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Quality of life in patients with gastroenteropancreatic tumours: A systematic literature review

World Journal of Gastroenterology 2020年第25期26卷 3686-3711页

作者： catherine watson Craig William Tallentire John K Ramage Rajaventhan Srirajaskanthan Oscar RLeeuwenkamp Donna Fountain PHMR Health Economics Pricing and ReimbursementLondon NW18XYUnited Kingdom Kings Health Partners NET centre Kings College Hospital LondonLondon SE59RSUnited Kingdom Advanced Accelerator Applications Geneva 1204Switzerland

BACKGROUND Gastroenteropancreatic neuroendocrine tumours(GEP-NETs)are slow-growing cancers that arise from diffuse endocrine cells in the gastrointestinal tract(GINETs)or the pancreas(P-NETs).They are relatively uncommon,accounting for 2%of all gastrointestinal *** usual treatment options in advanced GEP-NET patients with metastatic disease include chemotherapy,biological therapies,and peptide receptor radionuclide *** the impact of treatment on GEP-NET patients is paramount given the nature of the ***-related quality of life(HRQoL)is increasingly important as a concept reflecting the patients’perspective in conjunction with the disease presentation,severity and *** To conduct a systematic literature review to identify literature reporting HRQoL data in patients with GEP-NETs between January 1985 and November *** The PRISMA guiding principles were ***,Embase and the Cochrane library were *** extracted from the publications included type of study,patient population data(mid-gut/hind-gut/GI-NET/P-NET),sample size,intervention/comparators,HRQoL instruments,average and data spread of overall and sub-scores,and follow-up time for data *** Forty-three publications met the inclusion *** heterogeneous nature of the different study populations was evident;the percentage of female participants ranged between 30%-60%,whilst average age ranged from 53.8 to 67.0 *** studies investigated GI-NET patients only,six studies focused exclusively on P-NET patients and the remaining studies involved both patient populations or did not report the location of the primary *** most commonly used instrument was the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-C30(n=28)with consistent results across studies;the GI-NET-specific module Quality of Life Questionnaire-GINET21 was used in six of these studies.A number of randomised tria

关键词： Gastroenteropancreatic neuroendocrine tumours Health-related quality of life Systematic literature review Chemotherapy Biological therapies Peptide receptor radionuclide therapy

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Large-scale forest inventories of the United States and China reveal positive effects of biodiversity on productivity

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Forest Ecosystems 2015年第4期2卷 272-287页

作者： James V watson Jingjing Liang Patrick C Tobin Xiangdong Lei James S Rentch catherine E Artis Davis College of Agriculture Natural Resources and DesignWest Virginia University Forest Service U.S.Department of AgricultureNorthern Research Station School of Environmental and Forest Sciences University of Washington Research Institute of Forest Resource Information Techniques Chinese Academy of Forestry

Background： With the loss of species worldwide due to anthropogenic factors, especially in forested ecosystems, it has become more urgent than ever to understand the biodiversity-ecosystem functioning relationship （BEFR）. BEFR research in forested ecosystems is very limited and thus studies that incorporate greater geographic coverage and structural complexity are needed. Methods： We compiled ground-measured data from approx, one half million forest inventory sample plots across the contiguous United States, Alaska, and northeastern China to map tree species richness, forest stocking, and productivity at a continental scale. Based on these data, we investigated the relationship between forest productivity and tree species diversity, using a multiple regression analysis and a non-parametric approach to account for spatial autocorrelation. Results： In general, forests in the eastern United States consisted of more tree species than any other regions in the country. The highest forest stocking values over the entire study area were concentrated in the western United States and Central Appalachia. Overall, 96.4 % of sample plots （477,281） showed a significant positive effect of species richness on site productivity, and only 3.6 % （17,349） had an insignificant or negative effect. Conclusions： The large number of ground-measured plots, as well as the magnitude of geographic scale, rendered overwhelming evidence in support of a positive BEFR. This empirical evidence provides insights to forest management and biological conservation across different types of forested ecosystems. Forest timber productivity may be impaired by the loss of species in forests, and biological conservation, due to its potential benefits on maintaining species richness and productivity, can have profound impacts on the functioning and services of forested ecosystems.

关键词： Tree species diversity Forest management Biological conservation Continental map of forest diversity Spatial autocorrelation Bootstrap

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Development of a simple tool for diagnosis and initial approach to hypertension and pre-hypertension in children and youth

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Open Journal of Pediatrics 2012年第2期2卷 106-110页

作者： Silviu Grisaru Kay watson-Jarvis catherine M. McKenna Josephine Ho Joyce R. Harder Rebecca A. Trussell Alberta Children’s Hospital Alberta Health Services Calgary Canada Department of Family Medicine University of Calgary Calgary Canada

Background: Hypertension and pre-hypertension in children and adolescents are frequently missed despite current screening recommendations and the potential benefit for early diagnosis and intervention. Difficulty in interpretation of office blood pressure readings in children has been partially blamed for the significant under-diagnosis of childhood hypertension. The objective of our group was to develop and evaluate a simple tool designed to assist primary health care physicians to interpret office blood pressure readings in children and adolescents. Methods: A multi-disciplinary advisory group in our institution undertook the development of a diagnostic tool based on currently accepted gold standard parameters. Input from Family Physicians and Pediatricians was used in the design process. The tool was then distributed among Family Physicians in our catchment area and evaluated with a post-distribution survey. Results: A laminated one page summary of pediatric blood pressure parameters and initial approach to pediatric hypertension was created and distributed. Feedback from primary care physicians was mostly positive and supportive of this initiative. Conclusions: Innovating and simplifying the screening process for hypertension and pre-hypertension in childhood may promote early detection and intervention however the effect of such initiatives on the rate of diagnosis of pediatric hypertension will need to be tested prospectively by appropriately designed studies.

关键词： Hypertension Child Youth Diagnostic Tool Screening

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