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Thinking beyond Opisthorchis viverrini for risk of cholangiocarcinoma in the lower Mekong region:a systematic review and meta-analysis

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Infectious Diseases of Poverty 2018年第1期7卷 427-439页

作者： Jennifer A.Steele carsten H.Richter Pierre Echaubard Parichat Saenna Virginia Stout Paiboon Sithithaworn Bruce A.Wilcox Department of Infectious Disease and Global Health Tufts UniversityCummings School of Veterinary MedicineNorth GraftonMAUSA Global Health Asia Integrative Education and Research ProgrammeFaculty of Public HealthFaculty of Public Health StudiesBangkokThailand Center for Mountain Ecosystem Studies Kunming Institute of BotanyChinese Academy of SciencesKunmingChina Department of Biology Laurentian UniversityGreater SudburyONCanada Department of Science Education Khon Kaen UniversityFaculty of EducationKhon KaenThailand Department of Parasitology Khon Kaen UniversityFaculty of MedicineKhon KaenThailand

Background:Cholangiocarcinoma(CCA)is a fatal bile duct cancer associated with infection by the liver fluke,Opisthorchis viverrini,in the lower Mekong *** public health interventions have focused on reducing exposure to ***,but incidence of CCA in the region remains *** this may indicate the inefficacy of public health interventions due to complex social and cultural factors,it may further indicate other risk factors or interactions with the parasite are important in pathogenesis of *** systematic review aims to provide a comprehensive analysis of described risk factors for CCA in addition to *** to guide future integrative *** body:We searched five international and seven Thai research databases to identify studies relevant to risk factors for CCA in the lower Mekong *** studies were assessed for risk of bias and quality in terms of study design,population,CCA diagnostic methods,and statistical *** final 18 included studies reported numerous risk factors which were grouped into behaviors,socioeconomics,diet,genetics,gender,immune response,other infections,and treatment for *** risk factors were reported by two or more studies and were assessed with random effects models during *** meta-analysis indicates that the combination of alcohol and smoking(OR=11.1,95%CI:5.63-21.92,P<0.0001)is most significantly associated with increased risk for CCA and is an even greater risk factor than *** *** analysis also suggests that family history of cancer,consumption of raw cyprinoid fish,consumption of high nitrate foods,and praziquantel treatment are associated with significantly increased *** risk factors may have complex relationships with the host,parasite,or pathogenesis of CCA,and many of these risk factors were found to interact with each other in one or more ***:Our findings suggest that a complex variety of risk factors in ad

关键词： Cholangiocarcinoma Risk factors Opisthorchis viverrini Mekong Southeast Asia Thailand Public health

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Calibrating partial factors for Danish railway embankments using probabilistic analyses

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Journal of Rock Mechanics and Geotechnical Engineering 2014年第2期6卷 150-155页

作者： Michael R.Lodahl Kristian T.Brdbk carsten S.Srensen COWI A/S

High costs are connected with upgrading railway embankments throughout Denmark using the partial factors for geotechnical design calibrated for general application. One way to reduce the costs is reliability-based calibration of the partial factors to a reasonable safety level taking into account the specific design situations and uncertainties relevant to railway embankments. A reliability-based design has been investigated, resulting in an optimal partial factor for the considered subsoil. With a stochastic soil model to simulate the undrained shear strength of soft soil deposits, the partial factor is calibrated using asymptotic sampling for the reliability assessment. The calibration shows that the partial factor can be reduced significantly compared to the value specified in the Danish National Annex to DS/EN 1997-1 （2007）, Eurocode 7.

关键词： Railway embankment Reliability index Partial factor Stochastic soil modelling

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Defective claudin-10 causes a novel variation of HELIX syndrome through compromised tight junction strand assembly

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Genes & Diseases 2022年第5期9卷 1301-1314页

作者： Sebastian Sewerin Jorg Piontek Ria Schonauer Sonja Grunewald Angelika Rauch Steffen Neuber carsten Bergmann Dorothee Gunzel Jan Halbritte Division of Nephrology University of Leipzig Medical CenterLeipzig 04103Germany Clinical Physiology/Nutritional Medicine Charitee Universitatsmedizin BerlinBerlin 12203Germany Division of Dermatology Venereologyand AllergologyUniversity of Leipzig Medical CenterLeipzig 04103Germany Division of Prosthodontics and Materials Science University of Leipzig Medical CenterLeipzig 04103Germany Center for Human Genetics BioscientiaIngelheim 55218Germany f Medizinische Genetik MainzLimbach GeneticsMainz 55128Germany

Formation of claudin-10 based tight junctions(TJs)is paramount to paracellular Na+transport in multiple *** variants in CLDN10 have been linked to HELIX syndrome,a salt-losing tubulopathy with altered handling of divalent cations accompanied by dysfunctional salivary,sweat,and lacrimal ***,we investigate molecular basis and phenotypic consequences of a newly identified homozygous CLDN10 variant that translates into a single amino acid substitution within the fourth transmembrane helix of *** addition to hypohidrosis(H),electrolyte(E)imbalance with impaired urine concentrating ability,and hypolacrimia(L),phenotypic findings include altered salivary electrolyte composition and amelogenesis imperfecta but neither ichthyosis(I)nor xerostomia(X).Employing cellular TJ reconstitution assays,we demonstrate perturbation of cis-and trans-interactions between mutant claudin-10 *** of reconstituted TJ strands show disturbed continuity and reduced abundance in the mutant ***,both major isoforms,claudin-10a and claudin-10b,are differentially affected with claudin-10b showing more severe molecular ***,expression of the mutant in renal epithelial cells with endogenous TJs results in wild-type-like ion selectivity and conductivity,indicating that aberrant claudin-10 is generally capable of forming functional paracellular ***,mutant proteins prove pathogenic by compromising claudin-10 TJ strand *** ex vivo investigations indicate their insertion into TJs to occur in a tissue-specific manner.

关键词： Claudin-10 HELIX syndrome Paracellular transport Salt-losing tubulopathy Tight junction

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NOD2/CARD15 gene polymorphism in patients with inflammatory bowel disease: Is Hungary different?

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World Journal of Gastroenterology 2005年第3期11卷 407-411页

作者： carsten Büning Tomas Molnar Ferenc Nagy Janos Lonovics Renita Weltrich Bettina Bochow Janine Genschel Hartmut Schmidt Herbert Lochs Department of Gastroenterology Department of Medicine

AIM: To analyse the impact of NOD2/CARD15 mutations on the clinical course of Crohn 's disease patients from an eastern European country (Hungary). METHODS: We investigated the prevalence of the three common NOD2/CARD15 mutations (Arg702Trp, Gly908Arg, 1007finsC) in 148 patients with Crohn's disease, 128 patients with ulcerative colitis and 208 controls recruited from the University of Szeged, Hungary. In patients with Crohn 's disease, the prevalence of NOD2/CARD15 mutations was correlated to the demographical and clinical parameters. RESULTS: In total, 32.4% of Crohn's disease patients carried at least one mutant allele within NOD2/CARD15 compared to 13.2% of patients with ulcerative colitis (P = 0.0002) and to 11.5% of controls (P

关键词： Crohn's disease NOD2/CARD15 gene Mutation

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Continuous cardiac output measured with a Swan-Ganz catheter reacts too slowly in animal experiments with sudden circulatory failure

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Animal Models and Experimental Medicine 2022年第3期5卷 258-265页

作者： Sigríður Olga Magnúsdóttir carsten Simonsen Bodil Steen Rasmussen Peter Enemark Lund Benedict Kjærgaard Biomedical Research Laboratory Aalborg University HospitalAalborgDenmark Department of Clinical Medicine Aalborg UniversityAalborgDenmark Department of Cardiothoracic Surgery Aalborg University HospitalAalborgDenmark Department of Anesthesia and Intensive Care Aalborg University HospitalAalborgDenmark Unit of Clinical Biostatistics Aalborg University HospitalAalborgDenmark

Background : In many animal experiments, it is vital to detect sudden changes in cardiac output(CO). This porcine study compared CO that was measured with a SwanGanz pulmonary catheter with the gold standard(which was a transit-time flow probe around the pulmonary artery) during interventions that caused hemodynamic *** : In one series, 7 pigs were exposed to sudden changes in CO. In another series, 9 pigs experienced more prolonged changes in CO. All the pigs had a Swan-Ganz catheter placed into the pulmonary artery and a flow probe around the pulmonary artery. Adrenaline infusion and controlled hemorrhage were used to increase and decrease CO, respectively. The measurements of CO before and after each intervention were compared for correlation, agreement, and the time delay that it took each method to detect at least a 30% change in CO. A Bland– Altman test was used to identify correlations and agreements between the *** : In the first series, there was a delay of 5– 7 min for the Swan Ganz catheter to register a 30% change in cardiac output, compared with the flow probe. However,during prolonged changes in CO in the second series, there was a good correlation between the 2 methods. Mixed venous oxygen saturation reacted faster to changes than did CO;both were measured via the Swan-Ganz *** : In many animal studies, the use of Swan-Ganz catheters is suitable;however, in experiments with sudden hemodynamic instability, the flow probe is the most advantageous method for measuring CO.

关键词： cardiac output flow probe hemodynamics pigs Swan-Ganz catheter

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Risk prediction models for biochemical recurrence after radical prostatectomy using prostate-specific antigen and Gleason score

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Asian Journal of Andrology 2014年第6期16卷 897-901页

作者： Xin-Hai Hu Henning Cammann Hellmuth-A Meyer Klaus Jung Hong-Biao Lu Natalia Levas Ahmed Magheli carsten Stephan Jonas Busch Department of Urology Charite - Universitatsmedizin Berlin Berlin Germany Institute of Medical Informatics Charite - Universitatsmedizin Berlin Berlin Germany Berlin Institute for Urologic Research Berlin Germany Department of Urology Changzhou No. 2 People's Hospital Changzhou China Stanford University School of Medicine Stanford CA USA.

Many computer models for predicting the risk of prostate cancer have been developed including for prediction of biochemical recurrence （BCR）. However, models for individual BCR free probability at individual time-points after a BCR free period are rare. Follow-up data from 1656 patients who underwent laparoscopic radical prostatectomy （LRP） were used to develop an artificial neural network （ANN） to predict BCR and to compare it with a logistic regression （LR） model using clinical and pathologic parameters, prostate-specific antigen （PSA）, margin status （RO/1）, pathological stage （pT）, and Gleason Score （GS）. For individual BCR prediction at any given time after operation, additional ANN, and LR models were calculated every 6 months for up to 7.5 years of follow-up. The areas under the receiver operating characteristic （ROC） curve （AUC） for the ANN （0.754） and LR models （0.755） calculated immediately following LRP, were larger than that for GS （AUC： 0.715; P= 0.0015 and 0.001）, pT or PSA （AUC： 0.619; Palways 〈0.0001） alone. The GS predicted the BCR better than PSA （P = 0.0001）, but there was no difference between the ANN and LR models （P = 0.39）. Our ANN and LR models predicted individual BCR risk from radical prostatectomy for up to 10 years postoperative. ANN and LR models equally and significantly improved the prediction of BCR compared with PSA and GS alone. When the GS and ANN output values are combined, a more accurate BCR prediction is possible, especially in high-risk patients with GS ≥7.

关键词： artificial neural network prostate cancer recurrence

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Recirculating IL-1R2^(+) Tregs fine-tune intrathymic Treg development under inflammatory conditions

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Cellular & Molecular Immunology 2021年第1期18卷 182-193页

作者： Eirini Nikolouli Yassin Elfaki Susanne Herppich carsten Schelmbauer Michael Delacher Christine Falk Ilgiz A.Mufazalov Ari Waisman Markus Feuerer Jochen Huehn Department of Experimental Immunology Helmholtz Centre for Infection ResearchBraunschweigGermany Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-University MainzMainzGermany Regensburg Center for Interventional Immunology(RCI) Chair for ImmunologyUniversity Regensburg and University Hospital RegensburgRegensburgGermany Institute of Transplant Immunology Integrated Research and Treatment Center TransplantationIFB-TxHannover Medical SchoolHannoverGermany Hannover Medical School HannoverGermany

The vast majority of Foxp3^(+)regulatory T cells(Tregs)are generated in the thymus,and several factors,such as cytokines and unique thymic antigen-presenting cells,are known to contribute to the development of these thymus-derived Tregs(tTregs).Here,we report the existence of a specific subset of Foxp3^(+)Tregs within the thymus that is characterized by the expression of IL-1R2,which is a decoy receptor for the inflammatory cytokine *** flow cytometric analysis of the thymocytes from Foxp3^(hCD2)xRAG1^(GFP) reporter mice revealed that the IL-1R2^(+)Tregs are mainly RAG1^(GFP-)and CCR6^(+)CCR7^(-),demonstrating that these Tregs are recirculating cells entering the thymus from the periphery and that they have an activated *** the spleen,the majority of IL-1R2^(+)Tregs express neuropilin-1(Nrp-1)and Helios,suggesting a thymic origin for these ***,among all tissues studied,the highest frequency of IL-1R2^(+)Tregs was observed in the thymus,indicating preferential recruitment of this Treg subset by the *** fetal thymic organ cultures(FTOCs),we demonstrated that increased concentrations of exogenous IL-1β blocked intrathymic Treg development resulting in a decreased frequency of CD25^(+)Foxp3^(+)tTregs and an accumulation of CD25^(+)Foxp3^(-)Treg ***,the addition of IL-1R2^(+)Tregs,but not IL-1R2^(+)Tregs,to reaggregated thymic organ cultures(RTOCs)abrogated the IL-1β-mediated blockade,demonstrating that these recirculating IL-1R2^(+)Tregs can quench IL-1 signaling in the thymus and thereby maintain thymic Treg development even under inflammatory conditions.

关键词： Thymus Treg development Inflammation IL-1 system

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Cardiovascular Involvement in Chronic Hepatitis C Virus Infections - Insight from Novel Antiviral Therapies

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Journal of Clinical and Translational Hepatology 2018年第2期6卷 161-167页

作者： Wolfgang Poller Arash Haghikia Mario Kasner Ziya Kaya Udo Bavendiek Heiner Wedemeier Hans-Jorg Epple carsten Skurk Ulf Landmesser Department of Cardiology CC11 Charite Campus Benjamin FranklinCharite-Universitatsmedizin BerlinBerlinGermany German Center for Cardiovascular Research(DZHK)Site Berlin BerlinGermany German Center for Cardiovascular Research(DZHK)Site Heidelberg HeidelbergGermany Department of Cardiology University HospitalHeidelbergGermany Department of Cardiology MHHHannoverGermany Department of Gastroenterology MHHHannoverGermany Department of Gastroenterology Infectiology and RheumatologyCC 13Charite Campus Benjamin FranklinCharite-Universitatsmedizin BerlinBerlinGermany

Whereas statistical association of hepatitis C virus(HCV)infection with cardiomyopathy is long known,establishment of a causal relationship has not been achieved so *** with advanced heart failure(HF)are mostly unable to tolerate interferon(IFN)-based treatment,resulting in limited experi-ence regarding the possible pathogenic role of HCV in this patient *** infection often triggers disease in a broad spectrum of extrahepatic organs,with innate immune and autoimmune pathogenic processes *** fact that worldwide more than 70 million patients are chronically infected with HCV illustrates the possible clinical impact arising if cardiomyopathies were induced or aggravated by HCV,resulting in progressive HF or severe arrhythmias.A novel path has been opened to finally resolve the long-standing question of cause-effect relationship between HCV infection and cardiac dysfunction,by the recent development of IFN-free,highly efficient,and well tolerable anti-HCV *** new direct-acting antiviral(DAA)agents are highly virus-specific and lack unspecific side-effects upon cardiac function which have always confounded the interpret-tation of IFN treatment *** actual frequency of un-explained HF in chronic HCV infection will be determined from a planned large-scale *** such patients probably constitute a rather small fraction of all those harboring HCV,they have major clinical *** is not yet known which fraction of these patients will significantly benefit from HCV eradication,but this issue will be addressed now in a prospective study.

关键词： Autoimmunity Cardiovascular immunity Cardiomyopathies Hepatitis C virus Antiviral therapies

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Peripheral retinal non-perfusion and treatment response in branch retinal vein occlusion

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International Journal of Ophthalmology(English edition) 2016年第6期9卷 858-862页

作者： Kaveh Abri Aghdam Lukas Reznicek Mostafa Soltan Sanjari carsten Framme Anna Bajor Annemarie Klingenstein Marcus Kernt Florian Seidensticker Department of Ophthalmology University Eye HospitalMedical School of Hannover Carl-Neuberg-Straβe 1Hannover 30625 Germany Department of Ophthalmology Ludwig Maximilians University Mathildenstr. 8 Munich 80336 Germany Eye Research Center Rassoul Akram Hospital lranUniversity of Medical Sciences Sattarkhan-Niayesh StreetTehran 14456-13131 Iran

AIM： To evaluate the association between the size of peripheral retinal non-perfusion and the number of intravitreal ranibizumab injections in patients with treatment-naive branch retinal vein occlusion （BRVO） and macular edema. METHODS： A total of 53 patients with treatment-naive BRVO and macular edema were included. Each patient underwent a full ophthalmologic examination including optical coherence tomography （OCT） imaging and ultra wide-field fluorescein angiography （UWFA）. Monthly intravitreal ranibizumab injections were applied according to the recommendations of the German Ophthalmological Society. Two independent, masked graders quantified the areas of peripheral retinal non-perfusion. RESULTS： Intravitreal injections improved bestcorrected visual acuity （BCVA） significantly from 22.23± 16.33 Early Treatment of Diabetic Retinopathy Study （ETDRS） letters to 36.23 ±15.19 letters （P〈0.001）, and mean central subfield thickness significantly reduced from 387±115 pm to 321±115 μm （P=0.01）. Mean number of intravitreal ranibizumab injections was 3.61±1.56. The size of retinal non-perfusion correlated significantly with the number of intravitreal ranibizumab injections （R= 0.724, P〈0.001）. CONCLUSION： Peripheral retinal non-perfusion in patients with BRVO associates significantly with intravitreal ranibizumab injections in patients with BRVO and macular edema.

关键词： angiography branch retinal vein occlusion non-perfusion retina wide-field

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Endoscopic ultrasound-fine needle biopsies of pancreatic lesions: Prospective study of histology quality using Franseen needle

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World Journal of Gastroenterology 2020年第37期26卷 5693-5704页

作者： Petros Stathopoulos Anika Pehl Lutz Philipp Breitling Christian Bauer Tobias Grote Thomas Mathias Gress carsten Denkert Ulrike Walburga Denzer Department of Gastroenterology EndocrinologyMetabolism and Clinical InfectiologyUniversity Hospital MarburgMarburg 35043HessenGermany Institute of pathology University Hospital MarburgMarburg 35043HessenGermany

BACKGROUND The introduction of fine needle biopsies(FNB)to clinical practice presents a changing trend towards histology in the endoscopic ultrasound-guided tissue acquisition(EUS-TA).AIM To evaluate the clinical performance of a new FNB needle,the 22-gauge(22G)Franseen needle,when sampling pancreatic solid *** Consecutive patients with an indication for EUS-TA for the assessment of pancreatic solid lesions were included in this prospective,single-center,singlearm *** patient underwent a puncture of the lesion two times using the 22G Franseen needle and the obtained samples were directly placed into formalin for histological *** primary study endpoint was the rate of high-quality obtained *** endpoints included the length and diameter of the core specimen,the diagnostic accuracy and the complication *** From June 2017 to December 2018,forty patients with pancreatic solid lesions(22 females;mean age 67.2 years)were *** acquisition was achieved in all ***-quality histology,rated with Payne score 3,was obtained in 37/40 cases(92.5%)after two needle *** mean size of the acquired histological core tissue was 1.54 mm×0.39 *** diagnostic accuracy for the correct diagnosis was 85%(34/40).Only one adverse event was occurred,consisting of a self-limiting bleeding in the puncture *** The 22G Franseen needle achieved according to our standardized protocol a high rate of histological core procurement,and a high diagnostic accuracy,with one minor adverse event reported.

关键词： Endosonography Fine needle biopsy Histology Pancreatic lesions Franseen needle

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