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World Journal of Nephrology 2013年第1期2卷 11-16页

作者： Alison C Berg catalina Chernavvsky-Sequeira Jennifer Lindsey R Ariel Gomez Maria Luisa S Sequeira-Lopez Department of Pediatrics University of Virginia School of MedicineCharlottesvilleVA 22908United States

AIM： To investigate renin expression in pericytes dur-ing normal kidney development and after deletion of angiotensinogen, the precursor for all ***： We examined the distribution of renin ex-pressing cells by immunoshistochemistry in the intersti-tial compartment of wild type （WT） and angiotensino-gen deficient （AGT -/-） mice at different developmental stages from embryonic day 18 （e18： WT, n = 4; AGT -/-, n = 5） and at day 1 （P1： WT, n = 5; AGT -/-, n = 5）, 5 （P5： WT, n = 7; AGT -/-, n = 8）, 10 （P10： WT, n = 3; AGT -/-, n = 5）, 21 （P21： WT, n = 7; AGT -/-, n =5）, 45 （P45： WT, n = 3; AGT -/-, n = 3）, and 70 （P70： WT, n = 2; AGT -/-, n = 2） of postnatal life. We quanti-fied the number of pericytes positive for renin at all the developmental stages mentioned above and compared the results of AGT -/- mice to their WT ***： In WT mice, renal interstitial pericytes syn-thesize renin in early life supporting a lineage relation-ship with renin cells in the vasculature. The number of pericytes positive for renin per area of 0.32 mm2 （density） in WT mice was maintained from fetal life till weaning age （e18 = 4.25 ± 0.63, P1 = 3.75 ± 0.48, P5 = 3.75 ± 0.48, P10 = 4 ± 0.71, P21 = 3.8 ± 0.58） and markedly decreased in adult life （P45 = 1.2 ± 0.37, P70 = 0.8 ± 0.20）. on the other hand, in AGT -/- mice the density of pericytes expressing renin was not signifi-cantly different from WT mice at e18 and P1： e18 = 5.75 ± 0.50 vs 4.25 ± 0.63 （ P = 0.106）, P1 = 9.25 ± 3.50 vs 3.75 ± 0.48 （ P = 0.175） but significantly increased from P5 till P70： P5 = 38.25 ± 5 vs 3.75 ± 0.48 （ P = 0.0004）, P10 = 173 ± 7.50 vs 4 ± 0.70 （ P = 5.24567 × 10^-7）, P21 = 83 ± 6.70 vs 3.8 ± 0.58 （P = 2.97358 × 10^-6）, P45 = 49 ± 3.50 vs 1.2 ± 0.37 （P = 8.18274 × 10^-7） and P70 = 17.8 ± 2.30 vs 0.8 ± 0.20 （ P = 3.51151 × 10^-5）. The AGT -/- mice showed a marked increase in the number of pericytes per field studied starting from P5, reaching its peak at P10, and then a gra

关键词： Interstitium Homeostasis Angiotensino-gen Kidney Renin angiotensin system Development Angiotensin deficiency Gene deletion

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Deciphering late Tertiary intra-continental deformation of Se Asia

Deciphering late Tertiary intra-continental deformation of S...

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2018年中国地球科学联合学术年会

作者： Fabio Speranza Bo Zhang Alessandra Pellegrino Siyu Chen Rosanna Maniscalco catalina Hernandez Moreno Istituto Nazionale di Geofisica e Vulcanologia Roma Peking University Universit? degli Studi di Catania Catania

The Tertiary intra-continental deformation of Se Asia has been classically related to India-Asia collision and consequent Tibet Plateau rise, supposedly yielding the Se-ward drift of wide lithosphe

关键词： Deciphering late Tertiary intra-continental deformation of Se Asia

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everolimus immunosuppression reduces the serum expression of fibrosis markers in liver transplant recipients

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World Journal of Transplantation 2014年第2期4卷 133-140页

作者： Ainhoa Fernández-Yunquera Cristina Ripoll Rafael Banares Marta Puerto Diego Rincón Ismael Yepes Vega catalina Magdalena Salcedo Department of Liver Transplantation Hospital General Gregorio Mara?ón28028 MadridSpain on-Line Bio-medical Investigation Center for Hepatic and Gastrointestinal Diseases 28028 MadridSpain

AIM: To evaluate the expression of serum fibrosis markers in liver transplantation(LT) recipients on everolimus monotherapy compared to patients on an anti-calcineurin ***: This cross-sectional case-control study included LT patients on everolimus monotherapy(cases)(e)(n = 30) and matched controls on an anticalcineurin regimen(calcineurin inhibitors, CNI), paired by etiology of liver disease and time since LT(n = 30). Clinical characteristics, blood tests and elastography were collected. Serum levels of transforming growth factor-β(TGF-β), angiopoietin-1, tumor necrosis factor(TNF), platelet derived growth factor, amino-terminal propeptide of type Ⅲ procollagen(PⅢNP), hyaluronicacid(HA), VCM-1(ng/m L), interleukin(IL)-10, interferoninducible protein 10(IP-10), vascular endothelial growth factor and hepatocyte growth factor(HGF)(pg/m L) were determined by enzyme-linked immunosorbent assay. expression of these markers between e and CNI was compared. Stratified analysis was done according to factors that may influence liver fibrosis. Variables are described with medians(interquartillic range) or ***: A total of 60 patients [age: 59(49-64), hepatitis C virus(HCV): n = 21(35%), time from LT: 73 mo(16-105)] were included. Patients had been on everolimus for a median of 15 mo. No differences in inflammatory activity, APRI test or liver elastography were found between the groups. No significant differences were observed between the groups in serum levels of PⅢ NP, metalloproteinase type = 1, angiopoietin, HGF, IP-10, TNF-α, IL-10 and vascular cell adhesion molecule. Patients on e had a lower expression of TGF-β [e: 12.7(3.7-133.6), CNI: 152.5(14.4-333.2), P = 0.009] and HA [e: 702.89(329.4-838.2), CNI: 1513.6(691.9-1951.4), P = 0.001] than those on CNI. This difference was maintained in the stratified analysis when recipient age is more than 50 years(TFG-β1: P = 0.06; HA: P = 0.005), in patients without active neoplasia(TFG-β1, P = 0.009; HA: P =

关键词： everolimus Rapamycin Liver fibrosis Mammalian target of rapamycin Transplantation

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Biodiversity, dynamics, and impact of chakras on the ecuadorian Amazon

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Journal of Plant ecology 2019年第1期12卷 34-44页

作者： Roy R.Vera V J.Hugo Cota-Sánchez Jorge e.Grijalva olmedo University of Saskatchewan Department of Biology112 Science PlaceSaskatoon SK S7N 5E2Canada University of Saskatchewan Department of Biology and W.P.Fraser Herbarium(SASK)112 Science PlaceSaskatoon SK S7N 5E2Canada Universidad Central del ecuador Facultad de Medicina Veterinaria y ZootecniaJerónimo Leiton y Gatto SobralQuito 170521Ecuador estación experimental Santa catalina Panamericana Sur Km1Instituto Nacional de Investigaciones AgropecuariasMejía 171101Ecuador

Aims Deforestation and biodiversity loss are two alarming,closely related problems,and the main factors triggering changes in land *** agricultural practices in the western Amazon Basin are known as chakras,and their structure and dynamics are seemingly optimal for forest ***,the variability in tree spe-cies and the degree of forest recovery after abandonment is poorly documented in this agroforestry system(AFS).The goals of this study were:(i)to investigate whether the different AFSs(chakras)preserve similar levels of forest diversity,(ii)to determine the effect of trans-formation of mature forests(MF)to chakras,in particular,forest alpha and beta diversity levels,and(iii)to investigate whether native tree species recovery leads to the original forest structure following chakra *** We assessed the floristic composition in three AFSs(cassava,corn,and cocoa),the secondary forest(SF),and the forest remnants in the buffer zone of the Northern ecuadorian Amazon(NeA).All tree spe-cies with a diameter at breast height(dbh)≥10 cm were inventoried in 61 plots(0.28 ha average)representing 17.44 *** diversity was calculated in all systems to determine the levels of variabil-ity using species richness and the Shannon diversity ***,beta diversity was examined to evaluate the degree of dissimilarity among all AFSs with the MF in order to analyze changes in floristic *** divergence between the SF and the MF was ana-lyzed to ascertain forest recovery after chakra *** Findings A total of 4,060 trees(dbh≥10 cm)representing 109 species,96 genera,and 43 plant families were inventoried in 17.44 ha sampled in five systems in the buffer zone of the *** most dominant plant families were Arecaceae,Myristicaceae,Fabaceae,Meliaceae,and Malvaceae,and the most representative genera included Iriartea,Virola,Guarea,ocotea,Cordia,Chrysophyllum,and *** MF in this zone is composed of 81 tree species circums

关键词： agroforestry biodiversity chakra climate change tropical forest

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全身性炎症是牙周炎和高血压之间缺失的一环吗?

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中华高血压杂志 2021年第7期29卷 655-655页

作者：袁源(摘译) 郑武洪(审校) Munoz Aguilera e Leira Y Miro catalina Q orlandi M Czesnikiewicz-Guzik M Guzik TJ Hingorani AD Nart J D'Aiuto F 不详

本研究旨在探究两项独立大型研究中牙周炎和高血压的相关性,明确全身性炎症对上述相关性是否有调节作用。方法:本研究为横断面研究,分析了来自美国[3460例,全国健康及营养状况调查(national health and nutrition examination survey,NH... 详细信息

本研究旨在探究两项独立大型研究中牙周炎和高血压的相关性,明确全身性炎症对上述相关性是否有调节作用。方法:本研究为横断面研究,分析了来自美国[3460例,全国健康及营养状况调查(national health and nutrition examination survey,NHANeS)2009-2010]和韩国[4539例,第六次韩国国民健康和营养状况调查(the 6^(th)-3 versions Korean national health and nutrition examination survey,KNHANeS Ⅵ-3)2015]的代表性样本。

关键词：国民健康横断面研究牙周炎营养状况调查代表性样本高血压

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中国云南地区构造与古地磁旋转模式（英文）

中国云南地区构造与古地磁旋转模式（英文）

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2017中国地球科学联合学术年会

作者： Fabio Speranza 张波 Alessandra G Pellegrino 阴从元陈思雨 Rosanna Maniscalco catalina Hernandez Moreno Istituto Nazionale di Geofisica e Vulcanologia 北京大学地球与空间科学学院 Università degli Studi di Catania

＜正＞A wealth of paleomagnetic data from Yunnan（China）showed in the past a predominant post-Cretaceous clockwise（CW）rotation pattern,mostly explained invoking huge（hundreds of km wide）blocks laterally escaping（and rotating）due to India-Asia collision,separated by major strike-slip shear *** we report on the paleomagnetism of the

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