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Off-Pump CABG for Mulitvessel Coronary Artery Disease-Safe Incorporation into Surgical Practice

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Open Journal of Thoracic Surgery 2012年第3期2卷 78-86页

作者： catharina Nesselmann Sadia Aftab Manikandan Chandran Fraser W. H. Sutherland Anaesthetic Department Royal Hospital for Sick Children Glasgow Scotland Department for Cardiothoracic Surgery Golden Jubilee National Hospital Glasgow Scotland Department of Cardiac Surgery University of Rostock Rostock Germany

Introduction: Since its revival two decades ago development of the surgical technique, along with evidence and clinical outcomes of off-pump coronary artery bypass surgery (OPCAB) were brought into focus. Methods: We report a single surgeon, single center experience of the first 37 consecutive patients undergoing off-pump surgery. Patients were selected for OPCAB (study group) individually and matched retrospectively to a control group of 113 patients performed over an identical time frame. Data were retrieved from a hospital data base (TOMCAT). Results: Mean Logistic European System of Cardiac Operative Risk Stratification (EuroSCORE) was slightly higher in the off-pump group (3.8% versus 2.9%). One patient died during the study and this was in the off-pump CAB group (OPCAB-30 day mortality 2.7%). Operating time was slightly shorter in the off-pump group (3 hours 28 minutes versus 3 hours 49 minutes, p = 0.15). After exclusion of outliers, total hospital stay was significantly shorter for off-pump cases (mean 6.8 days versus 8.37 days), while Intensive Care Unit (ICU) stay (1.2 versus 1.4 days) and ventilation time were only slightly shorter (9.35 hours versus 10.6 hours) for off-pump cases. Chest tube drainage was significantly lower in the off-pump group (484 ml versus 744 ml, p = 0.04) with correspondingly slightly lower transfusion requirements and significantly increased discharge haemoglobin concentrations in OPCAB. There was one cerebrovascular accident (CVA) in the off-pump group and none in the on-pump group. Conclusion: In this study we show short term outcomes for introduction of off-pump into surgical technique. Length of ICU stay, ventilation times, chest tube drainage, transfusion re0 quirements and pre-discharge haemoglobin concentration all appeared superior in the off pump group. The off-pump technique was safely introduced into the surgeon`s service with relatively little mortality. Experience of surgeon was considered advantageous for fast adapti

关键词： Off-Pump Versus On-Pump Coronary Artery Bypass Grafting Without Cardiopulmonary Bypass Cardiac Surgery

Behavioral Evidence for Cognitive Dysfunctions in the(BALB/cByJ-Kv1.1mceph/mceph)Mouse Model for Epilepsy

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Journal of Behavioral and Brain Science 2011年第4期1卷 210-228页

作者： Sarah Holst Elin Aberg Therese M.Eriksson catharina Lavebratt Sven Ove Ogren Department of Neuroscience Karolinska InstituteStockholmSweden Department of Molecular Medicine and Surgery Karolinska University HospitalStockholmSweden Center of Molecular Medicine Department of Physiology and PharmacologyKarolinska InstituteStockholmSweden Department of Clinical Neuroscience Karolinska InstituteStockholmSweden

The epileptic mouse model BALB/cByJ-Kv1.1mceph/mceph (mceph/mceph) is homozygous for a spontaneous mutation truncating the Shaker-like voltage gated potassium channel, Kv1.1 (Kcna1). The mceph/mceph mice are asymptomatic at birth, but develop from 3 weeks of age epileptic seizures, overgrowth and neuronal hyperplasia of the hippocampus. Hippocampal cognitive function of the mice was examined by investigating emotional memory using the aversive Passive Avoidance (PA) task combined with studies of explorative behavior using the non-aversive Novel Cage test (NCT). The behavioural results were examined by multivariate analysis. Compared to wild type and heterozygous mice, the mceph/mceph mice displayed lower exploratory and safety assessment behavior in the NCT and impairment in PA retention 24 hours after training, indicating an impairment in cognitive functions. In conclusion, the epileptic mouse model BALB/cByJ-Kv1.1mceph/mceph, with chronic epilepsy related to potassium-channelopathy, display a behavioural phenotype characterized by impairments in emotional memory and defensive motivational responses probably related to hippocampal dysfunctions.

关键词： Epilepsy Potassium Ion-Channelopathy Hippocampus Passive Avoidance Novel Cage Test Principal Component Analysis

Dissemination and Enrichment of Knowledge About Normal Birth to Bring About a Change to Society

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Psychology Research 2021年第5期11卷 208-235,I0004页

作者： Olga Gouni Eleni Hadjigeorgiou Dolores Ruiz-Berdún catharina Susanna Minnie Jean Calleja-Agius Cosmoanelixis Prenatal&Life SciencesPrenatal Sciences Research Institute SOPHIAAthensGreece Cyprus University of Technology LimassolCyprus University of Alcalá Alcaláde HenaresSpain North-West University PotchefstroomSouth Africa University of Malta MsidaMalta

The birth of a child is a pivotal time in the life of a mother,her family and *** health and well-being of a mother and child at birth largely determines the future health and wellness of the entire family(World Health Organization(WHO),2005).Normal birth has enormous benefits for mothers,neonates,families,and *** growing supportive evidence for the promotion of normal birth certainly relies on multidisciplinary collaborations to continue spreading knowledge about the advantages of normal birth and enhancing the understanding of how knowledge about normal birth can change *** about normal birth varies among different groups of healthcare professionals,and it would be useful to identify how it is clinically translated to become accessible to other professionals and research teams,consumers,the public,significant decision-or policy makers,the industry,funding bodies,and volunteer health teams.

关键词： normal birth childbirth delivery knowledge transfer knowledge translation applied knowledge healthcare implementation research implementation childbirth research translational science

Implementation of differentiated service delivery for paediatric HIV care and treatment:opportunities,challenges and experience from seven sub-Saharan African countries

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Family Medicine and Community Health 2020年第3期8卷 36-41页

作者： Rebecca Abelman catharina Alons Jeni Stockman Ivan Teri Anna Grimsrud Maryanne Ombija Christopher Makwindi Justine Odionyi Esther Tumbare Barry Longwe Mahoudo Bonou Juma Songoro Lawrence Mugumya Jennifer Cohn Internal Medicine Massachusetts General HospitalBostonMassachusettsUSA University of Pennsylvania Perelman School of Medicine PhiladelphiaPennsylvaniaUSA Technical Leaderhip and Program Optimization Elizabeth Glaser Pediatric AIDS FoundationWashingtonDistrict of ColumbiaUSA Elizabeth Glaser Pediatric AIDS Foundation WashingtonDistrict of ColumbiaUSA International AIDS Society Cape TownSouth Africa Elizabeth Glaser Pediatric AIDS Foundation MbabaneSwaziland Elizabeth Glaser Pediatric AIDS Foundation NairobiKenya Elizabeth Glaser Pediatric AIDS Foundation MaseruLesotho Elizabeth Glaser Pediatric AIDS Foundation LilongweMalawi Elizabeth Glaser Pediatric AIDS Foundation MaputoMozambique Elizabeth Glaser Pediatric AIDS Foundation Dar Es SalaamUnited Republic of Tanzania Elizabeth Glaser Pediatric AIDS Foundation KampalaUganda Infectious Diseases University of Pennsylvania Perelman School of MedicinePhiladelphiaPennsylvaniaUSA Elizabeth Glaser Pediatric AIDS Foundation GenevaSwitzerland

Differentiated service delivery(DSD)models for HIV often exclude children and *** that children and adolescents have lower rates of HIV diagnosis,treatment and viral load suppression,there is a need to use DSD to meet the needs of children and adolescents living with *** commentary reviews the concept of DSD,examines the application of DSD to the care of children and adolescents living with HIV,and describes national guidance on use of DSD for children and adolescents and implementation of DSD for HIV care and treatment in children and adolescents in Elizabeth Glaser Pediatric AIDS Foundation(EGPAF)-supported programmes in seven sub-Saharan countries between 2017 and *** descriptions include eligibility criteria,location and frequency of care delivery,healthcare cadre delivering the care,as well as the number of EGPAF-supported facilities supporting each type of DSD model.A range of DSD models were *** facility-based models predominate,several countries support community-based *** significant uptake of various DSD models for children and adolescents,there was variable coverage within countries and variability in age criteria for each *** the recent uptake of DSD models for children and adolescents suggests feasibility,more can be done to optimise and extend the use of DSD models for children and adolescents living with *** to further DSD uptake are described and solutions *** models for children and adolescents are a critical tool that can be optimised to improve the quality of HIV care and outcomes for children and adolescents.

关键词： treatment service supporting

鳞状上皮细胞癌抗原水平新检测方法在宫颈癌、肺癌和头颈部癌鉴别诊断中的性能及临床表现

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中国肺癌杂志 2018年第7期21卷 J0001-J0012页

作者： Stefan HOLDENRIEDER Rafael MOLINA Ling QIU Xiuyi ZHI Sandra RUTZ Christine ENGEL Pia KASPER- SAUER Farshid DAYYANI catharina Mkorse 波恩大学医院德国波恩巴塞罗那医院巴塞罗那大学西班牙巴塞罗那北京协和医院中国北京首都医科大学宣武医院中国北京罗氏诊断公司德国Penzberg 罗氏诊断公司德国Mannheim 罗氏诊断国际有限公司瑞士Rotkreuz 加利福尼亚大学美国Irvine CA 荷兰癌症研究院荷兰阿姆斯特丹

鳞状上皮细胞癌抗原水平在鳞状上皮细胞癌中通常升高。这项多中心研究评估了一种新的Elecsys?鳞状上皮细胞癌检测的检测性能,该检测方法是以等摩尔方式测量血清鳞状上皮细胞癌抗原1和2的水平,并研究了鳞状上皮细胞癌抗原用于宫颈癌、肺... 详细信息

鳞状上皮细胞癌抗原水平在鳞状上皮细胞癌中通常升高。这项多中心研究评估了一种新的Elecsys?鳞状上皮细胞癌检测的检测性能,该检测方法是以等摩尔方式测量血清鳞状上皮细胞癌抗原1和2的水平,并研究了鳞状上皮细胞癌抗原用于宫颈癌、肺癌和头颈部鳞状上皮细胞癌鉴别诊断的潜能。在欧洲三个研究中心进行了精确度和方法学比较实验。健康人群的参考区间使用来自欧洲和中国人群的样本确定的。鉴别诊断试验确定了鳞状上皮细胞癌抗原水平能否将宫颈癌、肺癌或头颈癌与表观健康的、良性的或其他恶性群组区分开来。根据95%特异性下的鳞状上皮细胞癌抗原水平计算出鳞状上皮细胞癌抗原医学截断值。9个分析浓度的重复性变异系数<5.3%,中间精密变异系数<0.3%。方法学比较显示,与Architect和Kryptor系统具有很好的相关性(斜率分别为1.1和1.5)。表观健康人群的第95百分位数的参考区间为2.3 ng/m L(95%置信区间:1.9-3.8;欧洲队列,n=153)和2.7 ng/m L(95%置信区间:2.2-3.3;中国队列,n=146)。最佳的鉴别诊断结果见于宫颈鳞状上皮细胞癌:受试者工作特征曲线分析显示鳞状上皮细胞癌抗原水平(2.9 ng/m L的医学截断值)鉴别宫颈鳞状上皮细胞癌(n=127)与表观健康女性(n=286;曲线下面积:86.2%;95%置信区间:81.8-90.6;灵敏度:61.4%;特异性:95.6%),良性疾病(n=187;曲线下面积:86.3%;95%置信区间:81.2-91.3;灵敏度:61.4%;特异性:95.0%)和其他宫颈癌(n=157;曲线下面积:78.9%;95%置信区间:70.8-87.1;灵敏度:61.4%;特异性:86.7%)。鳞状上皮细胞癌还可帮助鉴别诊断肺癌。Elecsys鳞状上皮细胞癌检测技术在宫颈鳞状上皮细胞癌的临床实践中表现出了良好的性能,适合用于鉴别诊断。

关键词：鳞状上皮细胞癌免疫检测颈部肺部头部颈部

Unbalanced biotransformation metabolism and oxidative stress status: implications for deficient fatty acid oxidation

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Health 2011年第1期3卷 43-48页

作者： catharina M. Mels Francois H. Van der Westhuizen Pieter J. Pretorius Elardus Erasmus 不详

The concept of accumulating xenobiotics within the human body as a health risk is well known. However, these compounds can also be endo-genous, as in the case of inborn errors of me-tabolism, and lead to some of the same symp-toms as seen in xenobiotic intoxication. Bio-transformation of both exogenous and endo-genous toxic compounds is an important function of the liver, and the critical balance between these systems is of fundamental importance for cellular health. We propose a novel model, to describe the critical balance between Phase I and Phase II biotransformation and how a disturbance in this balance will increase the oxidative stress status, with resulting pathological consequences. We further used deficient fatty acid oxidation to verify the proposed model, as deficient fatty acid oxidation is associated with the accumulation of characteristic metabolites. These accumulating metabolites undergo both Phase I and Phase II biotransformation reactions, with resulting depletion of biotransformation substrates and co-factors. Depletion of these important biomolecules is capable of disturbing the balance between Phase I and Phase II reactions, and disturbance of this balance will increase oxidative stress status. The value of the proposed model is illustrated by its application to a clinical case investigated in our laboratory. In this case the possibility of deficient fatty acid oxidation only became evident once the critical balance between Phase I and Phase II biotransformation was restored with oral replenishment of biotransformation substrates. In addition to bio-chemical improvement, there was also significant clinical improvement. The significance of this model lies within the treatment possibilities, as the assessment of biotransformation metabolism and oxidative stress status can lead to the development of nutritional treatment strategies to correct imbalances. This in turn may reduce the chances of, or delay the onset of certain disease states.

关键词： Biotransformation Metabolism Detoxification Fatty Acid Oxidation Oxidative Stress Status

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Monki——“扇贝之海”主题店铺设计

中国建筑装饰装修 2012年第7期 102-109页

作者： catharina Frankander Joel Degermark Sarah Otleyth Electric Dreams事务所

2012年2月25日开业的Monki伦敦店位于Monki Carnaby街,内部空间延续出第三种店面主题概念——＂扇贝之海＂。内部设计以卡其色为主色调,采用镜面天花板,银色照明,店铺50多个产品均是特别定制的。

关键词：内部设计店铺扇贝主题概念内部空间主色调天花板店面

Viability of Lactobacillus acidophilus La-5 in the Presence of Williopsis saturnus vat. suaveolens

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Journal of Food Science and Engineering 2013年第4期3卷 176-186页

作者： Sabrina Neves Casarotti Aline Teodoro de Paula Marilia Goncalves Cattelan catharina Calochi Pires de Carvalho Ana Lucia Barretto Penna Department of Food Engineering and Technology Sao Paulo State University Sao Jose do Rio Preto SP 15054000 Brazil

Maintaining the viability of probiotic microorganisms from production to consumption has long been a technological challenge for the food industry. The objectives of this study were to evaluate the in vitro interaction between Lactobacillus acidophilus La-5 and Williopsis saturnus var. suaveolens and the effect of this yeast on acidification kinetics, viability ofLactobacillus acidophilus and post-acidification in fermented milk during refrigerated storage at 5℃. The in vitro study showed a positive interaction between the acid cell free-supernatant （CFS） ofprobiotic bacteria La-5 and the yeast. The addition of W. saturnus var. suaveolens increased the fermentation time due to consumption of the organic acids produced by L. acidophilus. During the refrigerated storage of the samples, the presence of the yeast increased the viability of L. acidophilus and reduced post-acidification. However, the mechanism of such interaction of bacteria and yeast is not fully understood.

关键词： Probiotic lactic acid bacteria yeast W. saturnus var. suaveolens fermented dairy products viability

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生产可持续的安全优质的猪肉产品

国外畜牧学（猪与禽） 2019年第1期39卷 18-20页

作者：王晶晶(译) Anna catharina Berge 不详比利时Berge兽医咨询公司

安全优质的猪肉是消费者共同的追求,为了满足这些需求,我们需要提高动物的健康水平,改善饲养,提高生产力,并最终建立一个全球负责和可持续的系统。

关键词：猪肉食品安全抗菌剂成本效益