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Regioselective synthesis of α-D-glucopyranosiduronic acid derivatives and biological test against bacterial Staphylococcus aureus and Salmonella agona

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Science China Chemistry 2010年第4期53卷 877-883页

作者： cassidy Seamas Food Science and Environmental Health Department Dublin Institute of Technology Dublin 1 Ireland

α-D-Glucopyranosiduronides were stereoselectively synthesized from D-glucopyranosiduronic acid via the intermediate 1,6-lactone. Fatty acid esters were regioselectively introduced at the 2-O-position of α-D-glucopyranosiduronides using dibutyltin dimethoxide as the stannylating agent. Antibacterial tests show that methyl 2-O-lauroyl-O-D-glucopyranosiduronic acid and azido 2-O-lauroyl-O-D-glucopyranosid-uronic acid are effective inhibitors against Staphylococcus aureus.

关键词： dibutyltin dimethoxide stereoselectivity regioselectivity antibacterial

Epidemiology and Clonal Spread Evidence of Carbapenem-Resistant Organisms in the Center of Care and Protection of Orphaned Children, Vietnam

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Open Journal of Medical Microbiology 2024年第3期14卷 165-189页

作者： Van Kim Nguyen Pirom Noisumdaeng Pol. Maj. Katiya Ivanovitch Stephen Baker Eugene Athan Stephanie Jones Le Thi Lan Larry Croft Yin Peng Lee Tara cassidy Van Hung Tran Thi Hang Phan Huu Tinh Ho Faculty of Public Health Thammasat University Bangkok Thailand Department of Prevention and Infection Control Hung Vuong Hospital HCM City Vietnam Microbiology of Faculty of Public Health Thammasat University Bangkok Thailand Thammasat University Research Unit in Modern Microbiology and Public Health Genomics Thammasat University Bangkok Thailand National Heart & Lung Institute (NHLI) University of Cambridge Cambridge UK Barwon South West Public Health Unit Geelong Australia Center for Innovation in Infectious Disease and Immunology Research (CIIDIR) Geelong Australia School of Medicine Deakin University Burwood Australia Monash Health Berwick Australia Center of Care and Protection of Orphaned Children HCM City Vietnam Charles River Laboratories Microbial Solutions Melbourne Australia Personnel Department of Nhan Dan Gia Dinh Hospital HCM City Vietnam Hung Vuong Hospital HCM City Vietnam Department of Epidemiology Institute of Public Health HCM City Vietnam

Objective: To determine the prevalence of colonization and transmission of carbapenem-resistant Gram-negative organisms in order to develop of an effective infection prevention program. Design: Cross-sectional study with carbapenem-resistant organisms (CRO) colonization detection from the fecal specimens of 20 Health Care Workers (HCWs) and 67 residents and 175 random environment specimens from September 2022 to September 2023. Setting: A Care and Protection Centre of Orphaned Children in South of HCM City. Participants: It included 20 HCWs, 67 residents, and 175 randomly collected environmental specimens. Method: Rectal and environmental swabs were collected from 20 HCWs, 67 residents (most of them were children), and 175 environmental specimens. MELAB Chromogenic CARBA agar plates, Card NID, and NMIC-500 CPO of the BD Phoenix TM Automated Microbiology System and whole genome sequencing (WGS) were the tests to screen, confirm CROs, respectively and determine CRO colonization and transmission between HCWs, residents, and the environment. Result: We detected 36 CRO isolates, including 6, 11 and 19 CROs found in 6 HCWs, 10 residents and 19 environments. The prevalence of detectable CRO was 30% (6/20) in HCWs, 14.92% (10/67) in residents, and 10.86% (19/175) in environmental swabs in our study. WGS demonstrated CRO colonization and transmission with the clonal spread of E. coli and A. nosocomialis, among HCWs and residents (children). Conclusion: Significant CRO colonization and transmission was evident in HCWs, residents, and the center environment. Cleaning and disinfection of the environment and performing regular hand hygiene are priorities to reduce the risk of CRO colonization and transmission.

关键词： Carbapenem-Resistant Organisms Contamination Hand Hygiene Whole Genome Sequencing Infection Prevention

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北美灰熊返乡受阻

环球科学 2024年第13期 48-57页

作者：本杰明·卡西迪姜梦鸾(翻译) 罗述金(翻译) 不详北京大学生命科学学院

北喀斯喀特山脉的一项灰熊重引入计划,揭开了公众对人熊冲突的深切恐惧。斯科特·斯凯勒(Scott Schuyler)知道,纽黑勒姆镇的这一夜注定不会轻松。在这个偏远小镇的社区中心,数十位科学家、政府官员和居民齐聚一堂,讨论人类该如何与顶级... 详细信息

北喀斯喀特山脉的一项灰熊重引入计划,揭开了公众对人熊冲突的深切恐惧。斯科特·斯凯勒(Scott Schuyler)知道,纽黑勒姆镇的这一夜注定不会轻松。在这个偏远小镇的社区中心,数十位科学家、政府官员和居民齐聚一堂,讨论人类该如何与顶级捕食者共存。纽黑勒姆由西雅图市城市之光电力公司(Seattle City Light)所有和运营,毗邻美国北喀斯喀特国家公园(North Cascade National Park)。很久以前,这家公司在附近的斯卡吉特河(Skagit River)建造了一系列水坝,为华盛顿州最大的城市(即西雅图市)发电。

关键词：电力公司华盛顿州灰熊西雅图市斯科特捕食者返乡

Quark-Novae Ia in the Hubble diagram: implications for dark energy

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Research in Astronomy and Astrophysics 2014年第5期14卷 497-519页

作者： Rachid Ouyed Nico Koning Denis Leahy Jan E.Staff Daniel T.cassidy Department of Physics and Astronomy University of Calgary 2500 University Drive NWCalgary Alberta T2N 1N4 Canada Department of Physics and Astronomy Macquarie University NSW 2109 Australia Department of Engineering Physics McMaster University Hamilton Ontario L8S 4L7 Canada

The accelerated expansion of the Universe was proposed through the use of Type-Ia supernovae （SNe） as standard candles. The standardization depends on an empirical correlation between the stretch/color and peak luminosity of the light curves. The use of Type-Ia SNe as standard candles rests on the assumption that their properties （and this correlation） do not vary with redshift. We consider the possibility that the majority of Type-Ia SNe are in fact caused by a Quark-Nova detonation in a tight neutron-star-CO-white-dwarf binary system, which forms a Quark-Nova Ia （QN-Ia）. The spin-down energy injected by the Quark-Nova remnant （the quark star） contributes to the post-peak light curve and neatly explains the observed correlation between peak luminosity and light curve shape. We demonstrate that the parameters describing QN-Ia are NOT constant in redshift. Simulated QN-Ia light curves provide a test of the stretch/color correlation by comparing the true distance modulus with that determined using SN light curve fitters. We determine a correction between the true and fitted distance moduli, which when applied to Type-Ia SNe in the Hubble diagram recovers the ΩM = 1 cosmology. We conclude that Type-Ia SNe observations do not necessitate the need for an accelerating expansion of the Universe （if the observed SNe Ia are dominated by QNe Ia） and by association the need for dark energy.

关键词： dark energy -- cosmology observations -- supernovae general

Assessment of pipeline stability in the Gulf of Mexico during hurricanes using dynamic analysis

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Theoretical & Applied Mechanics Letters 2015年第2期5卷 74-79页

作者： Yinghui Tian Bassem Youssef Mark J.cassidy Centre for Offshore Foundation Systems and ARC CoE for Geotechnical Science and Engineering University of Western Australia Atteris Level 3220 St Georges TerracePerthWA6000Australia

Pipelines are the critical link between major offshore oil and gas developments and the mainland. Any inadequate on-bottom stability design could result in disruption and failure, having a devastating impact on the economy and environment. Predicting the stability behavior of offshore pipelines in hurricanes is therefore vital to the assessment of both new design and existing assets. The Gulf of Mexico has a very dense network of pipeline systems constructed on the seabed. During the last two decades, the Gulf of Mexico has experienced a series of strong hurricanes, which have destroyed, disrupted and destabilized many pipelines. This paper first reviews some of these engineering cases. Following that, three case studies are retrospectively simulated using an in-house developed program. The study utilizes the offshore pipeline and hurricane details to conduct a Dynamic Lateral Stability analysis, with the results providing evidence as to the accuracy of the modeling techniques developed.

关键词： Pipeline On-bottom stability Dynamic lateral stability analysis Force-resultant model Hydrodynamic load

The role of artificial intelligence technology in the care of diabetic foot ulcers: the past, the present, and the future

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World Journal of Diabetes 2022年第12期13卷 1131-1139页

作者： Joseph M Pappachan Bill cassidy Cornelius James Fernandez Vishnu Chandrabalan Moi Hoon Yap Department of Endocrinology&Metabolism Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom Faculty of Science and Engineering Manchester Metropolitan UniversityManchester M156BHUnited Kingdom Department of Endocrinology&Metabolism Pilgrim HospitalBoston PE219QSUnited Kingdom Department of Data Science Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom

Foot ulcers are common complications of diabetes mellitus and substantially increase the morbidity and mortality due to this *** care by regular monitoring of the progress of healing with clinical review of the ulcers,dressing changes,appropriate antibiotic therapy for infection and proper offloading of the ulcer are the cornerstones of the management of foot *** the progress of foot ulcers can be a challenge for the clinician and patient due to logistic issues such as regular attendance in the *** clinics are often busy and because of manpower issues,ulcer reviews can be delayed with detrimental effects on the healing as a result of a lack of appropriate and timely changes in *** photographs have been historically useful to assess the progress of diabetic foot ulcers over the past few *** phones with digital cameras have recently revolutionized the capture of foot ulcer *** can send ulcer photographs to diabetes care professionals electronically for remote monitoring,largely avoiding the logistics of patient transport to clinics with a reduction on clinic *** intelligence-based technologies have been developed in recent years to improve this remote monitoring of diabetic foot ulcers with the use of mobile *** is expected to make a huge impact on diabetic foot ulcer care with further research and development of more accurate and scientific technologies in *** clinical update review aims to compile evidence on this hot topic to empower clinicians with the latest developments in the field.

关键词： Diabetic foot ulcers Photographic monitoring Artificial intelligence technology Digital photography Mobile app COVID-19 pandemic

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锡类络合物在糖衍生物合成中的区域选择性

化学通报 2010年第4期73卷 308-313页

作者：楼鑫侯金松 Seamas cassidy 滁州学院化学与生命科学系安徽滁州239000 Food Science and Environmental Health Dublin Institute of Technology

锡类化合物在选择性糖衍生物合成中应用得相当广泛,亚甲锡烷基方法在吡喃糖衍生物合成中体现了高区域选择性。本文从三丁基锡醚和二丁基锡缩醛与糖类形成的络合物结构出发,揭示了其区域选择性的根本原因在于通过聚合作用使得处于不同位... 详细信息

锡类化合物在选择性糖衍生物合成中应用得相当广泛,亚甲锡烷基方法在吡喃糖衍生物合成中体现了高区域选择性。本文从三丁基锡醚和二丁基锡缩醛与糖类形成的络合物结构出发,揭示了其区域选择性的根本原因在于通过聚合作用使得处于不同位置的羟基显示不同的电负性和亲核性;还讨论了吡喃糖类中不同类型的多元醇系统和锡络合后所表现的区域选择性。

关键词：糖二丁基氧化锡三丁基锡醚区域选择性

The skeletal muscle fiber periphery:A nexus of mTOR-related anabolism

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运动医学与健康科学(英文) 2023年第1期5卷 10-19页

作者： cassidy T.Tinline-Goodfellow Matthew J.Lees Nathan Hodson Faculty of Kinesiology and Physical Education University of TorontoCanada Institute of Sport Manchester Metropolitan UniversityManchesterUnited Kingdom Department of Sport and Exercise Sciences Manchester Metropolitan UniversityManchesterUnited Kingdom

Skeletal muscle anabolism is driven by numerous stimuli such as growth factors,nutrients(i.e.,amino acids,glucose),and mechanical *** stimuli are integrated by the mechanistic target of rapamycin(mTOR)complex 1(mTORC1)signal transduction *** recent years,work from our laboratory and elsewhere has sought to unravel the molecular mechanisms underpinning the mTOR-related activation of muscle protein synthesis(MPS),as well as the spatial regulation of these mechanisms within the skeletal muscle *** studies have suggested that the skeletal muscle fiber periphery is a region of central importance in anabolism(i.e.,growth/MPS).Indeed,the fiber periphery is replete with the substrates,molecular machinery,and translational apparatus necessary to facilitate *** review provides a summary of the mechanisms underpinning the mTOR-associated activation of MPS from cell,rodent,and human *** also presents an overview of the spatial regulation of mTORC1 in response to anabolic stimuli and outlines the factors that distinguish the periphery of the cell as a highly notable region of skeletal muscle for the induction of *** research should seek to further explore the nutrient-induced activation of mTORC1 at the periphery of skeletal muscle fibers.

关键词： Skeletal muscle mTOR Periphery Muscle protein synthesis Hypertrophy Translation

Failure mechanisms of a spudcan penetrating next to an existing footprint

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Theoretical & Applied Mechanics Letters 2015年第2期5卷 64-68页

作者： Vickie Kong Mark J.cassidy Christophe Gaudin Fugro-Advanced Geomechanics Centre for Offshore Foundation Systems and ARC CoE for Geotechnical Science and Engineering University of Western Australia

Reinstallation of mobile jack-up rigs next to existing footprints is a problematic operation because the spudcan located near the footprints is subjected to eccentric and/or inclined loading conditions. Geotech- nical centrifuge studies have measured these loads for combinations of changing footprint geometry, footprint soil properties and the offset of the reinstallation from the footprint centre. These tests have been of full model spudcans in order to accurately measure the combined loads developed. They have not provided information on the mechanisms of failure occurring during this complex installation. Ob- servations from a visualisation test, where a half spudcan is penetrated against a transparent window in a geotechnical centrifuge, are reported in this paper. The mechanisms of failure at different stages during the nenetrntirm are nr^nted

关键词： Jack-up Footprint Combined loading Spudcan Offshore geotechnics