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Bayesian optimization with active learning of design constraints using an entropy-based approach

2003年

作者： Michael D. johnson

来源：畅想之星图书光盘版（南... 畅想之星图书光盘版（南... 评论

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npj Computational Materials 2023年第1期9卷 1866-1879页

作者： Danial Khatamsaz Brent Vela Prashant Singh Duane D.johnson Douglas Allaire Raymundo Arróyave J.Mike Walker’66 Department of Mechanical Engineering Texas A&M UniversityCollege StationTX 77843USA Department of Materials Science and Engineering Texas A&M UniversityCollege StationTX 77843USA Ames Laboratory U.S.Department of EnergyIowa State UniversityAmesIA 50011USA Department of Materials Science&Engineering Iowa State UniversityAmesIA 50011USA Department of Industrial and Systems Engineering Texas A&M UniversityCollege StationTX 77843USA

The design of alloys for use in gas turbine engine blades is a complex task that involves balancing multiple objectives and *** alloys must be ductile at room temperature and retain their yield strength at high temperatures,as well as possess low density,high thermal conductivity,narrow solidification range,high solidus temperature,and a small linear thermal expansion *** Integrated Computational Materials Engineering(ICME)methods are not sufficient for exploring combinatorially-vast alloy design spaces,optimizing for multiple objectives,nor ensuring that multiple constraints are *** this work,we propose an approach for solving a constrained multi-objective materials design problem over a large composition space,specifically focusing on the Mo-Nb-Ti-V-W system as a representative Multi-Principal Element Alloy(MPEA)for potential use in next-generation gas turbine *** approach is able to learn and adapt to unknown constraints in the design space,making decisions about the best course of action at each stage of the *** a result,we identify 21 Pareto-optimal alloys that satisfy all *** proposed framework is significantly more efficient and faster than a brute force approach.

关键词： alloys solidification alloy

Photocatalytic degradation of the dye sulforhodamine-B: A comparative study of different light sources

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Journal of Environmental Sciences 2007年第1期19卷 97-102页

作者： FANG Yan-fen HUANG Ying-ping LIU De-fu HUANG Yang GUO Wei DAVID johnson Center for Ecologic and Environmental Science Three Gorges University Yichang 443000 China Department of Chemistry and Environment Sciences Ferrum College VA 24088 USA

The photocatalytic degradation of dye pollutant sulforhodamine-B （SRB） in aqueous titanium dioxide （TiO2） dispersions was examined under three lighting regimes： UV light （330 nm〈λ〈 380 nm）, sunlight, and visible light （λ〉450 nm）, all investigated at pH=2.5. Total organic carbon （TOC） and chemical oxygen demand （CODer） assays show that the degradation rate of SRB is much higher when irradiated with UV and sunlight compared with visible light. The temporal concentration changes of SRB illustrated a first-order reaction and the rate constant, k, is 0.197 min^-1, 0.152 min^-1, 0.027 min^-1, respectively, under the three lighting conditions. The final mineralized products were amine compounds identified by infrared spectrophotometry. When irradiated with visible light, the photocatalytic degradation rate could be improved by lowering the H2O2 concentration and inhibited by increasing the H2O2 concentration, but results contrary to the above were obtained when UV light was used for irradiation.

关键词： TiO2 photocatalytic degradation sulforhodamine-B (SRB)

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Genetics on early onset inflammatory bowel disease:An update

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Genes & Diseases 2020年第1期7卷 93-106页

作者： johnson Nameirakpam Rashmi Rikhi Sanjay Singh Rawat Jyoti Sharma Deepti Suri Pediatric Allergy and Immunology Unit Department of PediatricsAdvanced Pediatrics CentrePostgraduate Institute of Medical Education and ResearchChandigarhIndia

Inflammatory bowel disease(IBD)is more common in adults than in *** of IBD before 17 years of age is referred as pediatric onset IBD and is further categorized as very early onset IBD(VEO-IBD)for children who are diagnosed before 6 years of age,infantile IBD who had the disease before 2 years of age and neonatal onset IBD for children less than 28 days of *** presenting with early onset disease may have a monogenic *** and awareness of the clinical manifestations facilitates early evaluation and *** generation sequencing is helpful in making the genetic *** of childhood IBD is difficult;targeted therapies and hematopoietic stem cell transplantation form the *** this review we aim to summarize the genetic defects associated with IBD *** describe genetic location and functions of various genetic defect associated with VEO-IBD with their key clinical *** also provide clinical clues to suspect these conditions and approaches to the diagnosis of these disorders and suitable treatment options.

关键词： Il-10 signalling defect IPEX Next generation sequencing Targeted therapy Very early onset inflammatory bowel disease

Bolstering functionality in multilayer and bilayer WS2 via focused laser micro-engraving

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Science China(Information Sciences) 2023年第6期66卷 94-101页

作者： Si Min CHAN Eng Tuan POH Jin Feng LEONG Kuan Eng johnson GOH Chorng Haur SOW Department of Physics National University of Singapore Institute of Materials Research and Engineering Agency for ScienceTechnology and Research (A~*STAR) Division of Physics and Applied Physics School of Physical and Mathematical SciencesNanyang Technological University

Laser thinning of multilayer transition metal dichalcogenide(TMD)crystals has long been explored for its potential to produce localized domains of optically functional monolayers. Despite the high spatial control and resolution of the laser, the range of appropriate applications for these laser-thinned domains is still limited by the peripheral regions of unaltered thick multilayers. Herein, we report a newfound property of the laser-thinned regions to adhere strongly to the underlying substrate when lasered down to the monolayer limit. Upon a brief sonication in various solvents, the surrounding pristine multilayers can be lifted off, solely leaving behind the post-lasered monolayer patterns. Coupled with the flexible maneuver of the laser, various monolayer designs can be achieved, including micro-antenna, waveguide, and electrode geometries with lateral line widths at 1.5 μm resolution. Furthermore, we also detail the optical properties of the monolayers obtained from laser thinning, with those acquired from multilayers containing more defectbound excitons, whereas those lasered from bilayers presenting a trion-dominated profile similar to as-grown monolayers. Together, these findings allow for faster and more efficient multilayer removal and areal shaping of optically active monolayer domains, in comparison to multistep and complex standard lithographic etching(lithography–etch–develop)procedures.

关键词： WS$_2$ monolayer micro-patterning focused laser sonication lift-off

Near shore waves,long-shore currents and sediment transport along micro-tidal beaches,central west coast of India

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International Journal of Sediment Research 2014年第03期29卷 402-413页

作者： Sajiv Philip CHEMPALAYIL V.Sanil KUMAR G.Udhaba DORA Glejin johnson CSIR-National Institute of Oceanagraphy Dona PaulaGoaIndia

Coastlines are undergoing constant geomorphologic changes with respect to the incident wave *** on waves measured at 9 m water depth,simulation of near shore wave transformation is done using REFDIF-1numerical model and the near shore breaker parameters are estimated at two micro-tidal beaches along central west coast of *** results are validated with measured *** the breaker parameters,long-shore current and long-shore sediment transport rates(LSTR) are computed by using semi-empirical *** long-shore current and LSTR are showing dramatic variations with respect to *** direction of LSTR is observed towards north since the approach waves are from south-west direction during pre-monsoon and post *** monsoon season,waves are from west south-west and resulted in southerly *** estimated annual net and gross LSTR by Cambridge Environmental Research Consultants(CERC) at two locations are in the same order whereas LSTR estimated by Walton & Bruno and Kamphuis equations are showing different estimations because of difference in surf-zone width and foreshore slope between the two *** micro-tidal beaches with length less than 6 km,Kamphuis equation is giving agreeable estimation of *** analysis of LSTR estimate shows that coastal inclination is the prominent factor in determining LSTR than incident wave angle.

关键词： Near-shore sedimentation Littoral zone Wave refraction Wave measurement Coastal zone management Karnataka coast

STUDIES ON SYNTHESIS, STRUCTURE AND REACTIVITY OF ACTIVATED Os_6 RAFT-LIKE CLUSTERS

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Science China Chemistry 1990年第4期33卷 385-392页

作者：刘家础 B.F.G.johnson J.LEWIS Fujian Institute of Research on the Structure of Matter Academia Sinica Fuzhou 350002PRC University Chemical Laboratory Lensfield Road Cambridge CB2 1EW U K

In this paper we report the synthesis and activation of OS-6 raft-llke planar clusters. The activated OS-66 raft-like clusters [OS-66(CO)_(20)(MeCN)] and [OS-66(CO)_(19) (MeCN)_2] have been prepared by involving PdCl_2 as catalyst. Trimethylamine oxide (Me_3NO) has been used as an activation reagent to oxidize several carbonyl ligands coordinated in the activated clusters and to get a series of activated OS-66 raft-like clusters [OS-66(CO)_(21-x)(MeCN)_x] (n = 1--5) and corresponding substituted clusters [OS-66(CO)_(21-x)(P(OMe)_3)_x] (n=1--5). The structures of these OS-66 raft-like clusters have been characterized by the infrared spectra (IR), nuclear magnetic resonance spectra (NMR) and mass spectra (MS), and the characters of the raft-like planar structure and reactivity above have also been discussed in this paper.

关键词： Os raft-like clusters coupling reaction aetivation.

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Primary mucosa-associated lymphoid tissue lymphoma of the liver: A report of two cases and review of the literature

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World Journal of Hepatology 2017年第3期9卷 155-160页

作者： Ifeyinwa E Obiorah Lynt johnson Metin Ozdemirli Department of Pathology Medstar Georgetown University Hospital Department of Surgery Medstar Georgetown University Hospital

Mucosa-associated lymphoid tissue(MALT) lymphoma of the liver is a very rare condition and thus the diag-nosis may be challeng-ing-. The clinical presentation is usually variable, rang-ing- from minimal clinical symptoms to severe end stag-e liver disease. In this paper, we describe the clinicopatholog-ic finding-s in two cases of primary hepatic MALT lymphoma. One case is an 80-year-old female with no underlying- chronic liver disease and the second case is a 30-year-old female with autoimmune hepatitis complicated by MALT lymphoma. In both specimens, there was diffuse infiltration of atypical B-lymphocytes that were positive for CD20 and CD79 a, but neg-ative for CD5, CD43 and CD10. There were occasional lymphoepithelial lesions involving- the hepatocytes or bile ducts. Polymerase chain reaction analysis showed monoclonal immunog-lobulin heavy chain g-ene rearrang-ement in both cases. The first case was treated with surg-ery but developed pulmonary recurrence a year after complete resection but went into remission following- treatment with rituximab. A second recurrence occurred in the rig-ht parotid g-land 7 years later, which was treated with idelalisib. The second case was effectively treated with rituximab. To our knowledg-e, the second case is the first reported case linked to autoimmune hepatitis.

关键词： Extranodal Mucosa-associated lymphoid tissue Lymphoepithelial Lymphoma Polymerase chain reaction

Clinical features of alcoholic hepatitis in latinos and caucasians: A single center experience

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World Journal of Gastroenterology 2017年第40期23卷 7274-7282页

作者： Rogelio Pinon-Gutierrez Blythe Durbin-johnson Charles H Halsted Valentina Medici Division of Gastroenterology and Hepatology Department of Internal Medicine University of California Davis Division of Biostatistics University of California Davis Department of Public Health Sciences

AIM To study differences of presentation, management, and prognosis of alcoholic hepatitis in Latinos compared to Caucasians. METHODS We retrospectively screened 876 charts of Caucasian and Latino patients who were evaluated at University of California Davis Medical Center between 1/1/2002-12/31/2014 with the diagnosis of alcoholic liver disease. We identified and collected data on 137 Caucasians and 64 Latinos who met criteria for alcoholic hepatitis, including chronic history of heavy alcohol use, at least one episode of jaundice with bilirubin ≥ 3.0 orcoagulopathy, new onset of liver decompensation or acute liver decompensation in known cirrhosis within 12 wk of last drink. RESULTS The mean age at presentation of alcoholic hepatitis was not significantly different between Latinos and Caucasians. There was significant lower rate of overall substance abuse in Caucasians compared to Latinos and Latinos had a higher rate of methamphetamine abuse(12.5% vs 0.7%) compared to Caucasians. Latinos had a higher mean number of hospitalizations(5.3 ± 5.6 vs 2.7 ± 2.7, P = 0.001) and mean Emergency Department visits(9.5 ± 10.8 vs 4.5 ± 4.1, P = 0.017) for alcohol related issues and complications compared to Caucasians. There was significantly higher rate of complications of portal hypertension including gastrointestinal bleeding(79.7% vs 45.3%, P < 0.001), spontaneous bacterial peritonitis(26.6% vs 9.5%, P = 0.003), and encephalopathy(81.2% vs 55.5%, P = 0.001) in Latinos compared to *** Latinos have significant higher rates of utilization of acute care services for manifestations alcoholic hepatitis and complications suggesting poor access to outpatient care.

关键词： Alcoholic hepatitis Latino Hispanic Caucasian Alcoholic liver disease

COVID-19 in early 2021: current status and looking forward

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Signal Transduction and Targeted Therapy 2021年第4期6卷 1128-1141页

作者： Chengdi Wang Zhoufeng Wang Guangyu Wang johnson Yiu-Nam Lau Kang Zhang Weimin Li Department of Respiratory and Critical Care Medicine National Clinical Research Center for GeriatricsFrontiers Science Center for Disease-related Molecular NetworkWest China HospitalWest China Medical SchoolSichuan UniversityChengduChina School of Information and Communication Engineering Beijing University of Posts and TelecommunicationsBeijingChina Department of Applied Biology and Chemical Technology Hong Kong Polytechnic UniversityHong KongChina Center for Biomedicine and Innovations Faculty of MedicineMacao University of Science and Technologyand University HospitalMacaoChina

Since the first description of a coronavirus-related pneumonia outbreak in December 2019,the virus SARS-CoV-2 that causes the infection/disease(COVID-19)has evolved into a pandemic,and as of today,>100 million people globally in over 210 countries have been confirmed to have been infected and two million people have died of *** brief review summarized what we have hitherto learned in the following areas:epidemiology,virology,and pathogenesis,diagnosis,use of artificial intelligence in assisting diagnosis,treatment,and vaccine *** there are a number of parallel developments in each of these areas and some of the development and deployment were at unprecedented speed,we also provided some specific dates for certain development and milestones so that the readers can appreciate the timing of some of these critical *** note is the fact that there are diagnostics,antiviral drugs,and vaccines developed and approved by a regulatory within 1 year after the virus was *** a number of developments were conducted in parallel,we also provided the specific dates of a number of critical events so that readers can appreciate the evolution of these research data and our *** world is working together to combat this *** review also highlights the research and development directions in these areas that will evolve rapidly in the near future.

关键词： diagnosis epidemiology looking