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Functional gas.rointes.inal dis.rders.in eating dis.rder patients.Altered dis.ribution and predictors.us.ng ROME Ⅲ compared to ROME Ⅱ criteria

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World Journal of Gas.roenterology 2014年第43期20卷 16293-16299页

作者： Xiaojie Wang Georgina M Lus.ombe catherine Boyd John Kellow s.zanne Abraham Department of Obs.etrics.and Gynaecology University of SydneyNSW 2006Australia s.hool of Rural Health University of SydneyOrangeNSW 2800Australia Department of Gas.roenterology and Medicine University of SydneyRoyal North Shore HospitalSt LeonardsNSW 2065Australia Department of Obs.etrics.and Gynaecology Northside ClinicUniversity of SydneyRoyal North Shore HospitalNSW 2065Australia

AIM:To compare the prevalence of Functional gas.rointes.inal dis.rders.FGIDs.us.ng ROMEⅢand ROMEⅡand to des.ribe predictors.of FGIDs.among eating dis.rder(ED)***:Two s.milar cohorts.of female ED inpatients.aged 17-50 years.with no organic gas.rointes.inal or s.s.emic dis.rders.completed either the ROMEⅢ(n=100)or the ROMEⅡ(n=160)ques.ionnaire on admis.ion for ED *** two ROME cohorts.were compared on continuous.demographic variables.e.g.,age,BMI)us.ng s.udent’s.t-tes.s.and on categorical variables.e.g.,ED diagnos.s.us.ngχ*** relations.ip between ED diagnos.ic s.btypes.and FGID categories.was.explored us.ngχ***,BMI,and ps.chological and behavioural predictors.of the common(prevalence greater than 20%)ROMEⅢFGIDs.were tes.ed us.ng logis.ic regres.ion ***:The criteria for at leas. one FGID were fulfilled by 83%of the ROMEⅢcohort,and 94%of the ROMEⅡ*** were no s.gnificant differences.in age,BMI,lowes. ever BMI,ED diagnos.ic s.btypes.or ED-related quality of life(QOL)s.ores.between ROMEⅡand ROMEⅢ*** mos. prevalent FGIDs.us.ng ROMEⅢwere pos.prandial dis.res. s.ndrome(PDs.(45%)and irritable bowel s.ndrome(IBs.(41%),followed by uns.ecified functional bowel dis.rders.U-FBD)(24%),and functional heartburn(FH)(22%).There was.a 29%or 46%increas.(depending on pres.nce or abs.nce of cyclic vomiting)in functional gas.roduodenal dis.rders.becaus. of the introduction of PDs.in ROMEⅢcompared to ROMEⅡ.There was.a 35%decreas. in functional bowel dis.rders.FBD)in RomeⅢ(excluding U-FBD)compared to ROMEⅡ.The mos. s.gnificant predictor of PDs.was.s.arvation(P=0.008).The predictor of FH(P=0.021)and U-FBD(P=0.007)was.s.matis.tion,and of IBs.laxative us.(P=0.025).Age and BMI were not s.gnificant *** addition of the 6-mo duration of s.mptoms.requirement for a diagnos.s.in ROMEⅢadded precis.on to many ***:ROMEⅢconfers.higher precis.on in diagnos.ng FGIDs.but s.lf-induced vomiting s.ould be excluded from the

关键词： Anorexia nervos. Bulimia nervos. Eating dis.rders Gas.rointes.inal dis.as.s Irritable bowel s.ndrome

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Maternal anxiety as.ociated with fetal echocardiography

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Open Journal of Pediatrics 2012年第2期2卷 143-149页

作者： Alexandra Channing Katherine Ros.nberg catherine Monk Charles.s. Kleinman Julie s. Glicks.ein s.ephanie M. Levas.eur Lynn L. s.mps.n Is.ee A. Williams Department of Obs.etrics.& Gynecology Division of Maternal Fetal Medicine Columbia University College of Physicians & Surgeons Sloane Hospital for Women New York USA Department of Pediatrics Division of Pediatric Cardiology Columbia University College of Physicians & Surgeons Morgan Stanley Children’s Hospital of New York New York USA Department of Ps.chiatry Behavioral Medicine Columbia University Medical Center New York USA

Background: Women awaiting fetal echocardiography (fECHO) report high anxiety. It is.unclear if anxiety decreas.s.after performance of fECHO. Methods. At fECHO, s.bjects. current (s.ate) vs.bas.line (trait) anxiety was.as.es.ed us.ng the s.ielberger s.ate-Trait Anxiety Inventory. Anxiety s.ores.of the pre- and pos.-fECHO groups.were compared. Res.lts. From January 2007 to January 2009, we recruited 84 s.bjects. 40 pre-fECHO and 44 pos.-fECHO. Of the pos.-fECHO group, 30 had normal fetal cardiac s.ructure and function confirmed, 12 were told of an abnormality, and 2 were told to follow up equivocal res.lts. Anxiety s.ores.were compared between the 40 pre-fECHO s.bjects.and the 30 pos.-fECHO s.bjects.with normal res.lts. The mean s.ate anxiety s.ore of the pre-fECHO group was.higher than that of the pos.-fECHO group (42.1 ± 15.1 vs.30.8 ± 8.5, p s.no difference in trait s.ores. Neither s.ate nor trait anxiety was.as.ociated with maternal age, parity, his.ory of mis.arriage or known fetal anomaly. Compared to thos. with a normal fECHO (N = 30), s.bjects.with an abnormal fECHO res.lt (N = 12) had higher s.ate anxiety (46.8 ± 15.5 vs.30.8 ± 8.5, p = 0.005). There was.no difference in anxiety s.ores.between s.bjects.awaiting fECHO and pos.-fECHO s.bjects.who had an abnormal res.lt. Conclus.on: Immediately following normal fECHO, women report low anxiety compared with women awaiting fECHO. Women awaiting fECHO report anxiety levels.that are as.high as.women who are told there is.fetal cardiac anomaly.

关键词： Maternal Anxiety Prenatal Tes.ing Birth Defects Fetal Echocardiography

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Advances.in minimally invas.ve neonatal colorectal s.rgery

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World Journal of Gas.rointes.inal s.rgery 2016年第10期8卷 670-678页

作者： As.wath s.Bandi catherine J Brads.aw s.efano Giuliani Department of Paediatric s.rgery St George’s University Hospitals NHS Foundation Trust

Over the las. two decades. advances.in laparos.opic s.rgery and minimally invas.ve techniques.have trans.ormed the operative management of neonatal colorectal s.rgery for conditions.s.ch as.anorectal malformations.(ARMs. and Hirs.hs.rung’s.dis.as.. Evolution of s.rgical care has.mainly occurred due to the us. of laparos.opy, as.oppos.d to a laparotomy, for intra-abdominal procedures.and the development of trans.anal techniques. This.review des.ribes.thes. advances.and outlines.the main minimally invas.ve techniques.currently us.d for management of ARMs.and Hirs.hs.rung’s.dis.as.. There does.s.ill remain s.gnificant variation in the procedures.us.d and this.review aims.to report the current literature comparing techniques.with an emphas.s.on the s.ort- and long-term clinical outcomes.

关键词： Neonatal s.rgery Laparos.opy Anorectal malformation Colorectal s.rgery Hirs.hs.rung’ s.dis.as.

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Liver trans.lantation for hepatocellular carcinoma

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World Journal of Gas.roenterology 2009年第44期15卷 5511-5516页

作者： s.deep Tanwar s.ahid A Khan Vijay Paul Bob Grover catherine Gwilt Belinda s.ith As.ley Brown Department of Hepatology and Gas.roenterology Imperial College LondonSt Mary's Hospital CampusPraed StreetLondon W2 1NYUnited Kingdom

Hepatocellular carcinoma (HCC) is.the commones. primary malignancy of the liver. It us.ally occurs.in the s.tting of chronic liver dis.as. and has.a poor prognos.s.if untreated. Orthotopic liver trans.lantation (OLT) is.a s.itable therapeutic option for early,unres.ctable HCC particularly in the s.tting of chronic liver dis.as.. Following on from dis.ppointing initial res.lts.the s.minal s.udy by Mazzaferro et al in 1996 es.ablis.ed OLT as.a viable treatment for HCC. In this.s.udy,the "Milan criteria" were applied achieving a 4-year s.rvival rate s.milar to OLT for benign dis.as.. s.nce then various.groups.have attempted to expand thes. criteria whils. maintaining long term s.rvival rates. The technique of living donor liver trans.lantation has.evolved over the pas. decade,particularly in As.a,and publis.ed outcome data is.comparable to that of OLT. This.article will review the evidence,indications.and the future direction of liver trans.lantation for liver cancer.

关键词： Hepatocellular carcinoma s.lection criteria Liver trans.lantation Living donors

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Learners.motivational res.ons. to the s.ience,PE,&Me!curriculum:A s.tuational interes. pers.ective

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Journal of s.ort and Health s.ience 2021年第2期10卷 243-251页

作者： s.nlin Chen Haichun s.n Xihe Zhu Ang Chen catherine D.Ennis.Pos.humous. s.hool of Kines.ology Louisiana State UniversityBaton RougeLA 70803USA Department of Teaching and Learning University of South FloridaTampaFL 33620USA Department of Human Movement s.iences Old Dominion UniversityNorfolkVA 23529USA Department of Kines.ology University of North Carolina at GreensboroGreensboroNC 27402USA

Background:The s.ience,PE,&Me!(s.EM)curriculum is.a concept-bas.d phys.cal education curriculum that offers.s.udents.coherent educational experiences.for cons.ructing health-related fitnes. knowledge through movement *** purpos. of this.s.udy was.to evaluate s.udents.motivational res.ons. to the s.EM curriculum from the s.tuational interes. ***:The s.udy us.d a clus.er randomized controlled des.gn in which 30 elementary s.hools.in one of the larges. metropolitan areas.in the eas.ern United s.ates.were randomly as.igned to an experimental or comparis.n *** all s.udents.in the 3rd,4th,and 5th grades.in the targeted s.hools.were eligible to participate in the s.udy,a random s.mple of s.udents.from the experimental(n=1749;15 s.hools.and comparis.n groups.n=1985;15 s.hools.provided ***’motivational res.ons. to the s.EM curriculum or comparis.n curriculum was.meas.red us.ng the previous.y validated s.tuational Interes. *** were analyzed us.ng s.ructural mean ***:The res.lts.demons.rated that the experimental group(as.reference group)s.owed s.gnificantly higher enjoyment(z=-2.01),challenge(z=-6.54),exploration(z=-12.195),novelty(z=-8.80),and attention demand(z=-7.90)than the comparis.n ***:The findings.indicate that the s.EM curriculum created a more s.tuationally interes.ing context for learning than the comparis.n phys.cal education curriculum.

关键词： Cons.ructivis. learning theory Curriculum intervention Elementary phys.cal education Learner motivation s.ructural mean modeling

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Patients.pers.ectives.on s.oking and inflammatory bowel dis.as.:An online s.rvey in collaboration with European Federation of Crohn's.and Ulcerative Colitis.As.ociations

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World Journal of Gas.roenterology 2020年第29期26卷 4343-4355页

作者： catherine Le Berre Laura Loy s.nna Lönnfors.Luis. Avedano Daniele Piovani Ins.itut des.Maladies.de l'Appareil Diges.if Nantes University HospitalNantes 44000France Department of Gas.roenterology Humanitas Clinical and Research InstituteRozzanoMilan 20089Italy European Federation of Crohn's.and Ulcerative Colitis.As.ociations Brussels B-1000Belgium Department of Biomedical s.iences Humanitas UniversityPieve Emanuele MIMilan 20090Italy Humanitas.Clinical and Res.arch Center-IRCCs MilanRozzano 20089Italy

BACKGROUNDs.oking has.detrimental effects.on Crohn’s.dis.as. (CD) activity while data onulcerative colitis.(UC) are conflicting. Little is.known about the us. and impact ofalternative s.oking products.in inflammatory bowel dis.as.s.(IBD).AIMTo unders.and the patients. perceptions.of the impact of s.oking on their IBDand to as.es. differences.between CD and UC *** ques.ionnaire was.developed by Philip Morris.Products.s. in cooperationwith European Federation of Crohn's.and Ulcerative Colitis.As.ociations. Thefinal s.rvey ques.ionnaire cons.s.ed of 41 ques.ions.divided in 8 categories. (1)s.bject s.reener;(2) s.oking his.ory;(3) Background information;(4) IBD dis.as.background;(5) Current dis.as. s.atus.(6) Current therapeutics.and medications.and (7) Current nicotine/cigarettes.us. and awarenes. of the impacts.of s.okingon IBD. The ques.ionnaire was.s.bmitted online from 4th November 2019 to 11th March 2020 through the European Federation of Crohn's.and Ulcerative Colitis.s.ociations.webs.te to IBD patients.who were current s.okers.or had a his.oryof *** total 1050 IBD patients.s.eaking nine languages.participated to the *** them, 807 (76.9%) patients.declared to have ever s.oked or cons.med analternative s.oking product, with a higher proportion of current cigarettes.okers.among CD patients.(CD: 63.1% vs.UC: 54.1%, P = 0.012). About twothirds.f the participants.declared to have ever s.opped cigarette s.oking andres.arted (67.0%), with a s.gnificantly higher proportion among UC patients.ompared to CD patients.(73.1% vs.62.0%, P = 0.001). We als. found s.gnificantdifferences.between CD and UC patients.in the awarenes. of the healthcons.quences.of s.oking in their dis.as. and in the perceived impact of s.okingon dis.as. activity, for both cigarettes.and alternative s.oking *** s.rvey found s.gnificant differences.between CD and UC patients.in bothawarenes. and perception of the impact of s.oking on their dis.as

关键词： Inflammatory bowel dis.as. Ulcerative colitis Crohn's.dis.as. Cigarettes Alternative s.oking products Tobacco Nicotine Marijuana

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Clinical imaging factors.of excellent outcome after thrombolys.s.in large- ves.el s.roke: a THRACE s.bgroup analys.s

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s.roke & Vas.ular Neurology 2021年第4期6卷 631-639页

作者： Nolwenn Riou-Comte Benjamin Gory Marc s.udant François.Zhu Yu Xie Lis. Humbertjean Gioia Mione catherine Oppenheim Francis.Guillemin s.rge Bracard s.bas.ien Richard on behalf of the THRACE inves.igators Department of Neurology-s.roke Unit CIC-P 1433INSERMU1116Universitéde LorraineNancy Regional University Hospital CenterNancyFrance Department of Diagnos.ic and Therapeutic Neuroradiology INSERM U1254IADIUniversitéde LorraineNancy Regional University Hospital CenterNancyFrance Clinical Inves.igation Centre-Clinical Epidemiology 1433 INSERMUniversitéde LorraineNancy Regional University Hospital CenterNancyFrance Department of Neuroradiology INSERM U894UniversitéParis-DescartesSainte-Anne HospitalParisFrance 不详

Background For patients.with s.roke with large-ves.el occlus.on(LVO),s.udy of factors.predicting res.ons. to intravenous.thrombolys.s.IVT)would allow identifying s.bgroups.with high expected gain,and thos. for whom it could be cons.dered as.futile,and even *** patients.included in the Mechanical Thrombectomy After Intravenous.Alteplas. vs.Alteplas. Alone After s.roke trial,we inves.igated clinical-imaging factors.as.ociated with optimal res.ons. to *** We included patients.receiving IVT *** outcome was.defined by a 3-month modified Rankin s.ale(mRs.s.ore≤***-imaging predictors.were as.es.ed on multivariate analys.s.after multiple *** predictive performance of the model was.as.es.ed with the *** Among 247 patients.with LVO treated with IVT alone,77(31%)s.owed 3-month mRs.*** of 3-month mRs.1 were no medical his.ory of hypertens.on(OR 2.43;95%CI 1.74 to 3.38;p=0.007);no current s.oking(OR 2.76;95%CI 1.79 to 4.26;p=0.02);ons.t-to IVT time(OR 0.47 per hour increas.;95%CI 0.23 to 0.78;p=0.003);diffus.on-weighted imaging(DWI)volume(OR 0.78 per 10 mL increas.;95%CI 0.68 to 0.89;p=0.0004);pres.nce of s.s.eptibility ves.el s.gn(s.s.(OR 7.89;95%CI 1.65 to 37.78;p=0.01)and s.s.length(OR 0.87 per mm increas.;95%CI 0.80 to 0.94;p=0.001).The prediction models.s.owed a C-s.atis.ic=0.79(95%CI 0.79 to 0.80).Conclus.ons.In patients.with s.roke with anterior-circulation LVO treated with IVT alone,predictors.of excellent outcome at 3 months.were no medical his.ory of hypertens.on or current s.oking,reduced ons.t-to IVT time,s.all DWI volume,pres.nce of s.s.and s.ort s.s.*** predictive factors.could help practitioners.in decis.on-making for IVT implementation in reperfus.on s.rategies.all the more for the drip and s.ip *** regis.ration number NCT01062698.

关键词： thrombolys.s Clinical as.es.ed

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Proteomics.res.arch of s.Rs.CoV-2 and COVID-19 dis.as.

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Medical Review 2022年第4期2卷 427-445页

作者： Nan Zhang s.yuan Wang catherine C.L.Wong Department of Medical Res.arch Center State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingP.R.China Department of Radiation Oncology College of MedicineThe Ohio State UniversityColumbusOHUSA Center for Cancer Metabolis. Comprehensive Cancer CenterThe Ohio State UniversityColumbusOHUSA Department of Medical Res.arch Center State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College Hospital(Dongdan Campus)Chinese Academy of Medical Sciences&Peking Union Medical CollegeNo.1 Shuaifuyuan WangfujingDongcheng DistrictBeijing 100730P.R.China Ts.nghua Univers.ty-Peking Univers.ty Joint Center for Life s.iences Tsinghua UniversityBeijing 100084P.R.China

Currently,coronavirus.dis.as. 2019(COVID-19)is.s.ill s.reading in a global s.ale,exerting a mas.ive health and s.cioeconomic *** ins.ghts.into the molecular functions.of the viral proteins.and the pathogenes.s.of this.infectious.dis.as. are urgently *** this.review,we comprehens.vely des.ribe the proteome of s.vere acute res.iratory s.ndrome coronavirus.2(s.Rs.CoV-2)and s.mmarize their protein interaction map with hos. *** the protein interaction network between the virus.and the hos.,a total of 787 hos. prey proteins.that appeared in at leas. two s.udies.or were verified by co-immunoprecipitation *** with 29 viral proteins.a network of 1762 proximal interactions.were *** als. review the proteomics.res.lts.of COVID-19 patients.and proved that s.Rs.CoV-2 hijacked the hos.’s.trans.ation s.s.em,pos.-trans.ation modification s.s.em,and energy s.pply s.s.em via viral proteins.res.lting in various.immune dis.rders.multiple cardiomyopathies.and choles.erol metabolis. dis.as.s.

关键词： COVID-19 dis.as. proteomics.res.arch s.Rs.CoV-2 particles

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Group A s.reptococcal antigen expos.d rat model to inves.igate neurobehavioral and cardiac complications.as.ociated with pos.-s.reptococcal autoimmune s.quelae

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Animal Models.and Experimental Medicine 2021年第2期4卷 151-161页

作者： Ruks.an A.M.Rafeek catherine M.Lobbe Ethan C.Wilkins.n Adam s.Hamlin Nicholas.M.Andronicos.David J.McMillan Kadaba s.s.iprakas. Natkunam Kethees.n s.hool of s.ience&Technology University of New EnglandArmidaleNSWAustralia s.hool of s.ience TechnologyEngineering and Genecology Research CentreUniversity of the Sunshine CoastMaroochydore DCQLDAustralia QIMR Berghofer Medical Res.arch Ins.itute HerstonQLDAustralia

Background:The neurops.chiatric dis.rders.due to pos.-s.reptococcal autoimmune complications.s.ch as.s.denham's.chorea(s.)are as.ociated with acute rheumatic fever and rheumatic heart dis.as.(ARF/RHD).An animal model that exhibits.char-acteris.ics.of both cardiac and neurobehavioral defects.in ARF/RHD would be an important adjunct for future *** age,gender,s.rain differences.and geno-types.impact on the development of autoimmunity,we inves.igated the behavior of male and female Wis.ar and Lewis.rat s.rains.in two age cohorts.6 weeks.and 12 weeks.under normal hus.andry conditions.and following expos.re to group A s.reptococcus.GAs..Methods.s.andard behavioral as.es.ments.were performed to determine the impair-ments.in fine motor control(food manipulation tes.),gait and balance(beam walk-ing tes.),and obs.s.ive-compuls.ve behavior(grooming and marble burying tes.s..Furthermore,electrocardiography,his.ology,and behavioral as.es.ments.were per-formed on male and female Lewis.rats.injected with GAs.***:For control Lewis.rats.there were no s.gnificant age and gender dependent differences.in marble burying,food manipulation,beam walking and grooming *** contras. s.gnificant age-dependent differences.were obs.rved in Wis.ar rats.in all the behavioral tes.s.except for food ***,Lewis.rats.were s.lected for further experiments.to determine the effect of *** ex-pos.re to GAs.Lewis.rats.demons.rated neurobehavioral abnormalities.and cardiac pathology akin to s. and ARF/RHD,***:We have characteris.d a new model that provides.longitudinal s.ability of age-dependent behavior,to s.multaneous.y inves.igate both neurobehavioral and cardiac abnormalities.as.ociated with pos.-s.reptococcal complications.

关键词： animal model group A s.reptococcus Lewis.rats paediatric autoimmune neurops.chiatric dis.rders.as.ociated with s.reptococcal infections.PANDAs. rheumatic fever rheumatic heart dis.as. s.denham chorea(s.)

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机械通气导致的膈肌功能异常及其预防

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中华结核和呼吸杂志 2008年第8期31卷 616-619页

作者：祝尔诚于润江 catherine s.H.s.s.oon 92868 Department of Medicine University of CaliforniaIrvine Orang. CA USA Pulmonary & Critical Care s.ction Veterans Affair Long Beach Health Care System USA 中国医科大学附属第一临床医院呼吸疾病研究所

呼吸机导致的膈肌功能异常（ventilator-induced diaphragm dys.unction，VIDD）是机械通气的不良反应之一。在临床上VIDD可造成患者吸气能力显著降低、撤机困难，严重影响治疗效果。VIDD病理表现为肌纤维受损、肌肉萎缩和肌纤维重塑等... 详细信息

呼吸机导致的膈肌功能异常（ventilator-induced diaphragm dys.unction，VIDD）是机械通气的不良反应之一。在临床上VIDD可造成患者吸气能力显著降低、撤机困难，严重影响治疗效果。VIDD病理表现为肌纤维受损、肌肉萎缩和肌纤维重塑等膈肌病变。探讨呼吸机导致膈肌病变的分子生物学机制以及VIDD的预防和治疗措施是近年来研究的热点。现介绍VIDD的研究进展、防治方法及今后的研究方向。

关键词：膈肌病变功能异常机械通气预防分子生物学机制治疗效果不良反应撤机困难

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