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Effect of Artemisia annua (Asteraceae) Extracts on Hemolysis in Individuals with G6PD-Deficiency

Journal of Biosciences and Medicines 2024年第3期12卷 303-315页

作者： Jescica Bonarck Sohou casimir Jiras Kpego Ligan Salomon Ezechiel Mahougnon Fiogbe Thierry Comlan Marc Medehouenou Fifame Esperance Elvire Kougnimon casimir dewanou akpovi Unité de Recherche sur les Maladies Non Transmissibles et le Cancer (UR-MNTC) Laboratoire de Recherche en Biologie Appliquée Ecole Polytechnique d’Abomey-Calavi University of Abomey-Calavi Cotonou Benin

Individuals with Glucose-6-phosphate dehydrogenase (G6PD) deficiency are susceptible to hemolytic anemia when exposed to pro-oxidant substances. This study investigates the hemolytic impact of Artemisia annua (A. annua) extracts in G6PD-deficient subjects through a mixed experimental approach. In the in vitro phase, red blood cells from G6PD-deficient individuals and rats induced with Dehydroepiandrosterone (DHEA) were exposed to various concentrations of A. annua infusion, with distilled water and physiological saline as positive and negative controls respectively. The in vivo study involved G6PD-deficient Wistar rats divided into three groups receiving A. annua infusion, quinine (positive control), and distilled water (negative control) via gavage. Blood samples were collected for biochemical and hematological analyses. Notably, at a 40% concentration of A. annua infusion, there was a significant increase in the hemolysis rate of G6PD-deficient red blood cells compared to controls (p A. annua exhibited elevated aspartate aminotransferase (129.25 ± 4.55 U/L vs. 80.09 ± 4.03 U/L;p A. annua infusion tested positive for saponins. These findings underscore the risk of hemolysis in G6PD-deficient individuals upon ingesting A. annua.

关键词： Artemisia annua Infusion Saponins G6PD Deficiency Hemolysis

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Phytochemical Screening, Antioxidant Activity and Safety of Petroselinum crispum (Mill.) AW Hill Apiaceae Leaves Grown in Benin

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Open Journal of Applied Sciences 2023年第1期13卷 36-50页

作者： Germaine Sènandjro Gnintoungbe Thierry C. Marc Medehouenou Ferdinand Adounkpe casimir akpovi Frédéric Loko Unité de Recherche sur les Maladies Non Transmissibles et le Cancer (UR-MNTC) Laboratoire de Recherche en Biologie Appliquée Ecole Polytechnique d’Abomey-Calavi Université d’Abomey-Calavi Cotonou Bénin Laboratoire National des Stupéfiants et de Toxicologie (LNST) Centre Béninois de la Recherche Scientifique et de l’Innovation (CBRSI) Université d’Abomey-Calavi (UAC) Cotonou Bénin

Petroselinum crispum (Mill.) AW Hill Apiaceae (Parsley) is a plant species commonly used for its culinary value, but little is known about its phytochemical composition and antioxidant properties. This study aimed to deepen knowledge of the Petroselinum crispum leaves (LPc) grown and consumed in Benin. The phytochemical screening of the LPc powder was done according to the method of Houghton and Raman at the Laboratory of Pharmacognosy and Essential Oils of the Institute of Applied Biomedical Sciences in Benin. The antioxidant activity (IC50) was evaluated by the DPPH reduction test. Phytochemical screening revealed the presence of chemical groups such as catechin tannins, gallic tannins, flavones, saponins, mucilages, coumarins, reducing agents and O-heterosides with reduced genins in the LPc powder. The aqueous extract of LPc showed antioxidant activity with an IC50 = 63.66 μg/mL and was found to be less active than ascorbic acid (IC50 = 0.111 μg/mL). No acute oral toxicity was observed and the LD50 of the aqueous extract of LPc is estimated to be greater than 5000 mg/kg in the Wistar rat. The absence of toxicity, its antioxidant activity associated with its richness in active ingredients makes Petroselinum crispum a promising species suitable for safe long-term use as food.

关键词： Parsley Phytochemistry Antioxidant Properties Toxicity Wistar Rat

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Phytochemical Screening, Antioxidant Activity and Safety of Petroselinum crispum (Mill.) AW Hill Apiaceae Leaves Grown in Benin

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Open Journal of Applied Sciences（应用科学） 2023年第1期

作者： Germaine Sènandjro Gnintoungbe Thierry C. Marc Medehouenou Ferdinand Adounkpe casimir akpovi FrédéricLoko

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