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Diagnosis of intraductal papillary mucinous neoplasm using endoscopic ultrasound guided microbiopsies:A case report

World Journal of Gastrointestinal Endoscopy 2018年第7期10卷 125-129页

作者： Charlotte Vestrup Rift Bojan Kovacevic John Gásdal Karstensen Julie Plougmann Pia Klausen Anders Toxvaerd Evangelos Kalaitzakis carsten palnaes hansen Jane Preuss Hasselby Peter Vilmann Department of Pathology Copenhagen University Hospital RigshospitaletCopenhagen 2100Denmark Gastro Unit Division of EndoscopyCopenhagen University Hospital Herlev and GentofteHerlev 2730Denmark Gastro Unit Division of SurgeryCopenhagen University HospitalHvidovre2650 HvidovreDenmark Department of Pathology Copenhagen University Hospital Herlev and GentofteHerlev 2730Denmark Department of Gastrointestinal surgery Copenhagen University Hospital RigshospitaletCopenhagen 2100Denmark

Pancreatic cysts are increasingly diagnosed due to expanding use of cross-sectional imaging,but current diagnostic modalities have limited diagnostic ***,a novel through-the-needle microbiopsy forceps has become available,offering the possibility of obtaining cyst-wall *** present a case of 41-year-old male with chronic pancreatitis and a 2-cm pancreatic cyst,initially considered a ***,endoscopic ultrasou-nd guided microbiopsies were successfully obtained,which surprisingly revealed an intraductal papillary mucinous neoplasm of mixed subtype with low grade *** conclusion,obtaining biopsies from the wall of the pancreatic cystic lesions with this novel instrument is feasible and,as demonstrated in this case,can possibly alter the clinical *** offered enough cellular material,allowing supplemental gene mutation analysis,which combined with other modalities could lead to a more individual approach when treating pancreatic ***,prospective studies are warranted before routine clinical implementation.

关键词： Microbiopsy Pancreatic cyst Endoscopic ultrasound-fine needle aspiration Intraductal papillary mucinous neoplasm Chronic pancreatitis

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Initial joint bleed volume in a delayed on-demand treatment setup correlates with subsequent synovial changes in hemophilic mice

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Animal Models and Experimental Medicine 2020年第2期3卷 160-168页

作者： Kare Kryger Vols Mads Kjelgaard-hansen carsten Dan Ley Axel Kornerup hansen Maj Petersen Global Drug Discovery Novo Nordisk A/SMaaloevDenmark Veterinary and Animal Sciences University of CopenhagenFrederiksbergDenmark Veterinary Clinical Sciences University of CopenhagenFrederiksbergDenmark

Background: Hemophilic arthropathy is a debilitating morbidity of hemophilia caused by recurrent joint bleeds. We investigated if the joint bleed volume, before initiation of treatment, was linked to the subsequent degree of histopathological changes and the development of bone pathology in a mouse model of hemophilic ***: FVIII knock-out(F8-KO) mice were dosed with a micro-CT blood pool agent prior to induction of hemarthrosis. Eight hours after induction, the bleed volume was quantified with micro computed tomography(micro-CT) and recombinant FVIII treatment initiated. On Day 8, inflammation in the knees was characterized by fluorescence molecular tomography. On Day 14, knee pathology was characterized by micro-CT and histopathology. In a second study, contrast agent was injected into the knee of wild-type(WT) mice, followed by histopathological evaluation on Day ***: The average joint bleed volume before treatment was 3.9 mm3. The inflammation-related fluorescent intensities in the injured knees were significantly increased on Day 8. The injured knees had significantly increased synovitis scores, vessel counts, and areas of hemosiderin compared to un-injured knees. However, no cartilage-or bone pathology was observed. The bleed volume before initiation of treatment correlated with the degree of synovitis and was associated with high fluorescent intensity on Day 8. In F8-KO and WT mice, persistence of contrast agent in the joint elicited morphological ***: When applying a delayed on-demand treatment regimen to hemophilic mice subjected to an induced knee hemarthrosis, the degree of histopathological changes on Day 14 reflected the bleed volume prior to initiation of treatment.

关键词： Animal models arthropathy hemarthrosis haemophilia A in vivo imaging micro-CT

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Engineered SPIONs functionalized with endothelin a receptor antagonist ameliorate liver fibrosis by inhibiting hepatic stellate cell activation

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Bioactive Materials 2024年第9期39卷 406-426页

作者： Marit ten Hove Andreas Smyris Richell Booijink Lydia Wachsmuth Uwe hansen Lejla Alic Cornelius Faber carsten Hӧltke Ruchi Bansal Personalized Diagnostics and Therapeutics Department of Bioengineering TechnologiesTechnical Medical CentreFaculty of Science and TechnologyUniversity of TwenteEnschedethe Netherlands Clinic of Radiology University Hospital MuensterMuensterGermany Institute for Musculoskeletal Medicine University Hospital MuensterMuensterGermany Department of Magnetic Detection and Imaging Technical Medical CentreFaculty of Science and TechnologyUniversity of TwenteEnschedethe Netherlands

Endothelin-1/endothelin A receptor(ET-1/ETAR)pathway plays an important role in the progression of liver fibrosis by activating hepatic stellate cells(HSCs)-a key cell type involved in the pathogenesis of liver *** HSCs by blocking the ET-1/ETAR pathway using a selective ETAR antagonist(ERA)represents a promising therapeutic approach for liver ***,small-molecule ERAs possess limited clinical potential due to poor bioavailability,short half-life,and rapid renal *** improve the clinical applicability,we conjugated ERA to superparamagnetic iron-oxide nanoparticles(SPIONs)and investigated the therapeutic efficacy of ERA and ERA-SPIONs in vitro and in vivo and analyzed liver uptake by in vivo and ex vivo magnetic resonance imaging(MRI),HSCs-specific localization,and ET-1/ETAR-pathway antagonism in *** murine and human liver fibrosis/cirrhosis,we observed overexpression of ET-1 and ETAR that correlated with HSC activation,and HSC-specific localization of *** and successfully synthesized ERA-SPIONs demonstrated significant attenuation in TGFβ-induced HSC activation,ECM production,migration,and *** an acute CCl4-induced liver fibrosis mouse model,ERA-SPIONs exhibited higher liver uptake,HSC-specific localization,and ET-1/ETAR pathway *** resulted in significantly reduced liver-to-body weight ratio,plasma ALT levels,andα-SMA and collagen-I expression,indicating attenuation of liver *** conclusion,our study demonstrates that the delivery of ERA using SPIONs enhances the therapeutic efficacy of ERA in *** approach holds promise as a theranostic strategy for the MRI-based diagnosis and treatment of liver fibrosis.

关键词： Endothelin A receptor SPIONs Hepatic stellate cells Liver fibrosis

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A Modified Treatment Failure Classification System with Complete and Exhaustive Accounting of Any Adverse Events Related to the Previous Percutaneous Coronary Intervention

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World Journal of Cardiovascular Diseases 2014年第9期4卷 405-415页

作者： Anders MGalloe Jorgen LJeppesen Soren Boesgaard John Godtfredsen Niels Bligaard Jens FLassen Henning Kelbaek Anders Junker Jan Ravkilde Peter Riis hansen carsten TLarsen Ghita BStephansen Ulrik Abildgaard Department of Cardiology Copenhagen University HospitalRoskildeDenmark Department of Medicine Copenhagen University HospitalGlostrupDenmark Department of Cardiology Copenhagen University HospitalRigshospitaletDenmark Department of Cardiology Copenhagen University HospitalHerlevDenmark Department of Cardiology Copenhagen University HospitalGentofteDenmark Department of Cardiology Aarhus University HospitalSkejbyDenmark Department of Cardiology Odense University HospitalDenmark Department of Cardiology Aalborg University HospitalDenmark

Objectives: To determine the clinical outcome related to treatment failure of the percutaneous coronary intervention (PCI) itself. Background: When considering the addition of PCI to the medical treatment of angina, it is necessary to know the balance between the benefit and the risk of the PCI itself, but the latter remains unknown. The usual outcome measures are imprecise because they contain events unrelated to the previous PCI and because some events clearly caused by PCI treatment failures are omitted. Methods: In total, 2098 unselected patients were randomized to receive either sirolimus-(n = 1065) or paclitaxel-(n = 1033) eluting coronary stents and followed for five years in the SORT OUT II. Any death, cardiac death, myocardial infarction (MI), stent thrombosis and documented stenosis was classified and combined to a “patient oriented clinical outcome” (POCO), the classical “major adverse cardiac events” (MACE) and the new “PCI-treatment oriented clinical outcome” (TOCO). Results: POCO occurred in 746 patients (35.6%), MACE in 467 patients (22.3%) and TOCO in 293 patients (14.0%), thus TOCO amounted to 39% of the POCO and to 63% of the MACE. Conclusion: By introduction of the present PCI treatment failure classification system, the clinical outcome of PCI-treatment itself may be credulously estimated by the rate of TOCO and eventually PCI is substantially better than what might be perceived from the classically used POCO and MACE rates.

关键词： PCI Angina Clinical Outcome

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音乐屋——奥尔堡创意中心

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城市环境设计 2020年第4期126卷 174-185页

作者：沃尔夫·狄·普瑞克斯 Marcelo Bernardi Jesper Bork Bo Stjerne hansen Roberta Jiraschek Daniel Krüger carsten Laursen Martin Oberascher Florian Pfeifer Robert Pippan Marita Schnepper Sigrid Svensson Eva Wolf Carola B?ker Moa Carlson Isak Foged Annina G?hwiler Patricia Gola Robin Heather Per Kruse Win Man Ruth Mandl Aline Müller Tenna Olsen Anke Pasolt Annemarie Pedersen Eva Ravnborg Carolin Schmitz-Remberg Tim Seidl Guro Sollid Michele Zanella Jan-Ruben Fischer Markus Pillhofer Markus Baumann Robin Heather Anja Sorger Bo Stjerne Thomsen Anna Wasserthal Philip Wilck Blaine Lepp Talya Kozminsky Hannes Walzl Morten Grau Jensen Stephanie Neufeld Tyler Bornstein Laura Githa Julia G?rtner Jenny Draxlbauer Duccio Malagamba Martin Schubert

项目大事记/CHRONOLOGY竞赛（第一名）/Competition （1st Place）:2003一期规划设计/Layout Planning Ho M I:2003—2005项目延期/Postponement of the Project:2006—2007二期规划设计/Start of Layout Planning Ho M II:2008二期动工/Start of Construction Ho M II:2010二期竣工/Completion Ho M II:2014项目参数/PROJECT DATA建筑净面积/Net Floor Area:17 637m2建筑毛面积/Gross Floor Area:20 257m2音乐厅/Concert Hall:1 298座/1 289 Seats

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