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Journal of Pharmacy and Pharmacology 2018年第11期6卷 965-969页

作者： Cecília da Silva Angelo(RN) Ademar Lopes(PhD) catharina ferreira de meira pachioni(MSc) Eduardo Henrique Giroud Joaquim(MSc) Samuel Aguiar Junior(PhD) Gustavo Cardoso Guimaraes(PhD) Glauco Baiocchi Neto(PhD) Felipe JoséFernandez Coimbra(PhD) Isabel Miranda Bonfim(MSc) Rita de Cassia Burgos de Oliveira(PhD) Tailine Ligia Tadini(RN) A.C.Camargo Cancer Center Sao Paulo04002-010Brazil

Purpose:This study aims at reporting the experience of a cancer hospital’s multiprofessional team with surgery patients in performing cytoreductive surgeries associated with hyperthermic intraperitoneal ***:It is a reporting about the experience of the multiprofessional team at AC Camargo Cancer Center’s surgery center,which operates in cytoreductive surgeries with hyperthermic intraperitoneal chemotherapy,thus guaranteeing the surgery patient’s ***:No safety report for the surgery patient subjected to intraperitoneal hypothermic chemotherapy was found in the ***,the surgery center’s multiprofessional team’s practice was based on standards for manipulating chemotherapeutic agents and for safely administering medication.A checklist was elaborated for cytoreductive surgeries with hyperthermic intraperitoneal chemotherapy based on the surgery patient safety protocol and the institution’s multiprofessional team’s ***:From the multiprofessional team’s experiences in cytoreductive surgeries with hyperthermic intraperitoneal chemotherapy,the importance of elaborating a checklist to promote the quality of assistance and guarantee patient safety during the entire intraoperative phase became evident.

关键词： Patient safety chemotherapy for cancer by regional perfusion checklist

Chemical composition of Rosmarinus officinalis essential oil and antioxidant action against gastric damage induced by absolute ethanol in the rat

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Asian Pacific Journal of Tropical Biomedicine 2016年第8期6卷 677-681页

作者： Christiane Takayama Felipe meira de-Faria Ana Cristina Alves de Almeida Ricardo Jose Dunder Luis Paulo Manzo Eduardo Augusto Rabelo Socca Leonia Maria Batista Marcos Jose Salvador Alba Regina Monteiro Souza-Brito Anderson Luiz-ferreira Functional and Structural Biology department Biology Institute Campinas State University Pharmacology department Faculty of Medical Sciences Campinas State University department of Pharmaceutical Sciences Federal University of Paraiba Plant Physiology department Biology Institute Campinas State University Federal University of Goias Institute of Biotechnology Nucleus of Biological Sciences Regional Catalao

Objective: To evaluate the antioxidant activity of the essential oil obtained from Rosmarinus officinalis(R. officinalis) in ethanol-induced gastric ulcer model in ***: The antioxidant properties of the essential oil obtained from R. officinalis were evaluated against gastric injury induced by absolute ethanol. Gastric tissues were prepared to enzymatic assays. The levels of glutathione, lipid peroxides, and the activities of glutathione peroxidase, superoxide dismutase and myeloperoxidase were ***: Ethanol produced severe hemorrhagic lesions in the stomach with ulcerative lesion of(140.2 ± 37.2) mm2. In animals pretreated with essential oil of R. officinalis(50 mg/kg, p.o.), a significant inhibition of mucosal injury of(21.2 ± 7.1) mm2(84%inhibition) was observed. The essential oil of R. officinalis protected the gastric mucosa probably by modulating the activities of the enzymes(superoxide dismutase and glutathione peroxidase) and increasing or maintaining the levels of glutathione. In addition,lipid peroxides levels were reduced. The essential oil of R. officinalis was analyzed by gas chromatography–mass spectrometer and the main constituents were cineole(28.5%),camphor(27.7%) and alpha-pinene(21.3%).Conclusions: We suggest that the monoterpenes present in the essential oil obtained from R. officinalis may be among the active principles responsible for the antioxidant activity shown by essential oil of R. officinalis.

关键词： Rosmarinus officinalis L. Antioxidant activity Gastric ulcer Antioxidant enzymes

Anti-inflammatory intestinal activity of Combretum duarteanum Cambess. in trinitrobenzene sulfonic acid colitis model

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World Journal of Gastroenterology 2017年第8期23卷 1353-1366页

作者： Gedson Rodrigues de Morais Lima Flavia Danniele Frota MachadoLarissa Lucena Périco Felipe meira de Faria Anderson Luiz-ferreira Alba Regina Monteiro Souza Brito Cláudia Helena Pellizzon Clélia Akiko Hiruma-Lima Josean Fechine Tavares JoséMaria Barbosa Filho LeOnia Maria Batista departamento de Ciências Farmacêuticas Centro de Ciências da SaúdeLaboratório de Farmacologia do Trato GastrintestinalUniversidade Federal da Paraíba(UFPB)Cidade Universitária departamento de Fisiologia Instituto de BiociênciasUniversidade Estadual Paulista departamento de Biologia Estrutural e Funcional Instituto de BiologiaUniversidade Estadual de Campinas(UNICAMP departamento de Ciencias Biológicas Instituto de BiotecnologiaUniversidade Federal de Goiás departamento de Morfologia Instituto de BiociênciasUniversidade Estadual Paulista

AIM To evaluate the anti-inflammatory intestinal effect of the ethanolic extract(EtO HE) and hexane phase(HexP) obtained from the leaves of Combretum duarteanum(Cd).METHODS Inflammatory bowel disease was induced using trinitrobenzenesulfonic acid in acute and relapsed ulcerative colitis in rat models. Damage scores, and biochemical, histological and immunohistochemical parameters were evaluated. RESULTS Both Cd-Et OHE and Cd-Hex P caused significant reductions in macroscopic lesion scores and ulcerative l e sionareas. The vegetable samples inhibited myeloperoxidase increase, as well as pro-inflammatory cytokines TNF-α and IL-1β. Anti-inflammatory cytokine IL-10 also increased in animals treated with the tested plant samples. The anti-inflammatory intestinal effect is related to decreased expression of cyclooxygenase-2, proliferating cell nuclear antigen, and an increase in superoxide dismutase. CONCLUSION The data indicate anti-inflammatory intestinal activity. The effects may also involve participation of the antioxidant system and principal cytokines relating to inflammatory bowel disease.

关键词： Combretum duarteanum 药用的植物 Combretaceae 煽动性的肠疾病反煽动性的肠的活动

Dynamical Donwscaling for Railroad Areas in Eastern Amazon and Southeastern Brazil:Current Climate and Near-Future Projections

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Atmospheric and Climate Sciences 2014年第2期4卷 155-163页

作者： Everaldo B.de Souza Bergson C.de Moraes Douglas B.S.ferreira Luiz Gylvan meira Filho Instituto Tecnológico VALE—ITV Grupo de Pesquisa sobre Mudancas do ClimaBelémBrazil

We performed a dynamic downscaling using REGCM4 regional model driven by MPI global model for current (1990/2012) and near-future (2015/2039) climate in order to characterize the seasonal rainfall regimes throughout the railroad areas in eastern Amazon and southeastern Brazil. The analysis of observational data for the current climate indicated the existence of pronounced spatial variations in rainfall regime across railroad regions during both the rainy and dry seasons. Although models have presented generalized underestimation, the regional model showed improvements on spatial representation and intensity of the rainfall in comparison with global model results. We reported the future projections taking into account the correction of simulated rainfall by the values of the biases found in each respective seasonal regime, so that the results are expressed by percentage changes of the future (2015/2037) relative to the current climate patterns. For the railroad in eastern Amazon, projections indicate a weak decrease of rainfall of about -15% in the rainy season (January to May), however during the dry season (June to October) are expected drastic reductions between -70% and -90% in south (Carajás in Pará state) and north (Sao Luis in Maranhao state) portions. Conversely, for the railroad in southeast Brazil, model projections point out for an increased rainfall regime during the rainy season (October to February) around +30% to +40% in the east part of the region over the Espírito Santo state.

关键词： Regional Climate Modeling Rainy and Dry Seasons Climate Change Brazil Climate REGCM4

Comparative Skill of Numerical Weather Forecasts in Eastern Amazonia

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Atmospheric and Climate Sciences 2013年第3期3卷 355-363页

作者： Bergson Cavalcanti de Moraes Douglas Batista da Silva ferreira Luiz Gylvan meira Filho Juarez Ventura de Oliveira Everaldo Barreiros de Souza Pedro Pereira ferreira Junior Renata Kelen Cardoso Camara Edson Jose Pda Rocha Joao Batista M.Ribeiro Vale Institute of Technology BelemBrazil Federal University of Para(UFPa) BelemBrazil

The present study evaluates the performance of three numerical weather forecasting models: Global Forecast System (GFS), Brazilian Regional Atmospheric Modelling System (BRAMS) and ETA Regional Model (ETA), by means of the Mean Error (ME) and the Root Mean Square Error (RMSE), during the most rainy four months period (January to April 2012) on Eastern Amazonia. The models displayed errors of superestimation and underestimation with respect to the observed precipitation, mainly over center-north of Pará and all of Amapá, where the precipitation is higher. Among the analyzed models, GFS shows the best performance, except during January and March, when the model to underestimated precipitation, possibly due to the anomalously high values recorded.

关键词： Meteorological Models Mean Error Root Mean Square Error Precipitation Eastern Amazonia

dental treatment of twin monozygotic brothers with Fragile X syndrome

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Health 2010年第10期2卷 1199-1203页

作者： Flavia Melo meira Luis Candido Pinto Silva Regina Haddad Rezek ferreira Roberval Almeida Cruz 不详

Fragile X syndrome (FXS) is the main cause of inherited mental retardation and is the result of transcriptional silencing of the fragile X mental retardation gene FMR1. An absence of the associated protein FMRP leads to the deregulation of many genes, which results in phenotypes of Attention-deficit Hyperactivity Disorder (ADHD), anxiety, epilepsy and autism. The aim of this article is to report the clinical case of twin siblings affected by FXS and to describe the procedures for dental treatment with intravenous sedation. Information regarding the characteristic manifestations of FXS not only aided in the handling of the patients but also enabled us to develop clinical programs to promote and maintain oral health using individualized and specific dental procedures.

关键词： Syndromes Head and Neck/cleft Lip and Palate Fragile X Syndrome Pain Control/Sedation Oral Medicine

Epidemiological Profile of Breast Neoplasia in the Municipality of Valença (RJ Brazil): Study from 2009 to 2017

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Journal of Biosciences and Medicines 2020年第6期8卷 179-187页

作者： catharina Ferrari Salgado Fernandes Helena Torres Passos Izabela Cristina ferreira Marina Coelho de Paulo Raquel Alencar Sampaio Ferraz Filomena Aste Silveira João Alfredo Seixas Daniel Almeida da Costa Faculty of Medicine of Valenç a UNIFAA Valen&ccedil a Brazil

Breast neoplasms are the main oncological pathology in Gynecology and Obstetrics, with increasing rates of incidence and mortality in the female population. According to the World Health Organization (WHO), more than 1 million new cases of breast cancer are diagnosed worldwide every year. This study aims to understand and analyze the epidemiological profile of patients diagnosed with breast cancer in the last nine years in the city of Valença—RJ, Brazil. A descriptive, documentary-retrospective analysis was carried out from January 2009 to december 2017, on 96 records of women who underwent breast biopsy at the Escola Escola de Valença (HEV), referred by the HEV Gynecology outpatient clinic. The results compared the variables age, race, parity, alcoholism, smoking, comorbidities, histological type, family history and screening performed with the scenario of breast cancer in the world, concluding that it is essential to identify patients at risk development of breast cancer to guide prevention, screening and early detection of pathology. The cases in the municipality are similar to other studies in relation to smoking, alcohol consumption, associated comorbidities, histological type and family history. However, the prevalence in younger people stands out, as well as the high percentage of women who have not had previous screening, which highlights the importance of the development and spread of women’s health in this city in the south of the state.

关键词： Breast Neoplasia Epidemiological Profile Comorbidity