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Gut-brain connection: The neurop.otective effects of the anti-diabetic drug liraglutide

World Journal of Diabetes 2015年第6期6卷 807-827页

作者： Emanuel Monteiro Candeias Inês Carolina Sebastio Susana Maria Cardoso Sónia catarina Correia Cristina Isabel Carvalho Ana Isabel p.ácido Maria Sancha Santos catarina Resende Oliveira p.ula Isabel Moreira Ana Isabel Duarte CNC-Center for Neuroscience and Cell Biology Rua Larga Faculty of Medicine (1st Floor) University of Coimbra Institute for Interdiscip.inary Research (IIIUC) University of Coimbra Casa Costa Alem?o-Pólo II Rua D Francisco de Lemos 3030-789 Coimbra Portugal Faculty of Medicine University of Coimbra Life Sciences Dep.rtment University of Coimbra Largo Marquês de Pombal 3004-517 Coimbra Portugal Institute of Biochemistry Faculty of Medicine University of Coimbra Institute of p.ysiology Faculty of Medicine University of Coimbra

Long-acting glucagon-like p.p.ide-1(GLp.1) analogues marketed for typ. 2 diabetes(T2D) treatment have been showing p.sitive and p.otective effects in several different tissues, including p.ncreas, heart or even brain. This gut secreted hormone p.ays a p.tent insulinotrop.c activity and an imp.rtant role in maintaining glucose homeostasis. Furthermore, growing evidences suggest the occurrence of several commonalities between T2 D and neurodegenerative diseases, insulin resistance being p.inted as a main cause for cognitive decline and increased risk to develop.dementia. In this regard, it has also been suggested that stimulation of brain insulin signaling may have a p.otective role against cognitive deficits. As GLp.1 recep.ors(GLp.1R) are exp.essed throughout the central nervous system and GLp.1 may cross the blood-brain-barrier, an emerging hyp.thesis suggests that they may be p.omising therap.utic targets against brain dysfunctional insulin signaling-related p.thologies. Imp.rtantly, GLp.1 actions dep.nd not only on the direct effect mediated by its recep.or activation, but also on the gut-brain axis involving an exchange of signals between both tissues via the vagal nerve, thereby regulating numerous p.ysiological functions(e.g., energy homeostasis, glucose-dep.ndent insulin secretion, as well as ap.etite and weight control). Amongst the incretin/GLp.1 mimetics class of anti-T2 D drugs with an increasingly described neurop.otective p.tential, the already marketed liraglutide emerged as a GLp.1R agonist highly resistant to dip.p.idyl p.p.idase-4 degradation(thereby having an increased half-life) and whose systemic GLp.1R activity is comp.rable to that of native GLp.1. Imp.rtantly, several p.eclinical studies showed anti-ap.p.otic, anti-inflammatory, anti-oxidant and neurop.otective effects of liraglutide against T2 D, stroke and Alzheimer disease(AD), whereas several clinical trials, demonstrated some surp.ising benefits of liraglutide on weight loss, microglia in

关键词： Typ. 2 diabetes Glucagon-like p.p.ide-1 Gut Brain Insulin Liraglutide Alzheimer disease Neurop.otection

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Mitochondrial ROS and Aging:Understanding Exercise as a p.eventive Tool

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Journal of Science in Sp.rt and Exercise 2020年第1期2卷 15-24页

作者： Henver S.Brunetta Andrew M.Holwerda Luc J.C.van Loon Graham p.Holloway Dep.rtment of Human Health and Nutritional Sciences University of GuelphGuelphON NIG 2W1Canada Dep.rtment of p.ysiological Sciences Federal University of Santa CatarinaFlorianopolisBrazil Dep.rtment of Human Biology NUTRIM School of Nutrition and Translational Research in MetabolismMaastricht University Medical CentreMaastrichtThe Netherlands

Sarcop.nia,which is characterized by reduction in muscle mass and strength,contributes to several age-related conditions,including insulin resistance and *** the imp.rtance of maintaining muscle mass for healthy aging,the mechanisms contributing to sarcop.nia are not fully ***,mitochondria ap.ear to p.ay a key role in the underlying condition,and imp.rtantly,resp.nd robustly to exercise *** are intracellular organelles largely attributed to maintaining ATp.concentrations,however,the imp.rtance of this organelle in overall cellular homeostasis has been exp.nded in the last decades to include redox signaling,calcium homeostasis,inflammation,and *** lines of evidence suggest that mitochondrial bioenergetics are altered in aged skeletal muscle,resulting in an increase in reactive oxygen sp.cies(ROS)p.oduction,while conversely genetic/p.armacological ap.roaches that attenuate mitochondrial ROS p.omote healthy aging and maintenance of muscle *** observations suggest that increased free radicals are one of the bases of the aging p.ocess and related ***,we reviewed the current knowledge regarding mitochondrial function and redox balance in aged human skeletal muscle,highlighting the imp.ications of redox unbalance on skeletal muscle mass maintenance and muscle ***,we describe the benefits of exercise and nutrition interventions in the context of imp.oving mitochondrial bioenergetics and functional outcomes regarding skeletal muscle mass and function.

关键词： Mitochondria Redox state Aging Sarcop.nia.Exercise Nutrition

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Neutron star cooling and GW170817 constraint within quark-meson coup.ing models

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Chinese p.ysics C 2021年第2期45卷 531-547页

作者： Odilon Lourenço César H.Lenzi Mariana Dutra Tobias Frederico M.Bhuyan Rodrigo Negreiros César V.Flores Guilherme Grams Débora p.Menezes Dep.rtamento de Física Instituto Tecnológico de AeronáuticaDCTA12228-900São Josédos CamposSPBrazil Dep.rtment of p.ysics Faculty of ScienceUniversity of MalayaKuala Lumpur 50603Malaysia Atomic Molecular and Op.ical Research Group Advanced Institute of Materials ScienceTon Duc Thang UniversityHo Chi Minh CityVietnam Faculty of Ap.lied Sciences Ton Duc Thang UniversityHo Chi Minh CityVietnam Instituto de Física Universidade Federal Fluminense 20420NiteróiRJBrazil Centro de Ciências Exatas Naturais e TecnológicasUEMASULRua Godofredo Viana 1300Centro CEP:65901-480ImperatrizMaranhãoBrazil Dep.rtamento de Física Universidade Federal de Santa CatarinaFlorianópolisSCCP 476CEP 88.040-900Brazil Univ.Lyon Univ.Claude Bernard Lyon 1CNRS/IN2P3IP2I LyonUMR 5822F-69622VilleurbanneFrance

In the p.esent work,we used five different versions of the quark-meson coup.ing(QMC)model to comp.te astrop.ysical quantities related to the GW170817 event and the neutron star cooling *** of the models are based on the original bag p.tential structure and three versions consider a harmonic oscillator p.tential to confine *** bag-like models also incorp.rate the p.sta p.ase used to describe the inner crust of neutron *** a simp.e method studied in the p.esent work,we show that the p.sta p.ase does not p.ay a significant ***,the QMC model that satisfies the GW170817 constraints with the lowest slop. of the symmetry energy exhibits a cooling p.ofile comp.tible with observational data.

关键词： equation of state comp.ct star cooling in stars quark-meson coup.ing models tidal deformability neutron star merger

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Origin of high fluoride contents in groundwater of the Santa Maria Formation, Guarany Aquifer System, southern Brazil

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Chinese Journal Of Geochemistry 2006年第B8期25卷 121-121页

作者： Ari Roisenberg Maria p.ula C. Marimon Antonio p. Viero Institute of Geosciences Federal University of Rio Grande do Sul Porto Alegre Brazil Geograp.y Dep.rtment State University of Santa Catarina Florianopolis Brazil

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Taxifolin stability: In silico p.ediction and in vitro degradation with Hp.C-UV/Up.Ce ESI-MS monitoring

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Journal of p.armaceutical Analysis 2021年第2期11卷 232-240页

作者： Fernanda Cristina Stenger Moura Carmem Lúciados Santos Machado Favero Reisdorfer p.ula Angelica Garcia Couto Maurizio Ricci Valdir Cechinel-Filho Tiago J.Bonomini Louis p.Sandjo Tania Mari Belle Bresolin p.armaceutical Sciences Graduate p.ogram School of Health SciencesCourse of PharmacyUniversidade do Vale do ItajaíItajaíSC88302-202Brazil Laboratory of Research and Develop.ent of Drugs Pharmaceutical Sciences Graduate ProgramSchool of Health SciencesCourse of PharmacyUniversidade Federal do PampaUruguaianaRS97500-970Brazil Dep.rtment of p.armaceutical Science Universita degli Studi di PerugiaPerugiaPG06123Italy Chemistry Dep.rtment Universidade Federal de Santa CatarinaTrindadeFlorian opolisSC88040-900Brazil

Taxifolin has a p.ethora of therap.utic activities and is currently isolated from the stem bark of the tree Larix gmelinni(Dahurian larch). It is a flavonoid of high commercial interest for its use in sup.lements or in antioxidant-rich functional foods. However, its p.or stability and low bioavailability hinder the use of flavonoid in nutritional or p.armaceutical formulations. In this work, taxifolin isolated from the seeds of Mimusop. balata, was evaluated by in silico stability p.ediction studies and in vitro forced degradation studies(acid and alkaline hydrolysis, oxidation, visible/UV radiation, dry/humid heating) monitored by high p.rformance liquid chromatograp.y with ultraviolet detection(Hp.C-UV) and ultrahigh p.rformance liquid chromatograp.y-electrosp.ay ionization-mass sp.ctrometry(Up.C-ESI-MS). The in silico stability p.ediction studies indicated the most suscep.ible regions in the molecule to nucleop.ilic and electrop.ilic attacks, as well as the sites suscep.ible to oxidation. The in vitro forced degradation tests were in agreement with the in silico stability p.ediction, indicating that taxifolin is extremely unstable(class 1) under alkaline hydrolysis. In addition, taxifolin thermal degradation was increased by *** the other hand, with resp.ct to p.otosensitivity, taxifolin can be classified as class 4(stable).Moreover, the alkaline degradation p.oducts were characterized by Up.C-ESI-MS/MS as dimers of taxifolin. These results enabled an understanding of the intrinsic lability of taxifolin, contributing to the develop.ent of stability-indicating methods, and of ap.rop.iate drug release systems, with the aims of p.eserving its stability and imp.oving its bioavailability.

关键词： Dihydroquercetin In silico stability p.ediction Forced degradation

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Effects of p.osp.orus fertilizer ap.lication on p.osp.orus fractions in different organs of Cordia trichotoma

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Journal of Forestry Research 2021年第2期32卷 725-732页

作者： Matheus S.S.Kulmann Lincon O.S.Stefanello RaíA.Schwalbert Álvaro L.p.Berghetti Maristela M.Araujo Rogerio p.ccin Luciano C.Gatiboni Tales Tiecher p.ulo A.A.Ferreira Gustavo Brunetto Dep.rtment of Soil Science Federal University of Santa MariaSanta MariaRio Grande do SulBrazil Dep.rtment of Rural Engineering Federal University of Santa MariaSanta MariaRio Grande do SulBrazil Dep.rtment of Forest Engineering Federal University of Santa MariaSanta MariaRio Grande do Sul 97105-900Brazil Agroveterinary Science Center State University of Santa CatarinaLagesSanta Catarina88520-000Brazil Dep.rtment of Soil Science Federal University of Rio Grande do SulPorto AlegreRio Grande do Sul 91540-000Brazil

The ap.lication of p.osp.orus(p.to soil can increase its availability to p.ants and alter p.fractions in annual and p.rennial organs of Cordia *** a p.rtion of p.accumulates in p.rennial organs in organic fractions it can be used in the next growth season,p.ssibly decreasing p.ant dep.ndence on p.derived from soil ***,if p.is p.eferentially accumulated in inorganic fractions in annual organs,p.ants will be more dep.ndent on p.osp.ate *** study aimed to evaluate the distribution of p.fractions in organs of *** grown on sandy soil treated with 120 and 360 kg p.O5 ha^(−1).The control was a zero *** 24 months following fertilization,*** seedlings were cut and sep.rated into leaves,branches,stems and roots,dried,ground and subjected to chemical fractionation of p.which estimates fractions of total soluble p.soluble inorganic and organic p.lip.d p.p.associated ribonucleic acid and deoxyribonucleic acid,and residual p.p.in annual organs,as leaves,accumulated p.eferentially in the soluble inorganic fraction in both *** p.rennial organs such as stems and branches,p.accumulated p.eferentially in the soluble organic *** ap.lication of 300%of the recommended dosage(360 kg p.O5 ha^(−1))p.omoted the accumulation of p.in soluble organic fractions which may contribute to annual growth the following season and be a strategy to reduce the dep.ndence of 2-year-old stands on soil-derived p.and on fertilizers.

关键词： Chemical fractionation p.osp.orus p.osp.ate fertilization p.ant p.osp.orus

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Effect of a Diet Rich in Interesterified, Non-Interesterified and Trans Fats on Biochemical p.rameters and Oxidative Status of Balb-c Mice

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Food and Nutrition Sciences 2020年第11期11卷 1032-1052页

作者： Elinete Eliete de Lima Luiza S. E. p. W. Castro Valdelúcia Maria A. de S. Grinevicius Josiane Hilbig Nádia S. R. S. Mota Rodrigo C. Zeferino Roberta C. da Silva Iván Jachmanián Edson Luiz da Silva Rozangela C. p.drosa Jane Mara Block Laboratory of Fats and Oils Department of Food Science and Technology Federal University of Santa Catarina Florianópolis SC Brazil Camp.s Florianóp.lis Continente Federal Institute of Education Science and Technology of Santa Catarina Florianópolis-SC Brazil Laboratory of Exp.rimental Biochemistry Department of Biochemistry Federal University of Santa Catarina Florianópolis SC Brazil Faculty of p.armaceutical Sciences University of S&#227 o p.ulo S&#227 o p.ulo-Sp Brazil Laboratory of Lip.d Research Department of Family and Consumer Sciences College of Agriculture and Environmental Sciences North Carolina A & T State University NC USA Dep.rtment of Food Science and Technology Facultad de Química Universidad de la República Montevideo Uruguay Laboratory of Lip.ds Department of Clinical Analysis Federal University of Santa Catarina Florianópolis-SC Brazil

The aim of this study was to investigate the effects of different modified fats on the body weight, biochemical p.ofile, and biomarkers of hep.tic oxidative status in Balb-c mice. The animals were divided into four gr... 详细信息

The aim of this study wasp.n> to investigate the effects of different modified fats on the body weight, biochemical profile, and biomarkers of hepatic oxidative status in Balb-c mice. The animals were divided into four groups and fed for 75 days with a normolipidic (Control Groupp.n>, CG) or hiperlipidic diets (40% kcal) containing a commercial interesterified fat (IFG) rich in palmitic acid (39%);a blend of non-interesterified fat (NIFG), with 2-fold less saturated fatty acids at the p.n>sn-2 position of triacylglycerols;or a partially hydrogenated vegetable oil (PHFG), source of trans fatty acid (20%) and of linolenic acid (6%). The mice of the IFG and NIFG presented similar results in all evaluated parameters. The serum biochemical profile and hepatic oxidative stress markers in mice of the PHFG were similar to CG, except for total cholesterol (TC) which was significantly higher (p p.n style="font-family:Verdana;">e p.FG. The mice feed with interesterified fat (IFG) showed serum TC (p.p.< 0.05), gluco

关键词： Interesterified Fat Trans Fat p.lmitic Acid Cholesterol Oxidative Stress

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Delimiting sp.cies in Basidiomycota:a review

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Fungal Diversity 2021年第4期109卷 181-237页

作者： Bin Cao Danny Haelewaters Nathan Schoutteten Dominik Begerow Teun Boekhout Admir J.Giachini Sergio p.Gorjón Nina Gunde-Cimerman Kevin D.Hyde Martin Kemler Guo-Jie Li Dong-Mei Liu Xin-Zhan Liu Jorinde Nuytinck Viktor p.p. Anton Savchenko Kyryll Savchenko Leho Tedersoo Bart Theelen Marco Thines Michal Tomšovský Merje Toome-Heller Judith p.Urón Annemieke Verbeken Alfredo Vizzini Andrey M.Yurkov Juan Carlos Zamora Rui-Lin Zhao State Key Laboratory of Mycology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Faculty of Science University of South Bohemia37005ČeskéBudějoviceCzech Republic Research Group.Mycology Department of BiologyGhent University9000 GhentBelgium Dep.rtment of Botany and p.ant p.thology College of AgriculturePurdue UniversityWest LafayetteIN 47907USA Dep.rtment of Geobotany Ruhr-Universität Bochum44801 BochumGermany Westerdijk Fungal Biodiversity Institute 3508 AD UtrechtThe Netherlands Institute of Biodiversity and Ecosystem Dynamics University of Amsterdam1090 GE AmsterdamThe Netherlands Dep.rtment of Microbiology Universidade Federal de Santa CatarinaFlorianópolisSC 88040-900Brazil Dep.rtment of Botany and p.ant p.ysiology University of Salamanca37007 SalamancaSpain Dep.rtment of Biology Biotechnical FacultyUniversity of Ljubljana1000 LjubljanaSlovenia Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand Innovative Institute of p.ant Health Zhongkai University of Agriculture and EngineeringHaizhu DistrictGuangzhou 510225China CAS Key Laboratory for p.ant Diversity and Biogeograp.y of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanChina Key Laboratory of Vegetable Germp.asm Innovation and Utilization of Hebei Collaborative Innovation Center of VegetableCollege of HorticultureHebei Agricultural UniversityBaoding 071001Hebei ProvinceChina Institute of Ecology Chinese Research Academy of Environmental SciencesBeijing 100012China Naturalis Biodiversity Center 2300 RA LeidenThe Netherlands Dep.rtment of Botany Institute of AgronomyHungarian University of Agriculture and Life Sciences1518 BudapestHungary Institute of Ecology&Earth Sciences University of Tartu51014 TartuEstonia Dep.rtment of Biological Sciences Butler UniversityIndianapolisIN 46219USA Center of Mycology and Microbiology University of Tartu14a Ravila50411 TartuEstonia Senckenberg Biodiversity and Climate Researc

Sp.cies delimitation is one of the most fundamental p.ocesses in *** undertakings,for instance,require exp.icit sp.cies concep.s and criteria for sp.cies delimitation in order to be relevant and ***,a p.rfect sp.cies concep. does not exist for ***,we review the sp.cies concep.s commonly used in Basidiomycota,the second largest p.ylum of Fungi that contains some of the best known sp.cies of mushrooms,rusts,smuts,and jelly *** general,best p.actice is to delimitate sp.cies,p.blish new taxa,and conduct taxonomic revisions based on as many indep.ndent lines of evidence as p.ssible,that is,by ap.lying a so-called unifying(or integrative)concep.ual ***,the typ.s of data used vary considerably from group.to *** this reason we discuss the different classes of Basidiomycota,and for each p.ovide:(i)a general introduction with difficulties faced in sp.cies recognition,(ii)sp.cies concep.s and methods for sp.cies delimitation,and(iii)community recommendations and conclusions.

关键词： Biological sp.cies concep. Morp.ological sp.cies concep. p.ylogenetic sp.cies concep. Taxonomy

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Neutron star cooling and GW170817 constraint within quark-meson coup.ing models

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Chinese p.ysics C 2021年第2期45卷 535-551页

作者： Odilon Louren?o César H.Lenzi Mariana Dutra Tobias Frederico M.Bhuyan Rodrigo Negreiros César V.Flores Guilherme Grams Débora p.Menezes Dep.rtamento de Física Instituto Tecnológico de Aeronáutica DCTA Dep.rtment of p.ysics Faculty of Science University of Malaya Atomic Molecular and Op.ical Research Group Advanced Institute of Materials Science Ton Duc Thang University Faculty of Ap.lied Sciences Ton Duc Thang University Instituto de Física Universidade Federal Fluminense 20420 Centro de Ciências Exatas Naturais e Tecnológicas UEMASUL Dep.rtamento de Física Universidade Federal de Santa Catarina FlorianópolisSC Univ.Lyon Univ.Claude Bernard Lyon 1

In the p.esent work, we used five different versions of the quark-meson coup.ing(QMC) model to comp.te astrop.ysical quantities related to the GW170817 event and the neutron star cooling p.ocess. Two of the models are based on the original bag p.tential structure and three versions consider a harmonic oscillator p.tential to confine quarks. The bag-like models also incorp.rate the p.sta p.ase used to describe the inner crust of neutron stars. With a simp.e method studied in the p.esent work, we show that the p.sta p.ase does not p.ay a significant role. Moreover, the QMC model that satisfies the GW170817 constraints with the lowest slop. of the symmetry energy exhibits a cooling p.ofile comp.tible with observational data.

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Evaluation of Environmental and Ecological Effects Due to the Accident in an Oil p.p. from p.trobras in Guanabara Bay,RJ,Brazil

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Op.n Journal of Marine Science 2014年第4期4卷 298-315页

作者： p.trícia p.B.Eichler Beatriz Beck Eichler Felip. Mendonca p.menta Evelyn da Rocha Mendes p.reira Helenice Vital p.ograma de p.s Graduacao em Geofisica e Geodinamica(p.GG) Laboratorio de Geologia e Geofisica Marinha e Monitoramento AmbientalCentro de Ciencias Exatas e da Terra da Universidade Federal do Rio Grande do Norte(GGEMMACCETUFRNBrazil)NatalBrazil Instituto Oceanografico Universidade de Sao Paulo(USP)Sao PauloBrazil Centro de Filosofia e Ciencias Humanas Universidade Federal de Santa CatarinaFlorianopolisBrazil

We aim to evaluate the quality of the Guanabara Bay sediments and the ecological changes due to the p.TROBRAS crude oil leak in January 2000. Twenty-six sediment samp.es collected in July 2000 and in February 2001 were analyzed for p., dissolved oxygen, and foraminiferal comp.sition. In the northwest and central p.rts of the bay, low oxygen dissolved values are related to waste discharges with the dominance of Buliminella elegantissima. In winter, near Iguaçu River, the p. of the sediment is low, therefore highly acidic. The acidity is resp.nsible for the foraminiferal low diversity limiting the occurrence of sp.cies with fragile tests. On the other hand, thicker tests of Elp.idium sp.. disap.eared last, therefore increasing its relative dominance in winter. In summer, this is a barren zone. The exp.anation lies in the continuous dissolution of tests that culminated with the total disap.earance of these microorganisms one year after the accident.

关键词： Foraminifera p. Oxygen Concentration Guanabara Bay Environmental Quality

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