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Redefining pandemic preparedness:Multidisciplinary insights from the CERP modelling workshop in infectious diseases,workshop report

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Infectious Disease Modelling 2024年第2期9卷 501-518页

作者： Marta C.Nunes Edward Thommes Holger Fröhlich Antoine Flahault Julien Arino Marc Baguelin Matthew Biggerstaff Gaston Bizel-Bizellot Rebecca Borchering Giacomo Cacciapaglia Simon Cauchemez Alex Barbier--Chebbah carsten Claussen Christine Choirat Monica Cojocaru Catherine Commaille-Chapus Chitin Hon Jude Kong Nicolas Lambert Katharina B.Lauer Thorsten Lehr Cédric Mahe Vincent Marechal Adel Mebarki Seyed Moghadas Rene Niehus Lulla Opatowski Francesco Parino Gery Pruvost Andreas Schuppert Rodolphe Thiébaut Andrea Thomas-Bachli Cecile Viboud Jianhong Wu Pascal Crépey PascalCrepey Center of Excellence in Respiratory Pathogens(CERP) Hospices Civils de Lyon(HCL)and Centre International de Recherche en Infectiologie(CIRI)Équipe SantéPubliqueÉpidémiologie etÉcologieÉvolutive des Maladies Infectieuses(PHE3ID)Inserm U1111CNRS UMR5308ENS de LyonUniversitéClaude Bernard Lyon 1LyonFrance South African Medical Research Council Vaccines&Infectious Diseases Analytics Research UnitFaculty of Health SciencesUniversity of the WitwatersrandJohannesburgSouth Africa New Products and Innovation(NPI) Sanofi Vaccines(Global)TorontoOntarioCanada Department of Mathematics and Statistics University of GuelphGuelphOntarioCanada Fraunhofer Institute for Algorithms and Scientific Computing(SCAI) Department of BioinformaticsSchloss BirlinghovenSankt AugustinGermany University of Bonn Bonn-Aachen International Center for IT(b-it)BonnGermany Institute of Global Health Faculty of MedicineUniversity of GenevaGenevaSwitzerland and Swiss School of Public HealthZürichSwitzerland Department of Mathematics University of ManitobaWinnipegManitobaCanada MRC Centre for Global Infectious Disease Analysis School of Public HealthImperial College LondonLondonUK Centre for Mathematical Modelling of Infectious Diseases Department of Infectious Disease EpidemiologyLondon School of Hygiene&Tropical MedicineLondonUK National Center for Immunization and Respiratory Diseases(NCIRD) US Centers for Disease Control and Prevention(CDC)AtlantaGAUSA Departement of Computational Biology Departement of Global HealthInstitut PasteurParisFrance Institut de Physique des Deux Infinis de Lyon(IP2I) UMR5822IN2P3/CNRSUniversitéClaude Bernard Lyon 1VilleurbanneFrance Mathematical Modelling of Infectious Diseases Unit Institut PasteurUniversitéParis CitéUMR2000 CNRSParisFrance Decision and Bayesian Computation Institut PasteurUniversitéParis CitéCNRS UMR 3571France Fraunhofer-Institute for Translational Medicine and Pharmacology HamburgGermany Institute of Global Health Faculty of MedicineUniversity of

In July 2023,the Center of Excellence in Respiratory Pathogens organized a two-day workshop on infectious diseases modelling and the lessons learnt from the Covid-19 *** report summarizes the rich discussions that occurred during the *** workshop participants discussed multisource data integration and highlighted the benefits of combining traditional surveillance with more novel data sources like mobility data,social media,and wastewater *** advancements were noted in the development of predictive models,with examples from various countries showcasing the use of machine learning and artificial intelligence in detecting and monitoring disease *** role of open collaboration between various stakeholders in modelling was stressed,advocating for the continuation of such partnerships beyond the pandemic.A major gap identified was the absence of a common international framework for data sharing,which is crucial for global pandemic ***,the workshop underscored the need for robust,adaptable modelling frameworks and the integration of different data sources and collaboration across sectors,as key elements in enhancing future pandemic response and preparedness.

关键词： Modelling Covid-19 Infectious diseases Pandemic preparedness Workshop

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NK cell detachment from target cells is regulated by successful cytotoxicity and influences cytokine production

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Cellular & Molecular Immunology 2020年第4期17卷 347-355页

作者： Moritz Anft Petra Netter Doris Urlaub Isabel Prager Samantha Schaffner carsten Watzl IfADo-Leibniz Research Centre for Working Environment and Human Factors Technical University DortmundDortmundGermany University of British Columbia VancouverBCCanada

Natural killer(NK)cells participate in early immune defenses against pathogens and tumors and play a major role as immune effector and regulatory *** NK cell-mediated elimination of an infected or cancerous cell is a highly regulated process that requires the formation of a cell contact,the establishment of an immunological synapse and the polarization and release of lytic ***,the detachment of NK cells from target cells is important for NK cells to bind and kill other cells in a process called serial ***,very little is known about this detachment ***,we show that NK detachment is directly connected to the successful killing of a target *** inhibition of killing due to reduced NK cell cytotoxicity or increased target cell resistance results in defective detachment and prolonged contact *** effect leads to sustained Ca^(2+) flux in NK cells and the hypersecretion of proinflammatory *** defective cytotoxicity with enhanced cytokine secretion via reduced detachment may explain inflammatory pathologies in several diseases.

关键词： Cellular cytotoxicity immunological synapse adhesion

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One decade(2011–2020)of European agricultural water stress monitoring by MSG-SEVIRI:workflow implementation on the Virtual Earth Laboratory(VLab)platform

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International Journal of Digital Earth 2022年第1期15卷 730-747页

作者： Bagher Bayat carsten Montzka Alexander Graf Gregory Giuliani Mattia Santoro Harry Vereecken Institute of Bio-and Geosciences:Agrosphere (IBG-3) Forschungszentrum Jülich GmbHJülichGermany Institute for Environmental Sciences EnviroSPACE labUniversity of GenevaGenevaSwitzerland Institute of Atmospheric Pollution Research National Research Council of Italy (CNR)Sesto FiorentinoItaly

Cloud computing facilities can provide crucial computing support for processing the time series of satellite data and exploiting their spatio-temporal information ***,dedicated efforts are still required to develop workflows,executable on cloud-based platforms,for ingesting the satellite data,performing the targeted processes,and generating the desired *** this study,an operational workflow is proposed,based on monthly Evaporative Stress Index(ESI)anomaly,and implemented in cloud-based online Virtual Earth Laboratory(VLab)platform,as a demonstration,to monitor European agricultural water *** this end,daily time-series of actual and reference evapotranspiration(ETa and ET0),from the Spinning Enhanced Visible and Infrared Imager(SEVIRI)sensor,were used to execute the proposed workflow successfully on *** execution of the workflow resulted in obtaining one decade(2011–2020)of European monthly agricultural water stress maps at 0.04˚spatial resolution and corresponding stress reports for each *** support open science,all the workflow outputs are stored in GeoServer,documented in GeoNetwork,and made available through *** enables creating a dashboard for better visualization of the results for *** results from this study demonstrate the capability of VLab platform for water stress detection from time series of SEVIRI-ET data.

关键词： ET SEVIRI ESI water stress workflow Europe VLab demonstration

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UV-LED projection photolithography for high-resolution functional photonic components

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Microsystems & Nanoengineering 2021年第4期7卷 149-159页

作者： Lei Zheng Urs Zywietz Tobias Birr Martin Duderstadt Ludger Overrmeyer Bernhard Roth carsten Reinhardt Hannover Centre for Optical Technologies Leibniz University HannoverHannoverLower Saxony 30167Germany Cluster of Excellence PhoenixD(Photonics Opticsand Engineering-Innovation Across Disciplines)HannoverLower Saxony 30167Germany Laser Zentrum Hannover e.V HannoverLower Saxony 30167Germany Institute of Transport and Automation Technology Leibniz University HannoverGarbsenLower Saxony 30823Germany Bremen University of Applied Science BremenBremen 28199Germany

The advancement of micro-and nanostructuring techniques in optics is driven by the demand for continuous miniaturization and the high geometrical accuracy of photonic devices and integrated ***,UV-LED projection photolithography is demonstrated as a simple and low-cost approach for rapid generation of two-dimensional optical micro-and nanostructures with high resolution and accuracy using standard optics *** developed system enables the projection of structure patterns onto a substrate with 1000-fold *** devices,e.g.,waveguides and microring resonators,on rigid or flexible substrates with varied geometrical complexity and overall structure dimensions from the nanometer to centimeter scale were successfully *** particular,high-resolution gratings with feature sizes down to 150 nm and periods as small as 400 nm were realized for the first time by this *** made of doped laser active materials were fabricated,and their spontaneous emission was *** demonstrated superior performance of the developed approach may find wide applications in photonics,plasmonics,and optical materials science,among others.

关键词： projection resolution optics

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Monitoring of central corneal thickness after phacoemulsification—comparison of statical and rotating Scheimpflug pachymetry,and spectral-domain OCT

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International Journal of Ophthalmology(English edition) 2022年第8期15卷 1266-1272页

作者： Daniel M.Handzel carsten H.Meyer Alfred Wegener Augenaerzte im Altstadt-Carree Fulda 36037Germany University Eye Hospital Philipps-UniversitätMarburg 35032Germany University Eye Hospital Rheinische Friedrich-WilhelmsUniveritätBonn 53124Germany

AIM:To explore the possibility of deploying three contactless devices(static and rotating Scheimpflug technology,spectral domain optical coherence tomography)for measuring central corneal thickness(CCT)in preoperative and postoperative examinations of cataract ***:Totally 72 patients who had undergone surgery without complications were *** CCT was measured prior to the operation,as well as on the first,5th-7th and 28th day following the operation using the Nidek NT 530-P,Sirius?,and Topcon OCT-2000 ***:A significant postoperative increase and subsequent decrease in CCT was identified with all three *** correlations were highly significant and thus reflect a very good degree of comparability at all times with the exception of the rotating Scheimpflug *** postoperative results from the latter differed significantly from the other *** correlations were Sirius/Topcon(P=0.010)and Sirius/Nidek(P<0.0005).No statistically significant difference could be identified in the comparison between Topcon and Nidek(P=0.056).CONCLUSION:All three devices are suitable for postoperative monitoring of *** measurement results are only comparable to a limited extent and not interchangeable in the course of treating a single *** is due to the different imaging technology used in the devices and the resulting modalities for conducting the measurements.

关键词： cataract surgery pachymetry corneal thickness Scheimpflug imaging optical coherence tomography

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Nafion/polypyrrole and Nafion/DMSO Organic Coatings for Magnesium Protection

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Journal of Materials Science & Technology 2007年第1期 141-143页

作者： carsten Blawert Wolfgang Dietzel Center for Magnesium Technology Institute of Materials ResearchGKSS-Forschungszentrum Geesthacht GmbHMax-Planck Straβe 1D-21502 GeesthachtGermany

Nafion/polypyrrole and Nafion/Dimethysulfoxid (DMSO) organic coatings were prepared on the surface of pure magnesium by simple immersion and heat treatment. The morphologies and corrosion resistance of the organic coatings were investigated by using optical microscopy and electrochemical corrosion testing, respectively. It is shown that Nafion/polypyrrole organic coatings resulted in the corrosion resistance of magnesium decreasing; while Nafion/DMSO organic coatings can effectively improve the corrosion resistance of magnesium. Also, the corrosion resistance increased with the thickness of the Nafion/DMSO organic coating increased.

关键词： Magnesium Naflon/polypyrrole organic coatings Nafion/DMSO organic coatings Corrosion resistance

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A computational fluid dynamics model for wind simulation:model implementation and experimental validation

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2012年第4期13卷 274-283页

作者： Zhuo-dong ZHANG Ralf WIELAND Matthias REICHE Roger FUNK carsten HOFFMANN Yong LI Michael SOMMER Institute of Soil Landscape Research Leibniz-Centre for Agricultural Landscape Research(ZALF)Muencheberg 15374Germany Institute of Landscape System Analysis Leibniz-Centre for Agricultural Landscape Research(ZALF)Muencheberg 15374Germany Institute of Agricultural Environment and Sustainable Development Chinese Academy of Agricultural Sciences(CAAS)Beijing 100081China Institute of Earth and Environmental Science University of PotsdamPotsdam 14476Germany

To provide physically based wind modelling for wind erosion research at regional scale, a 3D computational fluid dynamics (CFD) wind model was developed. The model was programmed in C language based on the Navier-Stokes equations, and it is freely available as open source. Integrated with the spatial analysis and modelling tool (SAMT), the wind model has convenient input preparation and powerful output visualization. To validate the wind model, a series of experiments was con- ducted in a wind tunnel. A blocking inflow experiment was designed to test the performance of the model on simulation of basic fluid processes. A round obstacle experiment was designed to check if the model could simulate the influences of the obstacle on wind field. Results show that measured and simulated wind fields have high correlations, and the wind model can simulate both the basic processes of the wind and the influences of the obstacle on the wind field. These results show the high reliability of the wind model. A digital elevation model (DEM) of an area (3800 m long and 1700 m wide) in the Xilingele grassland in Inner Mongolia (autonomous region, China) was applied to the model, and a 3D wind field has been successfully generated. The clear imple- mentation of the model and the adequate validation by wind tunnel experiments laid a solid foundation for the prediction and assessment of wind erosion at regional scale.

关键词： Wind model Computational fluid dynamics (CFD) Wind erosion Wind tunnel experiments Spatial analysis andmodelling tool (SAMT) Open source

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Teriflunomide provides protective properties after oxygen-glucose-deprivation in hippocampal and cerebellar slice cultures

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Neural Regeneration Research 2021年第11期16卷 2243-2249页

作者： Anna Wolters Judith Reuther Philipp Gude Thomas Weber carsten Theiss Heike Vogelsang Veronika Matschke Institute of Anatomy Department of CytologyMedical FacultyRuhr University BochumBochumGermany Department of Anaesthesiology and Intensive Care Medicine Ruhr University BochumSt.Josef HospitalBochumGermany

One of the major challenges in emergency medicine is out-of-hospital cardiac arrest(OHCA).Every year,about 53–62/100000 people worldwide suffer an out-of-hospital cardiac arrest with serious consequences,whereas persistent brain injury is a major cause of morbidity and mortality of those surviving a cardiac ***,only few and insufficient strategies are known to limit neurological damage of ischemia and reperfusion *** aim of the present study was to investigate whether teriflunomide,an approved drug for treatment of relapsing-remitting-multiple-sclerosis,exerts a protective effect on brain cells in an in vitro model of ***,organotypic slice cultures from rat hippocampus and cerebellum were exposed to oxygen-glucose-deprivation and subsequently treated with *** administration of teriflunomide in the reperfusion time on both hippocampal and cerebellar slice cultures significantly decreased the amount of detectable propidium iodide signal compared with an untreated culture,indicating that more cells survive after ***,hippocampal slice cultures showed a higher vulnerability to ischemic conditions and a more sensitive response to teriflunomide compared with cerebellar slice *** study suggests that teriflunomide,applied as a post-treatment after an oxygenglucose-deprivation,has a protective effect on hippocampal and cerebellar cells in organotypic slice cultures of *** procedures were conducted under established standards of the German federal state of North Rhine Westphalia,in accordance with the European Communities Council Directive 2010/63/EU on the protection of animals used for scientific purposes.

关键词： brain damage cardiac arrest cell death hypoxic chamber ischemia organotypic slice cultures post-treatment resuscitation

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Assessing hydrological and provisioning ecosystem services in a case study in Western Central Brazil

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Ecological Processes 2014年第1期3卷 248-262页

作者： Lars Koschke carsten Lorz Christine Fürst Tobias Lehmann Franz Makeschin Department of Soil Science and Site Ecology Dresden University of TechnologyPienner Str.1901737 TharandtGermany Faculty for Woods and Forestry Forest PedologyGeology and Site EcologyHochschuleWeihenstephan-TriesdorfUniversity of Applied SciencesFreisingGermany Center for Development Research Department of Ecology and Natural Resources ManagementUniversity of BonnWalter-Flex-Str.353113 BonnGermany

Introduction:Current land use in the Federal District,Western Central Brazil,causes problems related to the water supply which are linked to the regulation of ecosystem services(ES).In scope of an Integrated Water Resources Management concept,we further developed the web-based planning support tool GISCAME for the Pipiripau river basin case ***:We introduced analyses on ecosystem potentials in the raster-based tool to assess,in a spatially explicit manner,the scenario impact on water purification,sediment retention,water retention,and provision of food and fodder in order to identify potential pathways for conserving water *** demonstrate the method,we assess ES depending on a number of land use/land cover change(LULCC)***:We found that a considerable increase of water purification and sediment retention is difficult to achieve with realistic small scale LULCC,mainly because in areas with a low potential to provide hydrological ES and thus with a high demand for sustainable land use,such as native Savanna(Cerrado)and natural forests(Mata),favorable land uses were often already *** observed synergies in the response of regulating hydrological ES to LULCC but at the same time also trade-offs with provision of food and ***:Our findings suggest that further degradation and loss of Cerrado and Mata must be avoided and their restoration should be promoted in order to safeguard water *** suggest that restoration measures should be focused on arable land located at steep slopes near surface waters to effectively increase hydrological ES through the marginal reduction of provision services.

关键词： services retention provision

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Effects of progesterone on T-type-Ca^(2+)-channel expression in Purkinje cells

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Neural Regeneration Research 2022年第11期17卷 2465-2471页

作者： Annika Eickhoff Jonas Tjaden Sarah Stahlke Matthias Vorgerd Verena Theis Veronika Matschke carsten Theiss Department of Cytology Institute of AnatomyRuhr-University BochumBochumGermany Department of Neurology Neuromuscular Center RuhrgebietUniversity Hospital BergmannsheilRuhr-Universität BochumBochumGermany

Plasticity of cerebellar Purkinje cells(PC)is influenced by progeste rone via the classical progeste rone receptors PR-A and PR-B by stimulating dendritogenesis,spinogenesis,and synaptogenesis in these *** PC cultures were used to analyze progeste rone effects at a molecular level on the voltage-gated T-type-Ca^(2+)-channels Ca_(v)3.1,Ca_(v)3.2,and Ca_(v)3.3 as they helped determine neuronal plasticity by regulating Ca^(2+)-influx in neuronal *** results showed direct effects of progesterone on the mRNA expression of T-type-Ca^(2+)-channels,as well as on the protein kinases A and C being involved in downstream signaling pathways that play an important role in neuronal *** the mRNA expression studies of T-type-Ca^(2+)-channels and protein kinases of the signaling cascade,laser microdissection and purified PC cultures of diffe rent maturation stages were *** staining was also performed to characte rize the localization of T-type-Ca^(2+)-channels in *** rimental progesterone treatment was performed on the purified PC culture for 24 and 48 *** results show that progesterone increases the expression of Ca_(v)3.1 and Ca_(v)3.3 and associated protein kinases A and Cin PC at the mRNA level within 48 hours after treatment at *** effects extend the current knowledge of the function of progesterone in the central nervous system and provide an explanatory approach for its influence on neuronal plasticity.

关键词： Ca_(v)3.1 Ca_(v)3.2 Ca_(v)3.3 neuronal plasticity progesterone protein kinase A protein kinase C Purkinje cells rat cerebellum T-type-Ca^(2+)-channels

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