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Challenges for cysteamine stabilization,quantification,and biological effects improvement

Journal of Pharmaceutical Analysis 2020年第6期10卷 499-516页

作者： Carla Atallah cather.ne charcosset Helene Greige-Gerges Bioactive Molecules Research Laboratory Doctoral School of Sciences and TechnologiesFaculty of SciencesLebanese UniversityLebanon Laboratory of Automatic Control Chemical and Pharmaceutical EngineeringClaude Bernard Lyon 1 UniversityFrance

The aminothiol cysteamine,derived from coenzyme A degradation in mammalian cells,presents several biological ***,the bitter taste and sickening odor,chemical instability,hygroscopicity,and poor pharmacokinetic profile of cysteamine limit its *** use of encapsulation systems is a good methodology to overcome these undesirable properties and improve the pharmacokinetic behavior of ***,the conjugation of cysteamine to the surface of nanoparticles is generally proposed to improve the intra-oral delivery of cyclodextrin-drug inclusion complexes,as well as to enhance the colorimetric detection of compounds by a gold nanoparticle aggregation *** the other hand,the detection and quantification of cysteamine is a challenging mission due to the lack of a chromophore in its structure and its susceptibility to oxidation before or during the *** agents are therefore applied for the quantification of this *** our knowledge,the derivatization techniques and the encapsulation systems used for cysteamine delivery were not reviewed ***,this review aims to compile all the data on these methods as well as to provide an overview of the various biological applications of cysteamine focusing on its skin application.

关键词： Cysteamine Detection Encapsulation Skin Stability

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