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Transcatheter mitral valve repair is feasible and effective in oldest-old patients:results from real-world cohort

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j.urnal of Geriatric Cardiology 2022年第10期19卷 761-767页

作者： Mhd Nawar Alachkar Annemarie Kirschfink Anas Alnaimi j.rg Schröder Felix Vogt nikolaus Marx Ertunc Altiok Mohammad Almalla Department of Cardiology and Angiology REGIOMED Hospital CoburgCoburgGermany Department of Cardiology Angiology and Intensive CareMedical Clinic ⅠUniversity Hospital RWTH AachenAachenGermany

OBj.CTIVE To evaluate the safety and efficacy of transcatheter mitral valve repair(TMVR)using MitraClip^(■)devices in oldest-old patients compared to younger *** The study retrospectively included 340 consecutive patients who underwent *** were classified according to age into the oldest-old(age≥85 years)patient group or the younger(age<85 years)patient *** results of the procedure,intrahospital outcomes and one-year outcomes were *** Oldest-old patients represented 15.9%(n=54)of all *** success was comparable for the oldest-old patient group and the younger patient group(92.6%vs.95.8%,P=0.30),and there was no difference in intrahospital mortality(9.2%vs.4.2%,P=0.12).At a one-year follow-up(interquartile range:6–16 months),there was no significant difference in rehospitalization due to decompensated heart failure(25.5%vs.34.3%,P=0.24)or all-cause mortality(29.8%vs.22.2%,P=0.26)between the oldest-old patient group and the younger patient *** patients with available echocardiographic follow-up,severity of residual mitral regurgitation was also comparable between the oldest-old patient group and the younger patient *** TMVR seems to be feasible and effective in oldest-old patients and should be considered for oldest-old patients presenting with symptomatic severe mitral regurgitation and high surgical risk.

关键词： patients mitral mortality

Impact of Si on the high-temperature oxidation of AlCr(Si)N coatings

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j.urnal of Materials Science & Technology 2022年第5期100卷 91-100页

作者： nikolaus j.ger Michael Meindlhumer Michal Zitek Stefan Spor Hynek Hruby Farwah Nahif j.akko j.lin Martin Rosenthal j.zef Keckes Christian Mitterer Rostislav Daniel Christian Doppler Laboratory for Advanced Synthesis of Novel Multifunctional Coatings at the Department of Materials Science Montanuniversität LeobenAustria voestalpine eifeler Vacotec GmbH DüsseldorfGermany Institute of Ion Beam Physics and Materials Research Helmholtz-Zentrum Dresden-RossendorfDresdenGermany Department of Physics University of JyvaskylaFinland European Synchrotron Radiation Facility GrenobleFrance Erich Schmid Institute for Materials Science Austrian Academy of SciencesAustria Department of Materials Science Montanuniversität LeobenAustria

The resistance of wear protective coatings against oxidation is crucial for their use at high ***,three nanocomposite AlCr(Si)N coatings with a fixed Al/Cr atomic ratio of 70/30 and a varying Si-content of 0 at.%,2.5 at.% and 5 at.% were analyzed by differential scanning calorimetry,thermogravimetric analysis and X-ray in order to understand the oxidation behavior depending on their ***,a partially oxidized AlCrSiN coating with 5 at.%Si on a sapphire substrate was studied across the coating thickness by depth-resolved cross-sectional X-ray nanodiffraction and scanning trans-mission electron microscopy to investigate the elemental composition,morphology,phases and residual stress evolution of the oxide scale and the non-oxidized coating *** results reveal enhanced oxidation properties of the AlCr(Si)N coatings with increasing Si-content,as demonstrated by a retarded onset of oxidation to higher temperatures from 1100℃ for AlCrN to 1260℃ for the Si-containing coatings and a simultaneous deceleration of the oxidation *** annealing of the AlCrSiN sample with5 at.%Si at an extraordinary high temperature of 1400℃ for 60 min in ambient air,three zones developed throughout the coating strongly differing in their composition and structure:(i)a dense oxide layer comprising an Al-rich and a Cr-rich zone formed at the very top,followed by(ii)a fine-grained transition zone with incomplete oxidation and(iii)a non-oxidized zone with a porous *** varying elemental composition of these zones is furthermore accompanied by micro-structural variations and a complex residual stress development revealed by cross-sectional X-ray *** results provide a deeper understanding of the oxidation behavior of AlCr(Si)N coatings depending on their Si-content and the associated elemental,microstructural and residual stress evolution during high-temperature oxidation.

关键词： AlCrSiN Nanocomposite Cathodic arc Oxidation behaviour Cross-sectional X-ray nanodiffraction

Sediment generation and soil mound denudation in areas of high-density tree throw along a river valley in the j.ra Mountains, Switzerland

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j.urnal of Mountain Science 2021年第2期18卷 377-391页

作者： Philip GREENWOOD j.n BAUER nikolaus j.KUHN Physical Geography&Environmental Change Research Group Department of Environmental SciencesUniversity of BaselKlingelbergstrasse 27Basel-4056Switzerland

A preliminary field-based investigation was undertaken in a small(<10 km^(2))river valley located in the mountainous j.ra region of northwest *** aims of the work were to assess sediment generation and annual sediment... 详细信息

A preliminary field-based investigation was undertaken in a small(j.ra region of northwest *** aims of the work were to assess sediment generation and annual sediment transport rates by tree throw on forested hillslopes,and to document surface hydrology characteristics on four fresh soil mounds associated with recent tree throws over a 24-day monitoring *** the soil mounds,average sediment recovery ranged from 7.7-28.2 g(dry weight),equivalent to a suspended sediment concentration of 145.2-327.8 g L^(-1),and runoff coefficients ranged from 1.0%-4.2%.Based on a soil bulk density value of 1,044 kg m^(-3),upslope runoff generation areas were denuded by an average 0.14 mm by the end of the 24-day monitoring period,representing an erosion rate equivalent to 2.1 mm yr^(-1).A ca.50 cm high soil mound could therefore feasibly persist for around 200-250 *** tree throw work,the dimensions of 215 individual tree throws were measured and their locations mapped in 12 separate locations along the river valley representing a cumulative area equivalent to 5.3 ha(***,43 per ha).Tree throws generated a total of 20.1 m^(3) of fine-sediment(j.rity of tree throws,but instead,could be associated with root *** the high density of tree throws and their relative maturity(average age 41 years),we hypothesise that once tr

关键词： Tree throw Hillslope processes Sediment generation mechanism Sediment transport rate Soil mound Ibach river valley

Human intestinal acyl-CoA synthetase 5 is sensitive to the inhibitor triacsin C

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World j.urnal of Gastroenterology 2011年第44期17卷 4883-4889页

作者： Elke Kaemmerer Anne Peuscher Andrea Reinartz Christian Liedtke Ralf Weiskirchen j.rgen Kopitz nikolaus Gassler Department of Pediatrics RWTH Aachen UniversityAachenGermany Institute of Pathology RWTH Aachen University Department of Plant Biotechnology Fraunhofer Institute for Molecular Biology and Applied Ecology (IME) Institute of Pathology RWTH Aachen University Department of Medicine Ⅲ RWTH Aachen University Institute of Clinical Chemistry and Pathobiochemistry RWTH Aachen University Institute of Pathology University of Heidelberg

AIM:To investigate whether human acyl-CoA synthetase 5(ACSL5) is sensitive to the ACSL inhibitor triacsin ***:The ACSL isoforms ACSL1 and ACSL5 from rat as well as human ACSL5 were cloned and recombinantly expressed as 6xHis-tagged *** 2+-affinity purified recombinant enzymes were assayed at pH 7.5 or pH 9.5 in the presence or absence of triacsin *** addition,ACSL5 transfected CaCo2 cells and intestinal human mucosa were ***5 expression in cellular systems was verified using Western blot and *** ACSL assay mix included TrisHCl(pH 7.4),ATP,CoA,EDTA,DTT,MgCl 2,[9,103 H] palmitic acid,and triton *** 200 μL reaction was initiated with the addition of solubilized,purified recombinant proteins or cellular *** were terminated after 10,30 or 60 min of incubation with Doles ***:Expression of soluble recombinant ACSL proteins was found after incubation with isopropyl betaD-1-thiogalactopyranoside and after ultracentrifugation these were further purified to near homogeneity with Ni 2+-affinity *** C selectively and strongly inhibited recombinant human ACSL5 protein at pH 7.5 and pH 9.5,as well as recombinant rat ACSL1(sensitive control),but not recombinant rat ACSL5(insensitive control).The IC50 for human ACSL5 was about 10 μmol/*** inhibitory triacsin C effect was similar for different incubation times(10,30 and 60 min) and was not modified by the N-or C-terminal location of the *** order to evaluate ACSL5 sensitivity to triacsin C in a cellular environment,stable human ACSL5 CaCo2 transfectants and mechanically dissected normal human intestinal mucosa with high physiological expression of ACSL5 were *** both models,ACSL5 peak activity was found at pH 7.5 and pH 9.5,corresponding to the properties of recombinant human ACSL5 *** the presence of triacsin C(25 μmol/L),total ACSL activity was dramatically diminished in human ACSL5 transfectants as well as in AC

关键词：酰基辅酶A 肠道黏膜敏感性抑制剂合成酶重组表达亲和纯化 Triton

利用土壤颗粒的沉降粒级研究泥沙的迁移与分布规律

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土壤学报 2017年第5期54卷 1115-1124页

作者：胡亚鲜 nikolaus j.Kuhn 西北农林科技大学水土保持研究所陕西杨凌712100 中国科学院水利部水土保持研究所黄土高原土壤侵蚀与旱地农业国家重点实验室陕西杨凌712100 瑞士巴塞尔大学环境科学系

了解不同粒径泥沙迁移运动规律,有助于深入理解侵蚀条件下碳、氮、磷等元素的生物地球化学过程。土壤营养元素的迁移转化与泥沙颗粒的运动规律密切相关,而泥沙的运动规律由颗粒大小、性状、孔隙度和密度等因素共同决定。依据泥沙颗粒沉... 详细信息

了解不同粒径泥沙迁移运动规律,有助于深入理解侵蚀条件下碳、氮、磷等元素的生物地球化学过程。土壤营养元素的迁移转化与泥沙颗粒的运动规律密切相关,而泥沙的运动规律由颗粒大小、性状、孔隙度和密度等因素共同决定。依据泥沙颗粒沉降速度分选的原理,针对中国两种典型侵蚀土壤(红壤和黄绵土),分别进行了土壤机械组成(矿质土粒分选)和沉降速度分选测定。结果表明,土壤颗粒的沉降粒级可有效区分红壤和黄绵土中不同粒径团聚体的沉降速度,能够更加准确地反映出同一粒径颗粒因性状、密度和孔隙度的差异而形成的不同沉降速度。相对于质地疏松的黄绵土,红壤的机械组成显示,有86.9%的有机碳与≤32μm的矿物颗粒相结合,很有可能随悬移过程汇入下游水体。但土壤颗粒沉降速度分布表明,约有90.5%的红壤有机碳与等效石英粒径≥63μm的团聚体相结合,易在经历较短的迁移过程后,快速沉积于下坡面。这表明,现有的土壤侵蚀模型大多利用土壤机械组成(即矿质粒径大小)在反映泥沙运动或元素迁移规律方面存在片面性。土壤的团聚过程可有效缩减有机碳和无机碳的迁移距离,从而使其更易沉积于陆生环境。土壤颗粒的沉降速度分级对认识泥沙颗粒和养分元素在侵蚀—迁移—沉积过程中的生物地球化学过程提供了新的途径和视角。

关键词：沉降管法沉降速度团聚体迁移距离有机碳无机碳

Clinical algorithms for the prevention of variceal bleeding and rebleeding in patients with liver cirrhosis

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World j.urnal of Hepatology 2021年第7期13卷 731-746页

作者： nikolaus Pfisterer Lukas W Unger Thomas Reiberger Medizinische Abteilung für Gastroenterologie und Hepatologie Klinik Landstraße/Krankenanstalt RudolfstiftungVienna 1030Austria Vienna Hepatic Hemodynamic Lab Medical University of ViennaVienna 1090Austria Division of Visceral Surgery Department of General SurgeryMedical University of ViennaVienna 1090Austria Cambridge Institute of Therapeutic Immunology and Infectious Disease Jeffrey Cheah Biomedical CentreUniversity of CambridgeCambridge CB20AWUnited Kingdom Division of Gastroenterology and Hepatology Department of Medicine IIIMedical University of ViennaVienna 1090Austria Christian Doppler Laboratory for Portal Hypertension and Liver Fibrosis Medical University of ViennaVienna 1090Austria

Portal hypertension(PH),a common complication of liver cirrhosis,results in development of esophageal *** esophageal varices rupture,they cause significant upper gastrointestinal bleeding with mortality rates up to 20%despite state-of-the-art ***,prophylactic measures are of utmost importance to improve outcomes of patients with *** high-quality studies have demonstrated that non-selective beta blockers(NSBBs)or endoscopic band ligation(EBL)are effective for primary prophylaxis of variceal *** secondary prophylaxis,a combination of NSBB+EBL should be routinely *** esophageal varices develop and variceal bleeding occurs,standardized treatment algorithms should be followed to minimize bleeding-associated *** attention should be paid to avoidance of overtransfusion,early initiation of vasoconstrictive therapy,prophylactic antibiotics and early endoscopic ***-emptive transj.gular intrahepatic portosystemic shunt should be used in all Child C10-C13 patients experiencing variceal bleeding,and potentially in Child B patients with active bleeding at *** use of carvedilol,safety of NSBBs in advanced cirrhosis(*** refractory ascites)and assessment of hepatic venous pressure gradient response to NSBB is *** the present review,we give an overview on the rationale behind the latest guidelines and summarize key papers that have led to significant advances in the field.

关键词： Portal hypertension Endoscopy Non-selective betablockers Transj.gular intrahepatic portosystemic shunt

Modulating effects of acyl-CoA synthetase 5-derived mitochondrial Wnt2B palmitoylation on intestinal Wnt activity

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World j.urnal of Gastroenterology 2014年第40期20卷 14855-14864页

作者： Christina Klaus Ursula Schneider Christian Hedberg Anke K Schütz j.rgen Bernhagen Herbert Waldmann nikolaus Gassler Elke Kaemmerer Institute of Pathology RWTH Aachen University 52074 Aachen Germany Department of Chemical Biology Max Planck Institute of Molecular Physiology 44227 Dortmund Germany Department of Biochemistry and Molecular Cell Biology RWTH Aachen University 52074 Aachen Germany Department of Pediatrics RWTH Aachen University 52074 Aachen Germany

AIM:To investigate the role of acyl-CoA synthetase 5(ACSL5)activity in Wnt signaling in intestinal surface ***:Several cell lines were used to investigate the ACSL5-dependent expression and synthesis of Wnt2B,a mitochondrially expressed protein of the Wnt signaling *** activity was functionally assessed with a luciferase reporter ***5-related biochemical Wnt2B modifications were investigatedwith a modified acyl-exchange *** findings from the cell culture models were verified using an Apcmin/+mouse model as well as normal and neoplastic diseased human intestinal ***:In the presence of ACSL5,Wnt2B was unable to translocate into the nucleus and was enriched in mitochondria,which was paralleled by a significant decrease in Wnt ***5-dependent S-palmitoylation of Wnt2B was identified as a molecular reason for mitochondrial Wnt2B *** cell culture systems,a strong relation of ACSL5 expression,Wnt2B palmitoylation,and degree of malignancy were *** normal mucosa,the association of ACSL5 and Wnt2B was seen,but in intestinal neoplasias the mechanism was only rudimentarily ***:ACSL5 mediates antiproliferative activities via Wnt2B palmitoylation with diminished Wnt *** molecular pathway is probably relevant for intestinal homeostasis,overwhelmed by other pathways in carcinogenesis.

关键词： Acyl-CoA synthetases Wnt signaling Palmitoylation

Intestinal genetic inactivation of caspase-8 diminishes migration of enterocytes

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World j.urnal of Gastroenterology 2015年第15期21卷 4499-4508页

作者： Elke Kaemmerer Paula Kuhn Ursula Schneider Min Kyung j.on Christina Klaus Miriam Schiffer Danika Weisner Christian Liedtke j.rg j.kel Lieven Nils Kennes Ralf-Dieter Hilgers Norbert Wagner nikolaus Gassler Institute of Pathology RWTH Aachen University Department of Pediatrics RWTH Aachen University Department of Medicine Ⅲ RWTH Aachen University Department of Medical Statistics RWTH Aachen University

AIM: To verify the hypothesis that caspase-8(Casp8), which regulates cellular apoptosis and necroptosis, is critically involved in enterocyte ***: Casp8-silenced Caco2 cells were used in migration assays. In addition, enterocyte-specific Casp8 heterozygous(Casp8+/?int) or homozygous knockout mice(Casp8?int) were generated by crossing genetically modified mice carrying lox P recombination sites in intron 2 and 4 of the murine Casp8 gene with transgenic animals expressing a cre-transgene under control of the villin promoter in a pure C57/BL6 genetic background. The nucleoside analog Brd U was inj.cted i.p. in male Casp8+/?int and Casp8?int animals 4 h, 20 h, or 40 h before performing morphometric studies. Locations of anti-Brd U-immunostained cells(cellmax) in at least 50 hemi-crypts of 6 histoanatomically distinct intestinal mucosal regions were numbered and extracted for statistical procedures. For the mice cohort(n = 28), the walking distance of enterocytes was evaluated from cellmax within crypt(n = 57), plateau(n = 19), and villus(n = 172) positions, resulting in a total of 6838 observations. Data analysis was performed by fitting a three-level mixed effects modelto the ***: In cell culture experiments with Caco2 cells, Casp8 knockdown efficiency mediated by RNA interference on Casp8 transcripts was 80% controlled as determined by Western blotting. In the scratch assay, migration of Casp8-deleted Caco2 cells was significantly diminished when compared with controls(Casp8?scramble and Caco2). In Brd U-labeled Casp8?int mice, cellmax locations were found along the hemi-crypts in a lower position than it was for Casp8+/?int or control(cre-negative) animals. Statistical data analysis with a three-level mixed effects model revealed that in the six different intestinal locations(distinct segments of the small and large intestine), cell movement between the three mice groups differed widely. Especially in duodenal hemi-crypts, enterocyte movement w

关键词： Barrier function Caspase 8 Cell migration Inflammatory bowel disease Intestinal morphogenesis

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核聚变:瞄准安全和环境目标

国际原子能机构通报 1995年第4期37卷 22-25页

作者： Franz-nikolaus Flakus j.hn C.Cleveland T.j.Dolan IAEA核安全司 IAEA核能司 IAEA物理和化学科学处物理科

几十年来,人们一直在注意那个为太阳提供能量的过程——核聚变,把它看作地球能源问题的一个解决方案。核聚变能否满足我们的期望还有待观察:聚变电站设计者面对的技术问题是复杂的,至今尚未建造一座聚变电站。然而,已在实现聚变潜力方... 详细信息

几十年来,人们一直在注意那个为太阳提供能量的过程——核聚变,把它看作地球能源问题的一个解决方案。核聚变能否满足我们的期望还有待观察:聚变电站设计者面对的技术问题是复杂的,至今尚未建造一座聚变电站。然而,已在实现聚变潜力方面取得了显著的进展。

关键词：聚变电站等离子体约束核聚变环境目标聚变反应堆安全性基本安全标准放射性同位素托卡马克安全分析