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World History Studies 2016年第1期3卷 17-32页

作者： catherine volpilhac–auger (E)cole normale supérieure de LyonUMR 5317CNRS

The twenty–two volume edition of Montesquieu’s OEuvres complètes is a long–term project that requires the input of specializations and energies throughout the *** by Jean Ehrard in the late 1980s, it is now under the direction of Pierre Rétat and myself, who have also taken direct responsibility for several of the volumes;among these, the first volume devoted to reading notes and extracts under the title Geographica II. Published in 2007,1 this volume will soon be re–issued in the form of an electronic edition.2 We expect much interest from many scholars in this document, which provides evidence of Montesquieu’s interest in Chinese history and culture. In this context, the contribution of Professor Xu Minglong3 on part of this publication is welcome.

关键词： of des edition sur this under notes the

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让微笑展示健康牙齿

父母必读 2004年第3期 80-80页

作者： catherine auger

不要认为乳牙早晚要掉,就掉以轻心。健康乳牙为健康恒牙奠定了良好的基础。

关键词：六龄齿

Effective simulation of flexible lateral boundaries in two-and three-dimensional DEM simulations

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Particuology 2008年第6期6卷 483-500页

作者： Geraldine Cheung catherine O'Sullivan Department of Civil and Environmental Engineering Imperial College London

Discrete element method （DEM） models to simulate laboratory element tests play an important role in advancing our understanding of the mechanics of granular material response, including bonded or cemented, particulate materials. Comparisons of the macro-scale response observed in a real physical test and a ＂virtual＂ DEM-simulated test can calibrate or validate DEM models. The detailed, particle scale information provided in the DEM simulation can then be used to develop our understanding of the material behaviour. It is important to accurately model the physical test boundary conditions in these DEM simulations. This paper specifically considers triaxial tests as these tests are commonly used in soil mechanics. In a triaxial test, the test specimen of granular material is enclosed within a flexible latex membrane that allows the material to deform freely during testing, while maintaining a specified stress condition. Triaxial tests can only be realistically simulated in 3D DEM codes, however analogue, 2D, biaxial DEM simulations are also often considered as it is easier to visualize particle interactions in two dimensions. This paper describes algorithms to simulate the lateral boundary conditions imposed by the latex membrane used in physical triaxial tests in both 2D and 3D DEM simulations. The importance of carefully considering the lateral boundary conditions in DEM simulations is illustrated by considering a 2D biaxial test on a specimen of frictional unbonded disks and a 3D triaxial test on a bonded （cemented） specimen of spheres. The comparisons indicate that the lateral boundary conditions have a more significant influence on the local, particle-scale response in comparison with the overall macro-scale observations.

关键词： Triaxial testing Discrete element simulations Boundary conditions

Self-assembly of peptide-based nanostructures： Synthesis and biological activity

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Nano Research 2018年第5期11卷 2315-2335页

作者： Lena Guyon Elise Lepeltier catherine Passirani Micro & Nanomedecines Translationnelles-MINT UNIV Angers INSERM U 1066 CNRS UMR 6021 UBL Universite Bretagne Loire Angers F-49933 France

Peptide-based nanostructures have received much attention in the field of drug targeting. In fact, peptides have many advantages such as simplicity of the structure, biocompatibility, and chemical diversity. Moreover, some peptides, which are called cell-penetrating peptides, can cross cellular membranes and carry small molecules, small interfering RNA, or viruses inside live cells. These molecules are often covalently or noncovalently linked to cargoes, thus forming amphiphilic conjugates that can self-assemble. Supramolecular nanostructures formed from peptides are used in nanomedicine as a carrier to protect a drug and to target cancer cells. This review explores aliphatic-chain-conjugated peptides and drug-conjugated peptides that can self-assemble. Special emphasis is placed on the synthesis procedure, nanostructure formation, and biological activity.

关键词： self-assembly cell penetrating peptide nanoparticle peptide

Interaction of the Arabidopsis UV-B-Specific Signaling Component UVR8 with Chromatin

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Molecular Plant 2008年第1期1卷 118-128页

作者： catherine Cloix Gareth I. Jenkins Plant Science Group Division of Biochemistry and Molecular Biology Institute of Biomedical and Life Sciences Bower Building University of GlasgowGlasgow G12 BQQ UK

Arabidopsis UV RESISTANCE LOCUS8 （UVR8） is a UV-B-specific signaling component that regulates expression of a range of genes concerned with UV protection. Here, we investigate the interaction of UVR8 with chromatin. Using antibodies specific to UVR8 in chromatin immunoprecipitation （ChiP） assays with wild-type plants, we show that native UVR8 binds to chromatin in vivo. Similar experiments using an anti-GFP antibody with plants expressing a GFP-UVR8 fusion show that UVR8 associates with a relatively small region of chromatin containing the HY5 gene. UVR8 interacts with chromatin containing the promoter regions of other genes, but not with all the genes it regulates. UV-B is not required for the interaction of UVR8 with chromatin because association with several gene loci is observed in the absence of UV-B. Pulldown assays demonstrate that UVR8 associates with histones in vivo and competition experiments indicate that the interaction is preferentially with histone H2B. ChIP experiments using antibodies that recognize specific histone modifications indicate that the UV-B-stimulated transcription of some genes may be correlated with histone modification. In particular, the ELIP1 promoter showed a significant enrichment of diacetyl histone H3 （K9/K14） following UV-B exposure. These findings increase understanding of the interaction of the key UV-B-specific regulator UVR8 with chromatin.

关键词： .Wild-type Regulates Interacts Histones Arabidopsis UV Signaling Component UVR interaction of UVR native UVR anti-GFP UVR associates chromatin containing

Hepatocellular Carcinoma:Downstaging to Liver Transplantation as Curative Therapy

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Journal of Clinical and Translational Hepatology 2021年第2期9卷 220-226页

作者： Leana Frankul catherine Frenette Scripps Center for Organ Transplant Scripps Clinic/Green HospitalLa JollaCAUSA

Hepatocellular carcinoma(HCC)ranks among the leading cancer-related causes of morbidity and mortality *** of HCC has prevailed as a key method to curative therapy for patients who present with unresectable HCC outside of the listing criteria for liver transplantation(LT).Even though LT paves the way to lifesaving curative therapy for HCC,perpetually severe organ shortage limits its broader *** over the optimal protocol and assessment of response to downstaging treatment has fueled immense research activity and is pushing the boundaries of LT candidate selection *** implicit obligation of refining downstaging protocol is to ensure the maximization of the transplant survival benefit by taking into account the waitlist life *** the following review,we critically discuss strategies to best optimize downstaging HCC to LT on the basis of existing literature.

关键词： Downstaging Milan criteria Hepatocellular carcinoma Liver transplantation

THE SUSTAINABLE MICRO-SCALE MOVEMENT OF COMMUNITIES:CASE STUDIES OF SUBDIVIDED DEVELOPMENT AND ADAPTIVE REUSE OF SHARED SPACE IN NEW YORK CITY

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Journal of Green Building 2016年第1期11卷 23-37页

作者： Kyungsun Lee catherine Park School of Architecture Hongik UniversityWausan-roMapo-guSeoul 121-791 South Korea SoHa Atelier 27-28 Thomson Ave Suite#235 Long Island CityNY 11101 U.S.A.

*** In New York City a decline in manufacturing has propelled social and eco-nomic changes that have transformed certain districts[1,2].Unused building stock there has been the basis for adaptive reuse yielding new housing for families of varying *** constant pressure of the need for affordable housing has resulted in the conversion of existing abandoned industrial structures,pro-viding a green,environmentally friendly alternative to new construction[3,4,5].Adaptive reuse provides an opportunity to bring a building up to current codes,to make the layout and building systems more appropriate and efficient,and to help revitalize neighborhoods.

关键词： adaptive reuse New York City mixed-use non-governmental advocacy groups mega-city micro-scale subdivided development infrastructure development

Natural selection on flower size in invasive Cytisus scoparius along an elevation gradient

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Journal of Plant Ecology 2020年第2期13卷 165-170页

作者： Robert Frederick Bode catherine Dufresne Department of Natural Sciences College of Arts and SciencesSaint Martin’s UniversityLaceyWA 98503USA

Aims Established invasive plant species have more diverse gene pools than single populations in their home *** genetic and often phenotypic variation allows for natural selection to act and produce rapid adaptations as an invasive species interacts with other members of the *** an invasive flowering plant,interactions with pollinators may lead to adaptations to a heterogeneous pollinator *** variation in the pollinator community in the invaded range is similar to variation in the native range,suggesting that adaptations may mirror patterns seen in the home *** this study,we investigated variation in flower size in Cytisus scoparius,an invasive leguminous shrub,along an elevation *** This study took place in the Capitol State Forest in Washington *** measured flower widths and the proportion of visited flowers,using 10 plants per field *** were located along an elevation gradient and were visited three times to measure phenological variation on a per-plant *** Findings We saw positive selection for flower size,albeit without a distinct pattern of higher selection at higher *** pattern of natural selection could be seen both in terms of pollinator visitation rates and in seed *** also found that the largest contributor to changes in seed production was not elevation or flower size but management practices.

关键词： invasive pollinator evolution Cytisus elevation

Hirzebruch X_y genera of the Hilbert schemes of surfaces by localization formula

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Science China Mathematics 2002年第4期45卷 420-431页

作者：刘克锋 catherine YAN 周坚 Department of Mathematics UCLA Los Angeles CA 90024 U.S.A. Department of Mathematics Texas A & M University College Station TX 77843 U.S.A. Department of Mathematical Sciences Tsinghua University Beijing 100084 China

We use the Atiyah-Bott-Segal-Singer Lefschetz fixed point fornula to calculate the Hirzebruch Xy genus Xy(S[n]), where S[n] is the Hilbert scheme of points of length n of a surface 5. Combinatorial interpretation of the weights of the fixed points of the natural torus action on (C2)[n] is used. This is the first step to prove a conjectural formula about the elliptic genus of the Hilbert schemes.

关键词： genera, Hilbert schemes, localization formula.

An Electropolymerized Membrane Biosensor for Specific DNA Recognition

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Chinese Journal of Chemistry 2002年第4期20卷 362-367页

作者：彭图治程琼 YANG F.catherine Department of Chemistry Zhejiang University Xixi Campus Hangzhou Zhejiang 310028 China Department of Chemical Engineering Jiaxing College Jiaxing Zhejiang 314001 China Department of Chemistry Rowan University Glassboro NJ 08028–1701 USA

A sensitive electrochemical biosensor for detecting the sequence of short DNAoligomers is represented. The biosensor is based on a platinum electrode covered a polymerizedmembrane of conductive monomer N-[6-(thien-3-yl) acetoxy]-pyrrolidine-2, 5-dione (TAPD). Themembrane of TAPD immobilizes a probe DNA on the electrode. The hybridization of the probe with asequence-specific DNA in sample solutions is monitored by a self-synthesized electroactiveindicator, which specifically intercalates in the hybrids on the electrode surface. The currentsignal of the biosensor is proportional to the concentration of the target DNA in samples, and avery low detection limit of 5 x 10^(-10) mol/L is found. The biosensor has been used to detect theshort oligomers containing of HIV-1 and mycobacterrium nucleotide sequences.

关键词： biosensor electrochemical polymerization DNA sequence hybridization