn species as biomarkers of Parkinson’s disease(PD).PD and healthy control blood samples were collected along with extensive clinical history to determine whether total,phosphorylated,or aggregatedα-Syn derived from erythrocytes(the major source of bloodα-Syn)are more promising and consistent biomarkers for PD than are freeα-Syn species in serum or ***:Using newly developed electrochemiluminescence assays,concentrations of erythrocytic total,aggregated and phosphorylated at Ser129(pS129)α-Syn,separated into membrane and cytosolic components,were measured in 225 PD patients and 133 healthy controls and analyzed with extensive clinical ***:The total and aggregatedα-Syn levels were significantly higher in the membrane fraction of PD patients compared to healthy controls,but without alterations in the cytosolic *** pS129 level was remarkably higher in PD subjects than in controls in the cytosolic fraction,and to a lesser extent,higher in the membrane *** age,erythrocytic membrane aggregatedα-Syn,and cytosolic pS129 levels,a model generated by using logistic regression analysis was able to discriminate patients with PD from neurologically normal controls,with a sensitivity and a specificity of 72 and 68%,***:These results suggest that total,aggregated and phosphorylatedα-Syn levels are altered in PD erythrocytes and peripheral erythrocyticα-Syn is a potential PD biomarker that needs further validation.

关键词： Parkinson’s disease α-Synuclein Erythrocyte Electrochemiluminescence

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体育教学中影响学生热量消耗的因素(英文)

Journal of Sport and Health Science 2012年第1期1卷 49-56页

作者： Ang chen Haichun Sun Xihe Zhu catherine D.Ennis Department of Kinesiology School of Health and Human SciencesUniversity of North Carolina at GreensboroGreensboroNC 27412USA School of Physical Education & Exercise Science PED 228College of Education4202 E.Fowler AvenueEDU105University of South FloridaTampaFL 33620USA Department of Human Movement Sciences 2019 Student Recreation CenterOld Dominion UniversityNorfolkVA 23529USA

Background:Increasing caloric expenditure in physical education is considered an effective school-based approach to addressing the child obesity *** study was designed to determine synergistic influences of student characteristics and lesson factors on caloric expenditure in elementary and middle school physical education. Methods:The study used a multi-level ***-1 factors included personal characteristics:age,gender,and body mass ***-2 factors included lesson length,content,and school *** on the Center for Disease Control and Prevention age—gender adjusted growth chart,students in 87 classes from 14 elementary and 15 middle schools were pre-screened into "Overweight","Healthy weight",or "Thin" *** boy and one girl were randomly selected from each group in each class as data providers(264 elementary and 294 middle school students).Caloric expenditure was measured in 243 physical education lessons using accelerometers. Results:Analysis of variance revealed and hierarchical linear modeling confirmed separate age by body mass index,age by gender,and content by lesson—length interaction effects,suggesting that the personal and lesson factors influenced caloric expenditure *** male and heavier students burned more calories in all *** burned more calories in 45—60 min sport skill or fitness lessons than in shorter (30 min) or longer(75—90 min) game or multi-activity lessons. Conclusions:The hypothesized cross-level interaction was not observed in the *** expenditure can be optimized in 45—60 min sport skill or fitness development *** can be recommended that schools adopt 45—60 min lesson length and provide skill and fitness development tasks in physical education to maximize caloric expenditure.

关键词： Caloric expenditure Child obesity Personal factors