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Immunotherapy and immunoescape in colorectal cancer

World Journal of Gastroenterology 2007年第44期13卷 5822-5831页

作者： Guillermo mazzolini Oihana murillo catalina Atorrasagasti Juan Dubrot Iigo Tirapu miguel Rizzo Ainhoa Arina Carlos Alfaro Arantza Azpilicueta Carmen Berasain José L Perez-Gracia Alvaro Gonzalez Ignacio melero Liver Unit Facultad de Ciencias Biomédicas Universidad Austral Presidente Perón 1500 (1635) Derqui-Pilar Buenos Aires Argentina Centro de Investigación médica Aplicada and Clínica Universitaria Universidad de Navarra Pamplona Spain

Immunotherapy encompasses a variety of interventions and techniques with the common goal of eliciting tumor cell destructive immune responses. Colorectal carcinoma often presents as metastatic disease that impedes curative surgery. Novel strategies such as active immunization with dendritic cells (DCs), gene transfer of cytokines into tumor cells or administration of immunostimulatory monoclonal antibodies (such as anti-CD137 or anti-CTLA-4) have been assessed in preclinical studies and are at an early clinical development stage. Importantly, there is accumulating evidence that chemotherapy and immunotherapy can be combined in the treatment of some cases with colorectal cancer, with synergistic potentiation as a result of antigens cross-presented by dendritic cells and/or elimination of competitor or suppressive T lymphocyte populations (regulatory T-cells). However, genetic and epigenetic unstable carcinoma cells frequently evolve mechanisms of immunoevasion that are the result of either loss of antigen presentation, or an active expression of immunosuppressive substances. Some of these actively immunosuppressive mechanisms are inducible by cytokines that signify the arrival of an effector immune response. For example, induction of 2, 3 indoleamine dioxygenase (IDO) by IFNγ in colorectal carcinoma cells. Combinational and balanced strategies fostering antigen presentation, T-cell costimulation and interference with immune regulatory mechanisms will probably take the stage in translational research in the treatment of colorectal carcinoma.

关键词： Colorectal carcinoma Immunotherapy Gene therapy interleukin-12 Dendritic cells CD137 indoleamine 2, 3 dioxygenase

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Physical mathematical Evaluation of the Cardiac Dynamic Applying the Zipf-mandelbrot Law

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Journal of modern Physics 2015年第13期6卷 1881-1888页

作者： Javier Oswaldo Rodríguez Signed Esperanza Prieto Sandra catalina Correa Fernán mendoza Giora Weiz maría Yolanda Soracipa Nelly Velásquez Juan mauricio Pardo miguel martínez Freddy Barrios Insight Research Group Bogotá Colombia Clínica del Country Research Center Bogotá Colombia Fundación Clínica Abood Shaio Bogotá Colombia Universidad el Bosque Bogotá Colombia Columbia University medical Center Cardiology Shaare Zedek Medical Center Jerusalem Israel Hospital Universitario mayor méderi Bogotá Colombia Physiology Medicine Faculty Universidad Nacional de Colombia Bogotá Colombia

Introduction: The law of Zipf-mandelbrot is a power law, which has been observed in natural languages. A mathematical diagnosis of fetal cardiac dynamics has been developed with this law. Objective: To develop a methodology for diagnostic aid to assess the degree of complexity of adult cardiac dynamics by Zipf-mandelbrot law. methodology: A mathematical induction was done for this;two groups of Holter recordings were selected: 11 with normal diagnosis and 11 with acute disease of each group, one Holter of each group was chosen for the induction, the law of Zipf-mandelbrot was applied to evaluate the degree of complexity of each Holter, searching similarities or differences between the dynamics. A blind study was done with 20 Holters calculating sensitivity, specificity and the coefficient kappa. Results: The complexity grade of a normal cardiac dynamics varied between 0.9483 and 0.7046, and for an acute dynamic between 0.6707 and 0.4228. Conclusions: A new physical mathematical methodology for diagnostic aid was developed;it showed that the degree of complexity of normal cardiac dynamics was higher than those with acute disease, showing quantitatively how cardiac dynamics can evolve to acute state.

关键词： Heart Rate Cardiovascular Diseases Zipf-mandelbrot Law Complexity Grade

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maize forage aptitude: Combining ability of inbred lines and stability of hybrids

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The Crop Journal 2014年第6期2卷 407-418页

作者： Luis máximo Bertoia mónica Beatriz Aulicino Department of Plant Production Faculty of Agrosciences National University of Lomas de Zamora Camino de Cintura km 21832 Lomas de Zamora Buenos Aires Argentina Department of Genetics Faculty of Agrosciences National University of Lomas de Zamora Camino de Cintura km 2 1832 Lomas de ZamoraBuenos Aires Argentina Santa catalina Plant Breeding Institute National University of La Plata CC 4 1836 Llavallol Buenos Aires Argentina

Breeding of forage maize should combine improvement achieved for grain with the specific needs of forage hybrids. Production stability is important when maize is used for silage if the planting area is not in the ideal agronomic environment. The objectives of the present research were:(i) to quantify environmental and genetic and their interaction effects on maize silage traits;(ii) to identify possible heterotic groups for forage aptitude and suggest the formation of potential heterotic patterns, and(iii) to identify suitable inbred line combinations for producing hybrids with forage aptitude. Forty-five hybrids derived from diallelic crosses(without reciprocals) among ten inbred lines of maize were evaluated in this study. Combined ANOVA over environments showed differences between genotypes(G), environments(E), and their interactions(GEI). Heritability(H2), and genotypic and phenotypic correlations were estimated to evaluate the variation in and relationships between forage traits. Postdictive and predictive AmmI models were fitted to determine the importance of each source of variation, G, E, and GEI, and to select genotypes simultaneously on yield, quality and stability. A predominance of additive effects was found in the evaluated traits. The heterotic pattern Reid-BSSS × Argentine flint was confirmed for ear yield(EY) and harvest index(HI). High and broad genetic variation was found for stover and whole plant traits. Some inbred lines had genes with differential breeding aptitude for ear and stover. Stover and ear yield should be the main breeding objectives in maize forage breeding.

关键词： Zea mays L. Forage maize Combining ability GEI interaction Stover and ear digestibility

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全身性炎症是牙周炎和高血压之间缺失的一环吗?

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中华高血压杂志 2021年第7期29卷 655-655页

作者：袁源(摘译) 郑武洪(审校) munoz Aguilera E Leira Y miro catalina Q Orlandi m Czesnikiewicz-Guzik m Guzik TJ Hingorani AD Nart J D'Aiuto F 不详

本研究旨在探究两项独立大型研究中牙周炎和高血压的相关性,明确全身性炎症对上述相关性是否有调节作用。方法:本研究为横断面研究,分析了来自美国[3460例,全国健康及营养状况调查(national health and nutrition examination survey,NH... 详细信息

本研究旨在探究两项独立大型研究中牙周炎和高血压的相关性,明确全身性炎症对上述相关性是否有调节作用。方法:本研究为横断面研究,分析了来自美国[3460例,全国健康及营养状况调查(national health and nutrition examination survey,NHANES)2009-2010]和韩国[4539例,第六次韩国国民健康和营养状况调查(the 6^(th)-3 versions Korean national health and nutrition examination survey,KNHANES Ⅵ-3)2015]的代表性样本。

关键词：国民健康横断面研究牙周炎营养状况调查代表性样本高血压

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Selection of maize Genotypes with Tolerance to Osmotic Stress Associated with Salinity

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Agricultural Sciences 2016年第2期7卷 82-92页

作者： mónica B. Collado mónica B. Aulicino miguel J. Arturi maría del C. molina Instituto Fitotécnico de Santa catalina Facultad de Ciencias Agrarias y Forestales Universidad Nacional de La Plata Provincia de Buenos Aires Argentina CONICET

Thirteen different inbred lines in relation to the type of grain and life cycles were characterized by testing for osmotic stress associated with salinity. The identification of tolerant genotypes would be an effective strategy to overcome the saline stress. Osmotic stress reduces immediately the expansion of the roots and young leaves which determine a reduction in the size of the plant. A completely randomized design was adopted to test seedlings under controlled conditions of light and temperature. Two treatments were used: 0 mm NaCl (as control) and 100 mm NaCl. After 15 days of complete salinization, the seedlings were harvested and several morphological traits were measured. The morphological traits of growth were leaf growth (Ar1, Ar2, Ar3 and Ar4), dry masses of shoot and root (SDm and RDm, respectively). Also, traits associated with water economy were registered: leaf water loss (LWL) and relative water content (RWC). The morphological traits were expressed in relative terms, while the traits associated with the economy of water were expressed in absolute terms. Uni and multivariate techniques were applied to identify genotypes with divergent behaviors to osmotic stress tolerance. Also, a Tolerance Index was employed to identify superior genotypes. Four clusters were obtained after applying a Cluster Analysis and Principal Component Analysis (PCA). The genotypes were compared to each other with a test of DmS. The results obtained with different statistical techniques converged. Some variables presented a differential weight classification of genotypes. The morphological traits like RDm, SDm, Ar3, Ar4 and Ar5 were the most discriminating. Tolerance Index allowed to classify genotypes, thus SC2 and AD3 lines were that reached highest value of the index and therefore would be tolerant lines, while AF3 and LP3 had a low index and were seen as sensible.

关键词： maize Salinity Osmotic Stress Tolerance Selection Index

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具有中性降解性能的溶液共纺PLA纤维

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国际纺织导报 2018年第11期46卷 13-14页

作者： G.P.Paar K.m.Kossel C.molano A.Pich R.Fourné T.Gries S.Jockenhvel 段广宇亚琛工业大学皮毛纺织技术研究所生物共混与医用纺织品部(德国) DWI-Leiniz交互材料研究所(德国) Fourné maschinebau公司(德国) 亚琛工业大学皮毛纺织技术研究所(德国) 亚琛工业大学皮毛纺织技术研究所生物共混与医用纺织品部与AmE-Helmholtz生物医学工程研究所(德国)

由多羟基碳酸如聚乳酸(PLA)制备的移植物的降解,可引起宿主周围组织的局部酸中毒,导致严重的临床并发症。德国亚琛工业大学皮毛纺织技术研究所(ITA)开发出一种添加微凝胶的PLA纤维,其降解后pH值呈中性。通过双组分溶液纺丝工艺,可调控... 详细信息

由多羟基碳酸如聚乳酸(PLA)制备的移植物的降解,可引起宿主周围组织的局部酸中毒,导致严重的临床并发症。德国亚琛工业大学皮毛纺织技术研究所(ITA)开发出一种添加微凝胶的PLA纤维,其降解后pH值呈中性。通过双组分溶液纺丝工艺,可调控纤维中微凝胶的空间分布状态,赋予纤维一定的拉伸强度,以适应后续的纺织加工。

关键词：双组分溶液纺丝 PLA纤维 pH中性降解微凝胶

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Generational mean Analysis of Salt Tolerance during Osmotic Phase in maize Seedling

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American Journal of Plant Sciences 2019年第4期10卷 555-571页

This study details the nature and magnitude of the genetic effects associated with various quantitative characters (morphological and hydric relations) measured in maize seedlings during the osmotic phase of saline stress (100 mm NaCl). Three lines with differential behavior in salt stress: SC2 (tolerant), AFE (susceptible) and LP3 (moderately tolerant) were used to obtain contrasting crosses (SC2 × AFE) and (SC2 × LP3). An analysis of six generational means (P1, P2, F1, F2, BC1 and BC2) was applied for each cross. First a scaling test was applied and then a three and six-parameter genetic models were used to estimate various genetic components. In none of the traits studied there was evidence of adequacy to the three parameter model, which indicates important epistatic effects in genetic expression. The dominant genetic effects were greater than the additive ones for all the characters evaluated. LG showed positive and significant differences for [h] in both crosses, indicating the presence of hybrid vigor and its possible use in the improvement. Low value of [d] and high of [h] both significant in SC2 × AFE, indicates existence of genes dispersion between the parental lines. While, for the cross SC2 × LP3, the low and significant value of [d] and not significant value of [h], indicate greater genetic similarity. In the SC2 × LP3 cross, the negative interaction [l] confirms ambidirectional dominance, while for SC2 × LP3 the positive sign indicates directional dominance. The analysis of tolerance to salinity in the osmotic phase showed a complex polygenic inheritance for the traits used, determined by simple and interaction effects of different magnitudes and significance according to the cross considered.

关键词： maize Salinity Osmotic Stress Tolerance Genetic Effects Generation means Analysis

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Combining Ability in mixtures of Prairie Grass and Clovers

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American Journal of Plant Sciences 2012年第10期3卷 1355-1360页

作者： miguel Jacinto Arturi mónica Beatriz Aulicino Oscar Ansín Gustavo Gallinger Rodolfo Signorio Facultad de Ciencias Agrarias y Forestales Universidad Nacional de La PlataCalle 60 y 119 S/NCC·31(1900)La PlataProvincia de Buenos AiresArgentina Instituto Fitotécnico de Santa catalina FCAFUNLPGaribaldi 3400(1836)LlavallolProvincia de Buenos AiresArgentina Estación Experimental J.Hirschhorn FCAFUNLPCalle 66 y 166 S/NLos HornosProvincia de Buenos AiresArgentina

Our objective was to evaluate the combining ability among cultivars of forage species, commonly sown in temperate regions of Argentina using a short rotation system. Three genetically diverse cultivars of prairie brome grass (Bromus catharticus, cv Copetona, cv ?andú and cv Tango), a white clover cultivar (Trifolium repens, cv Lucero) and a red clover cultivar (T. pratense, cv Tropero) were evaluated. A randomized complete block design experiment was established in 2005. The treatments included five monocultures and ten binary mixtures. The experiment was harvested 6 times over an 18-month period. Cumulative dry matter yield (kg?ha–1) was calculated as the sum of the six individual harvests. Diallel analysis provided estimates of the general combining ability (GCA) and specific combining ability (SCA). Red clover in monoculture and mixtures produced the highest yields, with significant positive GCA effects (P P P P m nature of this study, we must limit our inference to short-term pastures (mbination with prairie brome grass.

关键词： Bromus catharticus Trifolium repens T. pretense Grass/Legume mixtures Dry matter Yield Argentina

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Incidence evaluation of <i>Crypticerya multicicatrices</i>and <i>maconellicoccus hirsutus</i>in Colombian Seaflower Biosphere Reserve

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Agricultural Sciences 2013年第12期4卷 654-665页

作者： marcela Silva-Gomez John A. Quiroz-Gamboa Francisco C. Yepes maría F. maya Adriana Santos Lilliana m. Hoyos-Carvajal Jardín Botánico de San Andrés Universidad Nacional de Colom-bia Sede Caribe San Andrés Colombia Universidad Nacional de Colombia Sede Medellín Medellín Colombia

An evaluation of the incidence of Crypticerya multicicatrices and maconellicoccus hirsutus in Colombian Seaflower Biosphere Reserve in San Andrés, Providence and Santa catalina islands, from mid-August to mid-November 2012 was made. 38 locations were sampled, and 34% of sites tested show an incidence of C. multicicatrices oscillating between a range of 80%-100%, 24% with 40%-80% of incidence, 18% between 10%-40% and 24% with a range of 0%-10%. The occurrence of m. hirsutus fluctuated between 0.5% and 17%. There were seven genera of ants associated C. multicicatrices and 94 hosts of this agriculturally important insect and we found high incidence of associated sooty mold in C. multicicatrices hosts. Observations also contained some developmental stages of C. multicatrices.

关键词： Colombia’s Caribbean Insular Pink Hibiscus mealybug multicicatrices Fluted Scale Sap Sucking Insects Honey Dew Sooty mold

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