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Electrical conduction in streptozotocin-induced diabetic rat ventricle

Electrical conduction in streptozotocin-induced diabetic rat...

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2008北京国际生理科学学术大会

作者： HOWARTH Frank jacobson Mike ZILAHI Erika QURESHI Anwar ADEGHATE Ernest Physiology Faculty of Medicine & Health SciencesUAE UniversityAl AinUAE

Diabetic patients show a higher incidence of cardiac arrhythmias,including ventricular fibrillation and sudden death compared to non-diabetic *** electrocardiogram of diabetic patients may show several alterations from normal patterns,many of them related to the QT *** investigated electrical conduction in the ventricles of streptozotocin(STZ)induced diabetic *** mellitus(DM)was induced with a single injection of STZ(60 mg/kg bodyweight,i.p.).The electrocardiogram was measured continuously,in vivo,using a biotelemetry *** potentials were measured with a suction electrode in isolated perfused *** of mRna transcripts for selected ion transport proteins were measured with real-time *** were performed 8-10 weeks after STZ *** project was approved by the FMHS,UAEU Ethics Committee. Diabetes was characterized by hyperglycemia(540±17 mg/dL,n=ll in diabetic rats compared to compared to 108±4 mg/dL,n=10 in age-matched controls),reduced body weight gain and heart *** and QT intervals were prolonged in diabetic rats at 8,9 and 10 weeks after STZ *** 10 weeks QRS and QT were 17.1±0.3 and 5.1±1.7 ms in diabetic compared to 15.5±0.3 and 0.6±2.1 ms in controls,*** heart rate was 170±9 BPM in diabetic compared to 221±21 BPM in *** potential durations at 50%and 70% repolarization from peak action potential in paced(5 Hz)heart were 37±5 and 56±6 ms in diabetic compared with 24±1 and 38±2 ms in controls,*** mRna expression for KCND2(transient outward K current)and b-subunit KCNE2(delayed rectifier,rapid K current)were significantly reduced whilst Cx40,Cx43,Cx45(gap junction),a-subunit KCNH2(delayed rectifier,rapid K current),KCNQl(delayed rectifier,slow Kcurrent)and NCX(na/Ca exchange current)were not altered in diabetic rats compared to *** of ion channels,and in particular K channels associated with action potential repolarization,

关键词： diabetes mellitus heart electrical conduction

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